Medical Radiology and Radiation Safety. 2014. Vol. 59. No. 3. P. 39-44

RADIATION THERAPY

A.O. Rasulov, D.V. Kuzmichev, S.I. Tkachev, V.F. Tsaryuk, S.S. Gordeyev, A.G. Perevoschikov, V.V. Glebovskaya, A.V. Polinovskiy

Factors of Chemoradiotherapy Efficacy of Localized Rectal Cancer

N.N. Blokhin Canser Research Center of RAMS, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: Factors of treatment response after chemoradiotherapy with fluorpyrimidines and radiosensitizers are discussed.

Methods: 137 patients, who received 5×5 Gy chemoradiotherapy were included in this study. A multifactor analysis was performed regarding the impact of sex, age, tumor histology, tumor size, treatment scheme, tumor stage (II or III) and time to surgery on tumor regression.

Results: No significant association was observed in investigated factors and grade III–IV treatment response. There was only low correlation between time to surgery and tumor regression.

Conclusions: We observed no impact of investigated factors on tumor regression. Complete and near-complete tumor regression in our study was associated with absence of local recurrences and distant metastases.

Key words: colorectal cancer, combined treatment, chemoradiotherapy, tumor regression