Medical Radiology and Radiation Safety. 2013. Vol. 58. No. 2. P. 62-68

RADIATION THERAPY

O.P. Trofimova, S.I. Tkachev, Z.P. Mikhina, Yu.I. Pryamikova, N.P. Shipilina, O.S. Zaichenko, I.V. Kolyadina, A.M. Malishev

The Addition of a Boost Dose on the Primary Tumor Bed after Breast Conserving Treatment for Breast Cancer Patients

N.N. Blokhin Russian Cancer Research Center of RAMS, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: To increase the radiation therapy efficacy in breast cancer patients.

Material and methods: Investigation includes 438 patients with verified breast cancer. All patients received breast conserving treatment within period of 2000–2012, including breast conserving surgery ± systemic therapy – 58 pt.; breast conserving surgery ± systemic therapy+ whole breast irradiation (50 Gy) – 313 pt.; breast conserving surgery ± systemic therapy+ whole breast irradiation (50 Gy) + boost dose on the primary tumor bed (10–16 Gy) – 72 pt.

Results: Local relapse after breast conserving surgery ± systemic therapy – 24.5 %; after breast conserving surgery ± systemic therapy+ whole breast irradiation (50 Gy) – 5.8 % (p < 0.05); after breast conserving surgery ± systemic therapy+ whole breast irradiation (50 Gy) + boost dose on the primary tumor bed (10–16 Gy) – 2.7 %.

Conclusion: The addition of a boost dose on the primary tumor bed after breast conserving treatment for breast cancer patients decrease local recurrences.

Key words: radiotherapy, breast cancer, local recurrens