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The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2019. Vol. 64. No. 2. P. 52–60
DOI: 10.12737/article_5ca5fc2765c9f5.02525917
V.S. Khoroshkov
History and Prospects of Proton Therapy
Institute for Theoretical and Experimental Physics, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
V.S. Khoroshkov – Head of Dep., Dr. Sci. Tech.
Abstract
Purpose: Presentation of the history, status and prospects for the development of proton therapy.
Material and methods: The history of proton therapy (PT) is divided into two periods. The first one – the experimental period lasted since 1954 to 1990, when proton therapy was carried out at the ten facilities in physical institutes. The research accelerators and the horizontal proton beams with a fixed direction are used. The second period is from 1990, when the first clinical proton center was commissioned in a multi-field hospital in the city of Loma Linda, USA. In the first period, the necessary technical tools were developed and the advantages of using accelerated protons in remote radiation therapy formulated by R. Wilson in 1946 were confirmed on a limited (about 9,000) patient population: halving the radiation load on the healthy tissues surrounding the tumor and on the organism as a whole compared to γ- and electron irradiation and high dose gradients at the borders of the dose distributions and the tumors. This allows to increase the dose in the tumor (target), increase the probability of the tumor resorption and at last to irradiate tumors, including small sizes, located near critical organs and structures. By 1990, in three experimental centers in Russia (JINR, ITEP, PNPI) accumulated about 30 % of world clinical experience.
Today, more than 70 multi-cabin and several single-cabin clinical based proton therapy centers operate in the world. Almost all centers are equipped with gantry installations for PT for 95 % of patients. Today proton therapy is indicated and is used for the treatment of 10–15 % of all malignancies of cancer incidence structure.
Results: Healthcare in Russia needs 10–15 multi-cabin proton (and ion) centers. Currently, there are one experimental PT center in the JINR, where up to 100 patients are exposed pea year. The modern proton center was commissioned at the Medical Institute Sergei Berezin in St. Petersburg with two gantry of company Varian. The IBA proton center in Dimitrovgrad is expected. The single-cabin proton complex of domestic production has been operating in Obninsk since 2017. 20th-century technologies and the horizontal beam (without the possibility of its rotation) are used in this complex for treatment of patients with small head and neck tumors.
Conclusion: Equipping the Russian health care facilities with proton therapy facilities is inevitable. Russia will buy them worldwide for decades, like almost all types of high-tech medical equipment, are bought today, or can produce them locally. All the prerequisites needed for production (rich physical – technical experience, scientific and industrial potential) are available.
Key words: proton therapy, cyclotron, synchrotron, gantry, Bragg curve, malignant neoplasm, local tumor control
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For citation: Khoroshkov VS. History and Prospects of Proton Therapy. Medical Radiology and Radiation Safety. 2019;64(2):52-60. (Russian).
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