Medical Radiology and Radiation Safety. 2017. Vol. 62. No. 6. P. 51-57


DOI: 10.12737/article_5a2541849d5335.59531206

Effect of Correction of Gamma-Radiation Absorption in the Study of Myocardial Perfusion by SPECT/CT

E.A. Khachirova1, L.E. Samoylenko2, O.P. Shevchenko1

1. N.I. Pirogov Russian National Research Medical University, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Russian Medical Academy of Postgraduate Education, Moscow, Russia

E.A. Khachirova – assistant; L.E. Samoylenko – Dr. Sc. Med., Prof.; O.P. Shevchenko – Dr. Sc. Med., Prof., Head the Department, Member of the European Society of Cardiology


Purpose: Assessment of the impact of absorption correction (AC) on quantitative parameters of myocardial perfusion and determination of the extent of stress-induced myocardial microcirculation disorders on SPECT/CT in patients with chest pain and unchanged coronary arteries.

Material and methods: the study included 35 patients, each of whom was carried a selective coronary angiography and rest/stress SPECT/CT of the myocardium with 99mTc -MIBI with- and without AC.

Results: In all patients with stress-induced myocardial ischemia was detected both without and with AC images. However, quantitative parameters of myocardial perfusion were lower after the AC: SSS 6.9 ± 1.2 vs. 7.7 ± 1.1; SDS 4.0 ± 0.8 vs. 4.9 ± 0.6; Stress ext. Total 11.2 ± 1.8 vs. 13.0 ± 1.9; Stress TPD total 9.3 ± 1.2 vs.10.9 ± 1.2; TPDi 4.1 ± 1.0 vs.5.9 ± 0.9 (for all p < 0.05). For SRS, Rest ext. Total, and Rest TPD total difference was not significant. The number of hypoperfused segments, according to the segmental analysis, was less after AC and was 126 vs. 153 at rest, 242 vs. 177 under stress. In women, significant difference was obtained for all parameters, for men – only for the SSS, SDS, Stress ext. Total, Stress TPD total. In patients with BMI ≥25 significant difference for all parameters was obtained. However, patients with the normal BMI (18,5–24,9; WHO, 2004) significant difference was obtained only for Stress ext. Total, Stress TPD total.

Conclusion: The use of SPECT/CT with AC allow to detect microcirculatory violations of perfusion and myocardial reserve perfusion in patients with pain in the chest with the unchanged AC, as evidenced by indicators of the average values of quantitative parameters of perfusion scintigram. The most significant impact on the quantitative perfusion parameters was observed in women with well-developed breasts and obese patients. The findings give reason to assume the use of AC to avoid revaluation incidence and severity of stress-induced myocardial perfusion disturbances.

Key words: SPECT/CT, gamma-ray emission, absorption correction, microvascular angina, myocardial perfusion


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For citation: Khachirova EA, Samoylenko LE, Shevchenko OP. Effect of Correction of Gamma-Radiation Absorption in the Study of Myocardial Perfusion by SPECT/CT. Medical Radiology and Radiation Safety. 2017;62(6):51–7. Russifn. DOI: 10.12737/article_5a2541849d5335.59531206

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