Medical Radiology and Radiation Safety. 2025. Vol. 70. № 4
DOI:10.33266/1024-6177-2025-70-4-25-32
E.A. Kodintseva1, A.А. Akleyev2
The Contribution of Effector Cells of the Innate and Adaptive Immunity to the Pathogenesis of Radiation-Induced Carcinogenesis. Review (Part 1)
1 Urals Research Center for Radiation Medicine, Chelyabinsk, Russia
2 Southern-Urals State Medical University, Chelyabinsk, Russia
Contact person: E.A. Kodintseva, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
CONTENTS
Background
1. Components of innate immunity and carcinogenesis
2. Tumor-associated myeloid cells and myeloid-derived suppressor cells
3. Tumor-associated neutrophils
4. Tumor-associated monocytes/macrophages
5. Natural killers of malignant neoplasm microenvironment
6. Conclusion
Keywords: peripheral blood cells, radiation exposure, malignant neoplasms, carcinogenesis, innate immunity, adaptive immunity, intercellular cooperation, radiosensitivity
For citation: Kodintseva EA, Akleyev AА. The Contribution of Effector Cells of the Innate and Adaptive Immunity to the Pathogenesis of Radiation-Induced Carcinogenesis. Review (Part 1). Medical Radiology and Radiation Safety. 2025;70(4):25–32. (In Russian). DOI:10.33266/1024-6177-2025-70-4-25-32
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Conflict of interest. The authors declare no conflict of interest.
Financing. The research work was carried out within the framework of the state assignment of the Federal Medical and Biological Agency of Russia on the topic ‘Study of the functional state of effector cells of human antitumour immunity during the implementation of carcinogenic effects of chronic radiation exposure’ (Agreement on granting a subsidy from the federal budget for financial provision of the state assignment for public services (works) No. 388-03-2025-085 dated 24 January 2025).
Contribution. All authors confirm that their authorship meets the international ICMJE criteria. Kodintseva Е.А. – conceived and designed the study, prepared the first draft of the article, read and approved the final version before publication. Akleуev А.А. – conceived and designed the study, scientific editing, read and approved the final version before publication.
Article received: 20.03.2025. Accepted for publication: 25.04.2025.