Journal Description

JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.

The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Выпуски журналов

CONTENTS № 2 - 2026

View or download the full issue in PDF (Russian)

RADIATION SAFETY	5	Improving Psychophysiological Support of Nuclear Industry Personnel by Integrating Modern Diagnostic Methods Tsarev A.N., Pustovoit V.I.
RADIATION MEDICINE	13	Perculiarities of Post-Irradiation Dynamics of the Absolute Peripheral Blood Neutrophil Count Following the Exposure to Gamma-Neutron Rays in Victims of Criticality Accidents Soloviev V.Yu., Bushmanov A.Yu., Karamullin M.A., Gudkov E.A., Mershin L.Yu., Galstyan I.A., Kretov A.S., Metlyaeva N.A.
	18	Dynamics of Psychological Adaptation in Patients with Acute Radiation Sickness: From the Acute Phase to 15–17 Years after the Chernobyl Accident Kosenkov A.A., Metlyaeva N.A., Goloborodko E.V., Erofeev G.G., Korenkov V.V., Lukyanova S.N.
RADIATION EPIDEMIOLOGY	26	Analysis of Cerebrovascular Disease Incidence Risk in the Cohort of Mayak Production Association Workers Azizova T.V., Moseeva M.B., Grigoryeva E.S.
	33	The Incidence Risk for Primary Glaucoma and Its Subtypes following Chronic Exposure to Ionizing Radiation in the Russian Cohort of Mayak Nuclear Workers Azizova T.V., Bragin E.V., Bannikova M.V., Hamada N., Grigoryeva E.S.
	40	Risk of Angina Pectoris in a Cohort of Nuclear Workers Briks K.V., Azizova T.V., Grigoryeva E.S., Bannikova M.V.
	48	The Offspring of the Liquidators of the Consequences of Mayak PA Accident in 1957: the Cohort Composition Sokolnikova S.S., Kabirova N.R., Okatenko P.V.
	53	Suicide Risk Among Nuclear Workers: Differences for Male and Female are Inverse to Population-Based Results (Synthetic Study). Report 1. Problem Statement, Search for Sources, and Characteristic of the Sample Koterov A.N., Ushenkova L.N., Wainson A.A., Tikhonova O.A., Kretov A.S., Parinov O.V., Lebedev A.O., Bushmanov A.Yu.
NUCLEAR MEDICINE	66	The Necessity of Employing SPECT/CT with ^99mTc-Pertechnetate for Diagnosing Autonomous Thyroid Adenoma in a Specific Patient Tomashevskiy I.O., Shatalova M.O.
	69	Pharmacokinetic Analysis of Accumulation of Gluconic Acid Complexes with ^99mTc and Mn(II) in Gliomas and Metastatic Brain Lesions, using Dynamic Magnetic Resonance Imaging and Single-Photon Emission Computed Tomography Ussov W.Yu., Belyanin M.L., Barysheva E.V., Tulupov A.A., Li Yong Ping, Borodin O.Y., Shan YaMing, Minin S.M., Sorokina K.N., Lishmanov Yu.B., Aleksandrova O.P., Zhou Jianghan Shimanovsky N.L.
	81	Is Dosimetry Necessary in Radionuclide Therapy of Patients with Metastases? Narkevich B.Ya.
RADIATION DIAGNOSTICS	93	Development of Evaluation Criteria for the Radiologist’s Work Function in Interpreting of Magnetic Resonance Imaging Results Matkevich E.I., Udalov Y.D., Rodionova A.O., Vasilieva I.V.
	101	Visual Similarity of Malignant Neoplasms and Alternative Lesions on Human Liver Tomograms Neustroev V.P.
	107	Image Segmentation of Brain Tumors Using K-means Cluster Technique Muaayed F. Al-Rawi, Muhanned AL-Rawi
	115	Role of Ultrasound in Salivary Gland Tumors: a Systematic Review Karthik Shunmugavelu, Evangeline Cynthia Dhinakaran
	122	Reccurent Papillary Necrosis of the Right Kidney in the Setting of Drud-Induced Nephritis: a Case Report on Radiologic Diagnosis Sazhina A.A., Bashkov A.N., Udalov Yu.D., Matkevich E.I., Lischuk S.V.
RADIATION THERAPY	129	Treatment of Total Necrosis of the Vagina with Vulvar Necrosis (Grade Iv) after Chemoradiotherapy of Cervical Cancer Sycheva I.V., Ivanov S.A., Kaprin A.D.
	135	Features of the Effect of Radiation Therapy on the Body in Patients with Breast Cancer (Literature Review) Lyubaeva E.S., Astrelina T.A., Kobzeva I.V., Udalov Yu.D.
RADIATION PHYSICS, TECHNIQUES AND DOSIMETRY	147	Predicting Gamma Passing Rate for Patient Specific Quality Assurance Using Machine and Deep Learning: A Review of Methodological Approaches Smirnova Zh.Zh., Bobrov D.Yu., Zavialov A.A.

Medical Radiology and Radiation Safety. 2026. Vol. 71. № 1

DOI:10.33266/1024-6177-2026-71-1-5-13

D.A. Kiseleva¹, S.V. An’kov¹, N.A. Zhukova¹, M.S. Borisova¹,
K.S. Bogatisheva¹, T.G. Tolstikova¹, M.A. Melchenco^{1, 2}, O.I. Yarovaya^{1, 2}

Radioprotective Effect of Ursolic Acid and Arabinogalactan Compositions in CD-1 Mice after a Single X-Ray Irradiation

¹N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Novosibirsk, Russia

²Novosibirsk State University, Novosibirsk, Russia

Contact person: D.A. Kiseleva, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: Experimental evaluation of radioprotective effects of ursolic acid (UA) and arabinogalactan (AG) compositions in CD-1 mice after a single sub-lethal X-ray irradiation.

Material and methods: The study was conducted on outbred male CD-1 mice weighing 25–30 g. Single total irradiation was performed on X-RAD 320 X-ray at a dose of 5 Gy. Test substances and their compositions in different ratios were administered for two weeks before and four weeks after irradiation. The severity of radiation damage and treatment effects were assessed in dynamics by survival rate, body weight, hematological parameters of blood, histological examination of thymus, heart, liver, spleen, kidneys.

Results: After irradiation with a dose of 5 Gy, the mortality rate of animals in the NC, AG100, AG200, UA:AG100:100, UA:AG50:200, UA:AG100:400 groups were 50 %, in the UA100 group – 40 %, and in the UA:AG100:200 – 30 %. In addition, on the 28th day after irradiation, partial recovery of hematological parameters relative to intact control was observed in the groups UA50, UA100, AG100, AG200, UA:AG100:100, UA:AG50:100, UA:AG100:400. Application of the UA:AG100:200 composition contributed to a statistically significant recovery of leukocytes, erythrocytes and hemoglobin number from the 14th to the 28th day after irradiation in comparison with the negative control group, as well as the recovery on the 28th day after irradiation of all studied hematological blood parameters to the values of intact control. In irradiated animals that received UA individually and in combination with AG, positive dynamics of reparative processes were noted, which were manifested to a greater extent in liver and kidneys.

Conclusion: The inclusion of UА in a composition with AG at a dose of 100:200 mg/kg led to a decrease in the toxic effects of X-ray radiation on CD-1 mice body, namely, positive dynamics of hematological parameters of blood, reparative processes in liver and kidneys, as well as an increase in animal survival of up to 70 % compared with negative controls, which indicates the prospects for further studies of UA compositions effects in comparison with a registered radioprotective drug as a positive control against exposure to ionizing radiation.

Keywords: ursolic acid, arabinogalactan, radioprotective properties, X-ray exposure, mice

For citation: Kiseleva DA, An’kov SV, Zhukova NA, Borisova MS, Bogatisheva KS, Tolstikova TG, Melchenco MA, Yarovaya OI. Radioprotective Effect of Ursolic Acid and Arabinogalactan Compositions in CD-1 Mice after a Single X-Ray Irradiation. Medical Radiology and Radiation Safety. 2026;71(1):5–13. (In Russian). DOI:10.33266/1024-6177-2026-71-1-5-13

References

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3. Васин М.В. Препарат Б-190 (индралин) в свете истории формирования представлений о механизме действия радиопротекторов // Радиационная биология. Радиоэкология. 2020. T.60. C. 378-395 [Vasin M.V. Drug B-190 (Indralin) in Light of the History of the Formation of Ideas about the Mechanism of Action of Radioprotectors. Radiatsionnaya biologiya. Radioekologiya = Radiation Biology. Radioecology. 2020;60:378-395 (In Russ.)]. Doi: 10.31857/S0869803120040128.

4. Dale D.C., Crawford J., Klippel Z., Reiner M., Osslund T., Fan E., Morrow P.K., Allcott K., Lyman G.H. A Systematic Literature Review of The Efficacy, Effectiveness, and Safety of Filgrastim. Support Care Cancer. 2018;26;1:7-20. Doi: 10.1007/s00520-017-3854-x.

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6. Kiseleva D.A., An’Kov S.V., Tolstikova T.G. Ursolic Acid: Sources, Synthesis, Properties, Modifications, Application. Russ J Bioorg Chem. 2025;51;2:508-532. Doi: 10.1134/S1068162024605974.

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PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The work was supported by the Russian Science Foundation (project No. 25-25-00119).

Contribution. Article was prepared with equal participation of the authors.

Article received: 20.11.2025. Accepted for publication: 25.12.2025.

Medical Radiology and Radiation Safety. 2026. Vol. 71. № 1

DOI:10.33266/1024-6177-2026-71-1-26-32

A.S. Kretov, A.A. Yarotskaya, F.S. Torubarov, O.V. Parinov, N.A. Metlyaeva,
O.A. Kasymova, I.V. Vlasova, O.V. Podgornova, E.V. Vodolazskaya,
E.A. Denisova, A.O. Lebedev

Analysis of the Results of Psychophysiological Examinations
of People Working under the Influence of Ionizing Radiation

A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia

Contact person: A.A. Yarotskaya, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

To date, the relationship between the employee’s health status and his reliability in professional activities is beyond doubt and does not need additional confirmation. As part of radiation safety measures, measures aimed at minimizing the risks associated with the human factor play a key role in preventing emergency situations caused by exposure to ionizing radiation. These measures are an integral element of an integrated radiation protection system aimed at ensuring a high level of occupational safety and preserving the health of workers under radiation exposure conditions.

In order to achieve these tasks, the operating organization, in accordance with Federal Law No. 170-FZ of November 21, 1995, must obtain special permits from Rostechnadzor to perform certain types of work in conditions associated with exposure to ionizing radiation. A prerequisite for obtaining such a permit for a specialist is the absence of psychophysiological contraindications based on the results of a psychophysiological examination.

Since 2021, in accordance with the order of the Ministry of Health of the Russian Federation No. 29n dated January 28, 2021, conducting a psychophysiological examination is mandatory for all categories of workers who work under the influence of ionizing radiation (class of working conditions for this production factor 3.1 and higher). This requirement is aimed at providing a comprehensive assessment of the functional state of the central nervous system of workers involved in the operation of radiation sources in order to timely identify potential risks of emergency situations caused by the “human factor” and develop measures to minimize them.

In the period from 2020 to 2023, specialists of the A.I. Burnazyan Federal Medical Biophysical Center conducted a detailed analysis of the results of psychophysiological examinations performed under the influence of ionizing radiation. The purpose of this work was to identify trends and features based on the results of a psychophysiological examination of workers exposed to ionizing radiation.

Keywords: personnel, psychophysiological examinations, psychophysiological contraindications, professional reliability, radiation safety, ionizing radiation

For citation: Kretov AS, Yarotskaya AA, Torubarov FS, Parinov OV, Metlyaeva NA, Kasymova OA, Vlasova IV, Podgornova OV, Vodolazskaya EV, Denisova EA, Lebedev AO. Analysis of the Results of Psychophysiological Examinations of People Working under the Influence of Ionizing Radiation. Medical Radiology and Radiation Safety. 2026;71(1):26–32. (In Russian). DOI:10.33266/1024-6177-2026-71-1-26-32

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3. Parinov O.V., Kasymova O.A., Torubarov F.S., Kretov A.S., Fortunatova L.I., Tsarev A.N., Simagova T.D., Galstyan I.A., Kalinina M.Yu., Afonin S.A., Denisova Ye.A., Vlasova I.V., Lomteva A.A., V’yunova A.A., Podgornova O.V. Organizatsiya Provedeniya Meditsinskikh Osmotrov i Psikhofiziologicheskikh Issledovaniy Proizvodit ob”Yekty Ispol’zovaniya Atomnoy Energii = Organization of Medical Examinations and Psychophysiological Assessments of Workers at Nuclear Facilities. Methodological Recommendations. Moscow, FMBTS im. A.I.Burnazyana FMBA Rossii Publ., 2022.

PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 20.11.2025. Accepted for publication: 25.12.2025.

Medical Radiology and Radiation Safety. 2026. Vol. 71. № 1

DOI:10.33266/1024-6177-2026-71-1-21-25

S.A. Abdullaev^{1, 2}, N.F. Raeva¹, D.V. Fomina¹, T.P. Kalinin¹, T.N. Maksimova³,
G.D. Zasukhina^{1, 4}

Features of the Effect of Low Doses of Radiation
and Prospects for Therapy of Certain Human Pathologies

¹A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia

²Institute of Theoretical and Experimental Biophysics, Pushchino, Russia

³I.M. Sechenov First Moscow State Medical University, Moscow, Russia

⁴ N.I. Vavilov Institute of General Genetics, Moscow, Russia

ABSTRACT

The review analyzes literature data on the effects of low doses of radiation on humans and animals, and their potential impact in various pathological conditions. Particular attention is paid to the possibilities of using low doses of radiation in the prevention and treatment of chronic and degenerative diseases, as well as safety issues and risks associated with radiation exposure. The data obtained allow us to draw conclusions about the possibilities of using low doses of radiation in medical practice.

Key words: low radiation doses, radio response, therapeutic effect, non-coding RNAs

For citation: Abdullaev SA, Raeva NF, Fomina DV, Kalinin TP, Maksimova TN, Zasukhina GD. Features of the Effect of Low Doses of Radiation and Prospects for Therapy of Certain Human Pathologies. Medical Radiology and Radiation Safety. 2026;71(1):21–25.
(In Russian). DOI:10.33266/1024-6177-2026-71-1-21-25

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PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The work was carried out on the topic “Technology-3” (State Assignment No. 123011300105-3).

Contribution. Article was prepared with equal participation of the authors.

Article received: 20.11.2025. Accepted for publication: 25.12.2025.

Medical Radiology and Radiation Safety. 2026. Vol. 71. № 1

DOI:10.33266/1024-6177-2026-71-1-33-38

O.D. Bragina^1,2, A.G. Ivanova¹, M.S. Larkina^{2, 3}, R.N. Varvashenya^{2, 3},
M.A. Vostrikova¹, N.O. Popova¹, V.E. Goldberg¹, V.I. Chernov^{1, 2}, S.V. Patalyak¹

Evaluation of the Safety and Pharmacokinetic Analysis
of the Radiopharmaceutical [^99mTc]Tc-DB8 in Breast Cancer Patients

¹ Tomsk National Research Medical Center, Tomsk, Russia
² National Research Tomsk Polytechnic University, Tomsk, Russia
³ Siberian State Medical University, Tomsk, Russia

Contact person: A.G. Ivanova, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: To evaluate the safety and pharmacokinetics of the radiopharmaceutical agent [^99mTc]Tc-DB8 in patients with breast cancer.

Material and methods: The study included 15 patients diagnosed with breast cancer (T_2‒4 N_0‒3M_0‒1) prior to any systemic or local treatment. Patients were divided into three groups based on the administered protein dose: 40 µg, 80 µg, and 120 µg (5 patients per group). Throughout the study, participants were under continuous clinical observation, which included assessment of symptoms, measurement of blood pressure (BP), body temperature, and heart rate prior to injection, and at 2, 4, 6, 24, and 48 hours post-injection. Additionally, complete blood count, biochemical blood analysis, and electrocardiography were performed before the injection, and again at 24 and 48 hours post-administration.

To assess the elimination rate of [^99mTc]Tc-DB8 from the bloodstream, its distribution in organs and tissues, and the associated radiation dose, whole-body planar scintigraphy was conducted at 2, 4, 6, and 24 hours after radiopharmaceutical administration at doses of 40, 80, and 120 µg. The average administered activity was 334 ± 84 MBq, with a radiochemical purity exceeding 95 %.

Results: Injection of [^99mTc]Tc-DB8 was not associated with any reported complaints or clinically significant changes in blood pressure, heart rate, or body temperature at any of the time points, regardless of dose. No significant deviations were observed in complete blood count, biochemical parameters, urinalysis, or ECG prior to injection, or at 48 hours and 7 days post-administration. The elimination half-life was 2.363 h for the 40 µg and 80 µg doses, and 2.233 h for the 120 µg dose. The highest absorbed doses were recorded in the mammary glands, kidneys, adrenal glands, pancreas, thyroid gland, urinary bladder and ovaries. The effective dose was 0.009 ± 0.001 mSv/MBq for the 40 µg dose, 0.011 ± 0.004 mSv/MBq for the 80 µg dose, and 0.014 ± 0.003 mSv/MBq for the 120 µg dose.

Conclusion: The drug is safe at all stages of dynamic follow-up, which is confirmed by the subjective feelings of breast cancer patients and the absence of pathological changes according to laboratory and instrumental studies, which allows the continuation of the next stages of clinical trials. Similarly, [^99mTc]Tc-DB8 demonstrated rapid elimination from the bloodstream when using 40, 80 and 120 micrograms of protein, and the highest absorption was recorded in the mammary gland, kidneys, adrenal glands, pancreas, thyroid, bladder and ovaries. Based on the results of the completed analysis, the use of the drug [^99mTc]Tc-DB8 served as the basis for further studies.

Keywords: target radionuclide diagnostics, luminal breast cancer, ^99mTc-DB-8

For citation: Bragina OD, Ivanova AG, Larkina MS, Varvashenya RN,Vostrikova MA, Popova NO, Goldberg VE, Chernov VI, Patalyak SV. Evaluation of the Safety and Pharmacokinetic Analysis of the Radiopharmaceutical [^99mTc]Tc-DB8 in Breast Cancer Patients. Medical Radiology and Radiation Safety. 2026;71(1):33–38. (In Russian). DOI:10.33266/1024-6177-2026-71-1-33-38

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PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The work was carried out within the framework of the Russian Science Foundation grant No. 22-15-00169 on the topic “Phenotype of BRCA-like tumors in the process of carcinogenesis and treatment”.

Contribution. O.D. Bragina – development of the study concept and design, data analysis and interpretation, discussion of the manuscript, and checking the critical intellectual content. A.G. Ivanova – data analysis and interpretation, discussion of the manuscript, and checking the critical intellectual content. M.S. Larkina ‒ data analysis and interpretation, discussion of the manuscript, and checking the critical intellectual content. R.N. Varvashenya – data analysis and interpretation, discussion of the manuscript, and checking the critical intellectual content. M.A. Vostrikova – data collection and processing. N.O. Popova ‒ data collection and processing. V.E. Goldberg ‒ data collection and processing. V.I. Chernov – development of the study concept and design, data analysis and interpretation, discussion of the manuscript, and checking the critical intellectual content. S.V. Patalyak ‒ data collection and processing.

Article received: 20.11.2025. Accepted for publication: 25.12.2025.

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MEDICAL RADIOLOGY AND RADIATION SAFETY