JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Выпуски журналов
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 6
DOI:10.33266/1024-6177-2024-69-6-12-18
D.A. Shaposhnikova1, E.Yu. Moskaleva1, O.V. Vysotskaya1,
O.V. Komova2, I.V. Koshlan2, K.V. Kondratiev1
The Response of Mouse Microglia Cells SIM-A9 to γ-Radiation
1 National Research Center “Kurchatov Institute”, Moscow, Russia
2 Joint Institute for Nuclear Research, Dubna, Russia
Contact person: D.A. Shaposhnikova, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Characterization of the response of mouse microglia cells of the SIM-A9 line to the γ-irradiation.
Material and methods: Irradiation of the cells in suspension was carried out using a GUT-200M installation (cobalt-60 γ-radiation source). The radiosensitivity of cells was assessed by the number of surviving cells and their clonogenic activity. The effect of γ-radiation on the phenotype and expression of colony-stimulating growth factor receptor-1 and of epidermal growth factor, which are required to stimulate microglial cells proliferation, was studied using flow cytometry after staining the cells with appropriate fluorescently labeled CD11b, CD45, TMEM119, CSF-1R и EGFR antibodies. Analysis of the relative expression of mRNA genes for the cytokines IL-1β, IL-6, and TNFα in response to γ-radiation was performed using RT-PCR. Statistical analysis was carried out using Student’s t-test in the Origin program.
Results: High radiosensitivity of SIM-A9 cells has been demonstrated. When analyzing the dependence of the clonogenic activity of cells on the radiation dose, it was shown that the D37 value for these cells was equal to 1 Gy. Irradiation caused a cell cycle block in the G0/G1 phase with a decrease in the proportion of cells in the S– and G2/M-phases. The cell death of irradiated SIM-A9 cells occurred by apoptosis. The peculiarity of SIM-A9 cells compared to brain microglia is their phenotype of activated microglia CD11b+/CD45high with an insignificant content of CD11b+/CD45-/low cells and no change in it after irradiation. An increase in the level of mRNA expression of the proinflammatory cytokine genes IL-1β, IL-6 and TNFα in response to γ-irradiation of SIM-A9 cells was shown, which reflects their activation and corresponds to the response of brain microglia cells during total mice irradiation and local cranial irradiation.
Conclusion: The obtained patterns indicate the possibility of using the SIM-A cell line in model radiobiological studies, including the study of intercellular interactions of brain cells of different types with microglia cells.
Keywords: microglia, SIM-A9 cell line, radiosensitivity, cell cycle, apoptosis, γ-radiation, gene expression, IL-1β, IL-6, TNFα
For citation: Shaposhnikova DA, Moskaleva EYu, Vysotskaya OV, Komova OV, Koshlan IV, Kondratiev KV. The Response of Mouse Microglia Cells SIM-A9 to γ-Radiation. Medical Radiology and Radiation Safety. 2024;69(6):12–18. (In Russian). DOI:10.33266/1024-6177-2024-69-6-12-18
References
1. Greene-Schloesser D., Robbins M.E. Radiation-Induced Cognitive Impairment-from Bench to Bedside. Neuro Oncol. 2012;14;4:iv37-iv44 doi:10.1093/neuonc/nos196.
2. Askew K., Li K., Olmos-Alonso A., Garcia-Moreno F., Liang Y., Richardson P., Tipton T., Chapman M.A., Riecken K., Beccari S., Sierra A., Molnár Z., Cragg M.S., Garaschuk O., Perry V.H., Gomez-Nicola D. Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain. Cell Rep. 2017;18;2:391-405. doi:10.1016/j.celrep.2016.12.041.
3. Chitu V., Gokhan Ş., Nandi S., Mehler M.F., Stanley E.R. Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System. Trends Neurosci. 2016;39;6:378-393. doi:10.1016/j.tins.2016.03.005.
4. Liu Q., Huang Y., Duan M., Yang Q., Ren B., Tang F. Microglia as Therapeutic Target for Radiation-Induced Brain Injury. Int J Mol Sci. 2022;23;15:82-86. doi:10.3390/ijms23158286.
5. Kreisel T., Wolf B., Keshet E., Licht T. Unique Role for Dentate Gyrus Microglia in Neuroblast Survival and in VEGF-Induced Activation. Glia. 2019;67;4:594-618. doi:10.1002/glia.23505.
6. Legroux L., Pittet C.L., Beauseigle D., Deblois G., Prat A., Arbour N. An Optimized Method to Process Mouse CNS to Simultaneously Analyze Neural Cells and Leukocytes by Flow Cytometry. J Neurosci Methods. 2015;247:23-31. doi:10.1016/j.jneumeth.2015.03.021.
7. Blasi E., Barluzzi R., Bocchini V., Mazzolla R., Bistoni F. Immortalization of Murine Microglial Cells by a V-Raf/V-Myc Carrying Retrovirus. J Neuroimmunol. 1990;27;2-3:229-237. doi:10.1016/0165-5728(90)90073-v.
8. Stansley B., Post J., Hensley K.A Comparative Review of Cell Culture Systems for the Study of Microglial Biology in Alzheimer’s Disease. J Neuroinflammation. 2012;9:115. doi:10.1186/1742-2094-9-115.
9. Nagamoto-Combs K., Kulas J., Combs C.K. A Novel Cell Line from Spontaneously Immortalized Murine Microglia. J Neurosci Methods. 2014;.233:187-198. doi:10.1016/j.jneumeth.2014.05.021.
10. Franken N.A., Rodermond H.M., Stap J., Haveman J., van Bree C. Clonogenic Assay of Cells in Vitro. Nat Protoc. 2006;1;5:2315-2319. doi:10.1038/nprot.2006.339.
11. Rodina A.V., Semochkina Y.P., Vysotskaya O.V., Parfenova A.A., Moskaleva E.Y. Radiation-Induced Neuroinflammation Monitoring by the Level of Peripheral Blood Monocytes with High Expression of Translocator Protein. Int J Radiat Biol. 2023;99;9:1364-1377. doi:10.1080/09553002.2023.2177765.
12. Шапошникова Д.А., Москалева Е.Ю., Сёмочкина Ю.П., Высоцкая О.В., Комова О.В., Насонова Е.А., Кошлань И.В. Характеристика клеток микроглии линии SIM-A9 – новые данные // Цитология. 2023.Т.65. №3. С. 259-272 [Shaposhnikova D.A., Moskaleva Ye.Yu., Somochkina Yu.P., Vysotskaya O.V., Komova O.V., Nasonova Ye.A., Koshlan’ I.V. Characteristics of SIM-A9 Microglial Cells – New Data. Tsitologiya = Tsitology. 2023;65;3:259-272 (In Russ.)]. doi: 10.1134/S1990519X23050127.
13. Родина А.В., Семочкина Ю.П., Ратушняк М.Г., Шуватова В.Г., Посыпанова Г.А., Москалёва Е.Ю. Анализ ориентировочно-исследовательской активности и уровня микроглии у мышей, подвергшихся воздействию γ-излучения в сублетальных дозах // Радиационная биология. Радиоэкология. 2019. Т.59. №6. С.575-584 [Rodina A.V., Semochkina Yu.P., Ratushnyak M.G., Shuvatova V.G., Posypanova G.A., Moskalova Ye.Yu. Analysis of Exploratory Activity and Microglia Levels in Mice Exposed to Sublethal Doses of Γ-Radiation. Radiatsionnaya Biologiya. Radioekologiya = Radiation Biology. Radioecology. 2019;59;6:575-584 (In Russ.)]. doi: 10.1134/S0869803119060092.
14. Родина А.В., Семочкина Ю.П., Ратушняк М.Г., Москалева Е.Ю. Динамика изменения субпопуляций клеток микроглии после γ-облучения головы мышей // Вестник ВИТ «ЭРА». 2020. Т.1. №1. С.30-33 [Rodina A.V., Semochkina Yu.P., Ratushnyak M.G., Moskaleva E.Yu. Dynamics of Changes in Microglial Cell Subpopulations after Γ-Irradiation of The Mouse Head. Vestnik VIT «ERA» = Vestnik VIT “ERA”. 2020;1;1:30-33 (In Russ.)].
15. Жирник А.С., Смирнова О.Д., Сёмочкина Ю.П., Шибаева К.Д., Родина А.В., Ратушняк М.Г., Москалева Е.Ю. Нарушение когнитивных функций и развитие нейровоспаления в отдаленный период после однократного γ-облучения головы мышей // Радиационная биология. Радиоэкология. 2021. Т.61. №1. С.32–43 [Zhirnik A.S., Smirnova O.D., Somochkina Yu.P., Shibayeva K.D., Rodina A.V., Ratushnyak M.G., Moskaleva Ye.Yu. Impairment Of Cognitive Functions and the Development of Neuroinflammation in the Late Period after a Single Γ-Irradiation of the Head of Mice. Radiatsionnaya Biologiya. Radioekologiya = Radiation Biology. Radioecology. 2021;61;1:32–43 (In Russ.)]. doi: 10.31857/S0869803121010112.
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The work was carried out as part of the fulfillment of the state task of the Kurchatov Institute Research Center.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2024. Accepted for publication: 25.09.2024.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 6
DOI:10.33266/1024-6177-2024-69-6-19-26
A.A. Kosenkov, A.M. Lyaginskaya
Expert Assessment of Nuclear Power Plant Personnel Performance as a Part of Professiography Research:
Problems and Solutions
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: A.A. Kosenkov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
The article describes the methodological approaches and principles used by the author to overcome the difficulties encountered in the process of conducting an expert assessment of the professional success of nuclear power plant personnel. This procedure was part of a professiography research, and its purpose was to identify groups of the most and least successful specialists of various profiles, followed by an analysis of their psychological and psychophysiological characteristics.
As a result of trial and error, the author concluded that reliable results can be obtained by consistently using a set of expert assessment methods, starting with a point assessment by experts of individual qualities of the evaluated specialists belonging to the same job group, continuing with the method of their alternative ranking based on professional success. At the final stage, the experts subdivided the ranked lists of evaluated persons of each job position into five qualitatively different levels according to this integral feature (from the most to the least successful).
The algorithm of expert personnel assessment described in this paper has allowed minimizing the impact of some traditional problems that inevitably occur when solving such tasks. It was successfully applied by the author and his colleagues in the process of professiography research conducted at nuclear power plants.
Keywords: nuclear power plants, operators, professional success, expert evaluation, integrated approach, point assessment, ranking method, consistency of opinions, professiography
For citation: Kosenkov AA, Lyaginskaya AM. Expert Assessment of Nuclear Power Plant Personnel Performance as a Part of Professiography Research: Problems and Solutions. Medical Radiology and Radiation Safety. 2024;69(6):19–26. (In Russian). DOI:10.33266/1024-6177-2024-69-6-19-26
References
1. Anokhin A.N. Metody Ekspertnykh Otsenok = Methods of Peer Review. A Textbook. Obninsk, Obninskiy Institut Atomnoy Energetiki Publ., 1996. 148 p. (In Russ.).
2. Anokhin A.N., Ostreykovskiy V.A., Kositskiy T.A., Vysotskiy V.G. Expert Assessment of the Technical Condition of the Logical Control Device of the Kalininskaya NPP Power Units. 10 let Kalininskoy Atomnoy Elektrostantsii. Sbornik Statey = 10 years of Kalinin Nuclear Power Plant. Obninsk, Obninskiy Institut Atomnoy Energetiki Publ., 1994. Pp. 50-54. Collection of Articles. Supplement to the Journal «Nuclear Energy. News of Universities» (In Rus.).
3. Orlov A.I. Ekspertnyye Otsenki = Expert Opinions. Textbook. Moscow, Moskovskiy Gosudarstvennyy Tekhnicheskiy Universitet im. N.E.Baumana Publ., 2002. 31 p. (In Russ.).
4. Orlov A.I. Organizatsionno-Ekonomicheskoye Modelirovaniye = Organizational and Economic Modelling: A Textbook: in 3 parts. Part 2: Expert Opinions. Moscow, Moskovskiy Gosudarstvennyy Tekhnicheskiy Universitet im. N.E.Baumana Publ., 2011. 486 p. (In Russ.).
5. Pande P., Kholp L. Chto Takoye «Shest’ Sigm»? Revolyutsionnyy Metod Upravleniya Kachestvom = What Is Six Sigma? A Revolutionary Method of Quality Management. Moscow, Al’pina Biznes Buks Publ., 2004. 158 p. (In Russ.).
6. Litvak B.G. Ekspertnyye Otsenki i Prinyatiye Resheniy = Expert Judgment and Decision Making. Moscow, Patent Publ., 1996. 271 p. (In Russ.).
7. Byuyul’ A., Tsefel’ P. SPSS: Iskusstvo Obrabotki Informatsii. Analiz Statisticheskikh Dannykh i Vosstanovleniye Skrytykh Zakonomernostey = SPSS: the Art of Information Processing. Analysis of Statistical Data and Restoration of Hidden Patterns. Translated from German. St. Petersburg, DiaSoft UP Publ., 2005. 608 p. (In Russ.).
8. Grigan A.M. Upravlencheskaya Diagnostika: Teoriya i Praktika = Managerial Diagnostics: Theory and Practice: Monograph. Rostov-na-Donu, Rostovskiy Sotsial’no-Ekonomicheskiy Institut Publ., 2009. 282 p. (In Russ.).
9. Volkova V.N., Denisov A.A. Metody Organizatsii Slozhnykh Ekspertiz = Methods of Organization of Complex Examinations. St. Petersburg, Politekh. Univ. Publ., 2010. 128 p. (In Russ.).
10. Kovalev V.V., Volkova O.N. Analiz Khozyaystvennoy Deyatel’nosti Predpriyatiya = Analysis of the Economic Activity of the Enterprise. Textbook. Moscow, TK Velbi Publ., 2007. 424 p. (In Russ.).
11. Dalkey N. C. The Delphi Method: An Experimental Study of Group Opinion. The Rand Corporation, RM-5888-PR. Santa Monica, 1969 June.
12. Antsupov A.Ya., Kovalev V.V. Sotsial’no-Psikhologicheskaya Otsenka Personala: Uchebnoye Posobiye dlya Studentov Vuzov = Socio-Psychological Assessment of Personnel: Theory and Practice: A Textbook. Moscow, Yuniti-Dana Publ., 2018. 303 p. (In Russ.).
13. Dugina O. The Method of the Assessment Center. The Place of Personnel Evaluation in HR Work. Kadrovyy Vestnik = Personnel Bulletin. 2000;2:54-60 (In Russ.).
14. Magura M.I., Kurbatova M.B. Otsenka Raboty Personala, Podgotovka i Provedeniye Attestatsii = Personnel Works Estimating. Certification Preparation and Realization. Moscow, Intel-Sintez Publ., 2002. 176 p. (In Russ.).
15. Sedin V.I. Psikhologicheskiye kriterii ob”yektivizatsii attestatsionnykh kharakteristik komandnogo sostava VMF. SPb.: VMII. 2003 80 s = Psychological Criteria for Objectifying of Attestation Characteristics of the Command Personnel of the Navy. St. Petersburg, Voyenno-Morskoy Inzhenernyy Institut Publ., 2003. 80 p. (In Russ).
16. Comer M.K., Seaver D.A., Stillwell W.G., Gaddy C.D. Ge-
nerating Human Reliability Estimates Using Expert Judgment. Report. 2. Appendices. General Physics Corporation and The Maxima Corporation. Maryland, 1984.
17. Spencer Jr.L.M., Spencer S.M. Kompetentsii na Rabote = Competencies at Work. Moscow, HIPPO Publ., 2005. 384 p. (In Russ.).
18. Tseluykina T.G. Handbook po Distsipline «Psikhologicheskiye Osnovy Otsenki Personala» = Handbook on the Subject “Psychological Foundations of Personnel Assessment”. Moscow, Sinergiya, 2016. 184 p. (In Russ.).
19. Abramova V.N., Belekhov V.V, Bel’skaya Ye.G., et al. Psikhologicheskiye Metody v Rabote s Kadrami na AES = Psychological Methods in Working with Key Personnel at Nuclear Power Plants. Moscow, Energoatomizdat Publ., 1988.192 p. (In Russ.).
20. Lukashin YU.P., Rakhlina L.I. Sovremennyye Napravleniya Statisticheskogo Analiza Vzaimosvyazey i Zavisimostey = Modern Trends in Statistical Analysis of the Linkages and Dependencies. Moscow, IMEMO RAN Publ., 2012. 54 p. (In Russ.).
21. Beshelev S.D., Gurvich F.G. Matematiko-Statisticheskiye Metody Ekspertnykh Otsenok = Mathematical and Statistical Methods of Expert Judgment. Moscow, Statistika Publ., 1980. 263 p. (In Russ.)
22. Ekspertnyye Otsenki = Expert Assessments. Collection of articles. Ed. B.G. Litvak, Yu.N. Tyurin. The series “Questions of Cybernetics”. Moscow, Cybernetics Publ., 1979. 199 p. (In Russ.).
23. Kosenkov A.A. Psychological Factors of Professional Success of Nuclear Power Plant Main Control Room Operators. Saratovskiy Nauchno-Meditsinskiy Zhurnal = Saratov Scientific Medical Journal. 2014;10;1:758-761 (In Russ.).
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The author declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with one participation of the authors.
Article received: 20.07.2024. Accepted for publication: 25.09.2024.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 6
DOI:10.33266/1024-6177-2024-69-6-33-37
A.V. Aksenenko, A.S. Samoilov, O.V. Parinov, A.Yu. Bushmanov, I.A. Galstyan,
A.A. Zavialov, G.E. Zimnikov, S.G. Kolyadin, Yu.G. Trofimenko, N.G. Stepanyanc,
G.A. Baksiyan, D.N. Astahov, M.Sh. Zugumova
Treatment and Rehabilitation of Professional Local Radiation Injury of the Hand, Using the Method of Transplanting the Toe to the Hand
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Abstract
Purpose: To introduce a wide range of specialists with the technique of reconstructive plastic surgery, which was first used in local radiation injury (LRI).
Material and methods: clinical analysis of the case histories of the severe LRI of the hand. The report describes the results of the first autotransplantation of the II toe in the position of the right hand III finger for the restoration of grip function in LRI.
Results: Patient L., 38 years old, was admitted to the A.I. Burnazyan Federal Medical Biophysical Center in 2010 for the treatment of late consequences of severe LRI of the right hand resulting from contact with a gamma radiation source (Ir 192) in 2008. In the period from 2010 to 2018, the patient underwent repeated surgical operations, including reconstructive plastic surgery, which made it possible to achieve healing of constantly recurring late radiation ulcers. However, multiple necrectomies, exarticulations, finger amputations and resections of the phalanges led to the formation of a functionally defective hand and persistent disability of the patient. In 2018, the patient was admitted to the clinic for reconstructive surgery to restore the function of hand grip - microsurgical transplantation of the II toe into the position of the III finger of the hand. As a result of the treatment, the function of grabbing objects with the right hand was restored, and the patient’s ability to work was largely restored.
Conclusions: The obtained long-term functional and aesthetic results allow us to consider the applied method of fingerless hand reconstruction by autotransplantation of the toe with the imposition of microvascular anastomoses optimal. It is advisable to use this type of surgical treatment more widely for the rehabilitation of patients with severe and extremely severe hand LRI.
Keywords: local radiation injury, hand, reconstructive plastic surgery, toe, autotransplantation
For citation: Aksenenko AV, Samoilov AS, Parinov OV, Bushmanov AYu, Galstyan IA, Zavialov AA, Zimnikov GE, Kolyadin SG, Trofimenko YuG, Stepanyanc NG, Baksiyan GA, Astahov DN, Zugumova MSh. Treatment and Rehabilitation of Professional Local Radiation Injury of the Hand, Using the Method of Transplanting the Toe to the Hand. Medical Radiology and Radiation Safety. 2024;69(6):33–37.
(In Russian). DOI:10.33266/1024-6177-2024-69-6-33-37
References
1. Radiatsionnaya Meditsina = Radiation Medicine. A Guide for Medical Reserchers and Health Care Organizers. 4-vol set. Ed. Ilyin LA. Vol. 2. Radiatsionnyye Porazheniya Cheloveka = Human Radiation Damage. Moscow Publ., 2001. 161 p. (In Russ.).
2. Milanov NO, Shilov BL. Plasticheskaya Khirurgiya Luchevykh Povrezhdeniy = Plastic Surgery Radiation Burns. Moscow, AIR-ART Publ., 1996. 99 p. (In Russ.).
3. Milanov NO, Filippov VV, Zelyanin AS., Nadezhina NM, et al. Microsurgical Autotransplantation of Tissues as a Pathogenetic Method of Treatment of Patients with Local Radiation Injuries. Khirurgiya. Zhurnal im. N.I.Pirogova = Surgery. Journal named after N.I.Pirogov. 2012;8:4-8 (In Russ.).
4. Petrovskiy BV., Krylov VS. Mikrokhirurgiia = Microsurgery. Moscow, Nauka Publ., 1976. 187 p. (In Russ.).
5. Samoylov FS, Bushmanov AY, Galstyan IA, et al. Local Radiolesion in X-Ray Inspection Specialists. Radiatsionnaya Dozimetriya = Radiat Prot Dosimrtry. 2016;171;1:117-120 (In Russ.). DOI: https://doi.org/doi:10:1093/rpd/ncw203 (In Russ.).
6. Cobbett JR. Free Digital Transfer. Report of a Case of Transfer of a Great Toe to Replace an Amputated Thumb. J Bone Joint Surg Br. 1969;51;4:677-679.
7. Chen ZW, Bao YS. Microsurgery in China. Clin Plast Surg. 1980;7;4:437-474.
8. Akchurin RS. Rekonstruktivnaya Mikrokhirurgiya Bespaloy Kisti = Reconstructive Microsurgery of the Fingerless Hand. Extended Abstract of Doctor’s Thesis (Med.). Moscow Publ., 1984. 26 p. (In Russ.).
9. Borovikov AM. Mikrokhirurgicheskaya Autotransplantatsiya v Lechenii Povrezhdeniy Verkhney Konechnosti = Microsurgical Autotransplantation in the Treatment of Upper Limb Injuries. Extended Abstract of Doctor’s Thesis (Med.). Moscow Publ., 1991. 47 p. (In Russ.).
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors confirm that their authorship meets the international ICMJE criteria (all authors have made a significant contribution to the development of the concept, research and preparation of the article, read and approved the final version before publication).
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2024. Accepted for publication: 25.09.2024.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 6
DOI:10.33266/1024-6177-2024-69-6-27-32
I.E. Andrianova, L.M. Rozhdestvensky, I.L. Efimova
At the Semipalatinsk Training Ground. Eyewitness Accounts
(on the 75th Anniversary of the Explosion of the First Soviet Atomic Bomb)
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: Irina Efimova, е-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
On August 29, 1949, exactly 75 years ago, the first test of the Soviet atomic bomb was conducted at the Semipalatinsk test site. More than one and a half thousand animals were brought to the landfill to conduct research, employees of the Institute of Biophysics of the Ministry of Health of the USSR under the leadership of B.M.Isaev provided equipment for conducting radiation reconnaissance on the ground, in the explosion area, for aviation reconnaissance and dosimetric control of irradiation of test participants.
In the following years, more than 300 scientists from different laboratories of the Institute of Biophysics visited the landfill. In the field, medical and biological studies were conducted on large and small laboratory animals, the course of acute radiation sickness was studied when exposed to radiation in various doses and the effectiveness of anti-radiation agents used. During the testing period, new sections of medical science were created: radiation pathology, clinical and field dosimetry, toxicology of radioactive fission products, radiation hygiene, radiation epidemiology.
It was during this period that original, modern anti-radiation agents for various purposes were developed: RS-10 and its analogue RS-11, prodigiozan (early treatment agents), B-190 (emergency radioprotector), hemosorption (detoxification method), as well as a scheme of complex therapy and means to combat early manifestations of the primary reaction to radiation exposure. One of the important stages of research in those years, along with preclinical studies, was the evaluation of the effectiveness of new drugs in conditions simulating radiation damage in a nuclear explosion. Such large-scale tests were conducted at the Semipalatinsk test site.
Keywords: nuclear explosion, dosimetry, landfill, biomedical research, anti-radiation drugs, radiation safety, vivarium, damaging factors
For citation: Andrianova IE, Rozhdestvensky LM, Efimova IL At the Semipalatinsk Training Ground. Eyewitness Accounts
(on the 75th Anniversary of the Explosion of the First Soviet Atomic Bomb). Medical Radiology and Radiation Safety. 2024;69(6):27–32.
(In Russian). DOI:10.33266/1024-6177-2024-69-6-27-32
References
1. Shalnova G.A. Bylo Takoye Chudo Institut Biofiziki = There was Such a Miracle. Institute of Biophysics. Moscow Publ., 2015. 267 p. (In Russ.).
2. Burnazyan A.I. Fantastic Reality. Bulletin of the Russian Academy of Sciences. 1993;63:248 (In Russ.).
3. Obespecheniye Radiatsionnoy Bezopasnosti pri Ispytaniyakh Yadernogo Oruzhiya. Federal’nomu Upravleniyu «Medbioekstrem» – 50 Let = Ensuring Radiation Safety during Nuclear Weapons Tests. Federal Office “Medbioextrem” – 50 years. Moscow Publ., 1997. P.3 (In Russ.).
4. Yatsenko V.N. Mificheskiye Istorii = Mythical Stories. Moscow Publ., 2022. 184 p. (In Russ.).
5. Petrov R.V. Na Yadernom Poligone. 55 Let Sluzheniya Meditsinskoy Nauke i Praktike = At the Nuclear Test Site. 55 years of Service to Medical Science and Practice. Moscow Publ., 2001. 238 p. (In Russ.).
6. Vospominaniya L.M.Rozhdestvenskogo = Memories of L.M.Rozhdestvensky / Museum Fund of the FMBC named after A.I. Burnazyan (In Russ.).
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2024. Accepted for publication: 25.09.2024.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 6
DOI:10.33266/1024-6177-2024-69-6-38-41
L.P. Sycheva1, A.F. Bobrov1, S.M. Kiselev1, T.M. Novikova2
Analysis of the Relationship of Biomarkers of Cytogenetic and Psychophysiological Status of Personnel under Conditions of the Combined Influence of Occupational Factors
1 A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
2 Central Medical and Sanitary Unit No. 91, Sverdlovsk region, Lesnoy
Contact person: L.P. Sycheva, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Background: Analysis of the Relationship of biomarkers of Cytogenetic and Psychophysiological Status (CGS and PPS) of personnel under conditions of the combined influence of occupational factors.
Material and methods: CGS was determined using a non-invasive Buccal Micronucleus Cytome Assay (BMCA) and determination of the accumulation index of cytogenetic damage and the level of cytogenetic stress. PPS of personnel was determined in accordance with
MR 2.2.9.84 – 2015 FMBA of Russia and the Health-Test program.
Results: People with average and high levels of psychophysiological adaptation have a low level of cytogenetic damages. Also, in the group with a high accumulation index of cytogenetic damages a low level of psychophysiological adaptation was determined.
Conclusion: An increased level of cytogenetic damages has been established in people with a low level of psychophysiological adaptation. Taking into account the literature data, we can assume an indirect dependence of the cytogenetic status of the organism on its psychophysiological adaptation, which may be due to hormonal imbalance and the induction of oxidative stress.
Keywords: personnel, ionizing radiation, chemical, cytogenetic status, psychophysiological status, buccal micronucleus cytome assay, micronucleus, apoptosis
For citation: Sycheva LP, Bobrov AF, Kiselev SM, Novikova TM. Analysis of the Relationship of Biomarkers of Cytogenetic and Psychophysiological Status of Personnel under Conditions of the Combined Influence of Occupational Factors. Medical Radiology and Radiation Safety. 2024;69(6):38–41. (In Russian). DOI:10.33266/1024-6177-2024-69-6-38-41
References
1. Holland N., Bolognesi C., Kirsch-Volders M., Bonassi S., Zeiger E., Knasmueller S., Fenech M. The Micronucleus Assay in Human Buccal Cells as a Tool for Biomonitoring DNA Damage: the HUMN Project Perspective on Current Status and Knowledge Gaps. Mutat. Res. 2008;659:93–108.
2. Fenech M., Holland N., Zeiger E., Chang W.P., Burgaz S., Thomas P., Bolognesi C., Knasmueller S., Kirsch-Volders M., Bonassi S. The HUMN and HUMNxL International Collaboration Projects on Human Micronucleus Assays in Lymphocytes and Buccal Cells - Past, Present and Future. Mutagenesis. 2011;26:239–245.
3. Organization and Conduct of Psychophysiological Examinations of Employees of Organizations Operating Especially Radiation-Hazardous and Nuclear-Hazardous Production Facilities and Facilities in the Field of Nuclear Energy Use, when Employees Undergo Medical Examinations in Medical Organizations of the Federal Medical and Biological Agency of Russia. 2.2.9.84 – 2015. (https://drive.google.com/file/d/0B_ WTIHndwyxNLXp4QTM1SkY3eVE/view?resourcekey=0-dpURYaUj69mF-HkAxbfTpQ) (In Russ.).
4. Bobrov A.F., Ivanov V.V., Kalinina M.Yu., Novikova T.M., Rataeva V.V., Sedin V.I., et al. Innovative Technology of Pre-Shift Psychophysiological Examination of Personnel as a Means of Increasing Radiation Exposure Safety. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost’ = Medical Radiology and Radiation Safety. 2018;5:5–10 (In Russ.).
5. HealthTest Program. Manual. Version: 10.2.1.26. Multidisciplinary Enterprise. St. Petersburg, ELSIS Publ. (In Russ.).
6. Fenech M., Knasmueller S., Knudsen L.E., Kirsch-Volders M., Deo P., Franzke B., Stopper H., Andreassi M.G., Bolognesi C., Dhillon V.S., Laffon B., Wagner K.H., Bonassi S. Micronuclei and Disease, Special Issue: Aims, Scope, and Synthesis of Outcomes. Mutat Res Rev Mutat Res. 2021;788:108384. doi: 10.1016/j.mrrev.2021.108384.
7. Abilev S.K., Glazer V.M., Aslanyan M.M. Osnovy Mutageneza i Toksikologii = Fundamentals of Mutagenesis and Toxicology. St. Petersburg, Nestor-Istoria Publ., 2012. 148 p. (In Russ.).
8. Durnev A.D., Zhanataev A.K., Eremina Yu.A. Geneticheskaya Toksikologiya = Genetic Toxicology. Moscow, Mittel Press Publ., 2022. 286 p. (In Russ.)
9. Radiation safety standards (NRB-99/2009). Sanitary and Epidemiological Rules and Regulations. Moscow, Federal Center for Hygiene and Epidemiology of Rospotrebnadzor Publ., 2009. 100 p. (In Russ.).
10. Sycheva L.P. Cytogenetic Monitoring to Assess the Safety of the Human Environment. Gigiyena i Sanitariya = Hygiene and Sanitation. 2012;91;6:68-72 (In Russ.).
11. Minkin V.A. Vibraimage, Cybernetics, Emotions. St. Petersburg, Renome Publ., 2020. 164 p. (In Russ.).
12. Gidron Y., Russ K., Tissarchondou H., Warner J. The Relation Between Psychological Factors and DNA-Damage: a Critical Review. Biological Psychology. 2006;72;3:291–304.
13. Bagchi D., Carryl O.R., Tran M.X., Bagchi M., Garg A., Milnes M.M., Williams C.B., Balmoori J., Bagchi D.J., Mitra S., Stohs S.J. Acute and Chronic Stress-Induced Oxidative Gastrointestinal Mucosal Injury in Rats and Protection by Bismuth Subsalicylate. Mol Cell Biochem. 1999;196;1-2:109-116.
14. Lesgards J.F., Durand P., Lassarre M., Stocker P., Lesgards G., Lanteaume A., Prost M., Lehucher-Michel M.P. Assessment of Lifestyle Effects on the Overall Antioxidant Capacity of Healthy Subjects. Environ Health Perspect. 2002;110;5:479-486.
15. Kang D.H. Oxidative Stress, DNA Damage, and Breast Cancer. AACN Clin Issues. 2002;13;4:540-549.
16. Hoeijmakers J.H. Genome Maintenance Mechanisms for Preventing Cancer. Nature. 2001;411;6835:366-374.
17. Bonassi S., El-Zein R., Bolognesi C., Fenech M. Micronuclei Frequency in Peripheral Blood Lymphocytes and Cancer Risk: Evidence from Human Studies. Mutagenesis. 2011;26;1:93-100.
18. Reimann H., Stopper H., Polak T., Lauer M., Herrmann M.J., Deckert J., Hintzsche H. Micronucleus Frequency in Buccal Mucosa Cells of Patients with Neurodegenerative Diseases. Sci Rep. 2020;10;1:22196.
19. Bolognesi C., Bonassi S., Knasmueller S, Fenech M., Bruzzone M., Lando C., Ceppi M. Clinical Application of Micronucleus Test in Exfoliated Buccal Cells: a Systematic Review and Metanalysis. Mutat Res Rev Mutat Res. 2015;766:20-31.
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Sycheva L.P.: research design development, research, collection and analysis of literary material, statistical data processing, writing and scientific text editing. Bobrov A.F.: development of the research concept, development of research design, conducting research, scientific text editing. Kiselev S.M.: development of the research concept, development of research design, conducting research, writing and scientific editing of the text.Novikova T.M.: conducting research, scientific text editing.
Article received: 20.07.2024. Accepted for publication: 25.09.2024.