JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Выпуски журналов
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 6
DOI:10.33266/1024-6177-2024-69-6-42-50
I.A. Galstian1, A.Yu. Bushmanov1, O.V. Shcherbatykh1, V.Yu. Nugis1,
N.A. Metlyaeva1, M.V. Konchalovsky1, V.I. Pustovoit1, A.S. Umnikov1,
A.V. Aksenenko1, K.E. Chekinev2, A.A. Kerimov3, D.A. Grechukhin3,
L.A. Yunanova1, A.A. Davtian1, D.A. Dubovoy1, V.Yu. Soloviev1
Features of Using the Lymphocyte Test to Determine the Degree of Severity of Acute Radiation Bone Marrow Syndrome in Combined Radiation and Mechanical Injury
1 A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
2 Tomsk Regional Clinical Hospital, Tomsk, Russia
3 N.N. Burdenko Main Military Clinical Hospital, Moscow, Russia
Contact person: I.A. Galstian, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To study the effect of the phenomenon of mutual aggravation on the early diagnosis of the severity of acute radiation bone marrow syndrome (ARBMS), which develops within the framework of combined radiation-mechanical injury (CRMI).
Material and methods: According to the general blood test data, the dynamics of the relative and absolute number of lymphocytes in 36 patients was studied during the first 10 days after receiving polytrauma. There are 35 men and one woman among them. The average age of the victims at the time of injury was 40.24 ± 4.07 years. The number of studied blood tests in one patient varied from one to 16 during the specified follow–up period (on average, 6). The dynamics of the absolute number of lymphocytes at the same time was also studied in 11 patients (men, average age – 30.00 ± 2.01 years) diagnosed with acute radiation syndrome (ARS) I and in 15 men diagnosed with ARS II (average age – 28.47 ± 2.03 years). Statistical processing of the material was performed using the IBM SPSS Statistics software package.23 using the Kraskal–Wallis criteria and the Mann–Whitney U-test for independent samples. The differences between the obtained results were considered statistically significant at p < 0.05.
Results: Relative lymphopenia was detected in 25 (69.4 %) patients diagnosed with polytrauma. A combination of absolute and relative lymphopenia was found in 15 (41.7 %) patients. Only transient relative lymphopenia was detected in 10 patients. The depth of absolute lymphopenia detected in polytrauma was compared with a similar indicator at the same time in ARS I and ARS II. The depth of absolute lymphopenia in trauma without exposure to ionizing radiation at the time when it is usually studied to determine the severity of ARBMS reached the indicators characteristic of ARS I and ARS II (up to 0.3–0.5 × 109/L.). At the same time, the nature of the dynamics of the absolute number of lymphocytes in trauma is radically different from that in acute radiation exposure.
Conclusion: The data obtained allow us to consider the possible deepening of absolute lymphopenia in CRMI in 42 % of cases as one of the manifestations of the phenomenon of mutual aggravation, which can lead to an early aggravation of the predicted severity of the developing ARBMS. The data obtained indicate that this weighting may be + 1, in rare cases +2 degrees of severity of ARS to the true degree of severity corresponding to the absorbed dose of radiation exposure.
Keywords: combined radiation-mechanical injury, acute radiation bone marrow syndrome, biodosimetry, early diagnosis, lymphocyte test
For citation: Galstian IA, Bushmanov AYu, Shcherbatykh OV, Nugis VYu, Metlyaeva NA, Konchalovsky MV, Pustovoit VI, Umnikov AS, Aksenenko AV, Chekinev KE, Kerimov AA, Grechukhin DA, Yunanova LA, Davtian AA, Dubovoy DA, Soloviev VYu. Features of Using the Lymphocyte Test to Determine the Degree of Severity of Acute Radiation Bone Marrow Syndrome in Combined Radiation and Mechanical Injury. Medical Radiology and Radiation Safety. 2024;69(6):42–50. (In Russian). DOI:10.33266/1024-6177-2024-69-6-42-50
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2024. Accepted for publication: 25.09.2024.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 6
DOI:10.33266/1024-6177-2024-69-6-51-55
D.A. Zavyalov, L.Yu. Krestinina
Analysis of the Incidence of Solid Malignant Neoplasms
in the Urals Cohort of Exposed Population Offspring
Ural Research Center for Radiation Medicine, Chelyabinsk, Russia
Contact person: Danila A. Zavyalov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: The study of regularities in the incidence of solid cancer in the Urals Cohort of the Exposed Population Offspring over a 65-year follow-up period.
Material and methods: The study was conducted by cohort method. The cohort under study is the Urals Cohort of the Exposed Population Offspring. It includes offspring of the population exposed in the period from 1950 to 1960 in the Southern Urals (on the Techa River and at the East Urals radioactive trace). The catchment area includes 5 districts of the Chelyabinsk region, as well as the city of Chelyabinsk and the city of Ozyorsk. The follow-up period was 65 years, from 01.01.1956 to 31.12.2020, the number of the analytical cohort for 2024 is 24952 people, the number of person-years under follow-up is 850698. Calculation of cases, incidence rates, person-years and statistical processing of data were performed by standard methods using the DATAB program module of the Epicure statistical package.
Results: During the 65-year period, 569 cases of solid cancers were registered in the catchment area. In women the most frequent cases were neoplasms of female reproductive organs, breast, thyroid gland, whole intestine and upper digestive tract organs; in men - respiratory organs, upper digestive tract and whole intestine. A significant increase in the incidence rates was found in women in age groups older than 20 years and in men in groups older than 30 years. Statistically significant sex-depended differences were observed only in the age groups between 30 and 50 years. No significant differences in the incidence rates among offspring of different ethnic groups were found. An assessment of incidence rates by calendar periods was carried out: in women, a significant increase in incidence rates began in 1990, in men in 2005 and significant differences by sex were observed only in the period from 2005 to 2020.
Conclusion: The study revealed patterns in the incidence of solid malignant neoplasms within the offspring cohort by sex, age and depending on the calendar period. These patterns will be taken into account in future studies when assessing the dependence of the incidence of solid malignant neoplasms in offspring on parental gonadal dose.
Keywords: Urals Cohort, Exposed Population Offspring, solid cancer, incidence rates, parental gonadal dose
For citation: Zavyalov DA, Krestinina LYu. Analysis of the Incidence of Solid Malignant Neoplasms in the Urals Cohort of Exposed Population Offspring. Medical Radiology and Radiation Safety. 2024;69(6):51–55. (In Russian). DOI:10.33266/1024-6177-2024-69-6-51-55
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The work was carried out within the framework of the implementation of the federal target program «Ensuring nuclear and radiation safety for 2016–2020 and for the period up to 2030».
Contribution. Zavyalov D.A. – morbidity analysis, discussion of results, writing an article, preparation of drawings. Krestinina L.Y. – research design, data interpretation, preparation of sections of the article.
Article received: 20.07.2024. Accepted for publication: 25.09.2024.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 6
DOI:10.33266/1024-6177-2024-69-6-64-70
Z.F. Zvereva1, N.P. Vanchakova2, E.V. Miroshnik1, F.S. Torubarov1
Methods for Evaluating the Energy Processes of the Brain (Literature Review)
1 A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
2 I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia
Contact person: Z.F. Zvereva, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Review of methods for assessing cerebral energy exchange in order to select a method that has sufficient information content and a good degree of accessibility when examining nuclear industry workers.
Results: To assess cerebral energy exchange, PET, SPECT, and measurement of local cerebral blood flow using isotope clearance are used. These techniques use the introduction of radioactive substances into the body. Their use is limited by the high cost of the equipment and its stationary nature. Also, to assess cerebral energy exchange, the polarographic method (invasive), REG and fMRI is used. REG provides insufficiently accurate data on cerebral energy exchange. fMRI provides fairly informative data, but is also a stationary method, which limits its use in the conditions of a comprehensive examination of people working at nuclear enterprises. A more accessible method is neuroenergy mapping, based on measuring the level of constant potential (LCP). Currently, this method is widely used in neurophysiological and neuropsychological studies. An equally accessible and effective method is EEG, based on the data of which the value of interhemispheric differences (VIHD) in the power of biopotentials of homologous leads is determined, based on the power characteristics of the EEG, reflecting the activity of nerve cells and metabolic processes in them. The indicator reveals the degree of uneven distribution of power characteristics between the hemispheres; this characterizes the interaction of the activating and inhibitory parts of the nonspecific brain system during the formation of functional interhemispheric asymmetry, which reflects the level of cerebral energy exchange. The advantage of the method is its close connection with EEG indicators, which makes it possible to simultaneously assess the functional activity of the brain and its energy processes.
Conclusion: The EEG indicator of VIHD power of biopotentials of homologous leads is sufficiently informative and accessible for assessing cerebral energy exchange in conditions of mass examination, in particular of nuclear industry workers.
Keywords: cerebral energy exchange, brain, methods, assessment of energy processes
For citation: Zvereva ZF, Vanchakova NP, Miroshnik EV, Torubarov FS. Methods for Evaluating the Energy Processes of the Brain (Literature Review). Medical Radiology and Radiation Safety. 2024;69(6):64–70. (In Russian). DOI:10.33266/1024-6177-2024-69-6-64-70
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2024. Accepted for publication: 25.09.2024.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 6
DOI:10.33266/1024-6177-2024-69-6-56-63
W.Yu. Ussov1, M.L. Belyanin2, O.Y. Borodin3, A.I. Bezlepkin4, A.A. Churin5,
N.L. Shimanovsky6
Preclinical Study of the Imaging Properties of the Mn(Ii)–D-Myo-Inositol-1, 2, 3, 4, 5, 6- Hexakisdihydrophosphoric Acid Complex as a Hepatospecific Paramagnetic Contrast Agent
1 E.N. Meshalkin National Medical Research Center, Novosibirsk, Russia
2 National Research Tomsk Polytechnic University, Tomsk, Russia
3 Tomsk Regional Oncological Dispensary, Tomsk, Russia
4 Aldan-Vet Veterinary Clinic LLC, Tomsk, Russia
5 E.D. Goldberg Institute of Pharmacology and Restorative Medicine, Tomsk, Russia
6 N.I. Pirogov Russian National Research Medical University, Moscow, Russia
Contact person: Wladimir Yuryevich Ussov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. , This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: We tried to create a hepatospecific paramagnetic contrast agent – a paramagnetic analogue of 99mTc-technefit, by obtaining a paramagnetic Mn(II) complex with phytic (D-myo-inositol-1, 2, 3, 4, 5, 6– hexakisdihydrophosphoric) acid.
Material and methods: A hepatotropic magnetic resonance contrast compound was obtained as an aqueous solution containing a paramagnetic Mn(II) complex with D-myo-inositol-1, 2, 3, 4, 5, 6-hexakis dihydrophosphoric (phytic) acid in a concentration of 0.5 M, with the addition of a 0.5M aqueous solution of meglumine (N-methylglucamine) in a ratio of 1:4 by volume to maintain pH in the range of 6.2–7.8, as well as to improve the stability of the solution. The working name of the Mn(II) complex with phytic acid phytomang®. The toxicological properties of the compound were evaluated when administered to laboratory mice, R1 relaxation and imaging properties in Wistar laboratory rats weighing 350-400 g, using low-field (field strength 0.2 T) and high-field (field strength 1.5 T) MR tomographs.
Results: For 0.5 M of an aqueous solution of Mn-phytate, with the addition of meglumine, LD50, when administered acutely to laboratory animals – mice, is more than 18.7 ml / kg of body weight, which allows this compound to be classified according to GOST 12.1.007-76 standards to group 4 – low-hazard substances. The thermodynamic stability constant was 17.5. Spin-lattice relaxivity R1 in aqueous solution at a field strength of 0.2T: R1 = 6.82 1/ms. After intravenous administration to healthy rats with preserved liver function, Mn-phytate is distributed in the bloodstream, with rapid absorption within 5 minutes by liver tissue, followed by partial (up to 7 ± 3 % of the dose) excretion into bile after 30 minutes or more. The total uptake of the drug by the liver is 72 ± 7 % of the administered dose.
Conclusion: The complex compound Mn (II) with D-myo-inositol-1, 2, 3, 4, 5, 6– hexakis dihydrophosphoric (phytic) acid belongs to low-toxic substances, is stable in aqueous media and has a high relaxability R1, selectively accumulates and intensively contrasts the liver parenchyma, and can be considered as the basis for creating a hepatospecific paramagnetic contrast preparation for use in MRI diagnostics liver in experimental and clinical studies.
Keywords: MRI, liver, paramagnetic contrast, Mn(II)-phytate, Phytomang, phytic acid, D-mio-inositol-1, 2, 3, 4, 5, 6-hexakisdihydrophosphoric acid, preclinical study
For citation: Ussov WYu, Belyanin ML, Borodin OY, Bezlepkin AI, Churin AA, Shimanovsky NL. Preclinical Study of the Imaging Properties of the Mn(Ii)–D-Myo-Inositol-1, 2, 3, 4, 5, 6-Hexakisdihydrophosphoric Acid Complex as a Hepatospecific Paramagnetic Contrast Agent. Medical Radiology and Radiation Safety. 2024;69(6):56–63. (In Russian). DOI:10.33266/1024-6177-2024-69-6-56-63
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2024. Accepted for publication: 25.09.2024.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 6
DOI:10.33266/1024-6177-2024-69-6-71-76
Yu.D. Udalov1, 2, A.A. Vorobyov1, A.V. Nezvetsky1, V.A.Kiselev1
Combined Method for Treating Orophynary Cancer
1 Federal Scientific Clinical Center for Medical Radiology and Oncology, Dimitrovgrad, Russia
2 A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: Alexey Alekseevich Vorobiev, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To demonstrate the possibility of a combined approach in the treatment of a patient with locally advanced squamous cell carcinoma of the nasopharynx, complicated by massive erosive bleeding using endovascular embolization, proton therapy and targeted therapy.
Material and methods: The Federal Scientific Research Center for Reconstruction and Research has developed a method of a combined approach to the treatment of patients with malignant neoplasms of the nasopharynx, during which endovascular embolization and proton beam therapy in combination with targeted therapy are consistently used.
Results: A set of sequential treatment procedures and drug administration allowed us to eliminate life-threatening bleeding, normalize the patient’s general condition, conduct a course of proton radiation therapy for a patient with locally advanced squamous cell carcinoma of the nasopharynx, complicated by massive bleeding, and achieve stable local control over the process.
Conclusion: The use of the described tactics in the treatment of tumors of the nasopharynx and oral cavity allows in a short period to move from urgent endovascular occlusion of bleeding vessels to the stages of special antitumor treatment, providing a combined approach to the treatment of head and neck tumors.
Keywords: nasopharyngeal cancer, squamous cell carcinoma, proton therapy, endovascular treatment, embolization, targeted therapy
For citation: Udalov YuD, Vorobiev AA, Nezvetsky AV, Kiselev VA. Combined Method for Treating Orophynary Cancer. Medical Radiology and Radiation Safety. 2024;69(6):71–76. (In Russian). DOI:10.33266/1024-6177-2024-69-6-71-76
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Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2024. Accepted for publication: 25.09.2024.