Journal Description

JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.

The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Выпуски журналов

Using AI tools

Due to the wide use AI in preparing, writing and peer-reviewing research papers the editorial team of the journal “Medical Radiology and Radiation Safety” is committed to ensure that such use aligns with our publishing requirements and ethical standards to meet the following provisions.

1. Responsibility and authorship

· Responsibility for the content of the manuscript, including the accuracy of data, correct citation and compliance with ethical standards, lies entirely with the authors, regardless of their use of generative AI tools (i.e., capable of creating new content). The authors guarantee that the final text of the manuscript is original, reflects the results of the research conducted by the authors.

· AI (chatbots, such as ChatGPT and similar tools) cannot be listed as authors of the article or as persons who contributed to the preparation of the manuscript. AI-based programs do not meet the criteria for authorship, as they are not liable for the content of the work, cannot declare conflicts of int

erest, or manage copyright.

2. Human oversight and validity

· When using AI tools as aids for text editing, literature search, data analysis and visualization, or idea generation, users are required to ensure human control at all stages of manuscript preparation, carefully checking all AI-generated outputs, including facts, citations, and analytical conclusions, for compliance with the relevance of the research data and accepted scientific standards.

· It is allowed to use AI to generate images (diagrams) illustrating processes, concepts, and mechanisms of action. It is prohibited to use AI to generate actual research results or modify images obtained during the study.

3. Transparency and disclosure

· Authors are required to indicate the use of generative AI tools when submitting a manuscript, including: the name and version of the AI tool; purpose of use (e.g. text mining/ editing, data analysis, generating processes flowcharts described in the work, used questionnaires, manuscript abstracts, etc.); prompts used in generative AI.

· Authors may not provide this information if non-generative AI was used or if generative AI did not significantly modify the content of the manuscript, for example:

o basic grammar checking;

o replacing only a few words in the text without changing the contextual meaning;

o a general literature search using AI without its interpretation and data synthesis;

o literature sources formatting without recommending/generating sources;

o general editing of images without their modification (cropping, increasing contrast, etc.).

· The editors may request additional information about the use of AI to ensure transparency and compliance with ethical standards.

4. Rights and privacy protection

· Authors and reviewers must ensure that the AI tools used:

o comply with the requirements for the protection of personal/ sensible data and confidentiality;

o do not violate the rights of third parties, including intellectual property and data privacy;

o do not gain the rights to content created by authors and do not use it to train AI models without the user's consent.

· By submitting material created using AI, authors guarantee that they have the right to use the generative content under the terms of the AI licenses.

5. Technical control by the editors

· The Journal uses specialized tools such as national industry leader Antiplagiat plagiarism checker to identify texts generated by AI. Manuscripts containing unjustified use of AI may be rejected or sent for revision.

6. Compliance with international standards and best practices

The editorial team of the journal "Medical Radiology and Radiation Safety" supports the provisions of Russian regulations, the position of the international publishing community and best practices presented in the following documents:

· Russian GOST 71657-2024 about the use of AI tools in writing scientific publications

· World Association of Medical Editors (WAME) – Chatbots, Generative AI, and Scholarly Manuscripts

· International Committee of Medical Journal Editors (ICMJE) – Recommendations, Part II, paragraph A4

· Editorial policy of Wiley and Springer Nature regarding the principles of using AI in scientific publications

Policy revision date: 14.04.2025

CONTENTS № 3 - 2025

View or download the full issue in PDF (Russian)

RADIATION BIOLOGY	5	Study of the Efficacy of Cell Therapy for Severe Local Radiation Injuries in the Use of Drugs Affecting the State of Irradiated Tissues Before Cell Transplantation Deshevoi Yu.B., Lebedev V.G., Nasonova T.A., Dobrynina O.A., Brunchukov V.A., Kobzeva I.V., Astrelina T.A., Samoylov A.S.
	11	Post-Irradiation Changes in the Number of γH2AX and patm Protein Foci in Human Mesenchymal Stem Cells Irradiated with 14.1 MeV Neutrons Korneva S.A., Chigasova A.K., Osipov A.A., Ignatov M.A., Vorobyova N.Yu., Saburov V.O., Kazakov E.I., Koryakin S.N., Fedotov Yu.A., Bushmanov A.Yu., Osipov A.N.
	16	Protective Effect of Dimethylsulphoxide in Combination with Gluthathione and Cysteamine Against the Damaging Effect of Ionizing Radiation on Spermatogenesis Mamina V.P.
	22	Biological Reactions under the Combined Action of Ionizing Radiation with Other Factors Romodin L.A., Umnikov A.S., Samoilov A.S.
RADIATION SAFETY	34	Radiation Health Physics to Assure Radiation Safety and Protection of the Public and Personnel: Case Study of the SRC-FMBC Shandala N.K., Samoylov A.S., Seregin V.A., Kiselev S.M., Kvacheva Yu.E., Metlyaev E.G., Kochetkov O.A., Klochkov V.N., Titov A.V., Kolyshkin A.E., Semenova M.P.
	48	The Current State and Problems of Health Protection of Women Working in Conditions of Radiation Hazard Arkhipova V.I., Lyaginskaya A.M., Parinov O.V., Metlyaev E.G., Samoylov A.S.
	54	Analysis of the Radiation Situation in Aviation Flights under Conditions of Solar Proton Events Burmistrov V.I., Matkevich E.I., Ivanov I.V.
RADIATION EPIDEMIOLOGY	70	‘Healthy Worker Effect’ In Employees of Medical-Biological and Chemical Laboratories: Comparison with Effects in Nuclear Workers, in other Professional Contingents (Meta-Analyses), and the Role of the Radiation Factor Koterov A.N., Ushenkova L.N., Wainson A.A., Usupzhanova D.Yu., Bushmanov A.Yu.
RADIATION DIAGNOSTICS	83	Using Machine Learning Algorithms to Detect Cancer Automatically Al-Rawi Muaayed F., Abboud Izz K., Al-Awad Nasir A.
RADIATION THERAPY	90	Pathomorphological Changes in Cell Structures of Cerebral Metastasis of Lung Adenocarcinoma after Neoadjuvant Gamma Knife Radiosurgy. A Case Report Koval K.V., Tokarev A.S., Kanibolotskiy A.A., Evdokimova O.L., Grin A.A.
NUCLEAR MEDICINE	99	Quantitative Brain SPECT/CT with ^99mTc-Technetril for Visualization and Assessment of the Functional State of Pituitary Adenomas Ussov W.Yu., Minin S.M., Anashbayev Zh.Zh., Sazonova S.I., Belichenko O.I., Golovina E.A., Lishmanov Yu.B., Cherniavsky A.M.
RADIATION PHYSICS, TECHNIQUE AND DOSIMETRY	108	Application of the Monte-Carlo Method for Calibration of a Gamma-ray Scintillation Spectrometer Arefyeva D.V., Firsanov V.B., Yarmiychuk S.V., Petushok A.V.
PROFESSIONAL EDUCATION	117	On the Legal Regulation of the Specialties Radiology and Radiotherapy in the Russian Federation Bezverkhov A.G., Alekhin E.N., Pyshkina Yu.S., Stanjevsky А.А., Logvinenko А.V.

CONTENTS № 1 - 2025

View or download the full issue in PDF (Russian)

RADIATION BIOLOGY	5	Evaluation of the Protective Effect of the Combined Use of Certain Natural Substances in Acute Exposure to Ionizing Radiation by Mice Physiological Parameters Romodin L.A., Moskovskij A.A., Nikitenko O.V., Bychkova T.M., Rodionova E.D., Tyukalova O.M.
	16	The Behavioral Effect of Low Dose Carbon Ions Irradiation on Mice in Short-Term Period Sorokina S.S., Pikalov V.A., Popova N.R.
	21	The Effect of Heavy Ion Irradiation on the Metabolism of Technologically and Biologically Significant Microorganisms: Biotechnological Prospects of Application Gutnov A.V., Belov O.V., Kachmazov G.S., Magkoev T.T., Popova N.R., Pukhaeva N.E.
RADIATION SAFETY	30	CT and MRI in Diagnostic Practice at the A.I. Burnazyan Federal Medical Biological Center: Opportunities for Optimizing Studies to Reduce Radiation Exposure Matkevich E.I., Bashkov A.N., Parinov O.V., Samoylov A.S.
	39	Digital Technologies in Recording Occupational Diseases and their Analysis Ziyatdinov M.N., Tukov A.R., Mikhailenko A.M., Archegova M.G.
	45	Radon Hazard Mapping of Pyatigorsk City Considering Geological Data Miklyaev P.S., Kaygorodov E.I., Petrova T.B., Marennyy A.M., Karl L.E., Shchitov D.V., Sidyakin P.A., Murzabekov M.A., Tsebro D.N., Gubanova Yu.K., Mnatsakanyan M.P., Gertsen G.P.
RADIATION MEDICINE	53	The Possibilities of Early Diagnosis of Acute Radiation Syndrome Combined with Mechanical Injury Galstian I.A., Bushmanov A.Yu., Torubarov F.S., Zvereva Z.F., Shcherbatykh O.V., Nugis V.Yu., Metlyaeva N.A., Pustovoit V.I., Umnikov A.S., Konchalovsky M.V., Aksenenko A.V., Korenkov V.V., Yunanova L.A., Kashirina O.G.
NON-IONIZING RADIATION	60	On the Concentration of External Electric Field Intensity on the Internal Surfaces of Blood Vessels Sachkov I.N.
RADIATION THERAPY	67	Modernized Software for Calculation and Optimization of Absorbed Dose Distribution in a Homogeneous Medium during Radiation Therapy with Fast Neutrons Vertinskiy A.V., Selikhova E.A., Sukhikh E.S., Velikaya V.V., Gribova O.V., Starceva Zh.A.
RADIATION DIAGNOSTICS	74	Priority Imaging Technique in Patients with Head and Neck Cancer and Dental Hardware: a Literature Review Vasilev Y.A., Kontorovich D.S., Reshetnikov R.V., Blokhin I.A., Semenov D.S.
	81	Potential Applications of Artificial Intelligence in Muscle Tissue Assessment by Computed Tomography Images: a Literature Review Smorchkova A.K., Petraikin A.V., Vasilev Yu.A.
NUCLEAR MEDICINE	93	Radiopharmaceuticals Based on Somatostatin Analogs and Technetium-99m Radionuclide for Diagnosis of Neuroendocrine Tumors: a Literature Review Tishchenko V.K., Vlasova O.P., Ivanov S.A., Kaprin A.D.
	102	Assessment of Radiation Burden on Organs and Tissues from the Aptamer-Based Radiopharmaceutical for PET/CT Imaging of Lung Cancer Ozerskaya A.V., Badmaev O.N., Shepelevich N.V., Tokarev N.A., Lipaikin S.Y., Chanchikova N.G., Luzan N.A., Koshmanova А.А., Zamay T.N., Voronkovskii I.I., Lunev A.S., Kichkailo A.S.
	109	The Gastrin-Releasing Peptide Receptor Antagonist [^99MTc]Tc-Rm26 is a Novel Radiopharmaceutical for Prostate Cancer Imaging Chernov V.I., Rybina A.N., Zelchan R.V., Medvedeva A.A., Bragina O.D., Lushnikova N.A., Usynin E.A., Abouzayed A., Rinne S.S., Sörensen J., Tolmachev V.М., Orlova A.М.
RADIATION PHYSICS, TECHNIQUE AND DOSIMETRY	115	Analysis of Possibility of Using an Algorithm for Correcting Metal Artifacts in CT-Images for Radiation Therapy Planning Petraikin A.V., Baulin А.А., Vasilev Y.A., Artyukova Z.R., Smorchkova A.K., Semenov D.S., Alihanov A.A., Erizhokov R.A., Omelyanskaya O.V.
ANNIVERSARY	122	Oleg Anatolyevich Kochetkov

CONTENTS № 2 - 2025

View or download the full issue in PDF (Russian)

RADIATION BIOLOGY	5	*Thymoquinone (a Component of Nigella Sativa) Reduces Toxic Effects of Radiotherapy and Has Anti-Cancer Potential* Abdullaev S.A., Raeva N.F., Fomina D.V., Kalinin T.P., Maksimova T.N., Zasukhina G.D.
	9	Repetitive Confined Migration Leads to an Increase in Clonogenic Activity and Chemoresistanse of Human Non-Small Cell Lung Cancer Cells, Regardless of Their Initial Chemo- and Radiosensitivity Malakhov P.A., Pustovalova M.V., Aleksandrova A.V., Kontareva E.G., Smirnova A.V., Nofal Z., Osipov A.N., Leonov S.V.
	16	Changes in the Copy Number and Gene Expression of mtdna in Various Tissues of Mice Exposed to Local Brain Irradiation Abdullaev S.A., Fomina D.V., Menukhov V.O., Dushenko M.V., Tochilenko A.V., Kalinin T.P., Evdokimovskii E.V.
	23	*Low Efficiency of DNA Repair in Human Peripheral Blood Lymphocytes Irradiated ex vivo* by 14.1 MeV Neutrons** Zrilova Yu.A., Chigasova A.K., Ignatov M.A., Vorobyеva N.Yu., Osipov A.A., Saburov V.O., Kazakov E.I., Koryakin S.N., Fedotov Yu.A., Bushmanov A.Yu., Osipov A.N.
	27	MiR-16-1-3p and miR-16-2-3p Overexpression Confers Tumor Suppressive and Antimetastatic Properties in Radioresistant A549 Non-Small Cell Lung Cancer Cells Malakhov P.A., Maximov V.V., Pustovalova M.V., Smirnova A.V., Nofal Z., Saburov V., Osipov A.N., Kuzmin D.V., Leonov S.V.
	35	Synthesized Using β-Cyclodextrin Silver and Gold Nanoparticles as Radiosensitizers in Breast Cancer Radiotherapy Pustovalova M.V., Nekrasov V.D., Andreev E.V., Fadeikina I.N., Leonov S.V., Nechaev A.N., Osipov A.N.
RADIATION SAFETY	40	Formation of Radon Situation in Buildings of Educational Institutions of Lermontov Town Miklyaev P.S., Petrova T.B., Sidyakin P.A., Marennyy A.M., Tekeev R.A., Tsapalov A.A., Shchitov D.V., Tsebro D.N., Murzabekov M.A., Karl L.E., Gavriliev S.G.
	49	The Expert Group Actions Algorithms of the Emergency Medical Radiation Dosimetry Center in Various Scenarios of Radiation Accidents Molokanov A.A., Grachev M.I., Salenko Yu.A., Frolov G.P., Tsovyanov A.G., Tesnov I.K., Barchukov V.V.
	57	Risks in the System “Human-Industrial Environment”: Conceptual Model, Concept of Assessment and Management Bobrov A.F., Proskuryakova N.L., Fortunatova L.I.
RADIATION EPIDEMIOLOGY	63	The Incidence of Occupational Diseases of Employees of Enterprises and Organizations of the Russian Nuclear Industry Samoilov A.S., Bushmanov А.Yu., Tukov A.R., Ziyatdinov M.N., Kalinina M.Yu., Mihajlenko A.M., Kalinina M.V., Kretov A.S., Archegova M.G.
	71	Characteristics of the Uranium Cohort of Personnel of the Radiochemical Production of the Siberian Chemical Plant Kalinkin D.E., Milto I.V., Smaglii L.V., Gorina G.V., Litvinova O.V., Samoilova Yu.A., Avkhimenko V.А., Takhauov R.M.
	75	Lung Cancer Incidence in the Southern Urals Population Exposed to Radiation Cohort Silkin S.S.
	81	Epidemiological Analysis of Thyroid Cancer in the System of FMBA of Russia Sychev P.V., Udalov Yu.D., Mayakova E.V., Kaidash Yu.A., Shcherbakov M.I, Baryshnikov I.A.
	88	Industry Bibliographical Databases: Perspectives of Use in the Fmba of Russia for Scientific Expertise in Decision-Making. Report 1. General Issues and Database on Health and Other Effects in Nuclear Workers Koterov A.N., Ushenkova L.N., Bulanova T.M., Bogdanenko N.A.
RADIATION DIAGNOSTICS	107	X-Ray Computed Tomography in Complex Diagnosis of Thyroid Diseases Shatalova M.O., Tomashevskiy I.O.
NUCLEAR MEDICINE	113	Results of Evaluation of Four Cycles of Radionuclide Therapy with a Domestic Radiopharmaceutical Based on Radium-223 Chloride for the Treatment of Bone Metastases Sychev P.V., Udalov Yu.D.
	119	¹¹C-Methionine and ¹⁸F-Fluorodeoxyglucose PET/CT in Multiple Myeloma Patients – One-Day Investigation Manukova V.A., Aslanidis I.P., Mukhortova O.V., Metelkina M.V., Ekaeva I.V., Rumyantsev A.S., Silchenko A.V.
ANNIVERSARY	126	Memorizing Professor V.V. Shikhodyrov (to the 100^th Anniversary of Birth) Kvacheva Yu.E.
	130	Nina Alexandrovna Koshurnikova

Medical Radiology and Radiation Safety. 2024. Vol. 69. № 6

DOI:10.33266/1024-6177-2024-69-6-5-11

Yu.B. Deshevoi, V.G. Lebedev, T.A. Nasonova, O.A. Dobrynina,
A.S. Umnikov, T.A. Astrelina, A.S. Samoylov, V.Yu. Soloviev

Comparison of the Efficacy of Different Methods of Treatment
of Severe Local Radiation Injuries in an Experiment

A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia

Contact person: Yu.B. Deshevoi, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: To compare the effectiveness of different methods of treating severe local radiation injuries (LRI) under the same experimental conditions.
Material and methods: Male rats of the Wistar-Kyoto inbred line were locally irradiated in the ilioplumbar region of the back using an X-ray unit LNK-268 at a dose of 110 Gy (tube voltage 30 kV, current 6.1 mA, Al filter 0.1 mm thick), at a dose rate of 20.0 Gy/min. The area of the irradiation field was 8.2 cm². Such radiation exposure led to the occurrence of severe LRI in rats with long-term non-healing skin ulcers, without critical radiation exposure to the underlying tissues.
For the treatment of severe LRI, surgical methods, cell or drug therapy were used, which were used separately from each other. Treatment began on the 28th day after local irradiation, that is, during the period when the radiation ulcer had already formed and regenerative processes began to activate in the affected area. Various surgical approaches were used: from complete excision of the radiation ulcer to removal of various volumes of necrotic tissue within the radiation ulcer. Cell therapy consisted of transplantation of syngeneous cells of the stromal vascular fraction of adipose tissue or cultured syngeneous multipotent mesenchymal stromal cells. The cells were injected subcutaneously around the radiation ulcer twice at 1-week intervals. For drug therapy of severe local radiation injuries, we used a veterinary complex antibiotic ‒ levotetrasulfin forte, as well as drugs that affect the microcirculation and trophism of irradiated tissues – pentoxifylline and detralex. The drugs were used once a day from the 28th to the 49th day after irradiation.
Results and coclusion: The use of surgical methods, cell or drug therapy facilitated the course of the pathological process and accelerated the healing of radiation ulcers. However, different treatments for severe LRI have had different efficacy. In terms of the rate and quality of healing of severe local radiation injuries, drug therapy is less effective than cellular therapy, and cell therapy is less effective than complete surgical excision of radiation ulcers.

Keywords: radiation ulcer, surgical excision, transplantation, stromal-vascular fraction of adipose tissue, multipotent mesenchymal stromal cells, drug therapy, rats

For citation: Deshevoi YuB, Lebedev VG, Nasonova TA, Dobrynina OA, Umnikov AS, Astrelina TA, Samoylov AS, Soloviev VYu. Comparison of the Efficacy of Different Methods of Treatment of Severe Local Radiation Injuries in an Experiment. Medical Radiology and Radiation Safety. 2024;69(6):5–11. (In Russian). DOI:10.33266/1024-6177-2024-69-6-5-11

References

1. Radiatsionnaya Meditsina. Rukovodstvo dlya Vrachey-Issledovateley i Organizatorov Zdravookhraneniya = Radiation Medicine: A Guide for Medical Researchers and Health Care Organizers. Vol.2 Ed. L.A. Il’in Moscow, IzdAT Publ., 2001. 432 p. (In Russ.).

2. Nadezhina N.M., Galstyan I.A. Lecheniye Mestnykh Luchevykh Porazheniy = Treatment of Local Radiation Lesions. Ed. K.V.Kotenko., A.Yu.Bushmanov. Moscow, Burnasyan Federal Medical Biophysical Centre Publ., 2013. 99 p. (In Russ.).

3. Masaki Fujioka. Surgical Reconstruction of Radiation Injuries. Advances in Wound Care. 2014;3;1:25-37.

4. Francois S., Mouiseddine M., Mathieu N., Semont A., Monti P.,
Dudoignon N., Sache A., Boutarfa A., Thierry D., Gourme-
lion P., Chapel A. Human Mesenchymal Stem Cells Favour Healing of the Cutaneous Radiation Syndrome in a Xenogenic Transplant Model. Annals of Hematology. 2007;86;1:1–8.

5. Kotenko K.V., Eremin I.I., Moroz B.B., Bushmanov A.Yu., Nadezhina N.M., Galstyan I.A., Deshevoy Yu.B., Lebedev V.G., Nasonova T.A., Dobrynina O.A., Lyrshchikova A.V. Cell Technologies in the Treatment of Radiation Burns: Experience Burnasyan Federal Medical Biophysical Centre. Kletochnaya Transplantologiya i Tkanevaya Inzheneriya = Cell Transplantology and Tissue Engineering. 2012;7;2:97-102 (In Russ.).

6. Deshevoy Yu.B., Nasonova T.A., Dobrynina O.A., Deyev R.V., Lebedev V.G., Lyrshchikova A.V., Astrelina T.A., Moroz B.B. Experence of Application of Syngeneic Multipotent Mesenchymal Stem Cells (MMSC) Adipose Tissue for Treatment of Severe Radiation Skin Lesions at Various Intervals after Exposure in the Experiments. Radiatsionnaya Biologiya. Radioekologiya = Radiation Biology. Radioecology. 2020;60;1: 26-33 (In Russ.).

7. Deshevoy Yu.B., Lebedev V.G., Nasonova T.A., Dobrynina O.A., Lyrshchikova A.V., Astrelina T.A., Moroz B.B. Comparative Effectiveness of Singful Cultivated Mesenchymal Stem Cells (MMSC) and Freshly Isolated Cells of Stromal-Vascular Fraction (SVF) of Fat Tissue in the Treatment of Severe Local Radiation Lesions in the Experiment. Radiatsionnaya Biologiya. Radioekologiya = Radiation Biology. Radioecology. 2021;61;2:151-157 (In Russ.)

8. Brunchukov V.A., Astrelina T.A., Nikitina I.V., Kobzeva I.V., Suchkova Yu.B., Usupzhanova D.Yu., Rastorguyeva A.A., Karaseva T.V., Gordeyev A.V., Maksimova L.A., Naumova L.A., Lishchuk S.V., Dubova Ye.A., Pavlov K.A., Brumberg V.A., Makhova A.Ye., Lomonosova Ye.Ye., Dobrovol’skaya Ye.I., Bushmanov A.YU., Samoylov A.S. Experimental Treatment of Radiation Skin Lesions with Mesenchymal Stem Cells and with Conditioned Media. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost’ = Medical Radiology and Radiation Safety. 2020;65;1:5-12 (In Russ.).

9. Deshevoy Yu.B., Nasonova T.A., Dobrynina O.A., Lebedev VG, Astrelina T.A., Samoylov A.S. The Effect of Drugs that Normalize Blood Supply and Trophism of Irradiated Tissues, as well as a Broad-Spectrum Antibiotic on the Course of Severe Local Radiation Injuries in Rats. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost’ = Radiation Biology. Radioecology. 2021;66;2:5-12 (In Russ.).

10. Kotenko K.V., Moroz B.B., Nasonova T.A., Dobrynina O.A, Lipengol’ts A.D., Gimadova T.I., Deshevoy YU.B., Lebedev V.G., Lyrshchikova A.V., Yeremin I.I. Experimental Model of Severe Local Radiation Injuries of the Skin After X-Rays. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya = Pathological Physiology and Experimental Therapy. 2013;57;4:121-123 (In Russ.).

11. Isakson M., C.de Blacam, Whelan D. McArdle A., Glove A.J. Mesenchymal Stem Cells and Cutaneous Wound Healing: Current Evidence and Future Potential. Review Article. Hundawi Publishing Corporation. Stem Cells International (Internet). 2015. Article ID 831095. 12 p. URL: https://dx.doi.org/10.1155/2015/831095.

12. Benfar M., Javanmardi S., Sarrafzadeh-Rezaei F. Comparative Study on Functional Effects Allotransplantation of Bone Marrow Stromal Cells and Adipose Derived Stromal Vascular Fraction on Tendon Repair: a Biomechanical Study in Rabbits. Cell J. 2014;16;3:263-270.

13. Bourin P., Bunnell B.A., Casteilla L., Dominici M., Katz A.J., March K.L., Rendl H., Rubin J.P., Yoshimura K., Gimble J.M. Stromal Cells from the Adipose Tissue-Derived Stromal Vascular Fraction and Cultured Expanded Adipose Tissue-Derived Stromal/Stem Cells: a Joint Statement of the International Federation for Adipose Therapeutics and the International Society for Cellular Therapy (ISCT). Cytotherapy. 2013;15:641-648.

14. Kolev M., Donchev N., Borov M. Experimental Research on the Toxicity of Pharmapentoxifylline. Exp. Med. Morphol. 1990;29;4:57-61.

15. Product Monograph. PrTRENTAL®. ATC Code: C04AD03. Sanofi-Aventis Canada Inc. Date of Revision: March 30, 2011. 21 p.

16. Man M.Q., Yang B., Elias P.M. Benefits of Hesperidin For Cutaneous Functions. Hindawi Evidence-Based Complementary and Alternative Medicine (Internet). 2019. Article ID 2676307. 19 p. URL: https://doi.org/10.1155/2019/2676307.

17. Gunik A.V., Parshin P.A., Vostroilova G.A. Parameters of Toxicity of the Complex Antimicrobial Drug Levoterasulfine Forte. The Materials of the International Scientific And Practical Conference Aktual’nyye Problemy Bolezney Molodnyaka v Sovremennykh Usloviyakh =Actual Problems of Diseases of Young Animals in Modern Conditions, September 23-25, 2002. Voronezh Publ., 2002. P.11 (In Russ.).

18. Lataillade J.J., Doucet C., Bey E., Carsin H., Huet C., Clairand I., Bottollier-Depois J.F., Chapel A., Ernou I., Gourven M., Boutin L., Hayden A., Carcano C., Buglova E., Joussemet M., Revel T., Gourmelon P. New Approach to Radiation Burn Treatment by Dosimetry-Guided Surgery Combined with Autologous Mesenchymal Stem Cell Therapy. Regen. Med. 2007;2:785–794.

PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 20.07.2024. Accepted for publication: 25.09.2024.

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MEDICAL RADIOLOGY AND RADIATION SAFETY