SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.

The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Issues journals

Medical Radiology and Radiation Safety. 2020. Vol. 65. No. 4. P. 5–11

D.E. Kalinkin1,2, R.M. Takhauov1,2 A.B. Karpov2, Yu.A. Samoilova3, M.B. Plaksin3, Yu.V. Semenova3, A.R. Takhauov1, E.N. Kiriakidi2, L.R. Takhauova2

Factors Influencing the Health Condition of the Adult Population Residing in the Activity Area of Atomic Industry Enterprise

1 Seversk Biophysical Research Center, Seversk, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
2 Siberian State Medical University, Tomsk, Russia
3 Siberian Federal Scientific Clinical Center, Seversk, Russia

Abstract

Purpose: Development of the basic directions of a modern strategy for protecting the health of the adult population living in the activity zone of nuclear industry enterprises (using the example of the Seversk population).

Material and methods: The object of the study was the population of the city of Seversk, formed around the Siberian Group of Chemical Enterprises. The subject of the study was demographic indicators; disability; incidence of malignant neoplasms, diseases of the circulatory system, injuries and accidents); socio-economic, behavioral and technological risk factors affecting the occurrence of major diseases.

Results: It was established that by the end of the study period (1970–2017), the studied population was in a state of natural population decline due to a decrease in the birth rate and an increase in mortality, while the mortality rate exceeded the birth rate.

During the period under review, the primary incidence of malignant neoplasia significantly increased; at the same time, the incidence of cardiovascular diseases, as well as the frequency of injuries and poisoning, decreased. Among the adult population of Seversk, behavioral factors (the habit of smoking, regular use of alcohol, a sedentary lifestyle, lack of regular physical activity) are more common than socio-economic (living conditions, financial situation) risk factors. Important risk factors are incorrect assessment by citizens of their own health and the reasons for its violation. Among Siberian Group of Chemical Enterprises workers exposed to tekhnogenic risk factor (long-term occupational exposure), there is an increased risk of cancer death of all localizations taken together, respiratory and digestive organs; bones, joints, mesothelium, soft tissues and genitals. At the same time, the risk of oncological mortality during irradiation was not exceeded in the range of small doses of (up to 100 mSv), and for any of the localization of malignant neoplasms this effect is not dose-dependent.

Conclusion: The data obtained made it possible to specify and substantiate the basic directions of the modern strategy for protecting the health of the adult population living in the activity zone of nuclear industry enterprises (using the example of the Seversk population).

Key words: population, health condition, risk factors, occupational exposure, atomic industry enterprise

For citation: Kalinkin DE, Takhauov RM, Karpov AB, Samoilova YuA, Plaksin MB, Semenova YuV, Takhauov AR, Kiriakidi EN, Takhauova LR. Factors Influencing the Health Condition of the Adult Population Residing in the Activity Area of Atomic Industry Enterprise. Medical Radiology and Radiation Safety. 2020;65(4):5-11 (In Russ.).

DOI: 10.12737/1024-6177-2020-65-4-5-11

Список литературы / References

  1. Гланц С. Медико-биологическая статистика: Пер. с англ. М.: Практика, 1998. 459 с. [Glants S. Biomedical statistics. Moscow. 1998. 459 p. (In Russ.)].
  2. Медик ВА, Токмачёв МС. Руководство по статистике здоровья и здравоохранения. М.: Медицина, 2006. 528 с. [Medik VA, Tokmachev MS. Guide to Health and Health Statistics. Moscow. 2006. 528 p. (In Russ.)].
  3. Ahlbom A, Norell S. Introduction to Modern Epidemiology. 2nd Ed. Epidemiology Resources Inc, 1990. 222 p.
  4. Сабгайда ТП, Иванова АЕ, Землянова ЕВ. Прежде­вре­мен­ная смертность и факторы риска как индикаторы программ снижения смертности в России. Социальные аспекты здоровья населения [электронный научный журнал]. 2017;55(3). URL: http://vestnik.mednet.ru/content/view/831/30/lang,ru/ (дата обращения 30.09.2019). [Sabgayda TP, Ivanova AE, Zemlyanova EV. Premature mortality and risk factors as indicators of mortality reduction programs in Russia. Social aspects of population health [serial online] 2017;55(3). Available from: http://vestnik.mednet.ru/content/view/831/30/lang,ru/ (accessed September 30, 2019). (In Russ.)]. DOI: 10.21045/2071-5021-2017-55-3-1.
  5. Жилина НМ. Состояние здоровья трудящегося населения промышленного центра Сибири в 2008–2015 гг. Социальные аспекты здоровья населения [электронный научный журнал]. 2017;56(4). URL: http://vestnik.mednet.ru/content/view/846/30/lang,ru/ (дата обращения 30.09.2019). [Zhilina NM. The health status of the working population of the industrial center of Siberia in 2008–2015. Social aspects of population health [serial online] 2017;56(4). Available from: http://vestnik.mednet.ru/content/view/846/30/lang,ru/ (accessed September 30, 2019). (In Russ.)]. DOI: 10.21045/2071-5021-2017-56-4-3.
  6. Савина АА, Леонов СА, Сон ИМ, Фейгинова СИ, Вайс­ман ДШ. Тенденции показателей заболеваемости населения Алтайского края. Социальные аспекты здоровья населения [электронный научный журнал]. 2019;67(3). URL: http://vestnik.mednet.ru/content/view/1073/30/lang,ru/ (дата обращения 29.09.2019). [Savina AA, Leonov SA, Son IM, Feyginova SI, Vaysman DSh. Trends in the incidence rate of the Altai Territory population. Social aspects of population health [serial online] 2019; 67(3). Available from: http://vestnik.mednet.ru/content/view/1073/30/lang,ru/ (accessed September 29, 2019). (In Russ.)]. DOI: 10.21045/2071-5021-2019-65-3-4.
  7. Гордиенко ВП, Вахненко АА, Янушевский КВ. Основные показатели заболеваемости и смертности населения от злокачественных новообразований в Дальневосточном федеральном округе. Социальные аспекты здоровья населения [электронный научный журнал]. 2018;64(7). URL: http://vestnik.mednet.ru/content/view/1027/30/lang,ru/ (дата обращения 30.09.2019). [Gordienko VP, Vakhnenko AA, Yanushevskiy KV. The main indicators of morbidity and mortality from malignant neoplasms in the Far Eastern Federal District. Social aspects of population health [serial online] 2018; 64(7). Available from: http://vestnik.mednet.ru/content/view/1027/30/lang,ru/ (accessed September 30, 2019). (In Russ.)]. DOI: 10.21045/2071-5021-2018-64-6-5.
  8. Немцов АВ. Сердечно-сосудистые и прочие смерти в России, 2004–2006 гг. Социальные аспекты здоровья населения [электронный научный журнал]. 2018;60(2). URL: http://vestnik.mednet.ru/content/view/967/30/lang,ru/ (дата обращения 30.09.2019). [Nemtsov AV. Cardiovascular and other deaths in Russia, 2004–2006. Social aspects of population health [serial online] 2018;60(2). Available from: http://vestnik.mednet.ru/content/view/967/30/lang,ru/ (accessed September 30, 2019). (In Russ.)]. DOI: 10.21045/2071-5021-2018-60-2-6.
  9. Савина АА, Леонов СА, Сон ИМ, Фейгинова СИ. Вклад отдельных возрастных групп в формирование общей заболеваемости по обращаемости в федеральных округах Российской Федерации. Социальные аспекты здоровья населения [электронный научный журнал]. 2018;61(3). URL: http://vestnik.mednet.ru/content/view/978/30/lang,ru/ (дата обращения 30.09.2019). [Savina AA, Leonov SA, Son IM, Feyginova SI. Contribution of Individual Age Groups in Prevalence Based On Care Seeking Data in the Federal Districts of the Russian Federation. Social aspects of population health [serial online] 2018;61(3). Available from: http://vestnik.mednet.ru/content/view/978/30/lang,ru/ (accessed September 30, 2019). (In Russ.)]. DOI: 10.21045/2071-5021-2018-61-3-1.
  10. Жилина НМ. Основные причины инвалидности и смертности населения в 2012–2016 годах на примере Новокузнецка. Социальные аспекты здоровья населения [электронный научный журнал]. 2018;60(2). URL: http://vestnik.mednet.ru/content/view/968/30/lang,ru/ (дата обращения 30.09.2019). [Zhilina NM. The main causes of disability and mortality in 2012–2016 on the example of Novokuznetsk. Social aspects of population health [serial online] 2018;60(2). Available from: http://vestnik.mednet.ru/content/view/968/30/lang,ru/ (accessed September 30, 2019). (In Russ.)]. DOI: 10.21045/2071-5021-2018-60-2-7
  11. Савина АА, Леонов СА, Сон ИМ, Михайлова ЮВ, Фейгина СИ. Основные тенденции первичной заболеваемости населения в субъектах Российской Федерации в 2008–2017 гг. Проблемы социальной гигиены, здравоохранения и истории медицины. 2019;27(2):118-22. [Savina AA, Leonov SA, Son IM, Mikhaylova YuV, Feygina SI. The main trends in the primary incidence of the population in the constituent entities of the Russian Federation in 2008–2017. Problems of Social Hygiene, Public Health And History of Medicine. 2019;27(2):118-22. (In Russ.)]. DOI: 10.32687/0869-866X-2019-27-2-118-122.
  12. Чигисова АН, Огарков МЮ, Максимов СА. Комплексная оценка факторов риска артериальной гипертензии у работников угольных шахт. Социальные аспекты здоровья населения [электронный научный журнал]. 2018;61(3). URL: http://vestnik.mednet.ru/content/view/985/30/lang,ru/ (дата обращения 30.09.2019). [Chigisova AN, Ogarkov MYu, Maksimov SA. Comprehensive assessment of risk factors for arterial hypertension in coal mine workers. Social aspects of population health [serial online] 2018;61(3). Available from: http://vestnik.mednet.ru/content/view/985/30/lang,ru/ (accessed September 30, 2019). (In Russ.)]. DOI: 10.21045/2071-5021-2018-61-3-8.
  13. Богдан ИВ, Гурылина МВ, Чистякова Д.П. Здоровый образ жизни: отношение населения и приоритетные направления. Проблемы социальной гигиены, здравоохранения и истории медицины. 2019;27(4):374-8. [Bogdan IV, Gurylina MV, Chistyakova DP. Healthy lifestyle: attitude of the population and priority areas. Problems of Social Hygiene, Public Health And History of Medicine. 2019;27(4):374-8.(In Russ.)]. DOI: 10.32687/0869-866X-2019-27-4-374-378.
  14. Тишук ЕА. Современное состояние и прогнозные оценки медико-демографических процессов в Российской Федерации. Проблемы социальной гигиены, здравоохранения и истории медицины. 2015;23(5):3-5. [Tishuk EA. Current state and forecast estimates of medical and demographic processes in the Russian Federation. Problems of Social Hygiene, Public Health And History of Medicine. 2015;23(5):3-5. (In Russ.)].
  15. Семенов ВЮ. Заболеваемость населения Российской Федерации: географические особенности. Проблемы социальной гигиены, здравоохранения и истории медицины. 2015;23(6):6-9. [Semenov VYu. The incidence of the population of the Russian Federation: geographical features. Problems of Social Hygiene, Public Health And History of Medicine. 2015;23(6):6-9. (In Russ.)].

PDF (RUS) Полная версия статьи

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.
Conflict of interest. The authors declare no conflict of interest.
Финансирование. Исследование не имело спонсорской поддержки.
Financing. The study had no sponsorship.
Участие авторов. Cтатья подготовлена с равным участием авторов.
Contribution. Article was prepared with equal participation of the authors.
Поступила: 29.07.2020. Принята к публикации: 10.09.2020.
Article received: 29.07.2020. Accepted for publication: 10.09.2020

Information about the autors

Kalinkin D.E. http://orcid.org/0000-0002-6948-6075
Takhauov R.M. http://orcid.org/0000-0002-1994-957X
Karpov A.B. http://orcid.org/0000-0002-0119-2740
Semenova Yu.V. http://orcid.org/0000-0001-5880-8588

Medical Radiology and Radiation Safety. 2020. Vol. 65. No. 4. P. 12–21

S.A. Sypko, G.N. Bobov, V.E. Vvedensky, A.V. Nazarenkova

Study of 239Pu Microdistribution in Lung of Mayak Workers Using Neutron-Activated Measurement Method

Southern Urals Biophysics Institute, Ozyorsk, Russia
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

This study quantitatively compares 239Pu microdistribution in lung of two deceased former Mayak PA workers who were exposed to 239Pu by inhalation and two deceased subject who had been never employed at Mayak PA. The comparison is made utilizing neutron-activation method of measurement. The results are compared to the results of less-sensitive autoradiographic method. The study demonstrated that the most of 239Pu activity in lung is concentrated in areas of interstitial sclerosis.

Key words: Plutonium-239, neutron-activation measurement method, track detectors, nanoparticles, microdistribution, Anatomical regions of the lung, Mayak PA, personnel

For citation: Sypko SA, Bobov GN, Vvedensky VE, Nazarenkova AV. Study of 239Pu Microdistribution in Lung of Mayak Workers Using Neutron-Activated Measurement Method. Medical Radiology and Radiation Safety. 2020;65(4):12-21 (In Russ.).

DOI: 10.12737/1024-6177-2020-65-4-12-21

Список литературы / References

  1. Рябухин ЮС. Низкие уровни ионизирующего облучения и здоровье: Системный подход (Аналитический обзор). Медицинская радиология. 2000;(4):5-45. [Ryabukhin YuS. Low levels of ionizing radiation and health: a Systematic approach (Analytical review). Medical Radiology. 2000;(4):5-45. (In Russ.)].
  2. Хохряков ВВ, Некрасов КА. О механизме образования наночастиц диоксида плутония. Вопросы радиационной безопасности. 2015(1):55-68. [Khokhryakov VV, Nekrasov KA. On the mechanism of formation of plutonium dioxide nanoparticles. Radiation Safety Issues. 2015(1):55-68. (In Russ.)].
  3. Хохряков ВВ, Сыпко СА. Исследования дисперсного состава альфа-излучающих аэрозолей в воздухе рабочих помещений ПО «Маяк». Вопросы радиационной безопасности. 2019(4):73-80. [Khokhryakov VV, Sypko CA. Studies of the dispersed composition of alpha-emitting aerosols in the air of the working premises of the PA Mayak. Radiation Safety Issues. 2019(4):73-80. (In Russ.)].
  4. Сыпко СА, Введенский ВЭ, Бобов ГН. Исследования статистических характеристик распределения размеров наночастиц 239PuO2 в воздухе отделения оксалатного осаждения завода регенерации топлива ПО «Маяк» с использованием нейтронно-индуцированного метода измерения. Вопросы радиационной безопасности. 2019(2):71-9. [Sypko SA, Vvedensky VE, Bobov GN. Studies of statistical characteristics of the size distribution of 239PuO2 nanoparticles in the air of the oxalate deposition Department of the PA Mayak fuel recovery plant using a neutron-induced measurement method. Radiation Safety Issues. 2019(2):71-9. (In Russ.)].
  5. Sturm R. Radioactivity and lung cancer-mathematical models of radionuclide deposition in the human lungs. J Thorac Dis. 2011;3:231-43. DOI: 10.3978/j.issn.2072-1439.2011.04.01.
  6. Fleischer RL, Raabe OG. On the Mechanism of “Dissolution” in Liquids of PuO2 by Alpha Decay. Health Phys. October 1978;35:545-8.
  7. Fleischer RL, Raabe OG. Fragmentation of respirable PuO2 particles in Water by Alpha Decay-a Mode of “Dissolution”. Health Phys. April 1977;32:253-7.
  8. Методика выполнения измерений плутония-239, содержащегося в промышленных альфа-излучающих наночастицах. Свидетельство об аттестации методики радиационного контроля № 4390.2.П397 от 27.09.2012. ФР.1.38.2012.13346. [Method for performing measurements of plutonium-239 contained in industrial alpha-emitting nanoparticles. Certificate of certification of radiation control methods № 4390.2.P397  27.09.2012. FR.1.38.2012.13346. (In Russ.)].
  9. Хохряков ВВ, Введенский ВЭ, Сыпко СА, Бобов ГН, Корпачев АВ, Хохряков ИВ. Результаты исследований по разработке нейтронно-индуцированного метода измерения размеров наночастиц диоксида 239Pu. Вопросы радиационной безопасности. 2014;(3):69-81. [Khokhryakov VV, Vvedensky VE, Sypko SA, Bobov GN, Korpachev AB, Khokhryakov IV. Results of research on the development of a neutron-induced method for measuring the size of 239Pu dioxide nanoparticles. Radiation Safety Issues. 2014;(3):69-81. (In Russ.)].
  10. Введенский ВЭ, Сыпко СА, Бобов ГН. Совершенствование нейтронно-индуцированного метода измерений размеров наночастиц диоксида 239Pu. АНРИ. 2019;(2):79-90. [Vvedensky VE, Sypko SA, Bobov GN. Improvement of the neutron-induced method for measuring the size of 239Pu dioxide nanoparticles. ANRI. 2019;(2):79-90. (In Russ.)].
  11. Введенский ВЭ, Сыпко СА, Бобов ГН. Определение диаметра наночастицы 239PuO2 с использованием нейтронно-индуцированного метода и расчет стандартной неопределенности диаметра наночастицы. АНРИ. 2019;(4):38-50. [Vvedensky VE, Sypko SA, Bobov GN. Determination of the diameter of the 239PuO2 nanoparticle using the neutron-induced method and calculation of the standard uncertainty of the nanoparticle diameter. ANRI. 2019;(4):38-50. (In Russ.)].
  12. Романов СА. Микрораспределение плутония в легких как основа коррекции дозиметрических моделей. М. Дисс. канд. биол. наук. 2003. 113 с. [Romanov SA. Microdistribution of plutonium in lungs as a basis for correction of dosimetric models. Biol. Sci. Moscow. 2003. 113 p. (In Russ.)].

PDF (RUS) Полная версия статьи

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.
Conflict of interest. The authors declare no conflict of interest.
Финансирование. Исследование не имело спонсорской поддержки.
Financing. The study had no sponsorship.
Участие авторов. Cтатья подготовлена с равным участием авторов.
Contribution. Article was prepared with equal participation of the authors.
Поступила: 27.08.2020. Принята к публикации: 31.08.2020.
Article received: 27.08.2020. Accepted for publication: 31.08.2020.


Medical Radiology and Radiation Safety. 2020. Vol. 65. No. 4. P. 29–35

A.A. Akleyev1,2

Immune Status of a Man Long after Chronic Radiation Exposure

1 Southern-Urals State Medical University, Chelyabinsk, Russia
2 Urals Research Center for Radiation Medicine, Chelyabinsk, Russa
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Purpose: Assessment of major parameters of the system immunity in 376 Techa riverside residents affected by external γ- and internal (mainly due to 90Sr) irradiation 60–68 years after the onset of exposure.

Material and methods: The study involved 376 residents of the settlements located in the basin of the Techa River which was contaminated due to releases of liquid radioactive waste of Mayak Production Association. Red bone marrow received the largest doses that reached 4457.1 mGy, mean dose value was 1080.8 ± 38.4 mGy. Doses to the thymus and peripheral organs of the immune system in the exposed individuals were much lower; mean dose value was 65.3 ± 4.9 mGy. The study of the systemic immunity included the analysis of the parameters that characterize functional status of adaptive and innate immunity, as well as of the cytokine system.

Results: Pro-inflammatory changes of the cytokines spectrum (decrease of IL-4 in blood serum, increase of TNFα and IFNγ) were observed in exposed people with a background of involution changes.

Conclusion: Persistent reduction in the number of neutrophils in blood against normal levels of granulocyte colony-stimulating and granulocyte-macrophage colony-stimulating factors in blood serum could be indicative of certain inefficiency of hematopoietic stem cell pool. The most distinct features of immunity in exposed persons concerned the cytokine spectrum which were inflammatory in nature and on the one hand could be involved in the mechanisms of development of long-term effects of radiation and on the other could have a protective effect on the protection of the body from cells carrying sublethal abnormalities

Key words: chronic exposure, red bone marrow, adaptive and innate immunity, cytokines

For citation: Akleyev AA. Immune Status of a Man Long after Chronic Radiation Exposure. Medical Radiology and Radiation Safety. 2020;65(4):29-35 (In Russ.).

DOI: 10.12737/1024-6177-2020-65-4-29-35

Список литературы / References

  1. Аклеев АВ, Аклеев АА, Андреев СС, и др. Последствия радиоактивного загрязнения реки Течи. Под ред. А.В. Аклеева. Челябинск: Книга. 2016. 390 с. [Akleyev AV, Akleyev AA, Andreev CC, et al. Consequences of radioactive contamination of the Techa River. Akleyev AV (ed). Chelyabinsk. 2016. 390 p. (In Russ.)].
  2. Krestinina LY, Davis FG, Schonfeld S, Preston DL, Degteva M, Epifanova S, et al. Leukaemia incidence in the Techa River Cohort: 1953–2007. Br J Cancer. 2013;109:2886-93.
  3. ICRP Publication 118. Early and late effects of radiation in normal tissues and organs — threshold doses for tissue reactions in a radiation protection context. Pergamon Press. Oxford. 2012:322.
  4. UNSCEAR. Biological mechanisms of radiation actions at low doses. United Nations Scientific Committee on the Effects of Atomic Radiation. United Nations. New York. 2012.
  5. Hayashi T, Morishita Y, Kubo Y, Kusunoki Y, Hayashi I, Kasagi F, et al. Long-term effects of radiation dose on inflammatory markers in atomic bomb survivors. Am J Med. 2005;118(1):83-6.
  6. Глаголенко ЮВ, Дрожко ЕГ, Мокров ЮГ,  и др. Восстановление параметров источника сбросов жидких радиоактивных отходов радиохимического производства в р. Теча. Сообщение 1. Разработка методики и основные результаты. Вопросы радиационной безопасности. 2008. Спец. вып. С. 76-91. [Glagolenko YuV, Drozhko YeG, Mokrov YuG, Rovnyi SI, Stukalov PM, Ivanov IA, et al. Reconstruction of the source parameters of the releases of liquid radioactive waste of the radiochemical plant into the Techa River. Report 1. Method development and main results. Issues of Radiation Safety. Special issue. 2008:76-91. (In Russ.)].
  7. Тотолян АА, Фрейдлин ИС. Клетки иммунной системы. СПб.: Наука. 2000. 231 с. [Totolyan АА, Freidlin IS. Immune system cells. 2000:231. (In Russ.)].
  8. Маянский АН, Виксман МК. Способ оценки функциональной активности нейтрофилов человека по реакции восстановления нитросинего тетразолия: Методические рекомендации.  Казань. 1979. 11 с. [Mayansky AN, Wiksman MK. Method of assessment of functional activity of human neutrophils using nitroblue tetrazolium reduction test. Methodical recommendations. Kazan. 1979:11. (In Russ.)].
  9. Реброва ОЮ. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA. М.: Медиа Сфера. 2002. 312 с. [Rebrova OYu. Statistical analysis of medical data. Using the STATISTICA application package. Moscow. 2002: 312. (In Russ.)].
  10. Медико-биологические и экологические последствия радиоактивного загрязнения реки Теча. Под ред. АВ Аклеева, МФ Киселева. М.: Медбиоэкстрем. 2001. 531 с. [Medical-biological and ecological impacts of radioactive contamination of the Techa river. Edited by Akleyev AA, Kisselyov MF. Мoscow. 2001:531. (In Russ.)].
  11. Аклеев АВ, Косенко ММ. Обобщение результатов многолетнего изучения иммунитета у населения, подвергшегося облучению. Иммунология. 1991;6:4-10. [Akleyev AV, Kossenko MM. Generalization of the results of long-term study of immunity in the population exposed to radiation. Immunology. 1991;6:4-10. (In Russ.)].
  12. Akleyev AV, Veremeyeva GA, Silkina LA, Vozilova AV. Long term hemopoiesis and immunity status after chronic radiation exposure of red bone marrow in humans. CEJOEM. 1999; 5(2):113-29.
  13. Akleev AV, Veremeeva GA, Kyoizumi S. Long-term effects of chronic radiation exposure on the level of somatic mutations in peripheral blood cells. Radiat. Biol. Radioecol. 1998;38(4):573-85.
  14. Akleyev AV, Kossenko MM, Silkina LA, Degteva MO, Yachmenyov VA, Awa A, et al. Health effects of radiation incidents in the Southern Urals. Stem Cells. 1995;1:58-68.
  15. Akleyev AV. Chronic radiation syndrome. Springer. 2014:410.
  16. Пестерникова BC, Окладникова НД. Оценка костномозгового кроветворения у больных хронической лучевой болезнью через 40 лет наблюдения. Вопросы радиационной безопасности. 2004;4:41-5. [Pesternikova VS, Okladnikova ND. Assessment of bone marrow hematopoiesis in patients with chronic radiation sickness after 40 years of observation. Issues of Radiation Safety. 2004;4:41-5. (In Russ.)].
  17. Гребенюк АН, Антушевич АЕ, Беженарь ВФ,  и др. Нейтрофил и экстремальные воздействия. — СПб: Изд-во ВМА. 1998. 216 с. [Grebenyuk AN, Antushevich АЕ, Bejenar VF, Bovtushko VG, Kutsenko SA, Legeza VI, et al. Neutrophil and Extreme Effects. 1998. 216. (In Russ.)].
  18. Жербин ЕА, Чухловин АБ. Радиационная гематология. М.: Медицина. 1989. 176 с. [Jerbin ЕА, Chukhlovin АB. Radiation Hematology. Moscow. 1989. 176. (In Russ.)].
  19. Луцкий АА, Жирков АА, Лобзин ДЮ, Рао М, и др. Интерферон-γ: биологическая функция и значение для диагностики клеточного иммунного ответа. Журнал инфектологии. 2015;7(4):10-22. [Lutckii AA, Zhirkov AA, Lobzin DY, Rao M, Alekseeva LA, Maeurer M, et al. Interferon-γ: biological function and application for study of cellular immune response. Journal Infectology. 2015;7(4):10-22. (In Russ.)].
  20. Hanahan D, Weinberg RA. The hallmarks of cancer: the next generation. Cell. 2011;144(5):646-74.
  21. Аклеев АА. Апоптоз нейтрофилов у жителей прибрежных сел реки Теча в отдаленные сроки после хронического радиационного воздействия. Российский иммунологический журнал. 2015 Aug;2(2):3-5. [Akleyev AA. Neutrophil apoptosis among the residents of the Techa riverside villages in a long-term period of a chronic radiation exposure. Russ J Immunol. 2015 Aug;2(2):3-5. (In Russ.)].

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Финансирование. Работа выполнена по контрактам № 27.501.14.2 от 25.02.2014 г. и № 27.501.17.2 от 22.08.2017 г. в рамках федеральной целевой программы «Обеспечение ядерной и радиационной безопасности на 2008 год и на период до 2015 года» и «Обеспечение ядерной и радиационной безопасности на 2016–2020 годы и на период до 2030 года».
Financing. The work was performed under contracts No. 27.501.14.2 dated 25.02.2014 and No. 27.501.17.2 dated 22.08.2017 under the Federal target program «Ensuring nuclear and radiation safety for 2008 and for the period up to 2015» and «Ensuring nuclear and radiation safety for 2016-2020 and for the period up to 2030».
Благодарности. Автор выражает глубокую благодарность зав. отделом «База данных “Человек”» Н.В. Старцеву за помощь в формировании исследуемых групп и старшему лаборанту лаборатории молекулярно-клеточной радиобиологии Н.П. Литвиненко за техническое сопровождение лабораторных исследований.
Gratitudes. The author expresses deep gratitude to N. V. Startsev the head of department «Database “Man”» for assistance in forming the study groups and senior laboratory assistant of the laboratory of molecular cell radiobiology N. P. Litvinenko for technical support of laboratory research.
Поступила: 14.08.2020. Принята к публикации: 21.08.2020.
Article received: 14.08.2020. Accepted for publication: 21.08.2020.


Medical Radiology and Radiation Safety. 2020. Vol. 65. No. 4. P. 22–28

E.Y. Burtovaia, T.E. Kantina, E.A. Litvinchuk

Long-Term Mental Disorders in the Accident-Exposed Population of the Southern Urals

Urals Research Center for Radiation Medicine of FMBA of Russia, Chelyabinsk, Russia.
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Purpose: To study late mental and behavioral disorders (ICD-10) in individuals who were accidentally exposed in the Southern Urals.

Material and methods: The research subjects are the persons who were exposed to radiation as a result of dumping of radioactive waste into the Techa River (1949–1956), who were born before 1953 and lived in the Techa River basin between 1950 and 1960. The study group consists of 425 people, women predominate (72.5 %), people with secondary special education make up 44.5 %, and pensioners amount to 89.4 %. Mean age at examination was 67.3 ± 5.3 years. Information on radiation doses included data on the absorbed dose to the stomach, which was considered as an analog of brain exposure (50 ± 3 mGy). The paper uses clinical-anamnestic, clinical-psychopathological, clinical and instrumental methods.

Results: It has been demonstrated that in the long-term period, accidentally exposed individuals have organic nonpsychotic mental disorders (72.2 %), with the predominance of organic asthenic (29.6 %) and organic cognitive (36.5 %) disorders. Among the studied individuals, only 20.9 % showed no signs of mental illness. Higher absorbed doses to the stomach (70 ± 8 mGy, p = 0.01) was determined in patients with organic cognitive disorder. Concomitant somatic pathology is present in patients with organic cognitive disorder — hypertension (90.3 %, p = 0.005), ischemic heart disease (56.7, p = 0.004), chronic brain ischemia (43.2 %, p = 0.04). Patients with organic asthenic disorder may have hypertension (94.4 %, p = 0.0002), ischemic heart disease (51.6 %, p =  0.04), chronic brain ischemia (35.7 %, p = 0.02). In the group of patients without mental pathology, the most common were hypertension (76.4 %), diseases of the musculoskeletal system (61.7 %, p = 0.03), and ischemic heart disease (37.1 %). Multiple correlation analysis showed a weak statistically significant association of organic mental disorders with chronic brain ischemia, hypertension, ischemic heart disease and the age of patients.

Conclusion: The performed study complements the current understanding of long-term mental disorders in exposed individuals, and requires further research to study the pathogenesis of cerebrovascular and cardiovascular diseases in individuals exposed to radiation.

Key words: population, chronic radiation exposure, Southern Urals, accidental radiation exposure, mental disorders

For citation: Burtovaia EY, Kantina TE, Litvinchuk EA. Long-Term Mental Disorders in the Accident-Exposed Population of the Southern Urals. Medical Radiology and Radiation Safety. 2020;65(4):22-8 (In Russ.).

DOI: 10.12737/1024-6177-2020-65-4-22-28

Список литературы / References

  1. Румянцева ГМ, Муравьев АИ, Левина ТМ, Сидорюк ОВ. Распространенность психических расстройств среди населения, пострадавшего от радиационной аварии: структура, динамика, факторы риска. Радиац. гигиена. 2013;6(2):21-6. [Rumyantseva GM, Muravyov AI, Levina T.M, Sidoryuk OV. Оccurrence of mental disorders in population affected by radiation accident: structure, dynamics, risk factors. Radiation Hygiene. 2013;6(2):21-26 (In Russ.)].
  2. Чекин СЮ, Кащеев ВВ, Карпенко СВ. и др. Группы риска по классу болезней «Психические расстройства и расстройства поведения» среди участников ликвидации последствий аварии на Чернобыльской АЭС, проживающих в Калужской области. Радиация и риск. 2017;26(1):23-34. DOI: 10.21870/0131-3878-2017-26-1-23-34. [Chekin SJu, Kashheev VV, Karpenko SV, Lovachjov SS, Shhukina NV, Ivanov VK. Identification of groups at risk for mental and behavioral disorders among Chernobyl clean-up workers residing in the Kaluga oblast. Radiation and Risk. 2017;26(1):23-34. (In Russ.)].
  3. Ахаладзе НГ. Хиросима и Нагасаки, Чернобыль и Фукусима. Влияние отдаленных эффектов ионизирующего облучения на темп старения и жизнеспособность человека (обзор литературы). Проблемы старения и долголетия, 2016;25(3):369-79. [Ahaladze NG. Hiroshima and Nagasaki, Chernobyl and Fukushima. The influence of late effects of radiation exposure on the ageing speed and human vitality (literature review). Issues of Ageing and Longevity. 2016;25(3):369-79. (In Russ.)].
  4. Bromet EJ. Mental health consequences of the Chernobyl disaster. J Radiol Prot. 2012;32(1):N71–N75. DOI: 10.1088/0952-4746/32/1/N71.
  5. Laidra K, Rahu K, Kalaus KE, et al. Mental disorders among Chernobyl cleanup workers from Estonia: A clinical assessment. Psychol Trauma. 2017;9(Suppl 1):93–97. DOI: 10.1037/tra0000195.
  6. Lieber M. Assessing the Mental Health Impact of the 2011 Great Japan Earthquake, Tsunami, and Radiation Disaster on Elementary and Middle School Children in the Fukushima Prefecture of Japan. PLoS One. 2017;12(1):e0170402. DOI: 10.1371/journal.pone.0170402.
  7. Oe M, Fujii S, Maeda M, et al. Three-year trend survey of psychological distress, post-traumatic stress, and problem drinking among residents in the evacuation zone after the Fukushima Daiichi Nuclear Power Plant accident [The Fukushima Health Management Survey]. Psychiatry Clin Neurosci. 2016;70(6):245–52. DOI: 10.1111/pcn.12387.
  8. Буртовой МЮ. Генезис международного регулирования сотрудничества государств в сфере энергетических ресурсов. Вестник ЮУрГУ. Серия «Право». 2019;19(2):42-7. DOI: 10.14529/law190207. [Burtovoj MYu. Genesis of international regulation of cooperation of states in the field of energy resources. Bulletin of the South Ural State University. Ser. Law. 2019;19(2):42-7. (In Russ.)].
  9. Shalaginov SA, Akleev AV, Hall P, Granath F. Incidence of unspecified mental retardation among offspring of parents chronically exposed to radiation. Medical Radiology and radiation Safety. 2002;47(2):26-33.
  10. Шалагинов СА. Анализ радиационного, популяционно-генетических и общесредовых факторов в происхождении различных форм олигофрении у потомства населения, подвергшегося хроническому облучению: Автореф. дис. канд. мед. наук. М. 1998. [Shalaginov SA. Analysis of radiation, population genetic and general environmental factors in the genesis of various forms of oligophrenia in offspring of chronically exposed population: Extended abstract of Cand. Sci. (Medicine) Dissertation. Moscow. 1998. (In Russ.)].
  11. Буртовая ЕЮ, Кантина ТЭ, Литвинчук ЕА. Характеристика отдаленных психических (когнитивных) расстройств у лиц, подвергшихся радиационному воздействию на Южном Урале. Сибир. вестник психиатрии и наркологии. 2019;4(105):45-51. DOI: 10.26617/1810-3111-2019-4(105)-45-51 [Burtovaia EYu, Kantina TE, Litvinchuk EA. Characteristics of late mental (cognitive) impairments in persons exposed to irradiation in the South Urals. Siberian Herald of Psychiatry and Addiction Psychiatry (In Russ.)].
  12. Аклеев АВ. Хронический лучевой синдром у жителей прибрежных сел реки Теча. Челябинск: Книга, 2012. 464 с. [Akleev AV. Chronic radiation syndrom among residents of the coastal villages of the Techa river. Chelyabinsk. 2012 (In Russ.)].
  13. Подсонная ИВ, Шумахер ГИ, Головин ВА. Дисциркуляторная энцефалопатия у ликвидаторов последствий аварии на ЧАЭС (результаты двадцатилетнего наблюдения). Журн. неврол. и психиатрии им. С.С Корсакова. 2009(2)10-3. [Podsonnaya IV, Schuhmacher GI, Golovin VA. Dyscirculatory encephalopathy in Chernobyl NPP clean-up workers (findings of a 20-year follow-up). SS. Korsakov Journal of Neurology and Psychiatry. 2009(2)10-3. (In Russ.)].
  14. Иванов ВК, Максютов МА, Чекин СЮ. и др. Радиационно-эпидемиологический анализ неонкологической заболеваемости ликвидаторов Чернобыльской катастрофы. Радиация и риск. 2001;(12):82-98. [Ivanov VK, Maksyutov MA, Chekin SYu, Kruglova ZG, Petrov AV, Cyb AF. Radio-epidemiological analysis of incidence of non-cancer diseases among Chernobyl liquidators. Radiation and Risk. 2001;(12):82-98. (In Russ.)].
  15. Отчет МКРЗ по тканевым реакциям, ранним и отдаленным эффектам в нормальных тканях и органах — пороговые дозы для тканевых реакций в контексте радиационной защиты. [Ф.А. Стюарт и др.; ред.: АВ. Аклеев, М.Ф. Киселев; пер с англ.: Е.М. Жидкова, Н.С. Котова]. Челябинск: Книга, 2012. 384 с. (Труды МКРЗ; Публикация 118). [Stewart FA, Akleev AV, Kiselev M.F. ICRP Publication 118. Early and remote effects in normal tissues and organs ‒ threshold dose for tissue reaction in the context of radiation protection. Chelyabinsk. Publishing House Kniga. 2012 (In Russ.)].
  16. Preston DL, Shimizu Y, Pierce DA, et al. Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950–1997. Radiat Res, 2003,160(4):381-407.
  17. Крестинина ЛЮ, Силкин СС, Дегтева МО, Аклеев АВ. Риск смерти от болезней системы кровообращения в Уральской когорте аварийно-облученного населения за 1950-2015 годы. Радиац. гигиена. 2019;12(1):52-61. DOI: 10.21514/1998-426X-2019-12-1-52-61 [Krestinina LY, Silkin SS, Degteva MO, Akleyev AV. Risk analysis of the mortality from the diseases of the circulatory system in the Ural cohort of emergency-irradiated population for the years 1950–2015. Radiation Hygiene. 2019;12(1):52-61. (In Russ.)].

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Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.
Conflict of interest. The authors declare no conflict of interest.
Финансирование. Исследование не имело спонсорской поддержки.
Financing. The study had no sponsorship.
Участие авторов. Cтатья подготовлена с равным участием авторов.
Contribution. Article was prepared with equal participation of the authors.
Поступила: 14.08.2020. Принята к публикации: 21.08.2020.
Article received: 14.08.2020. Accepted for publication: 21.08.2020.

Information about the autors
Burtovaia E.Y. http://orcid.org/ 0000-0002-1260-7745
Kantina T.E. http://orcid.org/ 0000-0001-6001-4111
Litvinchuk E.A. http://orcid.org/ 0000-0003-0061-7134


Medical Radiology and Radiation Safety. 2020. Vol. 65. No. 4. P. 36–42

E.A. Blinova1,2, A.I. Kotikova1, М.А. Yanishevskaya1,2, A.V. Akleyev1,2

Apoptosis of Lymphocytes and Polymorphisms of Apoptosis Regulation Genes in Individuals Exposed to Chronic Radiation Exposure

1 Urals Research Center for Radiation Medicine, Chelyabinsk, Russa
2 Chelyabinsk State University, Chelyabinsk, Russia
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Purpose: Study the apoptotic death of peripheral blood lymphocytes in long-term period in persons exposed to chronic radiation exposure, and analysis of association of the polymorphic regions rs4645878, rs2279115, rs28362491, rs664677, rs1042522, rs1801270, rs2279744 of the BAX, BCL2, NFkB, ATM, TP53, CDKN1A, MDM2 genes with apoptotic lymphocytes frequency in residents of the coastal villages of the Techa River.

Material and methods: The study of apoptosis and genotyping was conducted in 390 persons exposed to chronic radiation exposure as a result of Mayak PA radioactive waste releases into the Techa–Iset–Tobol river system. The early stage of apoptosis was assessed on a flow cytometer by the presence of phosphatidylserine on the surface of the cell membranes using the Annexin V Apoptosis Detection Kit I and the late stage of apoptosis using the TUNEL method. Real-time PCR genotyping was performed of allelic variations of rs4645878, rs2279115, rs28362491, rs664677, rs1042522, rs1801270, rs2279744 of BAX, BCL2, NFkB, ATM, TP53, CDKN1A, MDM2 genes in a group of irradiated individuals.

Results: The number of cells at the early stage of apoptosis is statistically significantly increased in individuals whose irradiation began during the period of intrauterine development and continued in the postnatal period compared to individuals exposed only in the postnatal period. At the same time, the number of lymphocytes at the stage of DNA fragmentation in the group irradiated in utero is lower than in the group irradiated postnatally and non-irradiated individuals. Also, a weak negative correlation between intrauterine doses of RBM irradiation and the doses of thymus and peripheral lymphoid organs with the number of cells in the late stage of apoptosis in individuals irradiated in utero. The influence of allelic variation rs4645878 of the BAX gene was established on the number of lymphocytes at the early stage of apoptosis in residents of coastal villages of the Techa River. A statistically significant decrease in the number of cells at an early stage of apoptosis is observed in C/C genotype carriers according to the allelic variation rs4645878 of the BAX gene compared with carriers of the T/T and T/C genotypes.

Conclusion: Residents of coastal villages of the Techa River exposed to radiation during the period of prenatal development, there are differences in the frequency of apoptotic death of peripheral blood lymphocytes compared with non-irradiated persons and persons who were irradiated in the postnatal period. SNPs of apoptosis-regulating genes can modify the response of blood lymphocytes to radiation in a wide range of doses RBM.

Key words: lymphocytes, apoptosis, single-nucleotide polymorphism, chronic irradiation

For citation: Blinova EA, Kotikova AI, Yanishevskaya МА, Akleyev AV. Apoptosis of Lymphocytes and Polymorphisms of Apoptosis Regulation Genes in Individuals Exposed to Chronic Radiation Exposure. Medical Radiology and Radiation Safety. 2020;65(4):36-42 (In Russ.).

DOI: 10.12737/1024-6177-2020-65-4-36-42

Список литературы / References

  1. Zhou L, Yuan R, Lanata S. Molecular mechanisms of irradiation-induced apoptosis. Front Biosci. 2003;8:9-19.
  2. Schmitz A, Bayer J, Dechamps N, Goldin L, Thomas G, Heritability of susceptibility to ionizing radiation induced apoptosis of human lymphocyte subpopulations. Int J Radiat Oncol Biol Phys. 2007;68(4):1169-77.
  3. Белушкина НН, Хомякова ТН, Хомяков Ю.Н. Заболевания, связанные с нарушением регуляции программируемой клеточной гибели. Молекулярная медицина. 2012;2:3-10. [Belushkina N N, Khomyakova T I, Khomyakov Yu N. Diseases associated with disregulation of programmed cell death. Molecular Medicine. 2012;2:3-10. (In Russ.)].
  4. Донов ПН, Уржумов ПВ, Блинова ЕА, Аклеев АВ. Связь полиморфизмов генов цитокинов, оксидативного стресса, клеточного цикла и репарации с хромосомными аберрациями у лиц, подвергшихся радиационному воздействию на реке Теча. Вопросы радиационной безопасности. 2014;3(75):61-8 [Donov PN, Urzhumov PV, Blinova EA, Akleyev AV. The Link Between Polymorphisms in Genes of Cytokines, Oxidative Response, Cell Cycle and Reparation, and Chromosome Aberrations in People Exposed to Chronic Radiation Exposure on the Techa River. Issues of Radiation Safety. 2014;3(75):61-8 (In Russ.)].
  5. Халюзова МВ, Литвяков НВ, Исубакова ДС. и др. Валидация связи геномного полиморфизма с повышенной частотой хромосомных аберраций у работников радиационного производства. Радиационная биология. Радиоэкология. 2017;57(4):365-83. [Khalyuzova MV, Litviakov NV, Isubakova DS, Bronikovskaya EV, Usova TV, Albakh EN, et al. Validation of the Association between Gene Polymorphisms and the Frequency of Cytogenetic Abnormalities in the Cohort of Employees of Radiation Facilities. Radiation Biology. Radioecology. 2017;57(4):365-83. (In Russ.)].
  6. Matsuura S, Royaba E, Akutsu SN, Yanagihara H, Ochiai Y, Kudo Y, et al. Analysis of individual differences in radiosensitivity using genome editing. Annals of the ICRP 45. 2016:290-6.
  7. ICRP Proceedings. 2015, AGIR, 2013. Human Radiosensitivity. Report of the Independent Advisory Group on Ionising Radiation. Doc. HPA, RCE–21. Health Protection Agency.
  8. Дегтева МО, Напье БА, Толстых ЕИ, Шишкина ЕА, Бугров НГ, Крестинина ЛЮ, Аклеев АВ. Распределение индивидуальных доз в когорте людей, облученных в результате радиоактивного загрязнения реки Течи. Мед. радиол. и радиац. безопасность. 2019;64(3):46-53. [Degteva MO, Napier BA, Tolstykh EI, Shishkina EA, Bougrov NG, Krestinina LYu, Akleyev AV. Individual dose distribution in cohort of people exposed as a result of radioactive contamination of the Techa River. Medical Radiology and Radiation Safety. 2019;64(3):46-53. (In Russ.)].
  9. Санитарные правила и нормативы СанПиН 2.6.1.2523-09. Нормы радиационной безопасности НРБ-99/2009. п. 3.1.4. [Sanitary rules and regulations SanPiN 2.6.1.2523-09. Radiation Safety Standards NRB-99/2009. Paragraph 3.1. (In Russ.)].
  10. Single-nucleotide polymorphism database (SNP). URL: www.snpedia.com. Date of request: 28.05.2020.
  11. Vermes I. A novel assay for apoptosis flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods. 1995;184(1):39-51.
  12. Segawa K, Suzuki J, Nagata S. Constitutive exposure of phosphatidylserine on viable cells. Proc Natl Acad Sci USA. 2011;108:19246-51.
  13. Bevers EM, Williamson PL. Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma Membrane. Physiol Rev. 2016;96(2):605-45. DOI: 10.1152/physrev.00020.2015.
  14. Elliott MR, Ravichandran KS. Clearance of apoptotic cells: implications in health and disease. J Cell Biol. 2010;189:1059-70.
  15. Crowley LC. Detection of DNA Fragmentation in Apoptotic Cells by TUNEL. Cold Spring Harb Protoc. 2016;10. DOI: 10.1101/pdb.prot087221.
  16. Robert F, Pelletier J. Exploring the Impact of Single-Nucleotide Polymorphisms on Translation. Frontiers in Genetics. 2018;9:507. DOI: 10.3389/fgene.2018.00507.

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Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.
Conflict of interest. The authors declare no conflict of interest.
Финансирование. Исследование не имело спонсорской поддержки.
Financing. The study had no sponsorship.
Участие авторов. Cтатья подготовлена с равным участием авторов.
Contribution. Article was prepared with equal participation of the authors.
Поступила: 14.08.2020. Принята к публикации: 21.08.2020.
Article received: 14.08.2020. Accepted for publication: 21.08.2020.

Information about the authors:

Blinova E.A. https://orcid.org/0000-0002-2567-7945
Kotikova A.I. https://orcid.org/0000-0002-1695-1340
Yanishevskaya М.А. https://orcid.org/0000-0002-2649-5123
Akleyev A.V. https://orcid.org/0000-0003-2583-5808


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