JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2025. Vol. 70. № 3
DOI:10.33266/1024-6177-2025-70-3-5-10
Yu.B. Deshevoi, V.G. Lebedev, T.A. Nasonova, O.A. Dobrynina,
V.A. Brunchukov, I.V. Kobzeva, T.A. Astrelina, A.S. Samoylov
Study of the Efficacy of Cell Therapy for Severe Local Radiation Injuries in the Use of Drugs Affecting the State of Irradiated Tissues Before Cell Transplantation
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: Yu.B. Deshevoi, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To study the possibility of enhancing the therapeutic efficacy of multipotent mesenchymal stromal cells (MMSC) or stromal vascular fraction (SVF) cells in the treatment of severe local radiation injuries under the conditions of the use of pharmacological drugs, the use of which before and after cell transplantation can improve the condition of the irradiated tissue and thereby create favorable conditions for engraftment and functioning of the injected cells.
Material and methods: The work was carried out on male rats of the Wistar–Kyoto inbred line weighing 260–280 g. The animals were locally irradiated in the iliolumbar region of the back on an X-ray machine LNK-268 (RAP 100–10) at a dose of 110 Gy (voltage on the tube 30 kV, current 6.1 mA, Al filter with a thickness of 0.1 mm), at a dose rate of 20.0 Gy/min. The area of the irradiation field was 8.5 cm2. The severity of radiation damage to the skin and the effects of treatment were assessed in dynamics by clinical manifestations and using planimetry. After exposure to radiation, rats developed radiation ulcers of the skin that did not heal for a long time (up to 3–4 months). Cell and drug therapy were carried out in different periods after irradiation: from the 28th to the 49th or from the 35th to the 56th day. As drugs affecting the condition of the affected tissues surrounding the formed radiation ulcer, a complex antibiotic levotetrasulfin forte and drugs that affect the microcirculation and trophism of irradiated tissues – pentoxifylline and detralex were used. For cell therapy, syngeneous MMSC or SVF cells were used. In the cell therapy setting, the drugs were administered for one week before the first cell transplant, one week between the first and second transplantation, and one week after the second cell transplant.
Results and Conclusion: It was shown that the administration of drugs or the use of cell therapy when used separately stimulated the healing of radiation ulcers. Moreover, the therapeutic effect of cell therapy is more pronounced than with the use of drugs. However, in combination with drug and cell therapy, no enhancing effect of pharmacological agents on the therapeutic efficacy of transplantation of MMSC or SVF cells of adipose tissue was noted. Thus, these experiments showed the possibility of successful use of a complex antibiotic in combination with drugs that improve blood supply and trophism of irradiated tissues in the treatment of severe local radiation injuries and the inability of drug therapy under these conditions to enhance the therapeutic effectiveness of cell therapy.
Keywords: radiation ulcer, transplantation of cells, stromal-vascular fraction of adipose tissue, multipotent mesenchymal stromal cells, drug therapy
For citation: Deshevoi YuB, Lebedev VG, Nasonova TA, Dobrynina OA, Brunchukov VA, Kobzeva IV, Astrelina TA, Samoylov AS. Study of the Efficacy of Cell Therapy for Severe Local Radiation Injuries in the Use of Drugs Affecting the State of Irradiated Tissues Before Cell Transplantation. Medical Radiology and Radiation Safety. 2025;70(3):5–10. (In Russian). DOI:10.33266/1024-6177-2025-70-3-5-10
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9. Brunchukov V.A., Astrelina T.A., Nikitina I.V., Kobzeva I.V., Suchkova Yu.B., Usupzhanova D.Yu., Rastorguyeva A.A., Karaseva T.V., Gordeyev A.V., Maksimova L.A., Naumova L.A., Lishchuk S.V., Dubova Ye.A., Pavlov K.A., Brumberg V.A., Makhova A.Ye., Lomonosova Ye.Ye., Dobrovol’skaya Ye.I., Bushmanov A.Yu., Samoylov A.S. Experimental Treatment of Local Radiation Injuries with Mesenchymal Stem Cells and their Conditioned Environment. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost’ = Medical Radiology and Radiation Safety. 2020;1;65:5-12 (In Russ.).
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.02.2025. Accepted for publication: 25.03.2025.
Medical Radiology and Radiation Safety. 2025. Vol. 70. № 3
DOI:10.33266/1024-6177-2025-70-3-11-15
S.A. Korneva1, A.K. Chigasova1, 2, 3, A.A. Osipov2, M.A. Ignatov1, 2,
N.Yu. Vorobyova1, 2, V.O. Saburov4, E.I. Kazakov4, S.N. Koryakin4,
Yu.A. Fedotov1, 2, A.Yu. Bushmanov1, A.N. Osipov1, 2
Post-Irradiation Changes in the Number of γH2ax and patm Protein Foci in Human Mesenchymal Stem Cells Irradiated with 14.1 MeV Neutrons
1 A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
2 N.N. Semenov Federal Research Center for Chemical Physics, Moscow, Russia
3 Institute of Biochemical Physics, Moscow, Russia
4 A.F. Tsyb Medical Radiological Research Center, Obninsk, Russia
Contact person: A.N. Osipov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: Comparative analysis of dose-response dependences and kinetics of post-radiation changes in the number of γH2AX and pATM protein foci in human mesenchymal stem cells (MSCs) exposed to 14.1 MeV neutrons and cobalt-60 gamma-radiation.
Material and methods: The study used a primary culture of human MSCs obtained from the collection of BioloT LLC (Russia). The cells were irradiated using a neutron generator NG-14 (VNIIA, Russia), which provided neutron fluxes with an energy of 14.1 MeV, and a gamma-therapeutic device ROKUS-AM (JSC Ravenstvo, Russia; cobalt-60, dose rate 0.5 Gy/min) at doses of 0.1, 0.25 and 0.5 Gy. For quantitative assessment of γH2AX and pATM foci, immunocytochemical staining was done using antibodies to γH2AX and pATM, respectively. Statistical significance was assessed using analysis of variance (ANOVA).
Results: It was shown that the kinetics of post-radiation changes in the number of γH2AX foci in cells irradiated with neutrons is slower than after gamma irradiation. 24 h after irradiation with neutrons, ~ 62 % of γH2AX foci and ~ 52 % of pATM foci were recorded from their number 0.5 h after irradiation. These values were statistically significantly (p < 0.001) higher than the proportions of residual foci calculated after exposure to gamma-radiation: ~ 16 % and 6 %, respectively. The results obtained indicate that the proportion of complex, difficult-to-repair DNA damage in cells irradiated with neutrons is significantly higher than with gamma-radiation.
Keywords: mesenchymal stem cells, fast neutrons, gamma-radiation, γH2AX, рATM, DNA damage, DNA repair
For citation: Korneva SA, Chigasova AK, Osipov AA, Ignatov MA, Vorobyova NYu, Saburov VO, Kazakov EI, Koryakin SN, Fedotov YuA, Bushmanov AYu, Osipov AN. Post-Irradiation Changes in the Number of γH2AX and patm Protein Foci in Human Mesenchymal Stem Cells Irradiated with 14.1 MeV Neutrons. Medical Radiology and Radiation Safety. 2025;70(3):11–15. (In Russian). DOI:10.33266/1024-6177-2025-70-3-11-15
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The research was carried out within the framework of the state assignment of the Ministry of Science and Higher Education of the Russian Federation (No. 1023112000035-8, code “Cosmos-DNA”).
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.02.2025. Accepted for publication: 25.03.2025.
Medical Radiology and Radiation Safety. 2025. Vol. 70. № 3
DOI:10.33266/1024-6177-2025-70-3-22-33
L.A. Romodin, A.S. Umnikov, A.S. Samoilov
Biological Reactions under the Combined Action of Ionizing Radiation with Other Factors
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: L.A. Romodin, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
This review is devoted to the biological effects of combined exposure to ionizing radiation and factors of a different nature: temperature, non-ionizing radiation, various chemical agents, including heavy metals, immunogenic factors, emotional stress, etc. This effect is often called combined. If we are talking about the combined action of different types of ionizing radiation, for example, neutron and γ-radiation, then such an effect is called combined. The biological effects of the combined action of ionizing radiation and factors of a different nature have been studied by many authors, especially in the field of aerospace and military radiobiology. The review describes cases where the effect of the combined action of ionizing radiation and another factor is approximately equal to the sum of the effects from the action of these factors separately; these effects are called additive. The synergism of effects is described – an increase in the magnitude of the manifestation of effects with a combined action compared to their sum with separate exposure to the studied factors. Works devoted to the conditions for achieving synergistic effects and identifying those under which the degree of synergy will be maximum are analyzed. Cases of a decrease in the magnitude of effects under the combined influence of ionizing radiation and a factor of a different nature are shown in comparison with the effects observed when they act separately ‒ antagonism of effects. Understanding the mechanism of these phenomena is necessary for the successful development of radioprotective agents, the development of countermeasures in case of radiation accidents or the use of nuclear weapons, and the creation of effective means and methods of treating oncological diseases. The review also describes current problems in the use of radioprotectors.
Keywords: ionizing radiation, combined effect, synergism, additivity, antagonism, heavy metals, hyperthermia, non-ionizing radiation, neutrons, γ-radiation
For citation: Romodin LA, Umnikov AS, Samoilov AS. Biological Reactions under the Combined Action of Ionizing Radiation with Other Factors. Medical Radiology and Radiation Safety. 2025;70(3):22–33. (In Russian). DOI:10.33266/1024-6177-2025-70-3-22-33
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.02.2025. Accepted for publication: 25.03.2025.
Medical Radiology and Radiation Safety. 2025. Vol. 70. № 3
DOI:10.33266/1024-6177-2025-70-3-16-21
V.P. Mamina
Protective Effect of Dimethylsulphoxide in Combination with Gluthathione and Cysteamine Against the Damaging Effect of Ionizing Radiation on Spermatogenesis
Institute of Plant and Animal Ecology, Ekaterinburg, Russia
Contact person: Vera Pavlovna Mamina, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: Experimental assessment of the radioprotective effect of dimethylsulfoxide in combination with glutathione and cysteamine on spermatogenesis in BALB/c mice under acute γ-irradiation.
Material and мethods:A single external γ-irradiation of male mice at a dose of 6 Gy was carried out on an IGUR installation (137Cs, dose rate 0.85 Gy/min).The timing of death of mice was recorded within 1 month. Animals 20 minutes before irradiation received an intraperitoneal injection of a mixture of dimethyl sulfoxide (4.5 g/kg), reduced glutathione (500 mg/kg) and cysteamine (150 mg/kg).The disturbance of spermatogenesis and its correction with a mixture of radioprotectors was assessed by quantitative indicators of spermatogenic cells and the morphofunctional state of sperm.
Results: In mice, on the 8th day after irradiation, the number of spermatogonia decreases (6 % of the control), on the 24th day – the number of spermatocytes, spermatids and spermatozoa – to 3.5 %, 6 % and 4.5 % of the control, respectively. The mixture of radioprotectors contributed to an increase in the number of spermatogonia up to 33 %, spermatocytes – up to 7 %, spermatids – up to 25 %, spermatozoa – up to 27 %.The viability coefficient (QC) of spermatogenic cells decreases on the 8th day after irradiation from 11.6 in the control to 8.0, on the 16th day – to 7.0, on the 24th day – to 6.0, on 32 1st and 62nd days – up to 5.0. When using radioprotectors, QoL on the 8th day corresponded to 10.0 and in subsequent periods was kept within 9.0.The number of epididymal spermatozoa decreases on the 24th day after irradiation to 80 %, on the 32nd day – to 60%, on the 62nd day – to 45 %. The mixture of radioprotectors contributed to an increase in the number of sperm to 95 % and 60 %, respectively).The number of live sperm decreases on the 32nd and 62nd days after irradiation and amounts to 35 % and 18 %, respectively, when using radioprotectors – 45 % and 30 %, respectively. On the 24th, 32nd and 62nd days after irradiation, the number of sperm with an abnormal head increases by 2 times. Radioprotectors reduce the number of sperm with an abnormal head by 1.5 times.
Conclusion: The data obtained indicate the protective effect of this mixture of radioprotectors on spermatogenesis and its possible use for the correction of spermatogenesis disorders when exposed to ionizing radiation. The mixture of protectors provides protection for 95 % of mice, with 65 % death in irradiated controls.
Keywords: external acute γ-irradiation, spermatogenesis, spermatozoa, DMSO, glutathione, cysteamine, mice
For citation: Mamina VP. Protective Effect of Dimethylsulphoxide in Combination with Gluthathione and Cysteamine Against the Damaging Effect of Ionizing Radiation on Spermatogenesis. Medical Radiology and Radiation Safety. 2025;70(3):16–21. (In Russian). DOI:10.33266/1024-6177-2025-70-3-16-21
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The author declare no conflict of interest.
Financing. The study was carried out within the framework of state budget financing (No. 122 021000085-1).
Contribution. The article was prepared with the sole participation of the author.
Article received: 20.02.2025. Accepted for publication: 25.03.2025.
Medical Radiology and Radiation Safety. 2025. Vol. 70. № 3
DOI:10.33266/1024-6177-2025-70-3-34-47
N.K. Shandala, A.S. Samoylov, V.A. Seregin, S.M. Kiselev,
Yu.E. Kvacheva, E.G. Metlyaev, O.A. Kochetkov, V.N. Klochkov,
A.V. Titov, A.E. Kolyshkin, M.P. Semenova
Radiation Health Physics to Assure Radiation Safety and Protection of the Public and Personnel:
Case Study of the SRC-FMBC
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: N.K. Shandala, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To describe, based on our original innovative developments, the role of radiation health physics in assuring radiation safety and protection of a) the public living near operating, decommissed and remediated radiation hazardous facilities and sites; and b) nuclear wor-
kers .
Material and methods: The objects of the study included radiation hazardous facilities at different stages of the life cycle (operating, decommissioned, remediated), nuclear and uranium legacy sites, where samples of environmental and marine media (water, soil, vegetation, algae, bottom sediments) were collected, as well as local foodstuffs and drinking water. The samples were examined using dosimetric, radiometric, gamma-spectrometric and radiochemical methods. When studying the health status of the public living in the vicinity of these facilities, methods of radiation epidemiology were used, supplemented by our original innovative development of the health assessment.
Results: The conducted long-term studies allowed not only characterizing the facilities and sites under study, but also identification the features of the spatial and temporal distribution of radioactive materials including at the nuclear legacy sites. The presence of large volumes of artificially contaminated soils has been detected, which in some cases are classified as radioactive waste in terms of their activity values. It has been shown that man-made contamination spreads into ground waters as well as into local areas of coastal marine waters. The results of public health monitoring allow us to state that radiation hazardous facilities in Russia are operating safely. Five innovative hardware, methodological and dosimetric complexes have been created to support radiation safety of workers.
Conclusions: The radiation health physics is the radiation safety science developed by some generations of scientists and professionals of the SRC-FMBC. Today, this science helps to support the whole cycle of medical and health physics safety of nuclear workers and the public living in the areas affected by nuclear facilities – from the science based development to its implementation in practice.
The interdisciplinary approach implemented in the SRC-FMBC helps to comprehensively solve many difficult tasks of radiation safety and protection of the public and workers.
Keywords: radiation health physics, radiation health physics monitoring, radiation safety and protection of public and workers, radio-ecological survey, health state assessment, regulation, comprehensive approach, A.I. Burnazyan FMBC
For citation: Shandala NK, Samoylov AS, Seregin VA, Kiselev SM, Kvacheva YuE, Metlyaev EG, Kochetkov OA, Klochkov VN, Titov AV, Kolyshkin AE, Semenova MP. Radiation Health Physics to Assure Radiation Safety and Protection of the Public and Personnel: Case Study of the SRC-FMBC. Medical Radiology and Radiation Safety. 2025;70(3):34–47. (In Russian). DOI:10.33266/1024-6177-2025-70-3-34-47
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The work was financed under the Federal Target Programs “Nuclear and Radiation Safety for 2016-2020 and for the period until 2030” and “Industrial Decommissioning and Disposal of Weapons and Military Equipment of the Nuclear Complex”.
Contribution. Shandala N.K. – study conception and design, radiation health physics data collection and processing, writing the text; Samoylov A.S. – article conception and editing the text; Seregin V.A. – radiation health physics data collection and conducting radiation health physics monitoring at the uranium legacy sites in Central Asia; Kiselev S.M. – data collection on radiation health physics monitoring at the Russian nuclear legacy sites and on the public exposure assessment due to radon; Kvacheva Yu.E. – data collection on bio banking and medical nuclear forensics; Metlyaev E.G. – data collection on assessing the health status of the public and iodine prophylaxis; Kochetkov O.A. – data collection on radiation safety and protection of workers and regulatory framework for radiation safety; Klochkov V.N. – data collection on radiation safety and protection of workers and regulatory framework for radiation safety; Titov A.V. – collection and processing of data on radiation health physics monitoring at uranium legacy sites in Russia and Central Asia; A.E. Kolyshkin – data collection on nuclear power plants and comprehensive health physics assessment of occupational exposure; Semenova M.P. – data collection on radiation health physics monitoring at Russian uranium legacy sites, translation into English and text editing. All authors are responsible for approval of the final version of the article and integrity of all parts of the article.
Article received: 20.02.2025. Accepted for publication: 25.03.2025.