SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.

The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Issues journals

Medical Radiology and Radiation Safety. 2025. Vol. 70. № 5

DOI:10.33266/1024-6177-2025-70-5-75-81

I.A. Galstyan, A.Yu. Bushmanov, M.V. Konchalovsky, 
V.Yu. Nugis, N.A. Metlyaeva, O.V. Shcherbatykh, L.A. Yunanova

Peripheral Blood Indices at Different Periods of Chronic Radiation Syndrome (Literature Review)

A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia

Contact person: I.A. Galstyan, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

ABSTRACT

The article reviews literature data on the state of peripheral blood in different periods of chronic radiation syndrome (CRS). In the period of disease formation in workers of the Mayak Production Association when working under high dose rate irradiation conditions, the time of development of clinical manifestations was determined by the rate of accumulation of the threshold dose value and ranged from 1–2 to 5–8 years. Patients showed moderate leukopenia (2.6–4.0 × 109/l with normal values of 5.0–8.0 × 109/l), thrombocytopenia (70.0-160.0 × 109/l with the normal values of 200.0–300.0 × 109/l). In more severe cases, mainly at high dose rates (more than 1.0 Gy/year), anemic syndrome developed. Damage to hematopoiesis in most cases (except for 2 patients) did not reach the degree of aplastic anemia.

The population of the Techa River basin was more heterogeneous in age and health at the time of the onset of radiation exposure, which predetermined the characteristics of the clinical manifestations of CRS. A shortening of the latent period of CRS in children was noted. There were no cases of CRS of grade III severity. Anemic syndrome of radiation genesis was not observed. All identified anemias were associated with iron deficiency.

After the cessation of contact with gamma radiation, blood counts were restored, reaching physiological levels in the near future. The concentration of platelets reached the normal value, as a rule, within the next 5 years after withdrawal from production conditions. Leukopenia persisted for up to 25 years, especially in patients with CRS of grade III severity.

The reaction of the hematopoietic system to chronic intake of radionuclides is determined by the patterns of their distribution in the body. In the presence of incorporated osteotropic radionuclides, signs of incomplete hematopoiesis regeneration persisted in patients after cessation of irradiation.

Keywords: chronic radiation syndrome, peripheral blood, accumulated dose, dose rate, osteotropic radionuclides, leukopenia, thrombocytopenia, anemia

For citation: Galstyan IA, Bushmanov AYu, Konchalovsky MV, Nugis VYu, Metlyaeva NA, Shcherbatykh OV, Yunanova LA. Peripheral Blood Indices at Different Periods of Chronic Radiation Syndrome (Literature Review). Medical Radiology and Radiation Safety. 2025;70(5):75–81. (In Russian). DOI:10.33266/1024-6177-2025-70-5-75-81

 

References

1. Okladnikova N.D. Chronic Radiation Sickness in Humans Caused by External or Predominantly External Gamma Irradiation. Radiatsionnaya Meditsina = Radiation Medicine. Vol. 2. Moscow, IzdAT Publ., 2001. P. 253-274 (In Russ.).

2. Gus’kova A.K., Baysogolov G.D. Luchevaya Bolezn’ Cheloveka = Human Radiation Sickness. Moscow, Meditsina Publ., 1971. 384 p. (In Russ.).

3. Gus’kova A.K. Chronic Radiation Sickness from Uniform Irradiation. Radiatsionnyye Porazheniya Cheloveka = Radiation Injuries to Humans / Barabanova A.V., Baranov A.Ye., Bushmanov A.Yu., et al. Moscow, Slovo Publ., 2007. P. 85-102 (In Russ.).

4. Legeza V.I., Ushakov I.B., Grebenyuk A.N., et al. Radiobiologiya, Radiatsionnaya Fiziologiya i Meditsina = Radiobiology, Radiation Physiology and Medicine. Dictionary-Reference Book. St. Petersburg, Foliant, 2017. 175 p. (In Russ.).

5. Medical Management of Radiation Injuries. SRS N101. IAEA, 2020. 98 p.

6. Galstyan I.A., Bushmanov A.Yu., Metlyayeva N.A., et al. Chronic Radiation Sickness of Subacute Course from External Uneven Irradiation Upon Contact with a Lost Source. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost’ = Medical Radiology and Radiation Safety. 2021;66;4:62-69 (In Russ.).

7. Gus’kova A.K. Radiation Pathology of Man. Radiatsionnaya Meditsina = Radiation Medicine. Vol. 1. Moscow, IzdAT Publ., 2001. P. 90-121 (In Russ.).

8. Muksinova K.N., Mushkacheva G.S. Kletochnyye i Molekulyarnyye Osnovy Perestroyki Krovetvoreniya pri Dlitel’nom Radiatsionnom Vozdeystvii = Cellular and Molecular Bases of Hematopoiesis Restructuring during Prolonged Radiation Exposure. Moscow, Energoatomizdat Publ., 1990. 160 p. (In Russ.).

9. Moskalev Yu.I. Otdalennyye Posledstviya Vozdeystviya Ioniziruyushchikh Izlucheniy = Remote Consequences of Exposure to Ionizing Radiation. Moscow, Meditsina Publ., 1991. 462 p. (In Russ.).

10. Yegorov A.P., Bochkarev V.V. Krovetvoreniye i Ioniziruyushchaya Radiatsiya = Hematopoiesis and Ionizing Radiation. Moscow, Medgiz Publ., 1954. 259 p. (In Russ.).

11. Kurshakov N.A., Kirillov S.A. Chronic Radiation Sickness as a Consequence of External Irradiation. Izbrannyye Materialy «Byulletenya Radiatsionnoy Meditsiny» = Selected Materials of the “Bulletin of Radiation Medicine”. Vol. 2. Moscow, FMBC im. A.I.Burnazyana FMBA Rossii Publ., 2016. P. 215-230 (In Russ.).

12. Kudryavtseva V.N., Shalaginov V.A. The State of Peripheral Blood and Bone Marrow Hematopoiesis in Patients with Chronic Radiation Sickness in the Late Stages (After 17-20 Years). Izbrannyye Materialy «Byulletenya Radiatsionnoy Meditsiny» = Selected Materials of the “Bulletin of Radiation Medicine”. Vol.1. Moscow, FMBC im. A.I. Burnazyana FMBA Rossii Publ., 2016. P. 283-292 (In Russ.).

13. Baysogolov G.D. Dynamics of Peripheral Blood Indices in Patients with Chronic Radiation Sickness after Cessation of Radiation Exposure. Radiatsiya i Risk = Radiation and Risk. 2000;Special Issue:29-31 (In Russ.).

14. Akleyev A.V. Khronicheskiy Luchevoy Sindrom u Zhiteley Pribrezhnykh Sel Reki Techa = Chronic Radiation Syndrome in Residents of Coastal Villages of the Techa River. Chelyabinsk, Kniga Publ., 2012. 464 p. (In Russ.).

15. Baysogolov G.D., Doshchenko V.N., Yurkov N.N., et al. Late Manifestations of Chronic Radiation Sickness in Humans. Radiatsiya i Risk = Radiation and Risk. 1997;9:107-110 (In Russ.).

16. Pesternikova V.S. Hematopoiesis Status in Patients with Chronic Radiation Sickness 25-30 Years after Diagnosis of the Disease. Izbrannyye Materialy «Byulletenya Radiatsionnoy Meditsiny» = Selected Materials of the “Bulletin of Radiation Medicine”. Vol. 2. Moscow, FMBC im. A.I.Burnazyana FMBA Rossii Publ., 2016. P. 436-444 (In Russ.).

17. Vyalova N.A., Suvorova L.A., Gavrilova K.P., et al. Results of the Study of the Dependence of Hematological Changes in the Late Period of Chronic Radiation Sickness on the Dose of External Gamma Irradiation and Incorporation of Plutonium-239. Izbrannyye Materialy «Byulletenya Radiatsionnoy Meditsiny» = Selected Materials of the “Bulletin of Radiation Medicine”. Vol. 2. Moscow, FMBC im. A.I.Burnazyana FMBA Rossii Publ., 2016. P. 388-398 (In Russ.).

18. Doshchenko V.N. Structure of Causes of Death of Patients with Chronic Radiation Sickness and Persons Exposed to Chronic External and Internal Irradiation in Doses Exceeding Maximum Permissible. Izbrannyye Materialy «Byulletenya Radiatsionnoy Meditsiny» = Selected Materials of the “Bulletin of Radiation Medicine”. Vol.1. Moscow, FMBC im. A.I.Burnazyana FMBA Rossii Publ., 2016. P. 799-804 (In Russ.).

19. Shakhmatov V.I., Gavrilova K.P., Vorob’yev A.I., et al. Analysis of the Causes of Death of Persons Exposed to Chronic Occupational Irradiation at Nuclear Industry Enterprises (Clinical and Statistical Data). Izbrannyye Materialy «Byulletenya Radiatsionnoy Meditsiny» = Selected Materials of the “Bulletin of Radiation Medicine”. Vol.1. Moscow, FMBC im. A.I.Burnazyana FMBA Rossii Publ., 2016. P. 766-776
(In Russ.).

20. Kuznetsova I.S. Zabolevayemost’ i Smertnost’ ot Leykoza Sredi Personala PO “Mayak” i Ostal’nogo Naseleniya Goroda Ozerska = Morbidity and Mortality from Leukemia among the Personnel of the Mayak Production Association and the Rest of the Population of the City of Ozersk. Extended Abstract of Candidate’s Thesis (Biol.). Ozersk Publ, 2004. 25 p. (In Russ.).

21. Vyalova N.A., Suvorova L.A., Ivanova T.A., et al. Peculiarities of Hematopoiesis in Late Periods in Patients with Chronic Radiation Sickness. Izbrannyye Materialy «Byulletenya Radiatsionnoy Meditsiny» = Selected Materials of the “Bulletin of Radiation Medicine”. Vol. 2. Moscow, FMBC im. A.I.Burnazyana FMBA Rossii Publ., 2016. P. 408-421 (In Russ.).

22. Soldatova V.A., Solodova R.A., Gus’kova A.K. Clinical Characteristics of Chronic Radiation Sickness in the Recovery Period. Otdalennyye Posledstviya Luchevykh Porazheniy = Remote Consequences of Radiation Injuries. Moscow, Atomizdat Publ., 1971. P. 62-70
(In Russ.).

23. Okladnikova N.D., Gus’kova A.K., Khokhryakov V.F., et al. Working with Plutonium Compounds. Rukovodstvo po Organizatsii Meditsinskogo Obsluzhivaniya Lits, Podvergshikhsya Deystviyu Ioniziruyushchego Izlucheniya = Guidelines for Organizing Medical Care for Individuals Exposed to Ionizing Radiation. Moscow, Energoatomizdat Publ., 1985. P. 117-137 (In Russ.).

24. Okladnikova N.D., Pesternikova V.S., Sumina M.V., et al. Clinical Effects of 239Pu. Chronic Radiation Exposure: Risk of Remote Effects. Proceedings of the 1st International Symposium. Chelyabinsk, January 9-13, 1996. Chelyabinsk Publ., 1996. P. 110-112 (In Russ.).

25. Suvorova L.A., Nugis V.Yu., Gasteva G.N., et al. The State of Bone Marrow Hematopoiesis and Bone Tissue in Plutonium-239 Carriers. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost’ = Medical Radiology and Radiation Safety. 2007;52;5:13-19 (In Russ.).

26. Baysogolov G.D. Some Issues of Pathogenesis of Clinical Syndrome Developing in Individuals in Contact with Plutonium-239 Compounds. BRM. 1969;1:10-17 (In Russ.).

27. Buldakov L.A., Lyubchanskiy E.R., Moskalev Yu.M., et al. Problema Toksikologicheskogo Plutoniya = Problems of Plutonium Toxicology. Moscow, Atomizdat Publ., 1969. 367 p. (In Russ.).

 

 

 PDF (RUS) Full-text article (in Russian)

 

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 20.05.2025. Accepted for publication: 25.06.2025.

 

 

Medical Radiology and Radiation Safety. 2025. Vol. 70. № 5

DOI:10.33266/1024-6177-2025-70-5-82-86

A.Y. Vasiliev1, 2, S.V. Leonov1, 3, 7, N.N. Blinov (m)4, N.N. Potrakhov5,
L.A. Leonova1, 6, A.I. Sakharov6, 7

Chest X-Ray in the Diagnosis of Mine-Explosion Injury During Mass Examination of the Dead

1 Russian University of Medicine, Moscow, Russia

2 Russian Medical Academy of Continuing Professional Education, Moscow, Russia

3 A. Nevsky Military University, Moscow, Russia

4 M.F. Vladimirsky Moscow Regional Scientific Research Clinical Institute, Moscow, Russia 

5 V.I. Ulyanov St. Petersburg State Electrotechnical University “LETI”, Saint Petersburg, Russia

6 Bureau of the Main Forensic Medical Examination, Moscow, Russia

7. Medical and Biological University of Innovation and Continuing Education, Moscow, Russia

Contact person: L.A. Leonova, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

ABSTRACT

Due to the increasing number of deaths from mine-explosive chest injuries, the problem of diagnosing these injuries during the mass arrival of dead bodies has become urgent for forensic medicine. One of the possible solutions to this problem is an express X–ray diagnosis of mine and explosive damage to the chest organs during a mass examination of the dead. 

The purpose of the study: To study the possibilities of express X-ray diagnostics of mine-explosive wounds of the chest using a portable X-ray machine. 

Material and methods: Express chest X-ray was performed in 50 victims of the SMO. The entire study was conducted in atypical styling, “with your hands.” 

Results: 69 X-ray images were taken. Data were obtained that 66 % of the victims had damage to the bone structure of the chest, in other cases damage to internal organs and soft tissues was detected. In 10 % of cases, damage was caused by small fragments, in 14 % by large fragments, and in 32 % the damage was caused by fragments of various sizes. In 40 % of cases, combined lesions of the chest, skull, neck, abdominal cavity and upper extremities were found on radiographs. The peculiarity of the wounding projectile was clarified and the possibilities of determining the wound channel with visualization of the inlet and outlet openings were studied. X-ray analysis showed that the vast majority of chest injuries were accompanied by rib fractures and soft tissue injuries. 

Conclusions: Hand-held photography with a portable X-ray machine in atypical layouts did not create dynamic blurring. The use of a portable device made it possible to diagnose the length and shape of wound channels, allowing for a clear definition of the inlet and outlet openings, the contours of the channel and its direction, as well as minor injuring agents. Express X–ray diagnostics visualizes wounding projectiles well, regardless of what the foreign body is – a bullet or its fragments, a striking element, a fragment of a drone, a fragment of a projectile or a bone.

Keywords: radiography, mine explosion injury, chest, mass examination

For citation: Vasiliev AY, Leonov SV, Blinov (m) NN, Potrakhov NN, Leonova LA, Sakharov AI. Chest X-Ray in the Diagnosis of Mine-Explosion Injury During Mass Examination of the Dead. Medical Radiology and Radiation Safety. 2025;70(5):82–86. (In Russian). DOI:10.33266/1024-6177-2025-70-5-82-86

 

References

1. Dorokhov A.Ye., Akperova S.R., Prosvetov S.G. Analysis of the Nature of Injuries and Wounds Received during a Special Military Operation. Proceedings of the XIX International Burdenkov Scientific Conference, Voronezh, April 20-22, 2023. Voronezh, Voronezhskiy Gosudarstvennyy Meditsinskiy Universitet Publ., 2023. P. 138-139 (In Russ.).

2. Shchegolev A.I., Tumanova U.N. Possibilities of Postmortem Radiation Studies in Pathological Anatomical Practice. Sovremennaya Patologiya: Opyt, Problemy, Perspektivy = Modern Pathology: Experience, Problems, Prospects. Collection of Materials of the I All-Russian Scientific and Practical Conference with International Participation. Samara, Samarskiy Gosudarstvennyy Meditsinskiy Universitet Publ., 2020. P. 207-213 (In Russ.).

3. Shchegolev A.I., Tumanova U.N. Characteristics of the Features of Postmortem Radiation Studies. Luchevaya Diagnostika dlya Patologicheskoy Anatomii i Sudebno-Meditsinskoy Ekspertizy: ot Prizhiznennoy k Posmertnoy = Radiation Diagnostics for Pathological Anatomy and Forensic Medical Examination: from Intravital to Postmortem. Proceedings of the II scientific and practical conference of the Interregional Thanatoradiological Society. Moscow, October 7-8, 2022. Moscow, Mezhregional’noye Tanatoradiologicheskoye Obshchestvo Publ., 2022. P. 3-12 (In Russ.).

4. Shval’b A.P. On the Importance of Postmortem Radiation Research for Pathological Anatomy and Forensic Medicine. Tanatoradiologiya: ot Perinatologii do Gerontologii = Thanatoradiology: from Perinatology to Gerontology. Proceedings of the III Scientific and Practical Conference of the Interregional Tanatoradiological Society. Moscow, October 13-14, 2023. Moscow, Mezhregional’noye Tanatoradiologicheskoye Obshchestvo Publ., 2023. P. 146-156 (In Russ.).

5. Zakharov S.N., Pigolkin Yu.I. Application of Radiation Diagnostic Methods in Forensic Practice. Tanatoradiologiya: ot Perinatologii do Gerontologii = Thanatoradiology: from Perinatology to Gerontology. Proceedings of the III Scientific and Practical Conference of the Interregional Tanatoradiological Society. Moscow, October 13-14, 2023. Moscow, Mezhregional’noye Tanatoradiologicheskoye Obshchestvo Publ., 2023. P. 15-20 (In Russ.).

6. Makarov I.Yu., Bogomolov D.V., Gyul’mamedova N.D., Shay A.N. Some Modern Methods of Diagnosing Gunshot Injuries. Sudebno-Meditsinskaya Ekspertiza = Forensic Medical Expertise. 2019;2:55-60 ( In Russ.).

7. Sudebno-Meditsinskaya Radiologiya. Ot Identifikatsii Lichnosti do Posmertnoy Vizualizatsii = Forensic Radiology. From Personal Identification to Postmortem Visualization. Ed. Dzh. Lo Re, A. Argo, M. Midiri, K. Kattaneo. Moscow, Prakticheskaya Meditsina Publ., 2023. P. 61-62 (In Russ.).

8. Grabherr S., Grimm J. Forensic Radiology. Radiology. 2024;64:823–829. doi: 10.1007/s00117-024-01365-2.

9. Hofer P., Ferling C. Forensische Bildgebung der Scharfen Gewalt [Forensic Imaging of Sharp Force Injuries]. Radiologie (Heidelb). 2024 Nov;64;11:846-853. doi: 10.1007/s00117-024-01370-5.

10. Ohsaka H., Omori K., Takeuchi I., Yanagawa Y. Impalement Injury Diagnosed at the Scene by a Portable X-Ray System Transported by a Physician-Staffed Helicopter. J Emerg Trauma Shock. 2020 Jan-Mar;13;1:101-102. doi: 10.4103/JETS.JETS_164_19.

11. Omori K., Yanagawa Y., Muramatsu K.-i., Nagasawa H., Takeuchi I., Madokoro S., Jitsuiki K., Yatsu, Ohsaka S.H., Ishikawa K. Experience Using a Portable X-Ray System at the Scene Transported by a Physician-Staffed Helicopter. Acute Med Surg. 2019;6:396-399. doi: 10.1002/ams2.431.

12. Zhang M. Forensic Imaging: a Powerful Tool in Modern Forensic Investigation. Forensic Sci Res. 2022 Mar 7;7;3:385-392. doi:10.1080/20961790.2021.2008705.

13. Decker S.J., Braileanu M., Dey C., Lenchik L., Pickup M., Powell J., Tucker M., Probyn L. Forensic Radiology: a Primer. Acad Radiol. 2019 Jun;26;6:820-830. doi: 10.1016/j.acra.2019.03.006

14. Cafarelli F.P., Grilli G., Zizzo G., Bertozzi G., Giuliani N., Mahakkanukrauh P., Pinto A, Guglielmi G. Postmortem Imaging: an Update. Semin Ultrasound CT MR. 2019 Feb;40;1:86-93. Epub 2018 Oct 28. doi: 10.1053/j.sult.2018.10.012.

15. Zech W.D., Ruder T.D. Stumpfe Gewalt in der Forensischen Radiologie [Blunt Force Trauma in Forensic Radiology]. Radiologie (Heidelb). 2024 Nov;64;11:837-845. Epub 2024 Sep 25. doi: 10.1007/s00117-024-01366-1.

 

 

 PDF (RUS) Full-text article (in Russian)

 

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Vasiliev Alexander Yuryevich – formation of the idea of express X-ray diagnostics, goals, chest X–ray in corpses, writing the text, approval of the final version of the article – taking responsibility for all aspects of the work, the integrity of all parts of the article and its final version; Leonov Sergey Valeryevich – formation of goals for forensic medicine, autopsy, writing the text, correction of captions and approval of the final version; Nikolai Nikolaevich Blinov (m.) – collecting material, working with images and captions, writing text, searching for publications on the topic, analyzing literature, participating in the processing of material and calculating statistical indicators; Nikolai Nikolaevich Potrakhov – forming the idea of shooting in non-specialized conditions, preparing a device for forensic medicine, checking and correction of physical and technical conditions of shooting; Larisa Aleksandrovna – writing the article text, correcting the drawings and captions, checking the terms in forensic medicine, and scientific editing of the text; Sakharov Alexander Igorevich – writing the article text, correcting the drawings and captions, checking the terms in forensic medicine.

Article received: 20.05.2025. Accepted for publication: 25.06.2025.

 

Medical Radiology and Radiation Safety. 2025. Vol. 70. № 5

DOI:10.33266/1024-6177-2025-70-5-93-97

V.P. Neustroev1, Yu.D. Udalov2, M.I. Muslimov3, E.N. Mingazova3,4,5

Use of Radiomics in Mri Studies of Metastatic Liver Lesions

1 N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia

2 A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia

3 Russian Medical Academy of Continuous Professional Education, Moscow, Russia

4 N.A. Semashko National Research Institute of Public Health, Moscow, Russia

5 Kazan State Medical University, Kazan, Russia

Contact person: E.N. Mingazova, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Abstract

Currently, radiomics, as a rapidly developing technology, is increasingly used to solve diagnostic, prognostic and predictive problems in studies on liver metastases based on MRI images. In addition to its effectiveness in diagnosing and classifying tumors, radiomics demonstrates particularly impressive prognostic capabilities for malignant liver tumors (MLT) of the liver as a high-risk organ. Before the advent of radiomics, molecular genetic, biochemical and histological studies were used for these purposes. Radiomics of liver MLT is in its early stages of development, which suggests the presence of certain difficulties and obstacles, the elimination of which is the primary focus, in particular, in the field of developing standards necessary for use in clinical practice.

Keywords: radiomics, magnetic resonance imaging, MRI, medical imaging, texture analysis, metastasis, liver, precision medicine

For citation: Neustroev VP, Udalov YuD, Muslimov MI, Mingazova EN. Use of Radiomics in Mri Studies of Metastatic Liver Lesions. Medical Radiology and Radiation Safety. 2025;70(5):93–97. (In Russian). DOI:10.33266/1024-6177-2025-70-5-93-97

 

References

  1. Shur JD, Doran SJ, Kumar S, et al. Radiomics in Oncology: A Practical Guide. Radiographics. 2021;41(6):1717-1732. doi:10.1148/rg.2021210037.
  2. Kumar V, Gu Y, Basu S, et al. Radiomics: the process and the challenges. Magn Reson Imaging. 2012;30(9):1234-1248. doi:10.1016/j.mri.2012.06.010.
  3. Lambin P, Leijenaar RTH, Deist TM, et al. Radiomics: the bridge between medical imaging and personalized medicine. Nat Rev Clin Oncol. 2017;14(12):749-762. doi:10.1038/nrclinonc.2017.141.
  4. Parekh V, Jacobs MA. Radiomics: a new application from established techniques. Expert Rev Precis Med Drug Dev. 2016;1(2):207-226. doi:10.1080/23808993.2016.1164013.
  5. Rizzo S, Botta F, Raimondi S, et al. Radiomics: the facts and the challenges of image analysis. Eur Radiol Exp. 2018;2(1):36. Published 2018 Nov 14. doi:10.1186/s41747-018-0068-z.
  6. Alderson PO, Summers RM. The Evolving Status of Radiomics. J Natl Cancer Inst. 2020;112(9):869-870. doi:10.1093/jnci/djaa018.
  7. Ding H, Wu C, Liao N, et al. Radiomics in Oncology: A 10-Year Bibliometric Analysis. Front Oncol. 2021;11:689802. Published 2021 Sep 20. doi:10.3389/fonc.2021.689802.
  8. McCague C, Ramlee S, Reinius M, et al. Introduction to radiomics for a clinical audience. Clin Radiol. 2023;78(2):83-98. doi:10.1016/j.crad.2022.08.149.
  9. Maniaci A, Lavalle S, Gagliano C, et al. The Integration of Radiomics and Artificial Intelligence in Modern Medicine. Life (Basel). 2024;14(10):1248. Published 2024 Oct 1. doi:10.3390/life14101248.
  10. Maino C, Vernuccio F, Cannella R, et al. Radiomics and liver: Where we are and where we are headed?. Eur J Radiol. 2024;171:111297. doi:10.1016/j.ejrad.2024.111297.
  11. Hacking C, Southi J, Fahrenhorst-Jones T, Silverstone L., et al. Hepatic metastases. Reference article. Radiopaedia.org. 2025; doi:10.53347/rID-6931.
  12. Cervantes A, Adam R, Roselló S, et al. Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol. 2023;34(1):10-32. doi:10.1016/j.annonc.2022.10.003.
  13. Tsilimigras DI, Brodt P, Clavien PA, et al. Liver metastases. Nat Rev Dis Primers. 2021;7(1):27. Published 2021 Apr 15. doi:10.1038/s41572-021-00261-6.
  14. Stoletov K, Beatty PH, Lewis JD. Novel therapeutic targets for cancer metastasis. Expert Rev Anticancer Ther. 2020;20(2):97-109. doi:10.1080/14737140.2020.1718496.
  15. Chang HH, Leeper WR, Chan G, Quan D, Driman DK. Infarct-like necrosis: a distinct form of necrosis seen in colorectal carcinoma liver metastases treated with perioperative chemotherapy. Am J Surg Pathol. 2012;36(4):570-576. doi:10.1097/PAS.0b013e31824057e7.
  16. Zimmermann A. Metastatic Liver Disease: Secondary Alterations of Hepatic Metastases. Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. General and surgical pathology. Cham: Springer, 2017. Р. 1947–1964. doi:10.1007/978-3-319-26956-6_109.
  17. Çakır M, Tüzün S, Savaş A, Tosyalı Y. Two pseudotumor cases mimicking liver malignancy. Turk J Surg. 2015;33(3):212-216. Published 2015 Jul 2. doi:10.5152/UCD.2015.2912.
  18. Pohnan R, Ryska M, Hytych V, Matej R, Hrabal P, Pudil J. Echinococcosis mimicking liver malignancy: A case report. Int J Surg Case Rep. 2017;36:55-58. doi:10.1016/j.ijscr.2017.04.032.
  19. Khalil A, Taha A. Hepatic Sarcoid-Like Reaction Mimicking Liver Metastases in a 36-Year-Old Female With Rheumatoid Arthritis. Cureus. 2023;15(8):e43974. Published 2023 Aug 23. doi:10.7759/cureus.43974.
  20. Oyama A, Hiraoka Y, Obayashi I, et al. Hepatic tumor classification using texture and topology analysis of non-contrast-enhanced three-dimensional T1-weighted MR images with a radiomics approach. Sci Rep. 2019;9(1):8764. Published 2019 Jun 19. doi:10.1038/s41598-019-45283-z.
  21. Fiz F, Viganò L, Gennaro N, et al. Radiomics of Liver Metastases: A Systematic Review. Cancers (Basel). 2020;12(10):2881. Published 2020 Oct 7. doi:10.3390/cancers12102881.
  22. Li S, Li Z, Huang X, et al. CT, MRI, and radiomics studies of liver metastasis histopathological growth patterns: an up-to-date review. Abdom Radiol (NY). 2022;47(10):3494-3506. doi:10.1007/s00261-022-03616-z.
  23. Granata V, Fusco R, Setola SV, et al. Colorectal liver metastases patients prognostic assessment: prospects and limits of radiomics and radiogenomics. Infect Agent Cancer. 2023;18(1):18. Published 2023 Mar 16. doi:10.1186/s13027-023-00495-x.
  24. Baishya NK, Baishya K, Baishya K, Sarma R, Ray S. MRI Radiomics in Imaging of Focal Hepatic Lesions: A Narrative Review. Cureus. 2024;16(6):e62570. Published 2024 Jun 17. doi:10.7759/cureus.62570.
  25. Haghshomar M, Rodrigues D, Kalyan A, Velichko Y, Borhani A. Leveraging radiomics and AI for precision diagnosis and prognostication of liver malignancies. Front Oncol. 2024;14:1362737. Published 2024 May 8. doi:10.3389/fonc.2024.1362737.
  26. Shu Z, Fang S, Ding Z, et al. MRI-based Radiomics nomogram to detect primary rectal cancer with synchronous liver metastases. Sci Rep. 2019;9(1):3374. Published 2019 Mar 4. doi:10.1038/s41598-019-39651-y.
  27. Hu SX, Yang K, Wang XR, et al. Sichuan Da Xue Xue Bao Yi Xue Ban. 2021;52(2):311-318. doi:10.12182/20210360202.
  28. Granata V, Fusco R, De Muzio F, et al. Contrast MR-Based Radiomics and Machine Learning Analysis to Assess Clinical Outcomes following Liver Resection in Colorectal Liver Metastases: A Preliminary Study. Cancers (Basel). 2022;14(5):1110. Published 2022 Feb 22. doi:10.3390/cancers14051110.
  29. Granata V, Fusco R, De Muzio F, et al. Radiomics and machine learning analysis by computed tomography and magnetic resonance imaging in colorectal liver metastases prognostic assessment. Radiol Med. 2023;128(11):1310-1332. doi:10.1007/s11547-023-01710-w.
  30. Huang Y, Zhou S, Luo Y, et al. Development and validation of a radiomics model of magnetic resonance for predicting liver metastasis in resectable pancreatic ductal adenocarcinoma patients. Radiat Oncol. 2023;18(1):79. Published 2023 May 10. doi:10.1186/s13014-023-02273-w.
  31. Li ZF, Kang LQ, Liu FH, et al. Radiomics based on preoperative rectal cancer MRI to predict the metachronous liver metastasis. Abdom Radiol (NY). 2023;48(3):833-843. doi:10.1007/s00261-022-03773-1.
  32. Chen Y, Lu T, Zhang Y, Li H, Xu J, Li M. Baseline hepatobiliary MRI for predicting chemotherapeutic response and prognosis in initially unresectable colorectal cancer liver metastases. Abdom Radiol (NY). 2024;49(8):2585-2594. doi:10.1007/s00261-024-04492-5.
  33. Ma J, Nie X, Kong X, et al. MRI T2WI-based radiomics combined with KRAS gene mutation constructed models for predicting liver metastasis in rectal cancer. BMC Med Imaging. 2024;24(1):262. Published 2024 Oct 4. doi:10.1186/s12880-024-01439-6.
  34. Wang X, Liu Z, Yin X, Yang C, Zhang J. A radiomics model fusing clinical features to predict microsatellite status preoperatively in colorectal cancer liver metastasis. BMC Gastroenterol. 2023;23(1):308. Published 2023 Sep 12. doi:10.1186/s12876-023-02922-0.
  35. Jin WH, Simpson GN, Dogan N, et al. MRI-based delta-radiomic features for prediction of local control in liver lesions treated with stereotactic body radiation therapy. Sci Rep. 2022;12(1):18631. Published 2022 Nov 3. doi:10.1038/s41598-022-22826-5.
  36. Della Corte A, Mori M, Calabrese F, et al. Preoperative MRI radiomic analysis for predicting local tumor progression in colorectal liver metastases before microwave ablation. Int J Hyperthermia. 2024;41(1):2349059. doi:10.1080/02656736.2024.2349059.
  37. Yoon S, Kim YJ, Jeon JS, Ahn SJ, Choi SJ. Radiomics and machine learning analysis of liver magnetic resonance imaging for prediction and early detection of tumor response in colorectal liver metastases. Korean J Clin Oncol. 2024;20(1):27-35. doi:10.14216/kjco.24005.
  38. Song C, Li W, Cui J, et al. Pre-operative prediction of histopathological growth patterns of colorectal cancer liver metastasis using MRI-based radiomic models. Abdom Radiol (NY). 2024;49(12):4239-4248. doi:10.1007/s00261-024-04290-z.
  39. Lu W, Wu G, Miao X, et al. The radiomics nomogram predicts the prognosis of pancreatic cancer patients with hepatic metastasis after chemoimmunotherapy. Cancer Immunol Immunother. 2024;73(5):87. Published 2024 Mar 30. doi:10.1007/s00262-024-03644-2
  40. Bodalal Z, Bogveradze N, Ter Beek LC, et al. Radiomic signatures from T2W and DWI MRI are predictive of tumour hypoxia in colorectal liver metastases. Insights Imaging. 2023;14(1):133. Published 2023 Jul 21. doi:10.1186/s13244-023-01474-x.
  41. Yuan Z, Shu Z, Peng J, et al. Prediction of postoperative liver metastasis in pancreatic ductal adenocarcinoma based on multiparametric magnetic resonance radiomics combined with serological markers: a cohort study of machine learning. Abdom Radiol (NY). 2024;49(1):117-130. doi:10.1007/s00261-023-04047-0.
  42. van der Reijd DJ, Chupetlovska K, van Dijk E, et al. Multi-sequence MRI radiomics of colorectal liver metastases: Which features are reproducible across readers?. Eur J Radiol. 2024;172:111346. doi:10.1016/j.ejrad.2024.111346.
  43. Park JH, Cho ES, Yoon J, et al. MRI radiomics model differentiates small hepatic metastases and abscesses in periampullary cancer patients. Sci Rep. 2024;14(1):23541. Published 2024 Oct 9. doi:10.1038/s41598-024-74311-w.
  44. Zwanenburg A, Vallières M, Abdalah MA, et al. The Image Biomarker Standardization Initiative: Standardized Quantitative Radiomics for High-Throughput Image-based Phenotyping. Radiology. 2020;295(2):328-338. doi:10.1148/radiol.2020191145.
  45. Kocak B, Baessler B, Bakas S, et al. CheckList for EvaluAtion of Radiomics research (CLEAR): a step-by-step reporting guideline for authors and reviewers endorsed by ESR and EuSoMII. Insights Imaging. 2023;14(1):75. Published 2023 May 4. doi:10.1186/s13244-023-01415-8.
  46. Kocak B, Yuzkan S, Mutlu S, Bulut E, Kavukoglu I. Publications poorly report the essential RadiOmics ParametERs (PROPER): A meta-research on quality of reporting. Eur J Radiol. 2023;167:111088. doi:10.1016/j.ejrad.2023.111088.
  47. Kocak B, Akinci D’Antonoli T, Mercaldo N, et al. METhodological RadiomICs Score (METRICS): a quality scoring tool for radiomics research endorsed by EuSoMII. Insights Imaging. 2024;15(1):8. Published 2024 Jan 17. doi:10.1186/s13244-023-01572-w.
  48. Long ZD, Yu X, Xing ZX, Wang R. Multiparameter magnetic resonance imaging-based radiomics model for the prediction of rectal cancer metachronous liver metastasis. World J Gastrointest Oncol. 2025;17(1):96598. doi:10.4251/wjgo.v17.i1.96598
  49. Shahveranova A, Balli HT, Aikimbaev K, Piskin FC, Sozutok S, Yucel SP. Prediction of Local Tumor Progression After Microwave Ablation in Colorectal Carcinoma Liver Metastases Patients by MRI Radiomics and Clinical Characteristics-Based Combined Model: Preliminary Results. Cardiovasc Intervent Radiol. 2023;46(6):713-725. doi:10.1007/s00270-023-03454-6. 

 

 

 PDF (RUS) Full-text article (in Russian)

 

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 20.05.2025. Accepted for publication: 25.06.2025.

 

Medical Radiology and Radiation Safety. 2025. Vol. 70. № 5

DOI:10.33266/1024-6177-2025-70-5-87-92

E.I. Matkevich1, A.N. Bashkov1, Yu.A. Bazhanova1, V.I. Doga1,
I.V. Ivanov2,O.V. Parinov1

The Use of Radiation Diagnostic Techniques in Traumatic Pneumothorax (Clinical Case)

1 A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia

2 I.M. Sechenov First Moscow State Medical University, Moscow, Russia

Contact person: E.I. Matkevich, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Abstract

Purpose: To evaluate the informative value of magnetic resonance imaging, computed tomography and radiography in the radiation diagnosis of traumatic pneumothorax using the example of a clinical case.

Material and methods:  The examination data of patient I., 68 years old, who was admitted to the clinic after a chest injury with complaints of pain in his side and difficulty, painful breathing, were analyzed. Due to a suspected compression fracture of the vertebrae, the patient underwent MRI, CT, and then chest X-rays.

Results: In the presented clinical case, all three methods of radiation diagnostics (MRI, CT and radiography) allowed to detect rib fractures and pneumothorax of the right lung during the initial examination. On the chest X-rays dated 02/17/2025 in the direct projection (image on exhalation, standing position) a strip of free air with a thickness of up to 5.0 cm at the apex and up to 1.5 cm in the middle sections is determined an indication for emergency drainage of the pleural cavity. Inhomogeneous darkening of the lower sections of the right lung field without clear visualization of the contours of the dome of the diaphragm and sinuses due to the presence of fluid in the pleural cavity with a horizontal upper border along the anterior sections of the 5th-6th ribs. Fracture of the posterior section of the 8th rib on the right with displacement by the thickness of the cortical layer. A small (clinically insignificant) fracture of the middle segment of the 9th rib on the right was revealed during a CT scan.

Conclusion: Based on the principle of minimal sufficiency, it can be assumed that radiography is the method of choice in the diagnosis of traumatic pneumothorax, has a high degree of visualization, allows not increasing radiation risks of long-term consequences and provides the physician opportunity to repeatedly monitor the drainage position and the condition of the lung tissue.

Keywords: radiation diagnostics, magnetic resonance imaging, computed tomography, radiography, traumatic pneumothorax, drainage of the pleural cavity, clinical case

For citation: Matkevich EI, Bashkov AN, Bazhanova YuA, Doga VI, Ivanov IV, Parinov OV. The Use of Radiation Diagnostic Techniques in Traumatic Pneumothorax (Clinical Case). Medical Radiology and Radiation Safety. 2025;70(5):87–92. (In Russian). DOI:10.33266/1024-6177-2025-70-5-87-92

 

References

1. Ternovoy S.K., Sinitsyn V.Ye. Development of Computed Tomography and Progress in Radiation Diagnostics. Terapevticheskiy Arkhiv = Therapeutic Archive. 2006;78;1:10-12 (In Russ.). EDN HTBBSX.

2. Amosov V.I., Agafonov A.O., Afanas’yeva I.S., et al. Luchevaya Diagnostika Organov Grudnoy Kletki = Radiation Diagnostics of the Chest Organs. National Guidelines. Moscow, GEOTAR-Media Publ., 2025. 440 p. (In Russ.). doi: 10.33029/9704-8865-2-LDG-2025-1-440. EDN EOQBLN.

3. Morozov S.P., Nasnikova I.Yu., Sinitsyn V.Ye. Mul’tispiral’naya Komp’yuternaya Tomografiya = Multispiral Computed Tomography. Moscow, GEOTAR-Media Publ., 2009. 112 p. (In Russ.). EDN VRUGEV.

4. Kosterev V.V., Tsov’yanov A.G., Sivenkov A.G., Zhuravleva V.Ye. Population Radiation Dose in 2020. Yadernaya Fizika i Inzhiniring = Nuclear Physics and Engineering. 2022;13;6:594-600 (In Russ.). doi: 10.56304/S2079562922030277.

5. Otsenka Radiatsionnogo Riska u Patsiyentov pri Provedenii Rentgenoradiologicheskikh Issledovaniy = Assessment of Radiation Risk in Patients during X-ray and Radiological Examinations. Methodological Recommendations MR 2.6.1.0215-20. Moscow Publ., 2020. 29 p. (In Russ.).

 

 

 PDF (RUS) Full-text article (in Russian)

 

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 20.05.2025. Accepted for publication: 25.06.2025.

 

 

Medical Radiology and Radiation Safety. 2025. Vol. 70. № 5

DOI:10.33266/1024-6177-2025-70-5-98-103

T.F. Malivanova, T.A. Astrelina, I.V. Kobzeva, Y.B. Suchkova, D.Y. Usupzhanova,
V.A. Brunchukov, V.A. Nikitina, A.I. Golovkova, A.S. Ostashkin, E.S. Lubaeva,
M.Yu. Sukhova, Yu.D. Udalov

Heterogeneity of the Early Radiation-Induced Skin Damage to Adjuvant Radiation Therapy of Breast Cancer Patients Allele TNF-308A Carriers

A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia

Contact person: Tatyana Feodorovna Malivanova, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

ABSTRACT

Purpose: The use of ionizing radiation is a fundamental approach in the complex treatment of oncological diseases, including breast cancer (BC), the most common localization of malignancies in women. The degree of early radiation-induced skin damage (ERSD), a common complication of adjuvant radiation therapy (ART), can be considered as a criterion of individual radio sensitivity. An important link in the immune response to the damaging effects of ionizing radiation is the pro-inflammatory cytokine tumor necrosis factor (TNF). The TNF gene occupies a central position in the HLA gene complex and has a number of single-nucleotide polymorphisms. Approximately half of the carriers of the minor allele of TNF-308A/G polymorphism may be included in the ancestral haplotype AH8.1. The aim of the study was to assess the effect of polymorphisms of the TNF gene and genes of the HLA complex on the degree of ERSD in patients with breast cancer during the course of ART.

Material and methods: The study included 145 BC patients who underwent a course of ART (2 Gy in 25 fractions). The degree of ERSD was determined by a radiologist. Polymorphisms of genes TNF (–863C/A, –308G/A, –238G/A), HSPA1B+1267A/G and IKBL-62T/A and marker alleles of haplotype AH8.1 (HLA-A*01, HLA-B*08, HLA-DRB1*03) were determined by the PCR-SSP and PCR-RFLP.

Results: ERSD was detected in all BC patients during the course of ART: grade I – 57.9 %, grade II – 35.9 %, grade III – 6.2 %. Three genetic comparison groups were identified: carriers of the allele TNF-308A and simultaneously three marker alleles of haplotype AH8.1 (11.7 %); carriers of the allele TNF-308A without the AH8.1 haplotype (11.0 %); carriers of the wild allele homozygote TNF-308GG (77.3 %). The percentages of BC patients with grade II-III ERSD were significantly higher in carriers of the TNF-308A allele without the AH8.1 haplotype than in other BC patients (75.0 % and 38.0 %, respectively, p=0.0065; RR=1.97, 95 % CI [1.38, 2.83]). An increase in the proportion of BC patients with grade II-III ERSD with additional TNF-863CC homozygote to 85.7 %, compared with 37.4% for other breast cancer patients (p=0.0009), further increases the relative risk to RR=2.92, 95 % CI [1.68, 3.12]. The inclusion of other studied polymorphisms in the analysis did not have an additional effect.

Conclusion: For the first time, the heterogeneity of the reaction of allele TNF-308A carriers to radiation therapy has been revealed, which manifests itself depending on the inclusion or non-inclusion of this allele in the ancestral haplotype AH8.1 of the HLA complex. A genetic group with increased individual radio sensitivity has been identified as TNF-308A carriers without the haplotype AH8.1.

Keywords: adjuvant radiation therapy, early radiation-induced skin damage, breast cancer, tumor necrosis factor

For citation: Malivanova TF, Astrelina TA, Kobzeva IV, Suchkova YB, Usupzhanova DY, BrunchukovVA, Nikitina VA, Golovkova AI, Ostashkin AS, Lubaeva ES, Sukhova MYu, Udalov YuD. Heterogeneity of the Early Radiation-Induced Skin Damage to Adjuvant Radiation Therapy of Breast Cancer Patients Allele TNF-308A Carriers. Medical Radiology and Radiation Safety. 2025;70(5):98–103. (In Russian). DOI:10.33266/1024-6177-2025-70-5-98-103

 

References

1. Bennardo L., Passante M., Cameli N., Cristaudo A., Patruno C., Nistico S.P., Silvestri M. Skin Manifestations after Ionizing Radiation Exposure: a Systematic Review. Bioengineering 2021;8:153. doi: 10.3390/bioengineering8110153.

2. Smith A.O., Ju W., Adzraku S.Y., Wenyi L., Yuting C., Qiao J., Xu K., Zeng L. Gamma Radiation Induce Inflammasome Signaling and Pyroptosis in Microvascular Endothelial Cells. J Inflamm Res. 2021;14:3277-3288. doi: 10.2147/JIR.S318812.

3. De Sanctis V.D., Agolli L., Visco V., Monaco F., Muni R., Spagnoli A., Campanella B., Valeriani M., Minniti G., Osti M.F., Amanti C., Pellegrini P., Brunetti S., Costantini A., Alfo M., Torrisi M.R., Marchetti P., Enrici R.M. Cytokines, Fatigue, and Cutaneous Erythema in Early Stage Breast Cancer Patients Receiving Adjuvant Radiation Therapy. Biomed Res Int. 2014:523568. doi: 10.1155/2014/523568.

4. Canedo-Dorantes L., Canedo-Ayala M. Skin Acute Wound Healing: A Comprehensive Review. Int J Inflam. 2019:3706315. doi: 10.1155/2019/3706315.

5. Kulski J.K., Suzuki S., Shiina T. Human Leukocyte Antigen Super-Locus: Nexus of Genomic Supergenes, SNPs, Indels, Transcripts, and Haplotypes. Hum Genome Var. 2022;9;1:49. doi: 10.1038/s41439-022-00226-5.

6. Aly T.A., Eller E., Ide A., Gowan K., Babu S.R., Erlich H.A., Rewers M.J., Eisenbarth G.S., Fain P.R. Multi-SNP Analysis of MHC Region: Remarkable Conservation of HLA-A1-B8-DR3 Haplotype. Diabetes. 2006;55;5:1265-9. doi: 10.2337/db05-1276.

7. Talbot C.J., Tanteles G.A., Barnett G.C., Burnet N.G., Chang-Claude J., Coles C.E., Davidson S., Dunning A.M., Mills J., Murray R.J.S., Popanda O., Seibold P., West C.M.L., Yarnold J.R., Symonds R.P. A Replicated Association between Polymorphisms Near TNFα and Risk for Adverse Reactions to Radiotherapy. Br J Cancer. 2012;107;4:748-53. doi: 10.1038/bjc.2012.290.

8. Cordoba E.E., Lacunza E., Abba M.C., Fernandez E., Guerci A.M. Single Nucleotide Polymorphisms in ATM, TNF-α and IL6 Genes and Risk of Radiotoxicity in Breast Cancer Patients. Mutat Res Genet Toxicol Environ Mutagen. 2018;836;Pt B:84-89. doi: 10.1016/j.mrgentox.2018.06.005.

9. Malivanova T.F., Astrelina T.A., Kobzeva I.V., Nikitina V.A., Suchkova Y.B., Ostashkin A.S., Usupzhanova D.Y., Dobrovolskaya E.I., Brunchukov V.A., Rastorgueva A.A., Lomonosova E. E.,  Lubaeva E.S., Kretova E.Y., Stepanyants N.G., Sukhova M.Y., Samoilov A.S. Autoimmune Haplotype AH8.1 Normalizes the Level of Tumor Necrosis Factor in the Blood Sera of Breast-Cancer Patients. Mol. Genet. Microbiol. Virol. 2023;38:34-40. doi: 10.3103/S089141682301007X.

10. Elahi M.M., Asotra K., Matata B.M., Mastana S.S. Tumor Necrosis Factor Alpha -308 Gene Locus Promoter Polymorphism: an Analysis of Association with Health and Disease. Biochim Biophys Acta. 2009 Mar;1792;3:163-72. doi: 10.1016/j.bbadis.2009.01.007.

11. Pol J., Paillet J., Plantureux C., Kroemer G. Beneficial Autoimmunity and Maladaptive Inflammation Shape Epidemiological Links between Cancer and Immune-Inflammatory Diseases. Oncoimmunology. 2022;11;1:2029299. doi: 10.1080/2162402X.2022.202929912.

12. Shah A.A., Igusa T., Goldman D., Li J., Casciola-Rosen L., Rosen A., Petri M. Association of Systemic Lupus Erythematosus Autoantibody Diversity with Breast Cancer Protection. Arthritis Res Ther. 2021;23;1:64. doi: 10.1186/s13075-021-02449-3.

13. Barnett G.C., West C.M.L., Dunning A.M., Elliott R.M., Coles C.E., Pharoah P.D.P., Burnet N.G. Nat Rev Cancer. 2009;9;2:134-42. doi: 10.1038/nrc2587.

14. Pereira S., Orlandi E., Deneuve S., Barcellini A., Chalaszczyk A., Behm-Ansmant I., Hettal L., Rancati T., Vogin G., Thariat J. The Normal, the Radiosensitive, and the Ataxic in the Era of Precision Radiotherapy: a Narrative Review. Cancers 2022;14:6252. doi: 10.3390/cancers14246252.

15. Xia C., Qin L., Wang Y., Yao L., Shia B., Wu S-Y. Risk Factors and Specific Cancer Types of Second Primary Malignancies in Patients with Breast Cancer Receiving Adjuvant Radiotherapy: a Case-Control Cohort Study Based on the SEER Database. Am J Cancer Res. 2022;12;6:2744-2756. URL: www.ajcr.us /ISSN:2156-6976/ajcr0142447.

16. Rezaei S.J., Eid E., Tang J.Y., Kurian A.W., Kwong B.Y., Linos E. Incidence of Nonkeratinocyte Skin Cancer After Breast Cancer Radiation Therapy. JAMA Network Open. 2024;7;3:e241632. doi: 10.1001/jamanetworkopen.2024.1632.

17. Маливанова Т.Ф., Алфёрова Е.В., Осташкин А.С., Астрелина Т.А., Мазуренко Н.Н. Общая выживаемость больных раком молочной железы зависит от сочетания полиморфизмов гена фактора некроза опухоли и HLA-гаплотипов // Молекулярная генетика, микробиология и вирусология. 2020. Т.38. №1. С. 40-48 [Malivanova T.F., Alforova Ye.V., Ostashkin A.S., Astrelina T.A., Mazurenko N.N. Breast Cancer Patients Overall Survival Depends on a Combination of the Polymorphisms of Tumor Necrosis Factor Gene and HLA-Haplotypes. Molekulyarnaya Genetika, Mikrobiologiya i Virusologiya = Molecular Genetics, Microbiology and Virology. 2020;38;1:40-48 (In Russ.)]. doi: 10.17116/molgen2020380114.

18. Simman R., Bach K., Abbas F., Klomparens K., Brickman B.J. Management of Radiation-Induced Tissue Injuries: a Review of Current Treatment Strategies. Plast Reconstr Surg Glob Open. 2023 Jun 16;11;6:e5043. doi: 10.1097/GOX.0000000000005043.

 

 

 PDF (RUS) Full-text article (in Russian)

 

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 20.05.2025. Accepted for publication: 25.06.2025.

 

  1. 104-108_lebedenko_eng
  2. 5-9_melnikova_eng
  3. 10-15_molodtsova_eng
  4. 16-20_mysina_eng

Contact Information

 

46, Zhivopisnaya st., 123098, Moscow, Russia Phone: +7 (499) 190-95-51. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal location

Attendance

4003910
Today
Yesterday
This week
Last week
This month
Last month
For all time
4547
3887
17543
30856
133616
124261
4003910
Forecast today
4968

Your IP:216.73.217.31
Visitor Counter

© Журнал "Медицинская радиология и радиационная безопасность" 2020г.

Яндекс.Метрика

Наверх