Medical Radiology and Radiation Safety. 2025. Vol. 70. № 2

DOI:10.33266/1024-6177-2025-70-2-88-106

A.N. Koterov, L.N. Ushenkova, T.M. Bulanova, N.A. Bogdanenko

Industry Bibliographical Databases: Perspectives of Use in the FMBA of Russia for Scientific Expertise in Decision-Making. Report 1. General Issues and Database on Health and Other Effects in Nuclear Workers

A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia

Contact person: Alexey N. Koterov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Abstract

The presented review of three reports is devoted to bibliographic databases on health and other effects and indexes in nuclear workers (NW) and uranium miners (U miners), developed within the framework of the research theme of the Federal Medical and Biological Agency of Russia (FMBA) and registered with the state in Rospatent. Report 1 sets out introductory issues of the theory of databases, as well as registers, and provides detailed information on the database for NW.

The purpose of the database for NW creating was to form a repository for accessible for abstract and full-text search published data on themes relevant for conducting research examinations for expertise in the system of the FMBA, in other healthcare institutions dealing with the radiation factor, and, more broadly, for conducting fundamental and applied research in the field of professional exposures.

The main parts of the database are two separate sub-databases for Russian and foreign NW (Russian NW and Foreign NW), in which the sources are collected in alphabetical order by the authors of the publication or the organizations that created the document. The structural form of information is a catalog that includes primary (main) units of information in the form of an information file about the source (DOC), which contains the title of the publication/document, an abstract (sometimes additional information), and the full original publication (PDF, rarely HTML), available for 88–91 % of sources (the Russian and Foreign sub-databases contain 2078 and 2145 sources, respectively, as of the end of January 2025). 51 % of the works in the database correspond to studies for Russian NW; followed by the USA, Great Britain, Canada, France, and Japan.

Visual and/or software search of the material in the database it is supposed to be carried out both through the information names of the catalogs, including the themes of research, carried out using the list of abbreviations (metadata for the database), and through all the texts of the sources included in the database using the proposed programs.

Auxiliary elements of the database are fragments of two sub-bases that have undergone hierarchical thematic cataloging in accordance with the identified areas of research on the effects and indexes for NW. These elements are intended, firstly, for initial familiarization with the subject of the database for NW, and, secondly, they are significant as a final thematic base with a certain number of sources, which can be used directly for operational purposes.

The developed database for NW has no analogues among industry databases/registers for NW in various countries, nor among bibliographic and search systems. PubMed, Cochrane Library, EMBASE, CINAHL, ISRCTN, Web of Science and Google revealed 5–24 times fewer sources on the theme than the proposed database, and in most cases the world search systems do not provide for the extraction of original publications (as for the IAEA INIS bibliographic database on radiation effects). The depth of the search for works on effects and indexes for NW in the world systems is significantly inferior to the developed database (1960–1970s versus 1940–1950s).

It is concluded that the presented database on NW is unique for examination within the framework of the FMBA and other healthcare institutions, and has no complete replacement as a scientific reference and expert depot of sources.

Keywords: bibliographic database; nuclear workers; health effects

For citation: Koterov AN, Ushenkova LN, Bulanova TM, Bogdanenko NA. Industry Bibliographical Databases: Perspectives of Use in the Fmba of Russia for Scientific Expertise in Decision-Making. Report 1. General Issues and Database on Health and Other Effects in Nuclear Workers. Medical Radiology and Radiation Safety. 2025;70(2):88–106. (In Russian). DOI:10.33266/1024-6177-2025-70-2-88-106

 

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 PDF (RUS) Full-text article (in Russian)

 

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 20.02.2025. Accepted for publication: 25.03.2025.

 

 

 

 

Medical Radiology and Radiation Safety. 2025. Vol. 70. № 2

DOI:10.33266/1024-6177-2025-70-2-113-118

P.V. Sychev¹, Yu.D. Udalov^{1, 2}

Results of Evaluation of Four Cycles of Radionuclide Therapy with a Domestic Radiopharmaceutical Based on Radium-223 Chloride for the Treatment of Bone Metastases

¹ Federal Scientific Clinical Center for Medical Radiology and Oncology, Dimitrovgrad, Russia

² A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia

Contact person: Petr Vladimirovich Sychev, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

ABSTRACT

Purpose: The evaluation of the efficacy and safety of a domestic radiopharmaceutical drug based on Radium-223 chloride in patients with bone metastases in comparison with the original drug.

Material and methods: In the period from 2022 to 2023, a study was conducted that included 36 patients diagnosed with metastatic castration–resistant prostate cancer in the absence of visceral metastases, who underwent planar osteoscintigraphy in the whole body mode and PET/CT with ¹⁸F-PSMA. In all patients included in the study, the fact of metastatic skeletal lesions and the absence of visceral metastases were confirmed by diagnostic studies before inclusion in the study. The effectiveness was assessed by comparing the data of planar osteoscintigraphy and PET/CT before the start of treatment and after cycle 4, as well as by assessing the pain syndrome. The safety of the drug was monitored by assessing hematological toxicity in dynamics before and after each cycle. In the study group, 22 patients (84.6 %), and in the control group, 14 patients (93.3 %) received 4 cycles of treatment. The fatal outcome was found in the research group in 3 people (11.5 %), in the control group in 1 patient (6.7 %) with a diagnosis of Covid-19. The general condition of the patients at the time of the fourth treatment cycle was satisfactory, there were no side effects in the form of redness at the injection site, nausea and vomiting.

Results: There was a deviation from the lower limits of normal in the study group in terms of hemoglobin level in 9 patients (35 %), in the control group in 6 patients (40 %), in neutrophil levels in 1 patient in the study group (3.8 %), in platelet level in 6 patients in the study group (23 %), in 5 patients in the control group (33.3 %), in the level of lymphocytes in 6 patients in the study group (23 %), which is associated with the underlying disease. The minimum values ​of the indicators did not require correction.

Conclusions: The first results of therapy with a domestic drug based on radium-223 chloride are comparable with the original drug.

Keywords: castration-resistant prostate cancer (CRPC), bone metastases, radionuclide therapy, radium-223 chloride, single-photon emission computed tomography, positron emission tomography

For citation: Sychev PV, Udalov YuD. Results of Evaluation of Four Cycles of Radionuclide Therapy with a Domestic Radiopharmaceutical Based on Radium-223 Chloride for the Treatment of Bone Metastases. Medical Radiology and Radiation Safety. 2025;70(2):113–118. (In Russian). DOI:10.33266/1024-6177-2025-70-2-113-118

 

References

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5. Henriksen G., Breistol K., Bruland O.S., et al. Significant Antitumor Effect from Bone-Seeking, Alpha-Particle-Emitting (223)Ra Demonstrated in an Experimental Skeletal Metastases Model. Cancer Res. 2002;62:3120-3125.

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7. Parker C., Nilsson S., Heinrich D., Helle S.I., O’Sullivan J.M., Fosså S.D., Chodacki A., Wiechno P., Logue J., Seke M., Widmark A., Johannessen D.C., Hoskin P., Bottomley D., James N.D., Solberg A., Syndikus I., Kliment J., Wedel S., Boehmer S., Dall’Oglio M., Franzén L., Coleman R., Vogelzang N.J., O’Bryan-Tear C.G., Staudacher K., Garcia-Vargas J., Shan M., Bruland Ø.S., Sartor O. ALSYMPCA Investigators. Alpha Emitter Radium-223 and Survival in Metastatic Prostate Cancer. N Engl J Med. 2013 Jul 18;369;3:213-23. doi: 10.1056/NEJMoa1213755.

8. Shore N., Higano C.S., George D.J., et al. Concurrent or Layered Treatment with Radium-223 and Enzalutamide or Abiraterone/Prednisone: Real-World Clinical Outcomes in Patients with Metastatic Castration-Resistant Prostate Cancer. Prostate Cancer Prostatic. 2020;23:680–688. doi: 10.1038/s41391-020-0236-0.

 

 

 PDF (RUS) Full-text article (in Russian)

 

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 20.12.2024. Accepted for publication: 25.01.2025.

 

 

 

 

 

 

 

Medical Radiology and Radiation Safety. 2025. Vol. 70. № 2

DOI:10.33266/1024-6177-2025-70-2-107-112

M.O. Shatalova, I.O. Tomashevskiy 

X-Ray Computed Tomography in Complex Diagnosis of Thyroid Diseases

Central Clinical Hospital RZD-Medicine, Moscow, Russia

Contact person: I.O. Tomashevskiy, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Abstract

The literature review analyzed the use of X-ray computed tomography to assess thyroid function by X-ray density or with the use of special tomographs by the concentration of intrathyroidal iodine in absolute values (μg/g). Only the use of CT makes it possible to assess the risk of disruption of the hormone-forming function of the thyroid gland, diagnose hypothyroidism in the early stages, and, in case of dysfunction of the thyroid gland, determine the nature of the disorder: iodine-induced or iodine deficiency. For people living in regions with iodine deficiency, RCT makes it possible to assess the degree of iodine deficiency and, when carrying out iodine prophylaxis, to monitor its effectiveness. 

Based on literature data, fluctuations in the concentration of intrathyroidal stable iodine (ITI) and thyroid density during euthyroidism were determined for Moscow and the Moscow region, which amounted to 200‒700 μg/g for ITI and 85-140 units.

Keywords: X-ray computed tomography thyroid density, intrathyroidal iodine, intrathyroidal hormonogenesis

For citation: Shatalova MO, Tomashevskiy IO. X-Ray Computed Tomography in Complex Diagnosis of Thyroid Diseases. Medical Radiology and Radiation Safety. 2025;70(2):107–112. (In Russian). DOI:10.33266/1024-6177-2025-70-2-107-112

 

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 PDF (RUS) Full-text article (in Russian)

 

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 20.12.2024. Accepted for publication: 25.01.2025.

 

 

 

 

Medical Radiology and Radiation Safety. 2025. Vol. 70. № 2

DOI:10.33266/1024-6177-2025-70-2-119-125

V.A. Manukova, I.P. Aslanidis, O.V. Mukhortova,
M.V. Metelkina, I.V. Ekaeva, A.S. Rumyantsev, A.V. Silchenko

¹¹C-Methionine and ¹⁸F-Fluorodeoxyglucose PET/CT
in Multiple Myeloma Patients – One-Day Investigation

A.N. Bakulev Scientific Center for Cardiovascular Surgery, Moscow, Russia

Contact person: V.A. Manukova, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

ABSTRACT

Background: To evaluate the impact of PET/СT with ¹¹C-Methionine (MET) and ¹⁸F-fluorodeoxyglucose (FDG) on physiological distribution of FDG in patients with multiple myeloma (MM).

Material and methods: 40 patients with a history of MM were included in the analysis, 60 PET/CT exams were conducted: in the 1st group – 20 doubled PET/CT (MET PET/CT followed by FDG PET/CT); in the 2nd group – 20 FDG PET/CT. 

Results: Comparative analysis of the physiological accumulation of FDG in two groups of patients with MM – one group passed one day 11C-MET PET/CT followed by 18F-FDG PET/CT and another group passed standard  18F-FDG PET/CT – revealed no statistically significant difference. SUL_max and SUL_mean was calculated in the right lobe of the liver, in the ascending aorta and in the head of the pancreas. The mean values of liver SUL_max were: in the first group – 2.37 ± 0.36, in the second group – 2.46 ± 0.40, p = 0.1. The mean values of aortic SUL_max were: in the first group – 1.42 ± 0.25, in the second group – 1.51 ± 0.37, p = 0.11. The mean SUL_max values in the pancreatic head were: in the first group – 1.43 ± 0.26, in the second group – 1.59 ± 0.36, p = 0.08.

Conclusion: A one-day MET and FDG PET/CT does not affect the pharmacokinetics of FDG and can be used in MM patients.

Keywords: multiple myeloma, PET/CT, ¹¹C-Methionine, ¹⁸F-Fluorodeoxyglucose, one-day investigation

For citation: Manukova VA, Aslanidis IP, Mukhortova OV, Metelkina MV, Ekaeva IV, Rumyantsev AS, Silchenko AV. ¹¹C-Methionine and ¹⁸F-Fluorodeoxyglucose PET/CT in Multiple Myeloma Patients – One-Day Investigation. Medical Radiology and Radiation Safety. 2025;70(2):119–125. (In Russian). DOI:10.33266/1024-6177-2025-70-2-119-125

 

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Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Development of the research concept and design, research methods, collection and analysis of literary material, statistical data processing, writing and scientific editing of the text – V.A. Manukova, I.P. Aslanidi, O.V. Mukhortova, M.V. Metelkina, I.V. Yekaeva, A.S. Rumyantsev, A.V. Silchenko – in equal parts.

Article received: 20.12.2024. Accepted for publication: 25.01.2025.