SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.

The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Issues journals

Medical Radiology and Radiation Safety. 2020. Vol. 65. No. 2. P. 21–26

R.M. Takhauov1,2, D.S. Isubakova1, E.V. Bronikovskaya1, O.S. Tsymbal1, M.V.  Khalyuzova1, L.R. Takhauova2, A.B. Karpov1,2, N.V. Litviakov1,3, I.V. Milto1,2

The Bank of Biological Samples by Seversk Biophysical Research Center

1 Seversk Biophysical Research Center, Seversk, Russia
2 Siberian State Medical University, Tomsk, Russia
3 Tomsk Cancer Research Institute, Tomsk, Russia
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Purpose: Description of the collection, structure and development dynamics during the period from 2015 to 2019 of the biological material bank of the Seversk Biophysical Research Center, as well as research works carried out using biological material from its collection.

Material and methods: The collection of bank of biological material includes the following types of biological material: venous blood, genomic DNA of white blood cells, cytogenetic suspensions of blood lymphocytes, surgical, biopsy and autopsy material. Biological material was obtained from people exposed to chronic radiation exposure: employees of the nuclear industry and the population permanently residing in the territory located in the area of the nuclear industry.

Results: At present, the collection of the biological material bank contains more than 21,000 samples of biological material obtained from more than 8,000 donors. The collection of bank of biological material is represented by 4 main blocks: biological material of conditionally healthy employees of company of the nuclear industry (Siberian Chemical Combine); biological material of conditionally healthy people permanently residing in the territory located in the area of the nuclear industry enterprise (Seversk); biological material of patients (workers of the Siberian Chemical Combine and residents of Seversk) with malignant neoplasms and biological material of patients (workers of the Siberian Chemical Combine and residents of Seversk) with acute myocardial infarction. In the collection of bank of biological material, the proportion of samples of biological material of relatively healthy workers of the Siberian Chemical Combine is 33 %, residents of Seversk — 40.8 %, patients with malignant neoplasms — 22.2 %, patients with acute myocardial infarction — 4 %.

Conclusion: Biological material bank Seversk Biophysical Research Center is unique collection of biological material samples of healthy people and patients with socially significant diseases. A feature of the biological material of the biological material bank is that it is obtained from people who have been exposed to chronic low-intensity radiation exposure and can be used to evaluate its radiogenic effects.

Key words: bank of biological material, ionizing radiation, chromosomal aberration, malignant neoplasms, acute myocardial infarction

For citation: Takhauov RM, Isubakova DS, Bronikovskaya EV, Tsymbal OS, Khalyuzova MV, Takhauova LR, et al. The Bank of Biological Samples by Seversk Biophysical Research Center. Medical Radiology and Radiation Safety. 2020;65(2):21-6. (In Russ.).

DOI: 10.12737/1024-6177-2020-65-2-21-26

References

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PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 31.10.2019.

Accepted for publication: 12.03.2020.

Medical Radiology and Radiation Safety. 2020. Vol. 65. No. 2. P. 27–33

V.A. Rozhko1, I.V. Veyalkin2, T.M. Sharshakova1

Primary Incidence of Autoimmune Tyroiditis in the Republic of Belarus and Radiation Factor

1 Gomel State Medical University, Gomel, Belarus
2 Republican Scientific and Practical Center of Radiation Medicine and Human Ecology, Gomel, Belarus
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Actuality: In the Belarus, the primary incidence of thyroid pathology is in the 2d rank among endocrine diseases after diabetes. Studying the trends in the primary incidence of autoimmune thyroiditis (AIT) in the Belarus is important for improving organizational decisions and further improving the quality of medical care for the population.

Purpose: Is to conduct a comparative analysis of the incidence of AIT in the population and in the affected population based on an epidemiological study in the Belarus, taking into account the radiation and organizational components in the formation of pathology.

Material and methods: The data of the republican statistical reports and the data of the Chernobyl Register from 1997 to 2017 were analyzed. Standard methods of descriptive epidemiology were used in the work.

Results: According to Chernobyl Registry, during the observation period (1997–2017), the primary incidence of AIT decreased by 1.4 times (1997 – 135.1 ± 15.77 0/0000; 2017 – 98.4 ± 7.55 0/0000). The incidence was statistically significantly higher in women than men (ratios ranged from 2.39:1 in 2004 to 4.0:1 in 2000). Moreover, the incidence according to Chernobyl Registry was higher than in the adult population, but in children where was no difference with population data. This indicates a high-quality clinical examination of the children’s population. Two organizational and medical approaches have been formed in the republic. The first approach (Grodno, Brest, Minsk regions and Minsk) is characterized by periods of moderate growth, decline, and growth again. In the second approach (Vitebsk, Mogilev and Gomel regions), there are two periods when the increase in incidence sharply changes to decrease before the end of the study period. An analysis of the odds ratio allowed us to conclude that insignificant effect of radioactive iodine on the incidence of AIT in children at the time of the accident and its absence in the adult population.

Conclusion: The study confirms the importance of the organizational component in the early diagnosis of AIT.

Key words: autoimmune thyroiditis, primary incidence, organizational medical approach, radiation factor, Belarus

For citation: Rozhko VA, Veyalkin IV, Sharshakova TM. Primary Incidence of Autoimmune Tyroiditis in the Republic of Belarus and Radiation Factor. Medical Radiology and Radiation Safety. 2020;65(2):27-33. (In Russ.).

DOI: 10.12737/1024-6177-2020-65-2-27-33

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PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 26.02.2020.

Accepted for publication: 12.03.2020.

Medical Radiology and Radiation Safety. 2020. Vol. 65. No. 2. P. 44–49

K.Yu. Slashchuk, P.O. Rumyantsev, M.V. Degtyarev, S.S. Serzhenko, O.D. Baranova, A.A. Trukhin, Ya.I. Sirota

Molecular Imaging of Neuroendocrine Tumors by Somatostatin-Receptor Scintigraphy (SPECT/CT) with 99mTc-Tektrotyd

National Medical Research Centre of Endocrinology, Moscow, Russia

E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms constituting about 0.5 % of all cancer cases. In recent years, there has been a significant increase in the incidence of NETs, which is primarily due to the active development and improvement of medical imaging technologies. Successful treatment and prognosis for patients with NETs strongly depend on the stage of the disease. One of the effective methods of visualization and staging NETs in nuclear medicine is somatostin receptor scintigraphy (SRS), which is based on the use of partial somatostatin receptor agonists labeled with radioactive isotopes. The article presents an analysis of 55 patients with NETs of various localizations who underwent scintigraphy and SPECT/CT. Radiopharmaceutical was used as a tracer for SRS. It was prepared on the basis of a lyophilisate developed by Polatom (Poland) — Tektrotyd, labeled with 99mTc. According to the results of the study SRS with 99mTc-Tektrotyd is informative in the topical diagnosis of NETs, especially when PET/CT scan with 68Ga-labeled peptides is not available. Sensitivity varies depending on the NET localization. It is necessary to continue researches on the diagnostic value of SRS with 99mTc-Tektrotyd for tumors, in the pathogenesis of which somatostatin receptors play a significant role.

Key words: somatostatin-receptor scintigraphy, SPECT/CT, tektrotyd, octreoscan, neuroendocrine tumors

For citation: Slashchuk KYu, Rumyantsev PO, Degtyarev MV, Serzhenko SS, Baranova OD, Trukhin AA, Sirota YaI. Molecular Imaging of Neuroendocrine Tumors by Somatostatin-Receptor Scintigraphy (SPECT/CT) with 99mTc-Tektrotyd. Medical Radiology and Radiation Safety. 2020;65(2):44-9. (In Russ.).

DOI: 10.12737/1024-6177-2020-65-2-44-49

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  14. Boutsikou E, Porpodis K, Chatzipavlidou V, Hardavella G, Gerasimou G, Domvri K, Zarogoulidis K. Predictive Value of 99mTC-hynic-toc Scintigraphy in Lung Neuroendocrine Tumor Diagnosis. Technology in Cancer Research & Treatment, 2019;18:1-18. DOI: 10.1177/1533033819842586.

PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Informed consent. All patients signed an informed consent to participate in the study.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 18.12.2019.

Accepted for publication: 12.03.2020.

Medical Radiology and Radiation Safety. 2020. Vol. 65. No. 2. P. 34–43

A.S. Abdujapparov, S.I. Tkachev, V.A. Aliev, D.S. Romanov, A.V. Nazarenko, Yu.A. Barsukov, T.N. Borisova, V.V. Glebovskaya

Immediate Results of a Prolonged Course of Neoadjuvant Chemoradiotherapy for Patients with Locally Advanced Rectal Cancer: a Comparison of Classical and Hypofractional Regimes

N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Purpose: To compare the effectiveness of the hypofractional and classical modes of radiation therapy in a neoadjuvant prolonged course of chemoradiotherapy for patients with locally advanced rectal cancer (LARC).

Material and methods: This work is based on a retrospective analysis of the database of patients with LARC, who from 2013 to 2017 underwent a prolonged course of neoadjuvant chemoradiotherapy with subsequent surgical intervention. Patients were divided into two groups: the first (main) group, 71 patients with LARC, who, as part of the neoadjuvant treatment, underwent a course of chemoradiotherapy (CRT) in the hypofractionation mode (4 Gy, 3 fractions per week, 32 Gy to regional lymph nodes pelvis and up to 40 Gy to the primary tumor) in combination with chemotherapy with capecitabine 1650 mg/m2 in two doses daily on weekdays. The second group (control group) included 79 patients with LARC, who underwent CRT in the classical fractionation regimen (2 Gy, 5 fractions per week, 44 Gy to regional pelvic lymph nodes and up to 50–58 Gy to the primary tumor) in combination with capecitabine chemotherapy 1650 mg/m2 in two doses on the days of radiation therapy.

Results: The average duration of a prolonged course of CRT in the main group was 22.56 (95 % CI from 21.94 to 23.18) calendar days, in the control group — 38.84 (95 % CI from 38.12 to 39.54), p = 0.0001. Pathological response of the III degree in the main group was recorded in 23 % of cases, and of the IV degree in 18 %, in the control group these indicators were 19 % and 15 %, respectively, p = 0.4. A decrease in the stage of the tumor process was recorded in 50 (70.4 %) cases in the main group and in 47 (59.5 %) cases in the control group, p = 0.16. No statistically significant differences were observed in the incidence and severity of cases of hematological and local toxicity.

Conclusion: The results of our study confirm that the use of a prolonged course of neoadjuvant chemoradiotherapy in hypofractionation mode does not worsen oncological results, does not increase the frequency and severity of early and late radiation injuries, but at the same time reduces the duration of the course of treatment by two weeks. The hypofractionation regimen can be considered as an alternative and not inferior to the classical regimen in the neoadjuvant course of CRT of patients with LARC.

Key words: neoadjuvant chemoradiotherapy, locally advanced rectal cancer, hypofractional regimen, prolonged course

For citation: Abdujapparov AS, Tkachev SI, Aliev VA, Romanov DS, Nazarenko AV, Barsukov YuA, Borisova TN, Glebovskaya VV. Immediate Results of a Prolonged Course of Neoadjuvant Chemoradiotherapy for Patients with Locally Advanced Rectal Cancer: a Comparison of Classical and Hypofractional Regimes. Medical Radiology and Radiation Safety. 2020;65(2):34-43. (In Russ.).

DOI: 10.12737/1024-6177-2020-65-2-34-43

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PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 28.11.2019.

Accepted for publication: 12.03.2020.

Medical Radiology and Radiation Safety. 2020. Vol. 65. No. 2. P. 50–56

V.P. Pantelkin, V.E. Zhuravleva, A.G. Tsovyanov

Development of Chemical Samples Preparation Method to Reduce the Lower Limit of Absorbed Dose Assessment by Electron Paramagnetic Resonance Spectrometry

A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Purpose: Development of a method of chemical sample preparation to reduce the lower limit of the absorbed dose estimation by EPR spectrometry.

Material and methods: The required number of bone samples was prepared to study the effect of chemical treatment of bone material samples in organic solvents on their EPR spectra. They were subjected to primary treatment to separate the bones from the remains of soft biological tissue, then a dense bone was isolated and its defatting was carried out. Further, a series of parallel experiments on chemical treatment of bone materials in solutions of three organic reducing agents (hydrazine hydrate, ethylenediamine and diethylenetriamine) were done to reduce the magnitude of the native signal when carrying out works on reconstruction of absorbed doses using EPR spectroscopy. Recording of EPR spectra was performed on the ELEXSYS E500 Bruker spectrometer equipped with a high-q cylindrical resonator SHQE. Irradiation of the samples was carried out on the X-ray biological unit RUB RUST-M1.

Results: To reduce the lower limit of detection of the absorbed dose and improve the reliability of the assessment of the absorbed dose using the EPR method, it is required to reduce the native component of the EPR signal without affecting, if possible, the radiation component of the EPR signal. To achieve this effect, a chemical treatment in solutions of amines was proposed, which affect the collagen compounds that present in the bones and which are responsible for the appearance of a native signal in the EPR spectrum. After chemical treatment of bone material samples at 30°C for 30 minutes in a solution of different amines, there was a significant decrease in the amplitude of the native signal, which was: 4 for hydrazine hydrate, 3.3 for diethylenetriamine and 2.1 for ethylenediamine. For bone material samples that were subjected to the proposed chemical treatment in hydrazine hydrate, it is possible to confidently determine the amplitude of the radiation signal by a value of 2–3 Gy against the minimum dose values of 6–8 Gy for bone material samples that were not chemically treated.

Conclusion: It was found that during the chemical treatment there is a significant reduction of the native signal in the spectra of EPR of bone materials, the decrease of the radiation signal at the same time was slightly. Comparison of the results of treatment of bone materials in three organic reducing agents showed that the best results are obtained by the use of hydrazine hydrate at a temperature of 30°C for 30 minutes.

Key words: Electron Paramagnetic Resonance, radiation signal, native signal, absorbed dose, bone, chemical treatment

For citation: Pantelkin VP, Zhuravleva VE, Tsovyanov AG. Development of Chemical Samples Preparation Method to Reduce the Lower Limit of Absorbed Dose Assessment by Electron Paramagnetic Resonance Spectrometry. Medical Radiology and Radiation Safety. 2020;65(2):50-6. (In Russ.).

DOI: 10.12737/1024-6177-2020-65-2-50-56

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PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 17.12.2018.

Accepted for publication: 12.03.2020.

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