JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2013. Vol. 58. No. 3. P. 48–55
REVIEW
A.F. Tsyb1, E.V. Abakushina1,2, D.N. Abakushin2, Yu.S. Romanko1
Present and Future of Radioimmunotherapy
1. Medical Radiological Research Center, Obninsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Obninsk Institute for Nuclear Power Engineering of the NRNU MEPhI, Obninsk, Russia
Abstract
Molecular nuclear medicine plays an important role in the diagnosis and therapy of cancer and infectious diseases. Radioimmunodetection and radioimmunotherapy (RIT) involve the use of antibodies conjugated with diagnostic or therapeutic radionuclides, respectively. More often for RIT the radiolabeled monoclonal antibodies against tumor-associated antigens are used. Encouraging results have been achieved with this technology in the management of hematologic malignancies. On the contrary, solid tumors appeared to be less sensitive. Solid tumors are generally characterized by a limited vascular supply and heterogeneous uptake of the antibodies in the tumors. Radioimmunotherapy therefore is considered more suitable for the treatment of microscopic or minimal residual disease, allowing radiolabeled monoclonal antibodies to achieve uptake in tumors high enough to result in tumoricidal radiation doses. Despite these encouraging results, new treatment strategies are required for the cure of patients with cancer and no malignant diseases. More perspective new potential target for radioimmunodetection and RIT should be found. For this purpose, a series of experiments should be performed to investigate the biodistribution and the therapeutic efficacy of radiolabeled monoclonal antibodies in cell culture and animal models.
CONTENTS
Introduction
The selection of the radionuclide and conjugate
Radio immunotherapy of lymph proliferative diseases
Radio immunotherapy of solid cancers
Radio immunotherapy of metastatic cancer
Novel targets for radio immunotherapy
Conclusion
Key words: radioimmunotherapy, malignant diseases, monoclonal antibodies, tumor-associated antigens, radionuclide
Medical Radiology and Radiation Safety. 2013. Vol. 58. No. 3. P. 45–47
RADIATION PHYSICS, TECHNOLOGY AND DOSIMETRY
V.V. Kalashnikov1, E. P. Pavlov1, I.I. Samoilenko2, V.N. Korsunsky1
Individualization of the Sterility Test Duration for Some Irradiated Medical Products
1. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Gamaleya Institute of Epidemiology and Microbiology, Moscow, Russia
Abstract
Purpose: To study the possibility of shortening the test for sterility of medical products.
Material and methods: We used the methods of research, established the current regulatory documents. Results: In cases of non-sterility of products visual culture growth was observed, usually within the first 3 days of incubation. Control the growth of microcolonies reduced crop growth period of discovery for 1–2 days. After the radiation sterilization process in the surviving microorganisms observed delayed start of growth, the dynamics of the proliferative phase did not change significantly.
Conclusion: These data confirm the possibility reducing the period sterility test for some types of medical products to 7 days.
Key words: radiation sterilization, medical products, sterility control, sterility test duration
Medical Radiology and Radiation Safety. 2013. Vol. 58. No. 3. P. 34–38
RADIATION THERAPY
N.V. Belozor, T.V. Segeda, V.P. Starenkiy, N.A. Mitryaeva
Sfingomyelinasa for Monitoring of Chemoradioterapy Effectiveness in Cancer Treatment (Clinical and Experimental Investigation)
S.P. Grigoriev Medical Radiology Institute, National Academy of Medical Science of Ukraine, Kharkiv, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: To substantiate experimentally and investigate the possibility to use Zn2+-dependent acid sphingomyelinase (ASMase) in monitoring of efficacy of treatment for non-small-cell lung cancer (NSCLC).
Material and methods: The results of radiation therapy (RT) with two modes of accelerated fractionation and radiosensitizing with Etoposide in 45 patient with inoperable IIIA-IIIB NSCLC against a background of determining blood serum ASMase activity in the course of the treatment. ASMase activity, ceramide (CM) amount and sphingomyelin were investigated in the blood serum of rats with transplanted Guerin’s carcinoma at combined action of high-energy photon (HEP) radiation and Etoposide. The irradiation was delivered in two fractions up to 10 Gy with linear accelerator Clinac 600 Ϯ
Results: It was determined that blood serum ASMase activity in patients with NSCLC after chemoradiation treatment increased significantly in 2.9 times and was accompanied by the tumor regression (>50 %) in 73.3 % of cases. It was shown that increased activity of ASNase in 1.9 times, 4.7 time increase of and 2.5-time reduction of SPM were observed in the blood serum of the rat’s carriers of the tumor at combined action of HEP radiation and Etoposide.
Conclusion: ASMase activity level in the course of chemoradiation therapy against a background of determining the tumor regression can be used for monitoring of efficacy of chemoradiation treatment for NSCLC. This was substantiated by the findings of clinical investigations which allowed to suggest that a mechanism associated with ASMase activation is involved in induction of accumulation of pro-apoptotic lipid CM at combined action of irradiation and Etoposide. Therefore, the possibility to use determining ASMase activity as a serous marker of apoptosis ceramide pathway to assess the efficacy of chemoradiation therapy is obvious.
Key words: nonsmall lung cancer, chemoradiotherapy, Zn2+-dependent sphingomyelinase, ceramide, apoptosis
Medical Radiology and Radiation Safety. 2013. Vol. 58. No. 3. P. 39–44
NUCLEAR MEDICINE
Yu. B. Lishmanov, K.V. Zavadovskiy, V.V. Saushkin, S.V. Popov
Scintigraphic Semiotics of Arrhythmogenic Cardiac Dysfunction in Children and Teenagers with Ventricular Extrasystoles
Research Institute for Cardiology of SB RAMS, Tomsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: To develop the radionuclide semiotics of arrhythmogenic heart dysfunction in children and teenagers with ventricular extra systoles.
Material and methods: The study included 79 children and teenagers (mean age 12.9 ± 3.2 years) with ventricular extra systoles. Intracardiac electrophysiological study followed by radio frequency ablation foci of arrhythmogenic activity was carried out 24 patients. The comparison group included 15 patients of similar age and sex, with the exclusion of cardiac arrhythmias. All patients underwent gated blood pool SPECT. We have calculated the sensitivity, specificity, diagnostic accuracy, positive and negative predictive value. As a reference method we used intracardiac electrophysiological study of the heart. Results: In all patients with ventricular extra systoles we observed the areas of asynchronous contraction – the sign of myocardium mechanical heterogeneity. The most common site of these areas is the right ventricle. When the source of arrhythmia located in the right ventricular outflow tract – preliminary contraction areas are located in the anterior wall of the right ventricle. And when source of arrhythmia located in the left sinus of Valsalva, the asynchrony appears in the interventricular septum. In the group of children and teenagers with ventricular arrhythmia observed a moderate dilatation of the chambers and reduced contractile function of the heart, while this phenomenon is most pronounced for ectopic from the left sinus of Valsalva.
Conclusion: The existence of a zones of asynchronous contraction on the phase-polarity maps in children with ventricular arrhythmia can be considered pathognomonic symptom of the existence of scintigraphic ectopia.
Key words: right ventricle, left ventricle, quantitative blood pool SPECT, dyssynchrony, ventricular extrasystoles
Medical Radiology and Radiation Safety. 2013. Vol. 58. No. 3. P. 24–33
RADIATION MEDICINE
N.G. Vlasova
Methodological Approach to Individualized Dose Reconstruction of People Exposed Due to the Accident at the Chernobyl NPP
The Republican Research & Practical Centre for Radiation Medicine & Human Ecology”, Health Ministry of the Republic of Belarus, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: To reveal the stability of relative internal dose in individuals and families of rural society and justify the use of this law for individualized dose reconstruction of people exposed in the result of the Chernobyl accident.
Materials and methods: The material of the study were the data on internal doses estimated according to the results of the WBC-measurements of cesium content in inhabitants of the Kirov settlement, Narovlya district, Gomel region, for the period between 1990 and 1999, been contained in “Database of the WBC-measurements in Belarusian residents for the period between 1987 and 2008”, registration certificate 5870900637 from 20.05.2009.
The following methods of applied statistics have been used: analysis of variance, multivariate statistical analysis. To confirm the assumption about the stability of relative internal dose, the rank test of concordance has been used. The credibility of differences has been estimated according to the Mann–Whitney criteria in order to compare the samples, which do not submit to normal distribution shape. Statistical processing of the materials has been carried out with the use of statistical software package STATISTICA 6.0 and MICROSOFT EXCEL 2010.
Results: The conducted analysis of the internal dose distribution in residents of the Kirov settlement for a 10-year period has confirmed the hypothesis that the dose of each individual and each family has its certain place on the dose distribution curve, which is constant in time, in other words, the individuals, families and its members have the same relative doses. High values of concordance coefficient (0.889 and 0.851) confirm the assumption about a relatively stable rank of relative internal doses of the examined individuals and families.
The spring-summer season: March, April, May, June, July, and autumn-winter season: August, September, October, November, December, January, February, had been shared out according to the method of one-way ANOVA. The average internal doses for these seasons significantly differed. The stability of relative internal dose for individual residents and families had been also revealed for two seasons.
Conclusion: The established law can be used as methodological basis for individual dose reconstruction at any time period of the accident. It is of great practical importance for assessment of the individual dose included in the Belarusian State Register of people exposed in the result of the Chernobyl accident.
Key words: individual, family, internal dose distribution, stability, year seasons