JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2013. Vol. 58. No. 2. P. 30-38
RADIATION MEDICINE
N.A. Metlyaeva
Features of Social and Psychophysiological Adaptation of Three Patients Survived Acute Radiation Disease III and IV degree of Severity Complicated with Skin Radiation Injury Resulted from Chernobyl NPP Accident
Burnasyan Federal Medical Biophysical Center of the FMBA of Russia, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To evaluate the social and psychophysiological adaptation of three patients, survived acute radiation disease (ARD) 25 years ago.
Material and methods: Three patients were irradiated with gamma–beta radiation in time of Chernobyl NPP accident with estimated by cytogenetic methods total doses: 3,5 Gy, 4.3 Gy and 9.8 Gy. They were observed with using the automated program and methodical Expert complex intended for research of personal properties of the person, cognitive and intellectual features of the personality. Two of them suffered with ARD of the III degree severity and the third one suffered with ARD of IV degree. Also they had multiple skin beta radiation injuries.
Conclusion: Psychophysiological research of the 25 years follow-up study of three patients survived ARD of severe (III) and very severe (IY) degree resulted from Chernobyl nuclear accident shows that average profile of multilateral research of the third patient (ARD IV, dose 9.8 Gy) personality exceed borders of population statistical norm (<70>30) on a scale of T-points and testify to overstrain of mental adaptation. The same data were received for the second patient (ARD III, dose 4.3 Gy). Average profile of multilateral research of the personality of the patient (ARD III, dose 3.5 Gy) registered in borders of population statistical norm. That last patient had less significant skin radiation injuries.
strong>Key words: acute radiation disease, ionizing radiation, Chernobyl accident, local radiation injuries, adaptation, clinical case
Medical Radiology and Radiation Safety. 2013. Vol. 58. No. 2. P. 22-29
RADIATION SAFETY
A.K. Guskova
Creating Databases and Registers for Organization of Medical Monitoring and the Population Health Evaluation
Burnasyan Federal Medical Biophysical Center of the FMBA of Russia, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
This paper is an attempt to justify the scientific program of health care for people currently being exposed to ionizing radiation. The basic positions of such decisions being made twenty-five years ago are analyzed; they were established on the base of own experience and the literature data at that time. In the period passed there have been significant changes in the conditions of irradiation and understanding of some radiobiological positions. The basic postulate of radiobiology is still there: a quantitative dependence of the probability and implementation of radiobiological effects of spatial and temporal distribution of dose. Modification of the latter parameters occurred during the period mentioned above determined the need to change the medical decisions related to the huge number of groups of population and professionals. It is pointed out that the information accumulated in the radiological, dosimetrical, and clinical entities registers is informative and useful to assess the health of the population as a whole. Accordingly, the measures aimed to minimize the real risks and optimize the health outcomes are quite common. The great importance of socio-economic factors for the formation of the demographic characteristics of a region is underlined. There are some limitations in the selection of appropriate adequate groups of people living in the large areas for necessary comparison. For example, such an adequate control for the most affected by Chernobyl accident region (Bryansk) is the Ryazan region. A combination of adverse and favorable factors led to the absence of distortion of the demographic structure of the most affected regions of Russia.
Key words: radiation, control and the basic regions, irradiate of population, occupational irradiation, medical monitoring
Medical Radiology and Radiation Safety. 2013. Vol. 58. No. 3. P. 56-70
REVIEW
I.K. Belyaev, E.S. Zhorova, V.S. Kalistratova, P.G. Nisimov, I.M. Parfenova, G.S. Тischenko
Radio-active Caesium. Report 2: Acceleration of Elimination
Burnasyan Federal Medical Byophisical Center of the FMBA of Russia, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: To systematize literature and our own data on the accelerated elimination of radioactive cesium from the body, analysis of the problem on therapy and prophylaxis of cesium injuries.
Results: We present an analytical overview on the mechanisms of internal with radioactive cesium irradiation and corresponding protective means. A comparative analysis of decorporative preparations has been conducted.
Conclusions: The most effective mechanism for accelerated elimination of radiocaesium from the body and reducing the absorbed dose is sorption. Natural minerals, natural pectins and other foodstuff fibres are able to absorb up to 30–40 % of radioactive caesium, preventing its entering to blood circulation from the gastrointestinal tract. However their decorporative efficiency is not more than moderate. Ferrocyanide preparations, including ferrocyn, efficiency of which can reach 99 %, are leaders in the line of preparations tested as the blockers of 137Cs intake.
It is important to determine the level of radiocaesium intake at which the antidotes intervention is necessary.
The probleme of prevention of late consequences after prolong fwerrocin use remains unexplored since it is recommended for use not longer than 30 days.
Key words: Caesium, radionuclide, ionizing radiation, incorporation, dekorporation, sorbents, minerals, pectin, ferrocyanides
Medical Radiology and Radiation Safety. 2013. Vol. 58. No. 2. P. 5-21
RADIATION BIOLOGY
A.N. Koterov
From Very Low to Very Large Doses of Radiation: New Data on Ranges Definitions and Its Experimental and Epidemiological Basing
Burnasyan Federal Medical Biophysical Center of the FMBA of Russia, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
CONTENT
1. Brief historical introduction and problem actuality
2. Decrease by UNSCEAR of low dose radiation limit twice and its unification with other international organizations
3. Ambiguity of a substantiation of low dose radiation limit in 100 mGy
4. Absence of the proved molecular mechanisms and experimental confirmations of an induction of stochastic effects at doses up to 100 mGy
5. A new dose range – very low doses (up to 10 mGy)
6. Medium, high and very high (super-high) doses
7. Concepts about low dose rate
Conclusion
Key words: radiation dose ranges, low doses, very low doses, middle doses, large doses, low dose rate, definition, low LET radiation
Medical Radiology and Radiation Safety. 2013. Vol. 58. No. 3. P. 48–55
REVIEW
A.F. Tsyb1, E.V. Abakushina1,2, D.N. Abakushin2, Yu.S. Romanko1
Present and Future of Radioimmunotherapy
1. Medical Radiological Research Center, Obninsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Obninsk Institute for Nuclear Power Engineering of the NRNU MEPhI, Obninsk, Russia
Abstract
Molecular nuclear medicine plays an important role in the diagnosis and therapy of cancer and infectious diseases. Radioimmunodetection and radioimmunotherapy (RIT) involve the use of antibodies conjugated with diagnostic or therapeutic radionuclides, respectively. More often for RIT the radiolabeled monoclonal antibodies against tumor-associated antigens are used. Encouraging results have been achieved with this technology in the management of hematologic malignancies. On the contrary, solid tumors appeared to be less sensitive. Solid tumors are generally characterized by a limited vascular supply and heterogeneous uptake of the antibodies in the tumors. Radioimmunotherapy therefore is considered more suitable for the treatment of microscopic or minimal residual disease, allowing radiolabeled monoclonal antibodies to achieve uptake in tumors high enough to result in tumoricidal radiation doses. Despite these encouraging results, new treatment strategies are required for the cure of patients with cancer and no malignant diseases. More perspective new potential target for radioimmunodetection and RIT should be found. For this purpose, a series of experiments should be performed to investigate the biodistribution and the therapeutic efficacy of radiolabeled monoclonal antibodies in cell culture and animal models.
CONTENTS
Introduction
The selection of the radionuclide and conjugate
Radio immunotherapy of lymph proliferative diseases
Radio immunotherapy of solid cancers
Radio immunotherapy of metastatic cancer
Novel targets for radio immunotherapy
Conclusion
Key words: radioimmunotherapy, malignant diseases, monoclonal antibodies, tumor-associated antigens, radionuclide