SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.

The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Issues journals

Medical Radiology and Radiation Safety. 2019. Vol. 64. No. 1. P. 21–25

RADIATION MEDICINE

DOI: 10.12737/article_5c55fb247614e5.98844114

I.M. Petoyan, A.M. Lyaginskaya, A.P. Ermalitskiy, V.V. Kuptsov, N.M. Karelina, A.G. Tsoviyanov, A.S. Samoylov

The Reproductive Health of Male Staff of the Kursk Nuclear Power Plant

A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

I.M. Petoyan – Head of Lab., PhD Tech.;
A.M. Lyaginskaya – General Researcher, Dr. Sci. Biol., Prof.;
A.P. Ermalitskiy – Leading Researcher, PhD Med.;
V.V. Kuptsov – Senior Researcher;
N.M. Karelina – Research Worker;
A.G. Tsoviyanov – Head of Lab.;
A.S. Samoylov – Director General, Dr. Sci. Med., Prof. RAS

Abstract

Purpose: To assess the reproductive health of male staff in the main departments of the Kursk nuclear power plant (NPP).

Material and methods: The fertility and health of newborns were investigated. Data on marital status of 626 men of the staff and data about 813 newborns in families of male staff were analyzed. In the control group the data on the health status of newborns and pregnant groups of the population of Kurchatov city was used. Sources of information on doses to the personnel were the forms of a single system for monitoring and recording individual doses of radiation № 1-DOS “Information on the doses to persons in the conditions of normal operation of technogenic sources of ionizing radiation”.

Results: Total occupational doses to the end of the main reproductive period (20–40 years) did not exceed 210 mSv, which is significantly below the threshold for temporary sterility during long-term irradiation (400 mSv/year, ICRP). Cases of infertile marriages in the families of the men of the staff (0.17 %) are below the estimation of the frequency of male infertility in Russia (1–2 %).

Infant health in families of male staff and in the control group had no differences. The frequency of birth of health children was 65.3 % in families of male staff and 66.0 % for the control group. Frequency of birth of children with malformations was 35.7±6.5 per 1,000 live births and statistically (p = 0.84) did not differ from the frequency in the control group (37.4±5.3 per 1,000 live births) and was below the level adopted by the ICRP to calculate the radiation genetic risk (60 per 1,000 live births). There were no differences influenced by mother factors (age, diseases and complications during pregnancy) on fetal development and newborn health in families of the staff and control group.

According to the calculations, the total occupational doses to men before the conception of children for more than 98 % of cases did not exceed 100 mSv, i.e. it was below the doses (>100 mSv), for which the genetic effects were observed in the number of epidemiological studies. However, it should be noted that 25.6 % of childbirth were in families, where men were older than 30 years, i.e. at the age, which is not subject to the additional job restrictions under the planned increased exposure.

Conclusions: The impact of occupational exposure on the reproductive health status of men staff of the Kursk NPP was not identified.

Key words: Kursk NPP, male staff, reproductive health, infertility, health status, newborn children

REFERENCES

  1. Radiation safety standards (RSS-99/2009): Public health regulations. Moscow: Federal Center of Hygiene and Epidemiology of Rospotrebnadzor. 2009. 100 p. (Russian).
  2. ICRP Publication 103. Eds. Kiselev MF, Shandala NK. Moscow: PKF «Alana». 2009. 311 p. (Russian)
  3. Crow J.F. A comparison of fetal and infant death rates in progeny of radiologist. Amer J Roentgenol. 1955;73:467-71.
  4. Sever LE, Gilbert ES, Hessol NA, McIntyre JM. A case-control study of congenital malformations and occupational exposure to low-level ionizing radiation. Amer J Epidemiol. 1988;127:226-42.
  5. Parker L, Pearce MS, Dickinson HO, et al. Stillbirths among offspring of male radiation workers at Sellafield nuclear reprocessing plant. Lancet. 1999;354(9180):1407-14.
  6. Stepanova EI, Skvarskaya EA. Clinical-genetic and cytogenetic characteristics of children born to liquidator of the Chernobyl accident. Collection of research papers “Genetic consequences of emergency radiation situations”. Moscow: Publ. RUDN. 2002. P. 115-6. (Russian).
  7. Petrushkina NP. Health of children (1-2 generation) of workers of the first atomic industry Production Association “Mayak” (clinical and epidemiological study). Moscow: Dr. Sci. Med. Diss. 2003. 371 p. (Russian).
  8. Lyaginskaya AM, Tukov AR, Osipov VA, et al. Congenital malformation at posterity of the liquidators of the consequences of Chernobyl accident. Radiation biology. Radioecology. 2009;49(6):694-702. (Russian).
  9. Tsovianov AG, Kosterev VV, Kyuchkov VV, et al. Information-analytical reference book “Doses to personnel of organizations and the population in the areas served by the FMBA of Russia and the Russian Ministry of Defense in 2010”. Moscow. 2012. 86 p. (Russian).
  10. Merkov AM, Polyakov LE. Sanitary statistics (manual for physicians). Moscow. Medicine. 1974. 384 p. (Russian).
  11. Lebedev SV. Infertility: real statistic. 2009. http://www.probirka.org/ zhenskoe-besplodie/306-besplstat.html (Russian).
  12. Kerimova ZM. Intrauterine growth retardation. Principles of pregnancy. Moscow: Abstract of diss. to PhD Med. Sci. 2002. 25 p. (Russian).

For citation: Petoyan IM, Lyaginskaya AM, Ermalitskiy AP, Kuptsov VV, Karelina NM, Tsoviyanov AG, Samoylov AS. The Reproductive Health of Male Staff of the Kursk Nuclear Power Plant. Medical Radiology and Radiation Safety. 2018;63(3):21-5. (Russian).

DOI: 10.12737/article_5c55fb247614e5.98844114

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2019. Vol. 64. No. 1. P. 26–30

RADIATION MEDICINE

DOI: 10.12737/article_5c55fb303a76b7.90880128

I.A. Galstyan, A.S. Kretov, L.A. Merzlikin, I.V. Vlasova, A.Yu. Bushmanov, Yu.D. Udalov

Possible Criteria of the Diagnosis of Occupational Lung Cancer in Workers of Uranium Mines

A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

I.A. Galstyan – Head of Lab., Dr. Sci. Med.;
A.S. Kretov – Head of Dep.;
L.A. Merzlikin – Specialist in Occupational Medicine, Dr. Sci. Med., Prof.;
I.V. Vlasova – Specialist in Occupational Medicine;
A.Yu. Bushmanov – Deputy Director, Dr. Sci. Med., Prof.;
Yu.D. Udalov – Deputy Director General, PhD Med.

Abstract

Purpose: Search of possible criteria of the diagnosis of occupational lung cancer in workers of uranium mines on the basis of the analysis of literary data.

Material and methods: The analysis of literary data with the purpose of allocation of possible criteria and their use for the diagnosis of occupational lung cancer at 6 employees of uranium mines.

Results: The following criteria for the diagnosis of occupationally caused lung cancer at workers of uranium mines are marked out:

  • Total effective dose of radiation exposure is more 200–250 mSv (40–50 WLM).
  • Period in underground conditions is not less than 10 years.
  • Dust content in a workplace is more than 1 mg/m3.
  • Hygienic assessment of working conditions – the 3rd class, 3.2–3.4 degree.
  • The latent period of development of a tumor is not less 10 years.
  • Development of primary and multiple synchronous or metachronous lung cancer.

Also the diagnosis of occupational lung cancer the pulmonary anamnesis (frequent bronchitis, pneumonia, chronic bronchitis of the smoker) has to be considered.

On the basis of the marked-out criteria documents of 6 employees of uranium mines, at which lung cancer has been revealed, are considered. On the basis of the carried-out analysis at 5 patients relation of a disease with professional activity has been established. One patient was denied this relation.

Conclusion: Authors offer this expert approach to experts’ discussion as above-mentioned criteria is planned to be used by the pathologists who are carrying out observation of workers of uranium production and for the solution of questions of relation of a disease with professional activity of the patient.

Key words: uranium production, radon, lung cancer, occupational diseases, establishment criteria

REFERENCES

  1. ICRP Publication 103. Recommendations ICRP of 2007. Moscow. 2009: 312 p.
  2. Epidemiological studies of radiation and cancer. United Nations Scientific Committee on the Effects of Atomic Radiation. 54 session. Vienna. 2006: 350 p.
  3. List of occupational diseases. Annex of the Order of Ministry of Health and Social Development of Russia. April 27 2012. No. 417n. (Russian).
  4. ICRP Publication 126. Radiological Protection against Radon Exposure. Moscow. 2015: 91 p. (Russian).
  5. Lung cancer in workers of uranium mines. In «Lung cancer epidemiology». Ed. DG Zaridze, IK Pleshko, YuS Sidorenko, TV Shelyakina. Moscow. 1990: 240 p. (Russian).
  6. Gneusheva GI, Malashenko AV. Occupational pathology of lungs in workers of uranium mines. Moscow. 2007: 140 p. (Russian).
  7. Ahmed DU. Professional radiation safety at uranium mines and facilities. Bulletin IAEA. 1981;23(2):34-8.
  8. Shalaev IL, Glushinsky MV, Tokarev HM, Byzov EV. Epidemiological investigation of lung cancer mortality of uranium miners. BRM. 1986;1:80-5. (Russian).
  9. Belugina RN. Epidemiological investigation of uranium miners. BRM. 1986;1:48-52. (Russian).
  10. Malashenko AV, Nakatis YaA. Questions of professional lung pathology of uranium miners. Medicine of Extreme Situations. 2012;2:28-34. (Russian).
  11. Malashenko AV, Nakatis YaA. Ethiology and specificities of morphogenesis of lung cancer in workers of uranium miners. Clinic Hospital. 2017;19(1):17-22. (Russian).
  12. ICRP Publication 115. Risk of Lung Cancer Occurrence after Radon and it’s Decay Products Exposure. Radon statement. Moscow. 2013: 91 p. (Russian).
  13. Szymendera SD. The radiation exposure compensation act (RECA): compensation related to exposure to radiation from weapons testing and uranium mining. CRS Report. 2015: 17 p. (Russian).
  14. Ivanov AE, Kurshakova NN, Soloviev AI. Radiation lung cancer. Moscow. Medicine. 1990: 223 p. (Russian).
  15. Mahlay TN, Burenin PI. About relation of cancer of trachea, bronchial tubes, lung with nonspecific lung diseases in uranium facility workers. BRM.1983;3:35-40.
  16. Manual on hygienic assessment of working environment and labor process factors. Criteria and classification of labor conditions. 1.11.2005: 161 p.

For citation: Galstyan IA, Kretov AS, Merzlikin LA, Vlasova IV, Bushmanov AYu, Udalov YuD. Possible Criteria of the Diagnosis of Occupational Lung Cancer in Workers of Uranium Mines. Medical Radiology and Radiation Safety. 2019;64(1):26-30. (Russian).

DOI: 10.12737/article_5c55fb303a76b7.90880128

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2019. Vol. 64. No. 1. P. 38–44

DIAGNOSTIC RADIOLOGY

DOI: 10.12737/article_5c55fb466d7532.24221014

K.A. Khasanova1, I.E. Tyurin1, S.A. Ryzhov2, E.V. Kizhayev1

Radiation Dose Reduction in Pediatric Computed Tomography

1. Russian Medical Academy of Continuous Professional Education, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ;
2. Department of the Rospotrebnadzor, Moscow, Russia

K.A. Khasanova – Post-Graduate Student;
I.E. Tyurin – Head of Dep., Dr. Sci. Med., Prof.;
S.A. Ryzhov – Chief Expert;
E.V. Kizhayev – Head of Dep., Dr. Sci. Med., Prof.

Abstract

Purpose: To optimize the computed tomography protocol in pediatric Hodgkin lymphoma for radiation dose reduction by reducing the scanning phases.

Material and methods: A retrospective CT scan analysis of 48 children with newly diagnosed, verified Hodgkin’s lymphoma was performed at the primary staging and after the first chemotherapy. All studies were performed with contrast enhancement, scanning on a 16-slice computed tomography in the precontrast, arterial, venous and delayed phases. The radiation dose and the diagnostic value of each phase were assessed.

Results: Two-phase scanning (in the native and venous phases) for primary patients allows significantly reduce the cumulative effective dose (ED) almost in twofold. Conducting single-phase scanning can significantly reduce the received ED by 3.8 times in both the primary and dynamic studies. Using the abbreviated protocol does not reduce the diagnostic value of CT.

Conclusion: The greatest number of repeated CT examination is carried out in children with lymphomas. The radiation dose increases several times in multiphase scanning. New CT protocols reduces the radiation dose on children with Hodgkin lymphoma.

Key words: computed tomography, radiation dose, children, radiation safety, Hodgkin’s lymphoma, multiphase scanning

REFERENCES

  1. Berrington De Gonzalex A, Darby S. Risk of cancer from diagnostic X-rays: estimates for the UK and 14 other countries. Lancet. 2004;363:345-51. DOI: 10.1016/S0140-6736(04)15433-0.
  2. Krille L, Zeeb H, Jahnen A, et al. Computed tomographies and cancer risk in children: a literature overview of CT practices, risk estimations and an epidemiologic cohort study proposal. Radiation and Enviromental Biophysics. 2012;51:103-1. DOI: 10.1007/s00411-012-0405-1.
  3. Voss SD, Chen L, Constine LS, et al. Surveillance computed tomography imaging and detection of relapse in intermediate- and advanced-stage pediatric Hodgkin’s lymphoma: a report from the children’s oncology group. J Clin Oncol. 2012;30:2635-40. DOI: 10.1200/JCO.2011.40.7841
  4. Ansell MS, Stephen M. Hodgkin lymphoma-diagnosis and treatment. Mayo Clinic Proc. 2015;90(11):1574-83. https://doi.org/10.1016/j.mayocp.2015.07.005
  5. Thomas KE, Wang B. Age-specific effective doses for pediatric MSCT examinations at a large children’s hospital using DLP conversion coefficients: a simple estimation method. Pediatr Radiol. 2008;38:645-656. DOI: 10.1007/s00247-008-0794-0
  6. Vock P. CT radiation exposure in children: Consequences of the American discussion for Europe. Radiologe. 2002;42:697-702. DOI: 10.1007/s00117-002-0812-4
  7. Strauss KJ, Goske MJ, Kaste SC, et al. Image gently: ten steps you can take to optimize image quality and lower CT dose for pediatric patients. Amer J Roentgenol 2010;194(4):868-73. DOI: 10.2214/AJR.09.4091
  8. Chan MG, Cassidy FH, Andre MP. Imaging in routine CT examinations of the abdomen and pelvis: Is it worth the additional cost of radiation and time? Amer J Roentgenol 2014;202:329-335. DOI: 10.2214/AJR.12.10468
  9. Yoshida K, Krille L, Dreger S, et al. Pediatric computed tomography practice in Japanese university hospitals from 2008-2010: did it differ from German practice? // J Radiat Res. 2016; P. 1-7. DOI: https://doi.org/10.1093/jrr/rrw074
  10. Methodological instructive regulations 2.6.1.2944-11. Control of effective radiation doses of patients during medical X-ray studies; – Rospotrebnadzor, 2011 http://docs.cntd.ru/document/1200092857. (Russian).
  11. Decree of the Chief State Sanitary Doctor of the Russian Federation No. 40 dated April 26, 2010 (Edited on September 16, 2013) “On approval of SP 2.6.1.2612-10 Basic Sanitary Rules for Ensuring Radiation Safety (OSPORB-99/2010)”. (Russian).
  12. Yu T, Gao J, Liu ZM, et al. Contrast dose and radiation dose reduction in abdominal enhanced computerized tomography scans with single-phase dual-energy spectral computerized tomography mode for children with solid tumors. Chinese Medical Journal. 2017;130(7):823-31. DOI: 10.4103/0366-6999.202731.
  13. Sinitsyn VE, Glazkova MA, Mershina EA, Arhipova IM. Possibilities of decreasing radiation doses during MSRT coronarography: using adaptive statistic iterative reconstruction. Angiology and Vascular Surgery. 2012;18(3):44-8. (Russian).
  14. Blinov AB, Blinov NN. Radiation doses in X-ray computed tomography. Medical technology. 2010;5(263):23-5. http://mtjournal.ru/upload/iblock/7bb/7bbc77c447bf48351d3a79bbe44bdd06.pdf
  15. McCollough CH, Primak AN, Braun N, et al. Strategies for reducing radiation dose in CT. Radiologic Clinics of North America, 2009;47(1):27-40. DOI: 10.1016/j.rcl.2008.10.006
  16. Gombolevskii VA, Kotlyarov PM, Dacenko PV, Nudnov NV. Low dose CT protocol in Hodgkin’s lymphoma. RNCCR RF 2013;(13) (Russian). http://vestnik.rnc rr.ru/vestnik/v13/pape rs/gombolevskii_v13.html.

For citation: Khasanova KA, Tyurin IE, Ryzhov SA, Kizhayev EV. Radiation Dose Reduction in Pediatric Computed Tomography. Medical Radiology and Radiation Safety. 2019;64(1):38-44. (Russian).

DOI: 10.12737/article_5c55fb466d7532.24221014

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2019. Vol. 64. No. 1. P. 31–37

DIAGNOSTIC RADIOLOGY

DOI: 10.12737/article_5c55fc2cb98140.01495008

N.S. Vorotyntseva, V.V. Orlova

Radiation Examination of Newborns with General Therapeutic Hypothermia

Kursk State Medical University, Kursk Regional Perinatal Center, Kursk, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

N.S. Vorotyntseva – Head of Dep., Dr. Sci. Med., Prof.;
V.V. Orlova – Junior Researcher

Abstract

Purpose: Revealing the features of the parenchymal organs of newborns subjected to general non-invasive therapeutic hypothermia (GNTН) and the development of radiation monitoring for such patients.

Material and methods: Under our supervision were 69 children with a severe degree of perinatal asphyxia, born from January 2014 to April 2018 in the Kursk Regional Perinatal Center. In the first hours of life, 50 patients were initiated GNTH, expressed in a decrease in body temperature to 34 °C in the rectum. Hypothermia was not performed 19 newborns for objective reasons. All children underwent radiation examination, including ultrasound of the brain, heart and internal organs, chest x-ray.

Results and discussion: The study revealed a high neuroprotective effect (assessed by ultrasound) of general non-invasive therapeutic hypothermia, depending on the Apgar score at the 5th minute of life: 66.7 % of children had a normal ultrasound pattern of the brain with the 21st day ≥4 points and received GNTH, 50 % of children ≤ 3 points after therapeutic hypothermia and 36.8 % of newborns without GNTH (p ≤ 0.001). The complex 5-step radiation monitoring, which included chest x-ray, ultrasound of the brain, heart and internal organs (liver, pancreas, spleen, kidneys, adrenals), revealed the features of neonatal period in children in the background GNTH: increased risk of development of parenchymal hemorrhages on the 3rd day and postnatal pneumonia on the 7th day of life.

Conclusion: A complex stage radiological examination of newborns in need of GNTH is the key to timely effective diagnosis, prevention and treatment of severe pathological conditions of the neonatal period.

Key words: newborns, asphyxia of severe degree, general therapeutic hypothermia, radiation monitoring

REFERENCES

1. Medico-Demographic Indicators of the Russian Federation in 2014. Moscow. 2015. 186 p. (Russian).

2. Baranov AA, Ilyin AG, Konova SR, Antonova EV. Ways to improve the quality and accessibility of medical care for children in primary care. Questions of Modern Pediatrics. 2009;4(8):5-8. (Russian).

3. Jacobs SE, Morley CJ, Inder TE, et al. Infant Cooling Evaluation Collaboration. Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial. Arch Pediatr Adolesc Med. 2011;165(8):692-700.

4. TOBY Protocol and Handbook. 2009. Available at: https: www.npeu.ox.ac.uk./tobyregister/docs. (accessed 25 October 2015).

5. Robertson NJ, Nakakeeto M, Hagmann С, et al. Therapeutic hypothermia for birth asphyxia in low-resource settings: a pilot randomised controlled trial. Lancet. 2008;372(9641):801-3.

6. Shah P, Riphagen S, Beyene J, Perlman M. Multiorgan dys­func­tion in infants with post-asphyxial hypoxic-ishaemic ence­phalopathy. Arch Dis Child Fetal Neonatal Ed. 2004;89:152-5.

7. Ionov OV. The protocol of medical hypothermia of children born in asphyxia. Neonatology. 2014;2:43-5. (Russian).

8. Edwards AD, Brocklehurst P, Gunn AJ, et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischemic encephalopathy: synthesis and meta-analysis of trial data. BMJ. 2010;9:340-63.

9. Grigoryev EV, Shukevich DL, Plotnikov GP, Tikhonov NS. Therapeutic hypothermia: possibilities and prospects. Clinical Medicine. 2014;9:9-16. (Russian).

For citation: Vorotyntseva NS, Orlova VV. Radiation Examination of Newborns with General Therapeutic Hypothermia. Medical Radiology and Radiation Safety. 2019;64(1):31-7. (Russian).

DOI: 10.12737/article_5c55fc2cb98140.01495008

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2019. Vol. 64. No. 1. P. 45–52

RADIATION THERAPY

DOI: 10.12737/article_5c55fb4a074ee1.27347494

Е.S. Sukhikh1,2, L.G. Sukhikh2, О.Yu. Anikeeva3, P.V. Izhevsky4, I.N. Sheino4

Dosimetric Evaluation for Various Methods of Combined Radiotherapy of Cervical Cancer

1. Tomsk Regional Oncology Center, Tomsk, Russian Federation. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ;
2. National Research Tomsk Polytechnic University, Tomsk, Russia;
3. Medical and Rehabilitation Center, Moscow, Russia;
4. A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia

Е.S. Sukhikh – Head of Dep., PhD Phys-Math.;
L.G. Sukhikh – Director, PhD Phys.-Math.;
О.U. Anikeeva – Head of Dep., Dr. Sci. Med.;
P.V. Izhevsky – Leading Researcher, PhD Med., Assistant Prof.;
I.N. Sheino – Head of the Lab., PhD Phys.-Math.

Abstract

Purpose: Carrying out dosimetric investigation of possibility to replace a traditional combined radiation therapy of cervical cancer by combinations only external irradiation, without change of total course dose and number of fractions.

Material and methods: Eleven patients with a diagnosis of cervical cancer (stages T2bNхM0 and T3NхM0) who received a course of combined radiotherapy (CRT) have been considered in this study. The combination of dose delivery techniques 3D-CRT + high dose rate brachytherapy (HDR) was used as a basic one. The following fractionation regimes for CRT were simulated: external beam RT (EBRT) of the first stage – total dose 50 Gy and fraction dose 2 Gy (25 fractions), the second stage – total dose 28 Gy and fraction dose 7 Gy (4 fractions). Total CRT course dose was 89.7 Gy EQD2. Dosimetric planning of EBRT using conventional radiography and 3D-CRT has been carried out using XIO dosimetry planning system. Dosimetric planning of first-stage EBRT and second-stage EBRT using the VMAT technique has been performed in the Monaco dosimetry planning system. HDR of the second stage has been planned using the HDRplus dosimetric planning system for the Multisource HDR unit with a 60Co source.

Results: Coverage of the clinical volume of the tumor using HDR, on average, was equal to 95 % of the prescribed dose at 91.8 % of the volume, 110 % of the dose – 75.7 % of the volume. 60Co + VMAT results in the coverage level 95 % of the dose at 97.1 % of the volume and 110 % of the dose at 2.1 % of the volume. 3D-CRT + VMAT provide the coverage level of 95 % of the dose at 98 % of the volume and 110 % of the dose at 2.6 % of the volume. Using the combination VMAT + VMAT allows achieving the average coverage of the target at the level of 98 % of the dose at 97 % of the volume, 110 % of the dose at 8.8 % of the volume. The maximum dose per volume of the organs at risk equal to 2 cm3 did not exceed their tolerant levels both for the bladder and for the rectum.

Conclusion: At present, there is a technical possibility to replace the second stage of CRT cervical cancer by EBRT using the VMAT technique. Implementation of the VMAT technique allows to increase the uniformity of irradiated volume coverage comparing with traditional HDR. While using VMAT technique the tolerant levels of organs at risk are not exceeded.

Key words: combined radiotherapy, brachytherapy, external beam radiation therapy, cervical cancer, dosimetric evaluation

REFERENCES

  1. Kravchenko GR, Zharov AV, Vazhenin AV, et al. Results of multicomponent treatment of patients with locally advanced forms of cervical cancer. Siberian Oncological Journal. 2009;33(3):20-3. (Russian).
  2. Kravets OA, Andreeva YuV, Kozlov OV, Nechushkin MI. Clinical and radiobiological planning of brachytherapy of locally advanced cervical cancer. Medical Physics. 2009;33(2):10-7. (Russian).
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For citation: Sukhikh ЕS, Sukhikh LG, Anikeeva ОYu, Izhevsky PV, Sheino IN. Dosimetric Evaluation for Various Methods of Combined Radiotherapy of Cervical Cancer. Medical Radiology and Radiation Safety. 2019;64(1):45-52. (Russian).

DOI: 10.12737/article_5c55fb4a074ee1.27347494

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  1. 2019-1-53-57_Belousov_eng
  2. 2019-1-58-66_Matkevich_eng
  3. 2019-1-67-68_Mokrov_eng
  4. 2019-1-69-73_Krylov_eng

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