JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 5
DOI:10.33266/1024-6177-2023-68-5-50-59
Z.F. Zvereva1, F.S. Torubarov1, N.P. Vanchakova2, S.N. Lukyanova1,
E.V. Miroshnik1, E.A. Denisova1
Comparative Characteristics of Eeg Frequency Bands
and Cerebral Energy Exchange at a Low Level of Psychophysiological Adaptation in Employees of Nuclear Hazardous Enterprises and Productions
1 A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
2 First St. Petersburg State Medical University. I.P. Pavlova, St. Petersburg, Russia
Contact person: Z.F. Zvereva, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Comparative assessment of the functional state and energy processes of the brain in workers of nuclear hazardous enterprises and industries with high and low levels of psychophysiological adaptation (PPA). The parameters of the spectral power of the EEG frequency ranges and cerebral energy exchange at low and high levels of PPA, low and high functional activity (FA) of conditionally isolated structural and functional formations (SFF) characterizing: mental level of functioning − SFF-1, psychophysiological level − SFF-2, physiological − SFF-3 were compared.
Material and methods: 311 archived EEG – 159 individuals with a low level of PPA (50.8±4.6; 13 women); 152 EEG individuals with a high level of PPA (48.8±1.5; 12 women). The power of the frequency ranges of the EEG was evaluated by computer analysis using the fast Fourier transform algorithm; cerebral energy exchange using the value of the hemispheric differences in the power of biopotentials of EEG homologous leads.
Results: At a low level of PPA, higher activity of cortical structures and higher cerebral energy exchange were revealed. In the SFF the changes manifested themselves in different ways. Increased activity of cortical structures was noted in SFF-1 and SFF-3 (in all areas of the cortex, including temporal, associated with the limbic-reticular complex). In SFF-2, the activity of cortical structures weakened both in the anterior and posterior parts of the cortex, the activity of the temporal zones did not change. Increased cerebral energy exchange was noted in SFF-1 and SFF-2. It was detected in the anterior parts of the cortex, and was not detected in the posterior. In SFF-3, the cerebral energy exchange did not change – neither in the anterior nor posterior parts of the cortex.
Conclusion: Various SFF of the brain take part in ensuring brain activity at a low level of PPA, which is reflected in the characteristics of EEG frequency spectra and indicators of cerebral energy exchange of the brain regions concerned. The processes associated with the participation of structural and functional education reflecting the mental level of functioning (SFF-1) are characterized at a low level of PPA by increased activity of the anterior cortex, which is accompanied by increased cerebral energy exchange. The deepening of research in this direction may contribute to the identification of additional compensatory mechanisms of the brain aimed at ensuring the functional activity required for the exercise of professional activity by persons with a low level of PPA.
Keywords: staff, nuclear hazardous enterpreises, psychophysiological adaptation, central nervous system, EEG, bioelectrical activity, cerebral energy supply
For citation: Zvereva ZF, Torubarov FS, Vanchakova NP, Lukyanova SN, Miroshnik EV, Denisova EA. Comparative Characteristics of Eeg Frequency Bands and Cerebral Energy Exchange at a Low Level of Psychophysiological Adaptation in Employees of Nuclear Hazardous Enterprises and Productions. Medical Radiology and Radiation Safety. 2023;68(5):50–59. (In Russian). DOI:10.33266/1024-6177-2023-68-5-50-59
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.04.2023. Accepted for publication: 27.05.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 5
DOI:10.33266/1024-6177-2023-68-5-60-64
E.A. Kodintseva1, 2, A.А. Akleyev3
Individualized Approach to the Formation of High Cancer Risk Groups Based on the Assessment of Immunological Indicators
in Chronically Exposed People
1 Urals Research Center for Radiation Medicine, Chelyabinsk, Russia
2 Chelyabinsk State University, Chelyabinsk, Russia
3 Southern-Urals State Medical University, Chelyabinsk, Russia
CONTENTS
Introduction
1. Main risk factors of radiation-induced carcinogenesis
2. Stages of an individualized approach to the formation of high-risk groups for cancer
3. Comprehensive medical examination of a patient
4. Determination of risk of radiation-induced carcinogenesis
5. Measures for prevention and (or) early diagnosis of radiation-induced malignant neoplasms
6. Monitoring of immunity indicators in persons at high risk of radiation-induced carcinogenesis
Conclusion
Keywords: chronic radiation exposure, the Techa river, parameters of immunity, high-risk groups for cancer
For citation: Kodintseva EA, Akleyev AА.Individualized Approach to the Formation of High Cancer Risk Groups Based on the Assessment of Immunological Indicators in Chronically Exposed People. Medical Radiology and Radiation Safety. 2023;68(5):60–64.
(In Russian). DOI:10.33266/1024-6177-2023-68-5-60-64
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PDF (RUS) Full-text article (in Russian)
Acknowledgments. The authors would like to thank N. V. Startsev, Head of the Department of the Database “Man”.
Conflict of interest. The authors declare no conflict of interest.
Financing. This study was carried out within the framework of the state assignment of the FMBA of Russia: “The state of human cellular immunity in the period of the development of late effects of chronic radiation exposure”.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.04.2023. Accepted for publication: 27.05.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 5
DOI:10.33266/1024-6177-2023-68-5-71-76
V.V. Velikaya, Zh.A. Startseva, V.E. Goldberg, N.O. Popova
Ten-Year Results of Complex Treatment of Patients
with Primary Local Advanced Breast Cancer
Cancer Research Institute, Tomsk National Research Medical Center, Tomsk, Russia
Contact person: V.V. Velikaya, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: To present ten-year results of complex treatment of patients with primary locally advanced breast cancer, depending on the type of ionizing radiation used and chemotherapy regimens.
Material and methods: The study included 250 patients with stage T2‒4N0‒3M0 breast cancer, aged 34–69 years (mean age 48.1±5.6 years), who underwent complex treatment (courses of NChT and AChT, hormonal and targeted therapy (according to indications), radical mastectomy and radiation therapy with various types of ionizing radiation) at the Research Institute of Oncology from 2007 to 2020. The mean follow-up period was 10±2.7 years. Main group (n=110) ‒ neutron therapy, comparison group I (n=80) ‒ photon therapy, comparison group II
(n=60) ‒ electron therapy.
Results: Ten-year relapse-free survival of patients with locally advanced breast cancer
(PL BC) after adjuvant neutron therapy on the area of the anterior chest wall was 92.5±3.5 %, after photon therapy ‒ 70.9±5.6 %, after electron therapy ‒ 73.6±7.1 %. There were statistically significant differences between the main group and comparison groups (p<0.05). Overall survival over a ten-year follow-up period in the main group was 87.5±3.8%, in comparison group I ‒ 73.6±8.6 %, in comparison group II ‒ 38.8±10.0 %. Between neutron and electron therapy – p<0.05. In the group with neutron therapy and chemotherapy according to doxorubicin + taxane regimens, ten-year metastatic-free and overall survival was 72.8±10.0 % and 96.7±3.3 %, respectively, compared with neutron therapy and chemotherapy according to FAC/CAF regimens ‒ 44.0±14.7 % and 83.7±6.7 %, respectively (p<0.05). Neutron therapy was well tolerated by all breast cancer patients. Radiation reactions of the skin predominantly I‒II degree. Radiation pneumonitis after neutron therapy ‒ in 6 (5.4 %) out of 110 patients, after photon therapy ‒ in 17 (21.25 %) out of 80 patients with PL BC (p=0.023).
Conclusion: Thus, the use of adjuvant neutron therapy in patients with breast cancer T2‒4N0‒3M0 is a safe method and has significantly better results in ten-year relapse-free survival, which makes it possible to increase the effectiveness of complex treatment. In combination with doxorubicin + taxane chemotherapy regimens, neutron therapy increases the 10-year metastatic-free and overall survival rates.
Keywords: breast cancer, radiation therapy, neutron therapy, electron therapy, chemotherapy, local recurrence, radiation reactions, survival
For citation: Velikaya VV, Startseva ZhA, Goldberg VE, Popova NO. Ten-Year Results of Complex Treatment of Patients with Primary Local Advanced Breast Cancer. Medical Radiology and Radiation Safety. 2023;68(5):71–76. (In Russian). DOI:10.33266/1024-6177-2023-68-5-71-76
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.04.2023. Accepted for publication: 27.05.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 5
DOI:10.33266/1024-6177-2023-68-5-65-70
A.R. Tukov, I.L. Shafransky, O.N. Prohorova, A.M. Mikhaylenko, M.N. Ziyatdinov
Risk of Thyroid Diseases Associated with Iodine Deficiency
of Liquidators of the Consequences of the Accident
at the Chernobyl NPP ‒ Employees of Nuclear Industry Enterprises
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: A.R. Tukov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Assessment of thyroid disease risk associated with iodine deficiency, liquidators of the Chernobyl accident consequences, employees of nuclear industry enterprises depending on the doses of different types of exposure.
Material and methods: The dose-risk assessment study included 12663 men, 1327 of whom had occupational exposure data. A Poisson’s process with intensity parameter was chosen as a statistical model of morbidity risk. The statistical package of epidemiological data analysis EPICURE was used for the estimation of excess relative risk (ERR) of thyroid diseases related to iodine deficiency. There was conducted a cohort epidemiological study of a group of liquidators who worked in the 30-km zone in 1986‒1990 over a period of more than thirty years depending on the dose received both during liquidation of the Chernobyl accident consequences and during professional work with radioactive substances (RS) and ionizing radiation sources (IRS).
Results: As a result of the study direct estimates of radiogenic risk of thyroid diseases associated with iodine deficiency in the liquidators of the Chernobyl accident consequences were obtained for the first time using the data on doses of Chernobyl and the sum of these doses with the doses of occupational exposure. It is shown that the risk of disease per unit dose (ERR/Zv) for dose loads received both at liquidation of Chernobyl accident consequences and for total doses give different results.
Conclusion: Assessment of the risk of thyroid diseases associated with iodine deficiency, liquidators of the Chernobyl NPP accident consequences and workers of nuclear industry enterprises, serviced by FMBA health care institutions of Russia using the doses of different types of exposure gives different results.
Correct results of assessing the risk of radiation-related diseases can only be given by the register using the total radiation dose (occupational, accidental, medical, natural), as required by the directive documents.
Keywords: radiation, excessive relative risk, thyroid diseases, iodine deficiency, nuclear industry enterprises, industry registry, Chernobyl accident, EPICURE
For citation: Tukov AR, Shafransky IL, Prohorova ON, Mikhaylenko AM, Ziyatdinov MN. Risk of Thyroid Diseases Associated with Iodine Deficiency of Liquidators of the Consequences of the Accident at the Chernobyl NPP ‒ Employees of Nuclear Industry Enterprises. Medical Radiology and Radiation Safety. 2023;68(5):65–70. (In Russian). DOI:10.33266/1024-6177-2023-68-5-65-70
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.04.2023. Accepted for publication: 27.05.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 5
DOI:10.33266/1024-6177-2023-68-5-77-81
D.A. Plaskeeva1, A.I. Konovalov2, Zh.A. Startseva2, S.G. Afanasyev2
Thermoradiochemotherapy in the Combined Treatment of Rectal Cancer
1 Tomsk Regional Oncology Center, Tomsk, Russia
2 Tomsk National Research Medical Center, Tomsk, Russia
Contact person: D.A. Plaskeeva, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Currently, the treatment of rectal cancer requires a multidisciplinary approach. So the combined method of treatment, including chemoradiotherapy and the surgical stage, has proven itself reliably. However, the desired results that significantly increase the rates of relapse-free and metastatic survival have not yet been achieved. The use of radio modifiers makes it possible to enhance radiation exposure without increasing the total focal dose. One of the universal radio modifiers is local hyperthermia.
Purpose: To develop a method of thermoradiochemotherapy in the combined treatment of distal rectal cancer and evaluate its effectiveness.
Material and methods: This work is based on the analysis of the results of treatment of 141 patients with morphologically confirmed locally advanced distal rectal cancer. In accordance with the objectives of the study, all patients were divided into 2 groups. In the combined treatment of 75 patients, the first stage was performed chemoradiotherapy (CLT) in combination with local hyperthermia (LH). Local hyperthermia was not used in the treatment of 66 patients.
Results: Long-term results of complex treatment of patients with an independent course of chemoradiotherapy/thermochemoradiotherapy (dynamic observation group) and after surgical treatment are presented. One – year relapse-free survival in the group with an independent course of TRHT was 96.7 %, in the CLT group – 79.3 % (p=0.024). There was a significant increase in three–year relapse-free survival – 93.3 % versus 76.7 % in the control (p=0.041). Among patients who underwent surgical treatment at the second stage, the study of one-year relapse-free survival did not reveal statistical significance. Three – year relapse-free survival in patients with TRHT compared with the CLT group was 96.2 % versus 86.0 % (p=0.038). The effectiveness of thermoradiochemotherapy in patients of this category was evaluated. The tolerability of treatment in all patients is satisfactory. Among all radiation reactions, the most frequently observed phenomena of radiation epidermitis I–II art. in the projection of irradiation fields (Table 1). Acute radiation reactions were reversible and did not have a negative effect on the subsequent stages of treatment. Treatment for all patients (n=141) was implemented in full.
Keywords: rectal cancer, combined treatment, surgery, local hyperthermia, radiation therapy, chemotherapy
For citation: Plaskeeva DA, Konovalov AI, Startseva ZhA, Afanasyev SG. Thermoradiochemotherapy in the Combined Treatment of Rectal Cancer. Medical Radiology and Radiation Safety. 2023;68(5):77–81. (In Russian). DOI:10.33266/1024-6177-2023-68-5-77-81
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Startseva Zh.A.: scientific management of the research, correction of the content of the article, approval of the final version of the article; Afanasyev S.G.: scientific management of the research, correction of the content of the article, approval of the final version of the article; Plaskeeva D.A.: analysis and interpretation of the results of the work, writing the text, collecting clinical material; Konovalov A.I.: development of the concept and design of the study, correction of the content of the article.
Article received: 20.04.2023. Accepted for publication: 27.05.2023.