JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 6
DOI:10.33266/1024-6177-2023-68-6-27-41
I.G. Shatskiy1, P.S. Druzhinina1, Yu.N. Kapyrina2, M.V. Osipov3
Effective Doses of Children During X-Ray Diagnostic Examinations: A Literary Review
1 P.V. Ramzaev Saint-Petersburg Research Institute of Radiation Hygiene, Saint-Petersburg, Russia
2 St. Petersburg State Pediatric Medical University, Saint-Petersburg, Russia
3 Southern Urals Biophysics Institute, Ozersk, Russia
Contact person: Polina Sergeevna Druzhinina, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Contents:
Radiation diagnostics methods are widely used not only for the diagnosis of adult patients, but also in pediatrics. Children are the most radiosensitive group of the population, with a higher risk of developing long-term effects of ionizing radiation than adults. Therefore, control of exposure levels of pediatric patients is a priority. Nowadays, many publications have been devoted to the issues of radiation safety of children in foreign countries. There is no reliable information of diagnostic exposure levels of children in the Russian Federation. In domestic publications, these issues are considered insufficiently. Foreign and domestic publications of children exposure levels during X-ray, interventional and computed tomography examinations (CT-examinations) were analyzed. First of all, publications containing a quantitative characteristic of exposure levels in terms of effective dose (ED) were considered. Effective doses presented in the publications were recalculated in accordance with the division of age groups adopted in the Russian Federation for the convenience of comparing the values with each other: 0‒0.5; 0.5‒3; 3‒8; 8‒13; 13–18 years old. This study presents the average of weighted effective doses for children of all age groups for different types of radiography, interventional and CT-examinations. According to publications the average weighted effective doses of children on average for all types of X-ray diagnostics are lower in the Russian Federation than in foreign countries. To ensure the radiation protection of children in the Russian Federation during radiography, interventional and CT-examinations, it is necessary to increase the reliability of information of children exposure levels, by improving the systems for collecting data, monitoring and accounting of individual patient doses, and raising the level of awareness of specialists.
Keywords: children, effective doses, X-ray diagnostic examinations, radiography, CT, interventional radiology
For citation: Shatskiy IG, Druzhinina PS, Kapyrina YuN, Osipov MV.Effective Doses of Children During X-Ray Diagnostic Examinations: A Literary Review. Medical Radiology and Radiation Safety. 2023;68(6):27–41. (In Russian). DOI:10.33266/1024-6177-2023-68-6-27-41
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2023. Accepted for publication: 27.08.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 6
DOI:10.33266/1024-6177-2023-68-6-42-48
L.A. Ilyin , O.A. Kochetkov, A.V. Barabanova, V.G. Barchukov
Health Effects of Onboard Radiation Accidents in the Soviet Nuclear Submarines
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: V.G. Barchukov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: To analyze the health effects of onboard radiation accidents in the Soviet nuclear submarines.
Results: Over the entire operation period of Soviet nuclear submarines, eight severe accidents occurred related to nuclear power installations. These accidents occurred in a confined space and the associated radiation situation is more complex than in other conditions; therefore, health effects of such accidents are more significant. There were two types of onboard accidents: thermal accidents (five cases) associated with a failure during heat removal from the reactor core; and accidents (three cases) caused by a partial chain reaction. The first type of accidents occurred during the route operation of nuclear submarine, and the second one – during repair work. Thermal accidents were associated with varying degrees of depressurization of the primary circuit of the reactor, which increased the gamma and beta background due to the entry into the compartment of a large amount of radioactive noble gases (hereinafter – RBGs) and radioactive aerosols. It has been shown that in the confined space of nuclear submarines, RBG isotopes (mainly 85Кr, 133Хе, 135Хе) make a significant contribution to the individual dose and the skin is a critical organ.
Conclusion: An analysis of the health effects of thermal onboard accidents showed that radiation injuries were caused by external gamma- and beta-exposure, as well as the ingestion of radioactive aerosols. If accidents are accompanied by prolonged minor leaks leading to entry of RBG into the compartment, the main contribution is made by beta-exposure and the skin is a critical organ. If there is a simultaneous inflow of coolant into the compartment, combined radiation injuries are formed and, in this case, skin lesions aggravate the acute radiation sickness. In accidents induced by a partial chain reaction, the main radiation factor is external γ-n-exposure during an outbreak of a partial chain reaction, and in the case of a thermal explosion, a traumatic factor also affects a person, leading to injuries of varying severity in the victims.
Keywords: radiation accidents, submarines, nuclear power plants, radiation damage, skin, damage in a limited volume
For citation: Ilyin LA, Kochetkov OA, Barabanova AV, Barchukov VG. Health Effects of Onboard Radiation Accidents in the Soviet Nuclear Submarines. Medical Radiology and Radiation Safety. 2023;68(6):42–48. (In Russian). DOI:10.33266/1024-6177-2023-68-6-42-48
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2023. Accepted for publication: 27.08.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 6
DOI:10.33266/1024-6177-2023-68-6-55-59
E.A. Kodintseva1, 2, A.А. Akleyev3
Effect of Radiation and Non-Radiation Factors on the ТBX21 Concentration in lysates of the Mitogen-Stimulated Mononuclear Cells
1 Urals Research Center for Radiation Medicine, Chelyabinsk, Russia
2 Chelyabinsk State University, Chelyabinsk, Russia
3 South-Ural State Medical University, Chelyabinsk, Russia
Contact person: Екатерина Александровна Кодинцева, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To evaluate the effect of radiation and non-radiation factors on the intracellular concentration of the ТBX21 transcription factor in peripheral blood PHA-stimulated mononuclear cells of chronically exposed residents of the Techa Riverside settlements in the long-term period after the start of exposure.
Material and methods: The main group consisted of 30 people aged 67–80 years with the mean dose to the red bone marrow 867±136 mGy, to thymus and peripheral lymphoid organs 125±20 mGy. The comparison group included 10 unexposed people aged 63–82 years. The main and the comparison groups had similar sex and ethnic composition. Peripheral blood mononuclear cells were PHA-stimulated for 24 hours. Cellular lysates were normalized by total protein concentration prior to being used for ELISA test.
Results: After 24 hours of incubation the median and interquartile range of the intracellular TBX21 concentration in mononuclear cells was 34.2 (6.6–86.0) pg/ml after the mitogen stimulation, and 0 (0–24.9) pg/ml – without mitogen stimulation (р=0.001). In the comparison group these values made up 24.8 (0.2–47.6) and 13.0 (0–19.2) pg/ml, respectively
Conclusion: The intracellular TBX21 concentration after 24-hour mitogen stimulation did not differ statistically significantly in chronically exposed and unexposed people, as well as in people from different dose groups. Statistically significant increase in TBX21 concentration in the lysates of mononuclear cells that were PHA-stimulated for 24 hours relative to non-mitogen stimulated cells was noted in chronically exposed people with medium and high doses to the red bone marrow. No correlation was revealed between the TBX21 concentration and dose characteristics, sex, and ethnicity of the studied individuals. The results are preliminary.
Keywords: chronic radiation exposure, residents, the Techa River, peripheral blood, ТBX21 transcription factor, lysates of mononuclear cells, Phytohemagglutinin
For citation: Kodintseva ЕА, Akleyev АА. Effect of Radiation and Non-Radiation Factors on the ТBX21 Concentration in lysates of the Mitogen-Stimulated Mononuclear Cells. Medical Radiology and Radiation Safety. 2023;68(6):55–59. (In Russian). DOI:10.33266/1024-6177-2023-68-6-55-59
References
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. This study was carried out within the framework of the state assignment of the FMBA of Russia: “The state of human cellular immunity in the period of the development of the late effects of chronic radiation exposure”.
Contribution. All authors confirm that their authorship meets the international ICMJE criteria. Kodintseva Е.А. — participated in the development of the concept and design of the study, research, data analysis and interpretation, preparation of the article; read and approved the final version before publication. Akleуev А.А. — participated in the development of the concept and design of the study, interpretation of results, scientific editing; read and approved the final version before publication
Article received: 20.07.2023. Accepted for publication: 27.08.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 6
DOI:10.33266/1024-6177-2023-68-6-49-54
A.I. Kotikova, E.A. Blinova, A.V. Akleyev
Analysis of Vβ-Segment Diversity of T-Cell Receptor in Residents
of the Techa Riverside Villages Chronically Exposed to Radiation in the Long-Term Period
Urals Research Center for Radiation Medicine, Chelyabinsk, Russia
Chelyabinsk State University, Chelyabinsk, Russia
Contact person: Alisa Igorevna Kotikova, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: Study the repertoire of the T-cell receptor in persons chronically exposed to radiation in the long-term period.
Material and methods: The study involved 48 people, who were divided into two groups: a group of exposed persons –
31 individuals with the average accumulated dose to red bone marrow (RBM) of 981±130 mGy, and a comparison group –
17 individuals, the average accumulated dose to RBM was 25.3±5.91 mGy. The study groups did not differ significantly in age, gender and ethnicity. The repertoire of Vβ-segments of the T-cell receptor of the peripheral blood T-lymphocytes of exposed persons was analyzed by flow cytometry method. 24 Vβ-segments of the T-cell receptor were studied. Statistical processing of the obtained data was carried out using the Wilcoxon signed-rank test, and a direct description of Vβ-segment repertoire of the T-cell receptor was performed using the Lorenz curve and the Gini-TCR index.
Results: The study revealed a statistically significant increase in the number of Vβ3 and Vβ5.2 T-cell receptor segments in exposed individuals relative to the comparison group (p=0.03 and p=0.003, respectively). It was also shown that the distribution of the Vβ-segments of the T-cell receptor is uneven in both study groups. However, there was no significant difference between the repertoires of the T-cell receptor of the studied groups by the Gini-TCR index (p=0.14).
Keywords: chronic radiation exposure, residents, the Techa river, peripheral blood, T-cell receptor, immunity
For citation: Kotikova AI, Blinova EA, Akleyev AV. Analysis of Vβ-Segment Diversity of T-Cell Receptor in Residents of the Techa Riverside Villages Chronically Exposed to Radiation in the Long-Term Period. Medical Radiology and Radiation Safety. 2023;68(6):49–54. (In Russian). DOI:10.33266/1024-6177-2023-68-6-49-54
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing.The work was carried out as part of the: “Study on the effect of chronic radiation exposure on the state of the human T-cell immune system”.
Contribution. Kotikova A.I. – methodology development, laboratory research, statistical processing, article authoring; Blinova E.A. – methodology development, article authoring; Akleyev A.V. – development of the research concept, scientific supervision, article authoring.
Article received: 20.07.2023. Accepted for publication: 27.08.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 6
DOI:10.33266/1024-6177-2023-68-6-60-66
A.R. Tukov, I.L. Shafransky, O.N. Prokhorova, A.M. Mikhailenko, M.N. Ziyatdinov
Diabetes Mellitus Incidence and the Risk of its Occurrence in Liquidators of the Chnpp Accident Consequences including Nuclear Industry Workers
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: A.R. Tukov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Summary: Investigation purposes Diabetes mellitus (DM) occupies the largest share in the structure of endocrine system diseases, nutritional disorders and metabolic disorders, which is currently one of the important priorities of national health systems. Research on certain groups of the population with their own harmful occupational risk factors is relevant. Analysis of the incidence of diabetes mellitus of the second type - T2DM (ICD 10: E11-E11.9) of liquidators of the consequences of the Chernobyl accident ‒ workers of nuclear industry enterprises for 30 years of observation and assessment of the radiation risk of its occurrence.
Material and methods: The study includes data from the Industry register of persons exposed to radiation as a result of the Chernobyl accident over a thirty-year period, having a verified dose of external radiation received during work in the 30 km zone of the Chernobyl nuclear power plant, men – 12663 people, 1327, of whom have data on the dose of occupational irradiation. The Poisson process with an intensity parameter was chosen as a statistical model of morbidity.
Results: The incidence of T2DM in liquidators of the consequences of the Chernobyl accident was estimated by age and sex groups. On the basis of the obtained file of individual unstratified data, an analytical likelihood function for the Poisson process was constructed and the value of the excess relative risk (ERR) of T2DM incidence was calculated and the nature of the dose dependence of RR was investigated.
A cohort epidemiological study of a group of liquidators in 1986–1990 was carried out. over a thirty-year period, depending on the dose, both received during the liquidation of the consequences of the Chernobyl accident, and during professional work with radioactive substances (RS) and sources of ionizing radiation (IRS). Direct estimates of the radiogenic risk of diabetes mellitus are given. Different values of risk were noted when using doses from different types of radiation. There was no significant increase in the risk of disease per dose unit (ERR / Sv).
Conclusion: With the aging of the cohort of liquidators, an increase in the incidence of T2DM was noted in both men and women. The results obtained on the assessment of the radiation risk of T2DM at this stage are taken as preliminary, since the use of radiation risk in the development of radiation safety regulations requires a total dose from all types of exposure (professional, emergency, medical, natural).
Keywords: diabetes, incidence, radiation, relative risk, overweight, Chernobyl accident, employees of the nuclear industry, sectoral register
For citation: Tukov AR, Shafransky IL, Prokhorova ON, Mikhailenko AM, Ziyatdinov MN. Diabetes Mellitus Incidence and the Risk of its Occurrence in Liquidators of the Chnpp Accident Consequences including Nuclear Industry Workers. Medical Radiology and Radiation Safety. 2023;68(6):60–66. (In Russian). DOI:10.33266/1024-6177-2023-68-6-60-66
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Conflict of interest. The authors declare no conflict of interest.
Financing. The work was carried out as part of the implementation of the State Order.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2023. Accepted for publication: 27.08.2023.