JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 1
DOI:10.33266/1024-6177-2024-69-1-20-27
V.A. Anikina 1, S.S. Sorokina 1, A.E. Shemyakov 1,2, E.A. Zamyatina 1,
N.R. Popova 1
Comparative Assessment of the Effect of Local Proton Radiation
with a Dose of 30 Gy in BALB/c and C57BL/6 Mice
1 Institute of Theoretical and Experimental Biophysics, Moscow Region, Pushchino, Russia
2 Branch “Physio-Technical Center” of the P.N. Lebedev Physical Institute, Moscow Region, Protvino, Russia
Contact person: N.R. Popova, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To evaluate the effect of local proton irradiation at a dose of 30 Gy on Balb/c and C57BL/6 mice in terms of the degree and dynamics of radiation-induced skin damage formation, changes in body weight and peripheral blood elements count.
Material and methods: Experiments were performed on non-depilated male mice aged 7‒8 weeks from two strains: Balb/c and C57BL/6 (n=15). Local irradiation of the skin was carried out on the dorsal side of the animals using a scanning proton beam at an extended Bragg peak in the proton therapy complex «Prometheus» of the LPI Physico-technical Centre (Protvino) at a dose of 30 Gy with a proton energy of 87.8 MeV. During the irradiation session, animals were subjected to intraperitoneal anesthesia using a combination of Zoletil 100 (Virbac, France) and Xyla (Interchemie, Netherlands) in a previously determined ratio 1:3 (20‒40 mg/kg). Photographic documentation of radiation-induced skin damage was performed weekly for 70 days. Animals were examined daily for clinical manifestations of radiation-induced skin damage formation according to the RTOG international scale for 21 days following irradiation. The body weight dynamics of mice were evaluated one day before irradiation and then weekly for 70 days. Blood samples were collected from the tail vein by cutting the tip of the tail and analyzed using a DH36 Vet hematology analyzer (Dymind, China) one day before irradiation, one day and three days after irradiation, and weekly thereafter for 70 days. Experimental data were presented as mean ± standard deviation (M ± SD).
Results: In this study, the impact of a single local exposure to proton radiation at a dose of 30 Gy on the degree and dynamics of radiation-induced skin damage formation was evaluated. It was demonstrated that Balb/c mice exhibited a higher frequency and degree of radiation-induced skin damage formation compared to the C57BL/6 mice. Analysis of body weight in mice after radiation exposure revealed no significant decrease in either mouse strain. A comparative analysis of the number of platelets, erythrocytes and hemoglobin concentration in both mouse strains did not reveal any changes, while a tendency towards a decrease in the number of leukocytes, lymphocytes, and granulocytes was observed in the irradiated Balb/c mice group compared to the control group. Conversely, in irradiated C57BL/6 mice, the number of lymphocytes was higher compared to control animals.
Conclusion: In this study, Balb/c mice exhibited higher radiosensitivity compared to C57BL mice in response to a single local proton irradiation at a dose of 30 Gy.
Keywords: proton radiation, radiation dermatitis, radiation burn, hematological analysis, BALB/c and C57BL/6 mice
For citation: Anikina VA, Sorokina SS, Shemyakov AE, Zamyatina EA, Popova NR. Comparative Assessment of the Effect of Local Proton Radiation with a Dose of 30 Gy in BALB/c and C57BL/6 Mice. Medical Radiology and Radiation Safety. 2024;69(1):20–27. (In Russian). DOI:10.33266/1024-6177-2024-69-1-20-27
References
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18. Shakhovskaya O.V., Starodubtseva M.N., Medvedeva A.A. Characteristics of Radiosensitivity of Organisms Using Parameters of Redox Properties of Blood Plasma. Mediko-Biologicheskiye Problemy Zhiznedeyatelnosti = Medical and Biological Problems of Life Activity. 2023;1:43-48. DOI:10.58708/2074-2088.2023-1(29)-43-48
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19. Fabusheva K.M., Dvornik Yu.V. The Effect of Nicotinic Acid on the Level of Radiation-Induced DNA Damage in Mouse Bone Marrow Cells. VIII Mezhdunarodnaya Nauchno-Prakticheskaya Konferentsiya Molodyh Uchenyh: Biofizikov, Biotekhnologov, Molekulyarnyh Biologov i Virusologov – 2021 = VIII International Scientific and Practical Conference of Young Scientists: Biophysicists, Biotechnologists, Molecular Biologists and Virologists – 2021. Novosibirsk 2021, Oct 5-8. Novosibirsk Publ., 2021. P. 394-395 (In Russ.).
20. Mao X.W., Boerma M., Rodriguez D., Campbell-Beachler M., Jones T., Stanbouly S., Sridharan V., Nishiyama N.C., Wroe A., Nelson G.A. Combined Effects of Low-Dose Proton Radiation and Simulated Microgravity on the Mouse Retina and the Hematopoietic System. Radiat. Res. 2019;192;3:241–250.
21. Ware J., Sanzari J., Avery S., Sayers C., Krigsfeld G., Nuth M., Wan X.S., Kennedy A.R. Effects of Proton Radiation Dose, Dose Rate and Dose Fractionation on Hematopoietic Cells in Mice. Radiation Research. 2010;174:325–330.
22. Romero-Weaver A.L., Wan X.S., Diffenderfer E.S., Lin L., Kennedy A.R Effect of SPE-Like Proton or Photon Radiation on the Kinetics of Mouse Peripheral Blood Cells and Radiation Biological Effectiveness Determinations. Astrobiology. 2013;13;6:570–577.
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study was done with the support of the RNF grant No. 22-63-00082.
Contribution. Development of the research concept: Popova N.R., Sorokina S.S.; development of the research design: Popova N.R., Sorokina S.S., Anikina V.A.; conducting experiments: Anikina V.A., Zamyatina E.A., Shemyakov A.E., development and modification of research methods: Anikina V.A., Shemyakov A.E.; collection and analysis of literary material: Anikina V.A., Sorokina S.S., Popova N.R.; statistical data processing: Anikina V.A.; writing and scientific editing of the text: Sorokina S.S., Popova N.R.
Article received: 20.10.2023. Accepted for publication: 27.11.2023.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 1
DOI:10.33266/1024-6177-2024-69-1-28-32
L.A. Romodin1, E.I. Yashkina1, A.A. Moskovskij2
Fluorimetric Evaluation of the Effect of Malic, Succinic and Ascorbic Acids on the Growth Properties of A549 Cells in Culture
1 A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
2 Russian Biotechnological University, Moscow, Russia
Contact person: L.A. Romodin, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Relevance: A number of researchers consider the study of the radioprotective properties of non-toxic or low-toxic natural substances to be a promising direction. A special place among them is occupied by antioxidants and participants in the basic reactions of metabolism. In order to avoid methodological errors when performing these studies, it is necessary to conduct a number of additional experiments. For example, in order to study the properties of various substances on cell cultures using tablet readers, it is first necessary to make sure that these substances do not affect the ability of cells to adsorb to the bottom of the wells of the tablet and do not interfere with cell proliferation. And if such an influence is detected, further experiments with these substances should be planned taking into account the information received.
Purpose: To search the effect of ascorbic, malic and succinic acids on the ability of lung adenocarcinoma cells (A549) to adhere in a 96-well plate, followed by the onset of proliferation by fluorescence registration method using Hoechst-33342 fluorophore.
Methodology: The experiment was carried out in a 96-well tablet. The working concentration of Hoechst-33342 was 1 μg/ml (1.62 μM). Fluorescence was recorded at a wavelength of 460 nm when the samples were excited by light with a wavelength of 355 nm. In an experiment to study the effect of ascorbate, malate and succinate on cell adhesion and proliferation, 20,000 cells and a solution of one of these substances in a working concentration of 2 mM were introduced into the cells of the tablet. The number of cells in the wells was estimated based on the fluorescence of Hoechst-33342 after a day of incubation.
Result: In samples containing 2 mM succinic acid and ascorbic acid, a statistically significant decrease in the intensity of fluorescence was observed compared with a sample that did not contain the drug. This suggests that these compounds negatively affect the growth properties of the A549 culture: they inhibit cell adhesion or slow down their proliferation.
Scope of the results and conclusions:The results obtained are necessary for the methodologically correct planning of the most detailed studies on the A549 cell line model using fluorescent methods, including studies on the radioprotective properties of ascorbate, malate and succinate under the influence of rare ionizing and neutron radiation.
Keywords: cell culture, A549, ascorbic acid, succinate, malic acid, Hoechst-33342 flatbed fluorimeter, influence estimation
For citation: Romodin LA, Yashkina EI, Moskovskij AA. Fluorimetric Evaluation of the Effect of Malic, Succinic and Ascorbic Acids on the Growth Properties of A549 Cells in Culture. Medical Radiology and Radiation Safety. 2024;69(1):28–32. (In Russian). DOI:10.33266/1024-6177-2024-69-1-28-32
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The work was carried out within the framework of the research project “Technology-3” (registration number of the research project in the EGISU R&D system: 1230113001053).
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.10.2023. Accepted for publication: 27.11.2023.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 1
DOI:10.33266/1024-6177-2024-69-1-41-49
A.V. Titov, Iu.S. Belskikh, D.V. Isaev, N.K. Shandala, T.A. Doroneva,
I.I. Bogdanov, M.P. Semenova, A.A. Shitova, S.L. Burthev
Radio-Ecological Situation in the Area of the Uranium Legacy Site – Stepnaya Mine (Kalmykia)
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: A.V. Titov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To study the radio-ecological situation on the “uranium legacy” site of the former Stepnaya mine in the Republic of Kalmykia.
Material and methods: To measure the ambient dose equivalent rate (ADER), the pedestrian gamma survey method was used using a portable spectrometric complex MKC-01A Multirad-M and dosimeter-radiometer MKC-AT6101c.
The activity of gamma-emitting radionuclides in soil samples was measured using a stationary gamma spectrometer from CANBERRA. The activities of 210Po and 210Pb were measured using a radiometric installation UMF-2000 following their radiochemical separation from samples.
Short-term measurements of activity concentration (AC) and equivalent equilibrium activity concentration (EEAC) of radon were carried out with an aerosol alpha radiometer for radon and thoron RAA-20P2 Poisk.
Doses of radiation exposure to biological objects were estimated using dose coefficients provided by ICRP Publication 136 taking into account recommendations R52.18.820-2015.
Results: Gamma ADER values at the mine site vary over the range from 0.1 to 0.36 µSv/h, and on 80 % of the area these values do not exceed the background value of 0.14 µSv/h. Along the road from the mine to Narta village the ADER values do not exceed background values with exception of the area around the dam, where in a local part of this area of about 300 m2 these values reach 0.49 µSv/h.
The specific activities of natural radionuclides in the soil are below the criteria for classification as solid radioactive waste (SRW).
Under the certain weather conditions, radon EEAC inside the buildings on the site reaches 13 kBq/m3, and on the territory 1-1.5 kBq/m3.
Ecological risk for the terrestrial biological objects under consideration (grass, soil worm, snake and mouse-like rodents) does not exceed 0.025.
Conclusions: The radiation situation at the Stepnaya mine site meets the requirements of SP LKP-91, which were in force until 2020. However, in order to transfer the facility to a local government body, reclamation work should be carried out in accordance with the Federal Law “On the Transfer of Lands or Land Plots from One Category to Another” dated December 21, 2004 No. 172-FZ and GOST R 59057— 2020 «Environmental Protection. Lands. General Requirements for Reclamation of Affected Lands».
Doses of exposure to biological objects do not impact significantly on morbidity, reproduction and life expectancy of terrestrial biological objects.
Keywords: bioobject, gamma radiation, natural radionuclides, radio-ecological survey, mine, specific activity
For citation: Titov AV, Belskikh IuS, Isaev DV, Shandala NK, Doroneva TA, Bogdanov II, Semenova MP, Shitova AA, Burthev SL. Radio-Ecological Situation in the Area of the Uranium Legacy Site – Stepnaya Mine (Kalmykia). Medical Radiology and Radiation Safety. 2024;69(1):41–49. (In Russian). DOI:10.33266/1024-6177-2024-69-1-41-49
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The work was financed under the State Contract as part of the Federal Target Program «Nuclear and Radiation Safety for 2016-2020 and for the period until 2030».
Contribution. Titov A.V. – data collection and processing, writing the text; Belskikh Iu.S. – data collection and processing, writing the text; Isaev D.V. – data collection and processing, writing the text; Shandala N.K. – study conception and design, writing and editing the text; Doroneva T.A. – sample measurements, statistical data processing; Bogdanov I.I. – sample measurements, statistical data processing; Semenova M.P. – literary material analysis, editing the text; Burtсev S.L. – sample measurements. All authors are responsible for approval of the final version of the article and integrity of all parts of the article.
Article received: 20.10.2023. Accepted for publication: 27.11.2023.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 1
DOI:10.33266/1024-6177-2024-69-1-33-40
L.I. Baranov, A.N.Tsarev, F.S. Torubarov, A.S. Kretov, V.V. Petrova, E.Vasilyev,
S.M. Dumansky, O.A. Tikhonova, T.M. Bulanova, M.V. Kalinina, P.A. Shulepov,
I. Dibirgadzhiyev, A.S. Samoilov
Digital Twin of Worker of Nuclear Facility at the Stage of Pre-Shift Control
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: L.I. Baranov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Introduction. Digital twin. Digital twin in medicine using the example of Philips. Digital twin as an object of medical information space. Digital twin as an abstraction. Digital twin of worker of nuclear facility at the stage of pre-shift control. Conclusion.
Keywords: worker of nuclear facility, digital twin, pre-shift control, medical information space, abstraction
For citation: Baranov LI, Tsarev AN, Torubarov FS, Kretov AS, Petrova VV, Vasilyev EV, Dumansky SM, Tikhonova OA, Bulano-
va TM, Kalinina MV, Shulepov PA, Dibirgadzhiyev I, Samoilov AS. Digital Twin of Worker of Nuclear Facility at the Stage of Pre-Shift Control. Medical Radiology and Radiation Safety. 2024;69(1):33–40. (In Russian). DOI:10.33266/1024-6177-2024-69-1-33-40
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.10.2023. Accepted for publication: 27.11.2023.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 1
DOI:10.33266/1024-6177-2024-69-1-50-60
I.V. Ivanov1, 2, V.I. Burmistrov1, E.I. Matkevich3
Assessment of the Radiation Situation during Short-Term Flights to the Moon
1 N.F. Izmerov Research Institute of Occupational Health, Moscow, Russia
2 I.M. Sechenov First Moscow State Medical University, Moscow, Russia
3 A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: I.V. Ivanov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Background: The issue of assessing the features of factors affecting the formation of radiation doses of astronauts while in orbit of the Moon and on its surface remains insufficiently studied, which is important for ensuring the anti-radiation safety of astronauts on lunar missions.
Purpose: To analyze the factors influencing the formation of the radiation dose of astronauts at the stage of finding the spacecraft in orbit of the Moon and the lander on its surface.
Material and methods: The features of the dose load levels on astronauts at the stages of the Moon’s orbit and on the Moon’s surface are analyzed and generalized, calculation methods are used taking into account the orbit of the spacecraft around the Moon, the anti-radiation properties of the materials of the lander and spacesuit and the time spent in them during a short-term lunar mission.
Results: The total radiation doses of astronauts for 14 days, calculated according to dosimetric measurements during the years of low solar activity (2009 and 2018‒2019), are 19.5‒23.2 mSv for astronauts staying in a spacecraft in lunar orbit, and from 22,7 to 24,0 mSv for astronauts on the Lunar surface, depending on the mass thickness of the protection at the maximum permissible 250 mSv for 1 month. An increase in the mass thickness of the anti-radiation protection of the lander in the equivalent of aluminum from 1.5 to 3-5 g/cm2 and the lunar spacesuit in the equivalent of aluminum from 0.2 to 0.5‒1 g/cm2 will reduce the total radiation dose of astronauts no more than 1.3 times during a 14-day stay on the surface of the moon. The results indicate that in order to minimize the radiation doses that astronauts receive during a lunar mission, it is important to take into account the forecast of solar activity in order to optimize the launch time of the spacecraft in the «windows» with minimal levels of radiation exposure.
Conclusion: When predicting radiation hazard levels for astronauts during a short-term lunar mission, it is necessary to assess the levels of exposure to cosmic ionizing radiation both in the orbit of the Moon, depending on the lunar trajectory of the spacecraft, and on the surface of the Moon, taking into account the time spent in the lunar module and in a spacesuit, as well as levels of solar activity. It is important to take into account the analyzed features of the formation of cosmonauts’ radiation doses while orbiting the Moon and on its surface when predicting the time limits of the lunar mission, anti-radiation protection of astronauts and their compliance with the regulatory limits of exposure.
Keywords: space flights, the moon, astronauts, ionizing radiation, radiation doses, anti-radiation protection, lunar module, spacesuit
For citation: Ivanov IV, Burmistrov VI, Matkevich EI. Assessment of the Radiation Situation during Short-Term Flights to the Moon. Medical Radiology and Radiation Safety. 2024;69(1):50–60. (In Russian). DOI:10.33266/1024-6177-2024-69-1-50-60
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.10.2023. Accepted for publication: 27.11.2023.