JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 1
DOI:10.33266/1024-6177-2024-69-1-61-66
T.V. Vishnevskaya1, D.S. Isubakova1, M.Yu. Tsyplenkova1, O.S. Tsymbal1, I.V. Milto1, 2, R.M. Takhauov1, 2
Comparative Retrospective Analysis of the Results of Cytogenetic Studies of Employees of the Object of Use of Ionizing Radiation
1 Seversk Biophysical Research Center of the Federal Medical-Biological Agency, Seversk, Russia
2 Siberian State Medical University, Tomsk, Russia
Contact person: T.V. Vishnevskaya, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. , This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To conduct a comparative retrospective analysis of the results of cytogenetic studies of workers at facilities using ionizing radiation in 2003 and 2018.
Material and methods: The material for the study was the venous blood of workers at facilities using ionizing radiation. The study was conducted on conditionally healthy workers (n = 11), of which 2 groups were formed: the control group (blood sampling and cytogenetic study of blood lymphocytes were carried out in 2003) and the study group (blood sampling was carried out in 2018). For all examined individuals, blood lymphocytes were cultured and standard cytogenetic analysis followed by statistical processing of the results.
Results: A comparative retrospective analysis showed that in the study group (2018) compared to the control group (2003), the frequency of chromatid fragments was reduced (p = 0.0452). The frequencies of other types of cytogenetic disorders studied (aberrant cells, chromosomal fragments, dicentric and circular chromosomes) do not differ between groups.
Cytogenetic abnormalities in blood lymphocytes are a highly sensitive measure of the degree of radiation exposure in the early and late periods after exposure and can be used as a biological indicator of ionizing radiation.
The absence of differences in indicators of radiation exposure markers may be due to the large interval of time that elapsed after irradiation until the moment of examination (15 years), during which lymphocytes with chromosomal aberrations were eliminated from the blood. In the future, for the completeness of the retrospective analysis and the accuracy of the result, it is planned to conduct a study on a larger sample with a shorter time interval between cytogenetic studies.
Conclusion: The result of this work allows us to supplement the understanding of the mutation process in the somatic cells of individuals exposed to ionizing radiation in the course of professional activities and indicates genotoxicity.
Keywords: occupational exposure, cytogenetic study, retrospective analysis, chromosomal aberrations, blood lymphocytes
For citation: Vishnevskaya TV, Isubakova DS, Tsyplenkova MYu, Tsymbal OS, Milto IV, Takhauov RM.Comparative Retrospective Analysis of the Results of Cytogenetic Studies of Employees of the Object of Use of Ionizing Radiation. Medical Radiology and Radiation Safety. 2024;69(1):61–66. (In Russian). DOI:10.33266/1024-6177-2024-69-1-61-66
References
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11. Khalyuzova M.V., Tsyganov M.M., Isubakova D.S., Bronikovskaya E.V., Usova T.V., Litvyakov N.V., Karpov A.B., Takhauova L.R., Takhauov R.M. Genome-Wide Associative Study of the Association of Polymorphic Loci with an Increased Frequency of Chromosomal Aberrations in Individuals Exposed to Prolonged Radiation Exposure. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost = Medical Radiology and Radiation Safety. 2019;64;4:32–40. DOI: 10.12737/article_5d1103efefe893.65968050 (In Russ.).
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The research was carried out within the framework of the state task, the research topic is «Studying the relationship of single-nucleotide polymorphisms of cell cycle genes with the frequency of chromosomal aberrations in blood lymphocytes of employees of the Siberian Chemical Plant».
Contribution. Vishnevskaya T.V. – preparation of the text of the article, analysis and interpretation of data, conducting experiments, collection and analysis of literary material, development of the concept and design of the study; Isubakova D.S. – development of the concept and design of the study, internal audit; Tsyplenkova M.Yu., Tsymbal O.S. – conducting experiments and statistical data processing; Milto I.V. – scientific editing of the text, verification of critically important intellectual content; Takhauov R.M. – development of the concept and design of the study, approval of the final version of the manuscript.
Article received: 20.10.2023. Accepted for publication: 27.11.2023.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 1
DOI:10.33266/1024-6177-2024-69-1-67-72
G.V. Zhuntova, T.V. Azizova, M.V. Bannikova
Multiple Primary Malignant Tumors in Workers Chronically Exposed to Ionizing Radiation
Southern Urals Biophysics Institute, Ozyorsk, Russia
Contact person: G.V. Zhuntova, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To characterize multiple primary malignant tumors (MPMTs) in workers occupationally chronically exposed to ionizing radiation.
Material and methods: The study included 22,377 workers employed at reactors, plutonium-production plant and radiochemical plant of the Mayak Production Association (PA) who had been hired in 1948–1982. The study considered cases of MPMTs (verified with the morphological examination) that had been diagnosed in workers before 31 December 2018. The paper describes the structure and provides the comparative characteristics of synchronous and metachronous MPMTs.
Results: 320 cases of MPMTs that were verified with the morphological examination were registered in the cohort: 68.4 % in males and 31.6 % in females. 3 and more malignant tumors were registered in 20 % of workers with MPMTs. MPMTs accounted for 10.5 % of total malignant tumors registered in the cohort. Synchronous MPMTs accounted for 22.8 % in males and for 18.8 % in females. 36.6 % of metachronous MPMTs were diagnosed with an interval of more than 10 years. The structure of MPMTs was dominated by tumors of digestive organs, skin, genital organs (both sexes), respiratory organs (for males), and breast (for females). As for a histological type of tumor, adenocarcinomas and basal-cell carcinomas (both sexes), squamous-cell carcinomas (for males), ductal and lobular tumors (for females) were the most frequent.
Groups of workers with synchronous and metachronous MPMTs demonstrated some significant differences: synchronous MPMTs were diagnosed in later age than the primary metachronous tumor; the numbers of smokers and heavy alcohol drinkers were bigger in the group of workers with synchronous MPMTs, as well as the smoking index. Neither radiation doses nor the duration of occupational exposure at a date of diagnosis of synchronous MPMTs and a primary metachronous tumor were significantly different. Compared to the entire study cohort, the number of workers occupationally exposed at high doses was bigger in workers with MPMTs (above 1.0 Sv for external gamma-ray exposure, and above 1.0 Gy for internal alpha exposure).
Conclusion: MPMTs in workers of the nuclear enterprise were characterized in relation to non-radiation and occupation-related factors.
In the future it is planned to assess the impact of the occupational radiation exposure on the risk of MPMTs in workers of the study cohort considering non-radiation factors.
Keywords: occupational chronic exposure to ionizing radiation, Mayak PA workers, multiple primary malignant tumors, risk factors
For citation: Zhuntova GV, Azizova TV, Bannikova MV. Multiple Primary Malignant Tumors in Workers Chronically Exposed to Ionizing Radiation. Medical Radiology and Radiation Safety. 2024;69(1):67–72. (In Russian). DOI:10.33266/1024-6177-2024-69-1-67-72
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. This study was carried out with the support of the Federal Medical and Biological Agency of Russia under state contract No. 27.501.21.2 dated June 11, 2021. «Modernization of high-tech methods aimed at identifying the medical effects of radiation exposure on the personnel of the Mayak software and the population of the Ural region.»
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.10.2023. Accepted for publication: 27.11.2023.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 1
DOI:10.33266/1024-6177-2024-69-1-77-82
A. Shkuratov1, S. Golub1, 2, Y. Kirpichev1, A. Moiseev1, 3, I. Korovin1, A. Kryaneva1
Water Bolus Utilization for the Radiation Therapy of Patients
with Isolated Superficial Lesions of Cutaneous T-Cell Lymphoma
1 «Medscan» LLC, Moscow, Russia
2 «Peoples’ Friendship University of Russia», Moscow, Russia
3 «RT 7» LLC, Moscow, Russia
Contact person: A.V. Shkuratov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To demonstrate the effectiveness of water bolus, combined with individual immobilization for the treatment of lesions in the pedal region of the foot on a patient with isolated cutaneous T-cell lymphoma lesions.
Material and methods: Construction of individual immobilization devices, simultaneously functioning as a bolus, in two clinical cases of T-cell cutaneous lymphoma radiation therapy in the pedal region of the foot, along with 3D-CRT and VMAT treatment planning, accompanied by retrospective evaluation of interfractional motion.
Results: The proposed methodology demonstrates the effectiveness of the individual immobilization devices in minimizing interfractional motion, as well as the benefit of the bolus effect of the device in achieving optimal dose distribution in the treatment of superficial T-cell lymphoma lesions.
Keywords: radiation therapy, immobilization, bolus, dose evaluation, cutaneous T-cell lymphoma
For citation: Shkuratov A, Golub S, Kirpichev Y, Moiseev A, Korovin I, Kryaneva A.Water Bolus Utilization for the Radiation Therapy of Patients with Isolated Superficial Lesions of Cutaneous T-Cell Lymphoma. Medical Radiology and Radiation Safety. 2024;69(1):77–82. (In Russian). DOI:10.33266/1024-6177-2024-69-1-77-82
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.10.2023. Accepted for publication: 27.11.2023.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 1
DOI:10.33266/1024-6177-2024-69-1-73-76
Dmitry E. Kalinkin1, 2, Ivan V. Milto1, 2, Anas R. Takhauov1, Lilia R. Takhauova1, 2,
Yulia A. Samoilova3, Galina V. Gorina1, Olesya V. Litvinova1, Ravil M. Takhauov1, 2
The Sublimate Production Cohort of the Siberian Chemical Plant (Dosimetric Characteristics)
1 Seversk Biophysical Research Center, Seversk, Russia
2 Siberian State Medical University, Tomsk, Russia
3 Siberian Federal Scientific Clinical Center, Seversk, Russia
Contact person: Dmitry E. Kalinkin, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. , This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Introduction: Uranium, which is the raw material basis of the nuclear industry, is capable of causing adverse medical and biological consequences for workers who come into contact with its compounds in the course of their professional activities. In order to study this effect and to study in detail the biomedical consequences of the effects of uranium compounds on the body of personnel of nuclear power facilities, it is necessary to form a cohort of persons engaged in work with uranium compounds. One of the key elements of the uranium conversion technology carried out within the framework of sublimation production is the production of raw uranium hexafluoride for subsequent isotopic enrichment.
Purpose: To form and characterize a cohort of sublimate production of the personnel of the Siberian Chemical Plant involved in work with uranium compounds in the period 1953–2000.
Material and methods: The source of information was the regional medical dosimetric register of Seversk Biophysical Research Center, containing information on all current and former employees of the Siberian Chemical Plant (about 65,000 people) from the moment of the company’s foundation to the present.
Results: A cohort of Siberian Chemical Plant workers involved in work with uranium compounds in the period 1953–2000 has been formed and described. The cohort consists of 577 people (475 men and 102 women). Biomedical information and dosimetric information about the employees included in the cohort are included in the created database of the personnel of the Siberian Chemical Plant involved in working with uranium compounds in the period 1953–2000.
Conclusion: The formed cohort and database will allow conducting epidemiological studies to assess the morbidity and mortality of personnel due to malignant neoplasms, as well as making scientifically sound conclusions about the role of uranium compounds in the occurrence and mortality due to malignant neoplasms.
Keywords: uranium compounds, personnel of radiation hazardous production, cohort formation, epidemiology
For citation: Kalinkin DE, Milto IV, Takhauov AR, Takhauova LR, Samoilova YA, Gorina GV, Litvinova OV, Takhauov RM. The Sublimate Production Cohort of the Siberian Chemical Plant (Dosimetric Characteristics). Medical Radiology and Radiation Safety. 2024;69(1):73–76. (In Russian). DOI:10.33266/1024-6177-2024-69-1-73-76
References
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study was carried out within the framework of a state assignment, research topic “Assessment of the radiation situation and health status of personnel of the Siberian Chemical Plant involved in working with uranium compounds.”.
Contribution. Concept and design of the study: Kalinkin D.E., Milto I.V., Takhauov R.M.; data collection: Gorina G.V., Litvinova O.V., Samoilova Yu.A., Takhauov A.R., Takhauova L.R.; analysis and interpretation of results: Kalinkin D.E., Takhauov A.R.; literature review: Kalinkin D.E., Takhauova L.R.; preparation of the draft manuscript: Kalinkin D.E., Takhauov A.R., Milto I.V. All authors reviewed the results and approved the final version of the manuscript.
Article received: 20.10.2023. Accepted for publication: 27.11.2023.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 1
DOI:10.33266/1024-6177-2024-69-1-83-87
R.I. Tamrazov1, 2, R.D. Khusnutdinov2, E.N. Alekhin1, 2, N.V. Averina2,
Yu.S. Pyshkina1, 3, D.А. Pashkov1, 2
Own Experience of using the Radiopharmaceutical 99mTc-sentiskan in Visualization of Sentinel Lymph Nodes in Patients with Breast Cancer
1 Tyumen State Medical University, Tyumen, Russia
2 Medical City, Tyumen, Russia
3 Samara State Medical University, Samara, Russia
Contact person: Yu.S. Pyshkina, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To study the capabilities of the new radiopharmaceutical 99mTc-sentiscan in the visualization of sentinel lymph nodes in patients with breast cancer.
Material and methods: A survey of 178 people diagnosed with breast cancer. Patients were divided into two groups depending on the route of administration of the radiopharmaceutical. The day before surgical treatment, all subjects were injected with a radiopharmaceutical using a syringe with an activity of no more than 120 MBq, in a volume of 0.3‒0.4 ml. The visualized sentinel lymph nodes were marked on the skin using a patented device – «Device for external marking of sentinel lymph nodes during radionuclide visualization». Intraoperative search for sentinel lymph nodes was carried out using gamma detectors Gamma-Finder II or Radical, followed by urgent histological examination.
Results: Radioisotope visualization of sentinel lymph nodes using the domestic radiopharmaceutical 99mTc-sentiscan: in the first group (the drug was administered peritumorally) was 100 %, the average number of visualized lymph nodes in this group was 2.2; in the second group (the drug was administered subareolarly) ‒ 99.1 %, the average number of visualized lymph nodes ‒ 2.6. In the first group of patients, metastatic lesions of sentinel lymph nodes were detected in 8 cases (13.1 %), and in the second group ‒ in 14 (11.9 %). All lymph nodes were mapped in the axillary region on the side of the tumor process.
Conclusion: The possibility of the radiopharmaceutical 99mTc-sentiscan for the identification and biopsy of sentinel lymph nodes in patients with breast cancer was assessed. The use of the domestic 99mTc-sentiscan makes it possible to visualize sentinel lymph nodes in patients with breast cancer and detect their location in 99.1‒100 % of cases. Taking into account the results obtained, the expanded indications for the use of the radiopharmaceutical and the cost of the kits, 99mTc-sentiscan is more preferable for use in clinical practice.
Keywords: sentinel lymph node, breast cancer, scintigraphy, 99mTc-sentiscan
For citation: Tamrazov RI, Khusnutdinov RD, Alekhin EN, Averina NV, Pyshkina YuS, Pashkov DА. Own Experience of using the Radiopharmaceutical 99mTc-sentiskan in Visualization of Sentinel Lymph Nodes in Patients with Breast Cancer. Medical Radiology and Radiation Safety. 2024;69(1):83–87. (In Russian). DOI:10.33266/1024-6177-2024-69-1-83-87
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Tamrazov R.I.: development of the research concept, development of the research design; writing and scientific editing of the text; Khusnutdinov R.D.: development of research design, conduct of research, development and modification of research methods, collection and analysis of literary material, staatistical data processing, writing and scientific editing of the text; Alekhin E.N.: development of research design, conduct of research, development and modification of research methods, collection and analysis of literary material, statistical data processing, writing and scientific editing of the text; Averina N.V.: conducting research, developing and modifying research methods; Pyshkina Yu.S.: collection and analysis of literary material, statistical data processing, writing and scientific editing of the text; Pashkov D.A.: conducting research, developing and modifying research methods.
Article received: 20.10.2023. Accepted for publication: 27.11.2023.