JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 1
DOI:10.33266/1024-6177-2024-69-1-83-87
R.I. Tamrazov1, 2, R.D. Khusnutdinov2, E.N. Alekhin1, 2, N.V. Averina2,
Yu.S. Pyshkina1, 3, D.А. Pashkov1, 2
Own Experience of using the Radiopharmaceutical 99mTc-sentiskan in Visualization of Sentinel Lymph Nodes in Patients with Breast Cancer
1 Tyumen State Medical University, Tyumen, Russia
2 Medical City, Tyumen, Russia
3 Samara State Medical University, Samara, Russia
Contact person: Yu.S. Pyshkina, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To study the capabilities of the new radiopharmaceutical 99mTc-sentiscan in the visualization of sentinel lymph nodes in patients with breast cancer.
Material and methods: A survey of 178 people diagnosed with breast cancer. Patients were divided into two groups depending on the route of administration of the radiopharmaceutical. The day before surgical treatment, all subjects were injected with a radiopharmaceutical using a syringe with an activity of no more than 120 MBq, in a volume of 0.3‒0.4 ml. The visualized sentinel lymph nodes were marked on the skin using a patented device – «Device for external marking of sentinel lymph nodes during radionuclide visualization». Intraoperative search for sentinel lymph nodes was carried out using gamma detectors Gamma-Finder II or Radical, followed by urgent histological examination.
Results: Radioisotope visualization of sentinel lymph nodes using the domestic radiopharmaceutical 99mTc-sentiscan: in the first group (the drug was administered peritumorally) was 100 %, the average number of visualized lymph nodes in this group was 2.2; in the second group (the drug was administered subareolarly) ‒ 99.1 %, the average number of visualized lymph nodes ‒ 2.6. In the first group of patients, metastatic lesions of sentinel lymph nodes were detected in 8 cases (13.1 %), and in the second group ‒ in 14 (11.9 %). All lymph nodes were mapped in the axillary region on the side of the tumor process.
Conclusion: The possibility of the radiopharmaceutical 99mTc-sentiscan for the identification and biopsy of sentinel lymph nodes in patients with breast cancer was assessed. The use of the domestic 99mTc-sentiscan makes it possible to visualize sentinel lymph nodes in patients with breast cancer and detect their location in 99.1‒100 % of cases. Taking into account the results obtained, the expanded indications for the use of the radiopharmaceutical and the cost of the kits, 99mTc-sentiscan is more preferable for use in clinical practice.
Keywords: sentinel lymph node, breast cancer, scintigraphy, 99mTc-sentiscan
For citation: Tamrazov RI, Khusnutdinov RD, Alekhin EN, Averina NV, Pyshkina YuS, Pashkov DА. Own Experience of using the Radiopharmaceutical 99mTc-sentiskan in Visualization of Sentinel Lymph Nodes in Patients with Breast Cancer. Medical Radiology and Radiation Safety. 2024;69(1):83–87. (In Russian). DOI:10.33266/1024-6177-2024-69-1-83-87
References
1.Kudratova E.A., Fedorov N.M. Epidemiology of Breast Cancer in the Tyumen Region for the Period 2017-2021 During the COVID-19 Pandemic. Molodezhnaya Nauka i Sovremennost: Materialy 88 Mezhdunarodnoy Nauchnoy Konferencii Studentov i Molodyh Uchenyh = Youth science and modernity. Materials of the 88th International Scientific Conference of Students and Young Scientists. 2023. P. 163-165. URL: https://elibrary.ru/item.asp?id=53959934. (Access date: 06.10.2023) (In Russ.).
2.Nartokova A.S.Kh., Koychuyev A.A. Axillary Lymphadenectomy in Surgical Treatment of Breast Cancer. Experience Without Drainage Technique. Nauchnyy Medicinskiy Vestnik Yugry. 2022;32;2:117-118 doi: 10.25017/2306-1367-2022-32-2-117-118 (In Russ.).
3.Babayeva O.G., Kvon T.E., Shevchenko K.Yu., Sidorov S.V., Novikov S.S. Analysis of Relapse-Free and Overall Survival in Oncoplastic and Organ-Preserving Surgeries in Patients with Breast Cancer. Issledovaniya i Praktika v Medicine = Research’n Practical Medicine Journal. 2021;8;4:65-71. doi: 10.17709/2410-1893-2021-8-4-6 (In Russ.).
4.Kuru B. The Adventure of Axillary Treatment in Early Stage Breast Cancer. Eur. J. Breast Health. 2020;16;1:1-15. doi: 10.5152/ejbh.2019.5157.
5.Ermakov A.A., Zikiryahodzhayev A.D., Lazutina T.A., Leontyev A.V., Volchenko N.N., Belyakov M.M., Kaprin A.D., Kostin A.A. Sentinel Lymph Nodes Biopsy in Early Breast Cancer and Melanoma Patients Using “Tehnefit 99mTc” Radioactive Colloid Technetium 99mTc. Zlokachestvennyye Opuholi = Malignant Tumoursis. 2016;3:63-76. doi: 10.18027/2224-5057-2016-3-63-76 (In Russ.).
6.Eldaly A.S., Avila F.R., Torres-Guzman R.A., Maita K., Garcia J.P., Serrano L.P., Forte A.J. Radiomics and Artificial Intelligence in Predicting Axillary Lymph Node Metastasis in Breast Cancer: a Systematic Review. Curr. Med. Imaging. 2023;19;6:564-578. doi: 10.2174/1573405618666220822093226.
7.Khusnutdinov R.D., Alekhin E.N., Averina N.V., Elishev V.G., Tsarev O.N., Novozhenov Y.V., Borodina E.R., Ershova E.V. Sentinel Lymph Nodes Imaging with the Use of Periareolar Injection of Imaging Agent to Patients with Breast Cancer. Akademicheskiy Zhurnal Zapadnoy Sibiri = Academic Journal of West Siberia. 2016;4;65:40-41 (In Russ.).
8.Tamrazov R.I., Neverova E.N., Pavlova V.I., Averina N.V., Alekhin E.N., Khusnutdinov R.D., Korabelnikov M.A. Device for External Marking of Areas of Increased Accumulation of Radiopharmaceuticals with Radionuclide Imaging. Utility Model Patent 218690 U1, 06.06.2023. Application No. 2022115871 dated 06/10/2022 (In Russ.).
9.Bobirca F., Leventer M., Georgescu D.E., Dumitrescu D.A., Alexandru C., Serban D., Valeanu L., Pătrașcu T., Bobircă A. Variability of Sentinel Lymph Node Location in Patients with Trunk Melanoma. Diagnostics (Basel). 2023;13;17:2790. doi: 10.3390/diagnostics13172790.
10.You J.Y., Lee E.S., Lim S.K., Kwon Y., Jung S.Y. Could Axillary Lymph Node Dissection Be Omitted in the Mastectomy Patient with Tumor Positive Sentinel Node? Front Oncol. 2023;13:1181069. doi: 10.3389/fonc.2023.1181069.
11.Barker V.R., Naffouje S.A., Mallory M.A., Hoover S.A., Laronga C. Surgical Management of the Axilla in HR+/HER2- Breast Cancer in the Z1071 Era: A Propensity Score-Matched Analysis of the National Cancer Database. Ann. Surg. Oncol. 2023. doi: 10.1245/s10434-023-14029-7.
12.Muñoz-Alcaraz M.N., Jiménez-Vílchez A.J., Pérula-de Torres L.Á., Serrano-Merino J., García-Bustillo Á., Pardo-Hernández R., González-Bernal J.J., González-Santos J. Effect of Conservative Rehabilitation Interventions on Health-Related Quality of Life in Women with Upper Limb Lymphedema Secondary to Breast Cancer: A Systematic Review. Healthcare (Basel). 2023;11;18:2568. doi: 10.3390/healthcare11182568.
13.Giuliano A.E., Kirgan D.M., Guenther J.M., Morton D.L. Lymphatic Mapping and Sentinel Lymphadenectomy for Breast Cancer. Ann. Surg. 1994;220;3:391-398. doi: 10.1097/00000658-199409000-00015.
14.McIntosh S.A., Purushotham A.D. Lymphatic Mapping and Sentinel Node Biopsy in Breast Cancer. Br. J. Surg. 1998;85;10:1347-1356. doi: 10.1046/j.1365-2168.1998.00934.x.
15.Veronesi U., Paganelli G., Galimberti V., Viale G., Zurrida S., Bedoni M., Costa A., de Cicco C., Geraghty J.G., Luini A., Sacchini V., Veronesi P. Sentinel-Node Biopsy to Avoid Axillary Dissection in Breast Cancer with Clinically Negative Lymph-Nodes. Lancet. 1997;349;9069:1864-1867. doi: 10.1016/S0140-6736(97)01004-0.
16.Khusnutdinov R.D., Alekhin E.N., Fedorov N.M., Zotov P.B., Averina N.V., Borodina E.R., Novozhenov Y.V., Teffenberg D.V., Basova T.S. Visualization of Sentinel Lymph Nodes Using Radiopharmaceutical «Nanotop 99mТс » «Technefit 99mТс » in Patients with Breast Cancer. Scientific Forum. Siberia. 2020;6;1:42-43 (In Russ.).
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Tamrazov R.I.: development of the research concept, development of the research design; writing and scientific editing of the text; Khusnutdinov R.D.: development of research design, conduct of research, development and modification of research methods, collection and analysis of literary material, staatistical data processing, writing and scientific editing of the text; Alekhin E.N.: development of research design, conduct of research, development and modification of research methods, collection and analysis of literary material, statistical data processing, writing and scientific editing of the text; Averina N.V.: conducting research, developing and modifying research methods; Pyshkina Yu.S.: collection and analysis of literary material, statistical data processing, writing and scientific editing of the text; Pashkov D.A.: conducting research, developing and modifying research methods.
Article received: 20.10.2023. Accepted for publication: 27.11.2023.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 1
DOI:10.33266/1024-6177-2024-69-1-88-91
I.O. Tomashevsky, O.S. Kornikova
The Impotance of SPECT/CT in Simultaneous Assessment
of Calcinosis of Coronary Arteries, Perfusion and Contractile Function of the Myocardium among Females with Coronary Heart Disease
Central Clinical Hospital RZD-Medicine, Moscow, Russia
Contact person: Igor Ostapovich Tomashevsky, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To study the frequency of calcinosis of coronary arteries and its effect on myocardial perfusion and contractile function among females with coronary heart disease (CHD).
Material and methods: A survey was conducted among 141 females with coronary heart disease (CHD): simultaneous assessment of coronary artery calcinosis, perfusion and contractile function with 99m Tc-technetril SPECT/CT with ECG-synchronization and X-ray radiation correction, as well as comparison of data with the results of electrocardiography (ECG), echocardiography (ECHO-CG), clinical and biochemical blood tests.
Results: Coronary artery calcinosis was detected in 33 (23 %) females with coronary heart disease (CHD) out of all patients identified: over the age of 55 years (M = 67 years with variations from 58 to 83 years) ‒ in 25 (17.7 %), aged 41‒55 years (M = 50 years with variations from 46 to 54 years) ‒ in 7 (4.6 %), at the age of 25‒40 years ‒ in one female 35 years (0.7 %). The Agatston calcium score interval was set as follows: at the maximum degree > 400 ‒ for 6 females (4.2 % of all surveyed); at 101‒400 ‒ in 9 (6.4 %); at 11‒100 ‒ in 17 (12.0 %); at 1‒10 ‒ in one female (0.7 %); with a minimum degree of 0 ‒ in 108 females (76.7 % of all surveyed). In the presence of maximum degree of calcinosis (> 400 units), a slight significant decrease in perfusion, an increase in ejection fraction and diastole duration was revealed.
Conclusion: The use of combined SPECT/CT with ECG synchronization and CT radiation correction technology in 141 females with coronary artery disease made it possible to identify coronary artery calcinosis in 23 % of patiets.
Keywords: females, coronary heart disease, SPECT/CT, myocardium, calcinosis of coronary arteries, perfusion, contractile function of the myocardium
For citation: Tomashevsky IO, Kornikova OS. The Impotance of SPECT/CT in Simultaneous Assessment of Calcinosis of Coronary Arteries, Perfusion and Contractile Function of the Myocardium among Females with Coronary Heart Disease. Medical Radiology and Radiation Safety. 2024;69(1):88–91. (In Russian). DOI:10.33266/1024-6177-2024-69-1-88-91
References
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2. Cannon R.O. Microvascular Angina and the Continuing Dilemma of Chest Pain with Normal Coronary Angiograms. J. Am. Coll. Cardiol. 2009;54:877–885.
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9. Rudoy A.S., Zagashvili I.V. Microvascular Angina. Voyennaya Meditsina. 2013;1:143–148 (In Russ.).
10. Xiaoliang Shao, Xiaoliang Shao, Yuetao Wang, Ruijue Zhou, Jianfeng Wang. Characteristics of Coronary Artery Calcium in Chinese Patients with Suspected Coronary Artery Disease and Its Relationship with Myocardial Ischemia. Journal of Nuclear Medicine. 2016;57;2:339.
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. I.O. Tomashevsky took part in the development of the concept, design, theoretical basis, modification of research methods. O. Kornikova took part in the collection and analysis of literary material, statistical data processing, writing and scientific editing of the text.
Article received: 20.10.2023. Accepted for publication: 27.11.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 6
DOI:10.33266/1024-6177-2023-68-6-8-12
N.N. Omelchuk
The Significance of Corticosteroid Binding to Plasma Proteins in the Mechanism of the Effect
of the Radioprotector Rs-11 on the Function of the Adrenal Cortex in Acute Radiation Sickness
Russian University of Friendship of Peoples Patrice Lumumba, Moscow, Russia
Contact person: N.N. Omelchuk, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To study the role of binding of corticosteroids to blood plasma proteins in the mechanism of influence of the radioprotector RS-11 on the function of the adrenal cortex in irradiated animals.
Material and methods: The experiments were carried out on 30 male chinchilla rabbits weighing 2.5–3.0 kg. The first series of experiments is aimed at studying the reaction of the adrenal cortex and the processes of protein-steroid interaction after the administration of PC-11 to intact animals; in the second series – the same indicators in animals irradiated during the prophylactic administration of RS-11. The total content of 11-hydroxycorticosteroids (11-OKS) in blood plasma was determined by the fluorometric method of Guillemin et al in the author’s modification. The amount of free corticosteroids was determined by the difference in their content in whole plasma and in its protein fraction after separation on Sephadex G-25. Binding capacity of corticosteroid binding globulin (CSBG) was determined by gel filtration De Moor at al. in the author’s modification. Statistical analysis of the study results was carried out using the Student–Fisher method.
Results: In the group of intact rabbits under conditions of administration of PC-11, the reaction of the adrenal cortex after 2.5–3 hours was significantly higher compared to control animals. The increase in the free fraction of the hormone with the introduction of the radioprotector RS-11 during this period is associated with an increase in the total level of 11-OKS, since the binding ability of CSBG did not change. In the group of irradiated rabbits, 2.5–3 hours after irradiation, the administration of PC-11 also led to a significant increase in the total content of 11-OKS in the blood compared to the initial data. At the height of radiation sickness on the 4th day, RS-11 protected rabbits showed a significantly smaller decrease in the binding capacity of CSBG than control animals, and the total content of 11-OKS was higher than in the control. The level of free hormone on the 4th day was sharply reduced (8 % of the total 11-OKS content versus 41 % in the control). On the 8th day of radiation sickness, free 11-OKS in protected RS-11 and control rabbits was practically absent, however, in protected animals, the binding capacity of CSBG was 2 times higher than in control animals.
Conclusions: The influence of the radioprotector RS-11 leads in the first hours to an increase in the total concentration of 11-OX in the blood plasma and to an increase in the amount of free hormone in intact animals. The binding capacity does not change. Prophylactic administration of RS-11 inhibits, at the height of radiation sickness, the decrease in the binding capacity of CSBG in the blood plasma, and as a result, the increase in the level of free physiologically active hormone at a higher overall level of hormones in the blood. In the mechanism for reducing post-radiation hypercortisolism under conditions of protection with the drug RS-11, the main significance is the lesser degree of disruption of the binding ability of CSBG, and not a change in the overall level of hormones in the blood.
Keywords: acute radiation sickness, protein-steroid interaction, corticosteroids, hypercortisolism, chemical radioprotectors, RS-11
For citation: Omelchuk NN. The Significance of Corticosteroid Binding to Plasma Proteins in the Mechanism of the Effect of the Radioprotector Rs-11 on the Function of the Adrenal Cortex in Acute Radiation Sickness. Medical Radiology and Radiation Safety. 2023;68(6):8–12. (In Russian). DOI:10.33266/1024-6177-2023-68-6-8-12
References
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2.Rozhdestvenskij L.M. Past and future of radiobiology of anti-radiation agents at the Institute of Biophysics of the USSR Ministry of Health. FSBI State Scientific Center FMBC named after. A.I. Burnazyan FMBA of Russia. Medicinskaya radiologiya i radiacionnaya bezopasnost = Medical radiology and radiation safety. 2016; 5: 80-89 (In Russ.).
3.Rozhdestvenskij L.M. Problems of developing domestic anti-radiation agents during a crisis period: searching for current development directions. Radiacionnaya biologiya. Radioekologiya = Radiation biology. Radioecology. 2020; 60(3): 290-300 (In Russ.).
4.Khabriev R.U., Mingazova E.N., Sidorov V.V., Gureev S.A., Yusupova M.M. Biocompatible drugs-protectors against radiation exposure: a modern view of the problem. Remedium = Remedium. 2021; 4: 3-8 (In Russ.).
5.Kuruba V., Gollapalli P. Natural radioprotectors and their impact on cancer drug discovery. J. Radiation oncology. 2019; 36(4): 265-275. DOI: 10.3857/roj.2018.00381.
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7.Borisova L.Ya. The influence of radioprotective substances on the early radiation reaction of the pituitary-adrenal system. Radiobiologiya = Radiobiology. 1969; 9 (2): 246-248 (In Russ.). PMID: 5343951.
8.Omelchuk N.N. Analysis of the disturbance of corticosteroids with blood plasma proteins in the pathogenesis of acute radiation sickness. Radiaciya i risk = Radiation and risk. 2022; 31(3): 131-138 (In Russ.). DOI: 10.21870/0131-3878-2022-31-3-131-138.
9.Omelchuk N.N. The binding capacity of corticosteroid-binding globulin in blood plasma as a mechanism for increasing the free fraction of the hormone in the pathogenesis of acute radiation sickness. Radiaciya i risk = Radiation and risk. 2022; 31(3): 139-146 (In Russ.). DOI: 10.21870/0131-3878-2022-31-3-139-146.
10. Chernov G.A., Evdakov V.P., Kabanov V.A. Anti-radiation effect of ionic polymers. Selected materials from the Bulletin of Radiation Medicine / Ed. L.A. Ilyin and A.S. Samoilova. T. II. M.: FGBU GNC FMBC im. A.I. Burnazyana FMBA Rossii. Izbrannye materialy «Byulletenya radiacionnoj mediciny» = Institution State Scientific Center FMBC named after. A.I. Burnazyan FMBA of Russia, 2016. P. 607-619 (In Russ.).
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The author declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with one participation of the authors.
Article received: 20.07.2023. Accepted for publication: 27.08.2023.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 1
DOI:10.33266/1024-6177-2024-69-1-92-104
S.A. Sypko, G.N. Bobov, V.E. Vvedensky, A.V. Nazarenkova
Study of 239Pu Microdistribution in Liver of Mayak
Workers Using Neutron-Activated Measurement Method
Southern Urals Biophysics Institute, Ozyorsk, Russia
Contact person: V.E. Vvedensky, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: Conducted research was aimed at studying of microdistribution of 239Pu particles in liver tissues of former MAYAK PA workers. Current research is a continuation of studies of microdistribution of 239Pu particles in lung tissues of former MAYAK PA workers that were conducted earlier and published.
Material and methods: Neutron-induced track method was utilized for studying the distribution of sizes of 239Pu nanoparticles. At Southern Urals Biophysics Institute this method was improved, optimized and adapted for studying of plutonium microdistribution in biological tissues.
Liver samples studying started in 2020. Samples were chosen from Radiobiology Human Tissue Repository SUBI. Liver samples from Voronezh regional pathology and anatomical bureau and Tobolsk regional hospital #3 were obtained within the search of contemporary liver tissues.
Application of liver samples on track detectors and their assembling into plastic box for following irradiation in nuclear reactor at Joint stock company “Institute of Nuclear Materials” was provided similarly to lung samples. Standart pathohistological techniqes were applied. The thickness of liver slides was 5 micrometers.
Basic track count was conducted on the results of 36-minute etching. Single tracks and stars were counted. Stars with high density of tracks that exceeded counting abilities were counted on the results of 9-minute etching either directly (if all tracks were distinct) or in accordance with patent for invention RU 2733491 C2 that enables to calculate the number of tracks in a star by distinct peripheral tracks.
Results: This study quantitatively compares 239Pu microdistribution in liver of three deceased former Mayak PA workers who were exposed to 239Pu by inhalation and three deceased subjects who had been never employed at Mayak PA (from Ozyorsk, Voronezh, Tobolsk). The comparison is made utilizing neutron-activation method of measurement. The results are compared to the results of less-sensitive autoradiographic method. The study demonstrated that the most of 239Pu activity in liver is concentrated in liver lobules. 239PuO2 nanoparticles found didn’t exceed the size of 20 nm. Track density for three liver samples of subjects who had been never employed at Mayak PA differed for less than two times.
Keywords: Plutonium, neutron-activation measurement method, nanoparticles, microdistribution, liver, Mayak PA
For citation: Sypko SA, Bobov GN, Vvedensky VE, Nazarenkova AV. Study of 239Pu Microdistribution in Liver of Mayak Workers Using Neutron-Activated Measurement Method. Medical Radiology and Radiation Safety. 2024;69(1):92–104. (In Russian). DOI:10.33266/1024-6177-2024-69-1-92-104
References
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.10.2023. Accepted for publication: 27.11.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 6
DOI:10.33266/1024-6177-2023-68-6-13-19
V.S. Nikiforov1, 2, V.A. Krivoshchapov1, N.V. Startsev1
Unified Information System of The Urcrm of Fmba of Russia
1 Urals Research Center for Radiation Medicine, Chelyabinsk, Russia
2 Chelyabinsk State University, Chelyabinsk, Russia
Contact person: V.S. Nikiforov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. , This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
A great amount of scientific information on the effect of radiation on the human body in various fields of knowledge from genetics and molecular biology to radiation epidemiology has been accumulated over a long-term period of activity of the URCRM of the FMBA of Russia.
To get the best out of the use of numerous registers and databases maintained in the URCRM and to make interdisciplinary research possible, a Unified Information System was created, which consists of two parts: information complex REGISTR and complex Storage.
The creation of the Storage complex makes it possible to ensure the safety of scientific data obtained in the departments of the URCRM, as well as methods/techniques elaborated to obtain them. The development of the REGISTR complex, the creation of new functionality in it, have significantly increased the use of information resources, which allows for strategic planning of new research.
The paper describes in detail the basic functionality of the Unified Information System. The technical aspect of the usage of the REGISTR complex is presented. An example of the use of the Selections Constructor for planning of the study performed in the Laboratory of Molecular and Cellular Radiobiology of the URCRM of the FMBA of Russia is given.
Keywords: unified information system, the Register complex, the Storage complex, personal data protection, prospects for the development of the REGISTER complex
For citation: Nikiforov VS, Krivoshchapov VA, Startsev NV. Unified Information System of The Urcrm of Fmba of Russia. Medical Radiology and Radiation Safety. 2023;68(6):13–19. (In Russian). DOI:10.33266/1024-6177-2023-68-6-13-19
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2023. Accepted for publication: 27.08.2023.