JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 6
DOI:10.33266/1024-6177-2023-68-6-55-59
E.A. Kodintseva1, 2, A.А. Akleyev3
Effect of Radiation and Non-Radiation Factors on the ТBX21 Concentration in lysates of the Mitogen-Stimulated Mononuclear Cells
1 Urals Research Center for Radiation Medicine, Chelyabinsk, Russia
2 Chelyabinsk State University, Chelyabinsk, Russia
3 South-Ural State Medical University, Chelyabinsk, Russia
Contact person: Екатерина Александровна Кодинцева, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To evaluate the effect of radiation and non-radiation factors on the intracellular concentration of the ТBX21 transcription factor in peripheral blood PHA-stimulated mononuclear cells of chronically exposed residents of the Techa Riverside settlements in the long-term period after the start of exposure.
Material and methods: The main group consisted of 30 people aged 67–80 years with the mean dose to the red bone marrow 867±136 mGy, to thymus and peripheral lymphoid organs 125±20 mGy. The comparison group included 10 unexposed people aged 63–82 years. The main and the comparison groups had similar sex and ethnic composition. Peripheral blood mononuclear cells were PHA-stimulated for 24 hours. Cellular lysates were normalized by total protein concentration prior to being used for ELISA test.
Results: After 24 hours of incubation the median and interquartile range of the intracellular TBX21 concentration in mononuclear cells was 34.2 (6.6–86.0) pg/ml after the mitogen stimulation, and 0 (0–24.9) pg/ml – without mitogen stimulation (р=0.001). In the comparison group these values made up 24.8 (0.2–47.6) and 13.0 (0–19.2) pg/ml, respectively
Conclusion: The intracellular TBX21 concentration after 24-hour mitogen stimulation did not differ statistically significantly in chronically exposed and unexposed people, as well as in people from different dose groups. Statistically significant increase in TBX21 concentration in the lysates of mononuclear cells that were PHA-stimulated for 24 hours relative to non-mitogen stimulated cells was noted in chronically exposed people with medium and high doses to the red bone marrow. No correlation was revealed between the TBX21 concentration and dose characteristics, sex, and ethnicity of the studied individuals. The results are preliminary.
Keywords: chronic radiation exposure, residents, the Techa River, peripheral blood, ТBX21 transcription factor, lysates of mononuclear cells, Phytohemagglutinin
For citation: Kodintseva ЕА, Akleyev АА. Effect of Radiation and Non-Radiation Factors on the ТBX21 Concentration in lysates of the Mitogen-Stimulated Mononuclear Cells. Medical Radiology and Radiation Safety. 2023;68(6):55–59. (In Russian). DOI:10.33266/1024-6177-2023-68-6-55-59
References
1. Akleyev A.V., Varfolomeyeva T.A. Status of Hematopoiesis In Residents of the Techa Riverside Villages. Posledstviya Radioaktivnogo Zagryazneniya Reki Techi = Consequences of Radioactive Contamination of the Techa River. Ed. Akleyev A.V. Chelyabinsk, Kniga Publ., 2016. Р. 166–194. DOI: 10.7868/S0869803117020060 (In Russ.).
2. Krestinina L.Yu., Silkin S.S., Mikryukova L.D., Epifanova S.V., Akleyev A.V. Risk of Death from Solid Cancer Among Residents of the Techa Riverside and the East Urals Radioactive Trace Areas Exposed to Radiation: Comparative Analysis. Radiatsiya i Risk = Radiation and Risk. 2017;26;1:100–114. DOI: 10.21870/0131-3878-2017-26-1-100-114 (In Russ.).
3. Marchal J., Pifferi F., Aujard F. Resveratrol in Mammals: Effects on Aging Biomarkers, Age-Related Diseases, and Life Span. Annals of the New York Academy of Sciences. 2013;1290;1:67–73.
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5. Papaioannou V.E. The T-Box Gene Family: Emerging Roles in Development, Stem Cells and Cancer. Development. 2014;141:3819–3833.
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7. Ryan J.L. Ionizing Radiation: the Good, the Bad, and the Ugly. Journal of Investigative Dermatology. 2012;132:985–993.
8. Singh R., Miao T., Symonds A., Omodho B., Li S., Wang P. Egr2 and 3 inhibit T-bet mediated IFN-γ production in T cells. The Journal of Immunology. 2017;198:4394–4402.
9. Tang Y., Chen X., Zhang Y., Tang Z., Zhuo M., Li D., Wang P., Zang G., Yu Y. Fusion Protein of Tapasin and Hepatitis B Core Antigen 1827 Enhances T Helper Cell Type 1/2 Cytokine Ratio and Antiviral Immunity by Inhibiting Suppressors of Cytokine Signaling Family Members 1/3 in Hepatitis B Virus Transgenic Mice. Molecular Medicine Reports. 2014;9:1171–1178.
10. Akleyev AюV. Chronic Radiation Syndrome. Berlin-Heidelberg, Springer, 2014. 410 p. DOI: 10.1007/978-3-642-45117-1.
11. Degteva M.O., Napye B.A., Tolstykh E.I., Shishkina E.A., Bugrov N.G., Krestinina L.Yu., Akleyev A.V. Individual Dose Distribution in Cohort of People Exposed as a Result of Radioactive Contamination of the Techa River. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost = Medical Radiology and Radiation Safety. 2019;64;3:46–53. DOI: 10.12737/article_5cf2364cb49523.98590475 (In Russ.).
12. Kishkun A.A., Gilmanov A.Zh., Dolgikh T.I., Grishchenko D.A., Skorokhodova T.G. Organization of a Preanalytical Study with the Centralization of Laboratory Research. Guidelines. Poliklinika. 2013;2:6–27 (In Russ.).
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14. Grzhibovskiy A.M., Ivanov S.V., Gorbatova M.A. Correlation Analysis of Data Using Statistica and SPSS Software. Nauka i Zdravookhraneniye = Science & Healthcare. 2017;1:7–36. DOI: 10.34689/SH.2017.19.1.001 (In Russ.).
15. Haybar H., Rezaeeyan H., Shahjahani M., Shirzad R., Saki N. T‐Bet Transcription Factor in Cardiovascular Disease: Attenuation or Inflammation Factor? Journal of Cellular Physiology. 2019;234;6:7915–7922. DOI: 10.1002/jcp.27935.
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. This study was carried out within the framework of the state assignment of the FMBA of Russia: “The state of human cellular immunity in the period of the development of the late effects of chronic radiation exposure”.
Contribution. All authors confirm that their authorship meets the international ICMJE criteria. Kodintseva Е.А. — participated in the development of the concept and design of the study, research, data analysis and interpretation, preparation of the article; read and approved the final version before publication. Akleуev А.А. — participated in the development of the concept and design of the study, interpretation of results, scientific editing; read and approved the final version before publication
Article received: 20.07.2023. Accepted for publication: 27.08.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 6
DOI:10.33266/1024-6177-2023-68-6-60-66
A.R. Tukov, I.L. Shafransky, O.N. Prokhorova, A.M. Mikhailenko, M.N. Ziyatdinov
Diabetes Mellitus Incidence and the Risk of its Occurrence in Liquidators of the Chnpp Accident Consequences including Nuclear Industry Workers
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: A.R. Tukov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Summary: Investigation purposes Diabetes mellitus (DM) occupies the largest share in the structure of endocrine system diseases, nutritional disorders and metabolic disorders, which is currently one of the important priorities of national health systems. Research on certain groups of the population with their own harmful occupational risk factors is relevant. Analysis of the incidence of diabetes mellitus of the second type - T2DM (ICD 10: E11-E11.9) of liquidators of the consequences of the Chernobyl accident ‒ workers of nuclear industry enterprises for 30 years of observation and assessment of the radiation risk of its occurrence.
Material and methods: The study includes data from the Industry register of persons exposed to radiation as a result of the Chernobyl accident over a thirty-year period, having a verified dose of external radiation received during work in the 30 km zone of the Chernobyl nuclear power plant, men – 12663 people, 1327, of whom have data on the dose of occupational irradiation. The Poisson process with an intensity parameter was chosen as a statistical model of morbidity.
Results: The incidence of T2DM in liquidators of the consequences of the Chernobyl accident was estimated by age and sex groups. On the basis of the obtained file of individual unstratified data, an analytical likelihood function for the Poisson process was constructed and the value of the excess relative risk (ERR) of T2DM incidence was calculated and the nature of the dose dependence of RR was investigated.
A cohort epidemiological study of a group of liquidators in 1986–1990 was carried out. over a thirty-year period, depending on the dose, both received during the liquidation of the consequences of the Chernobyl accident, and during professional work with radioactive substances (RS) and sources of ionizing radiation (IRS). Direct estimates of the radiogenic risk of diabetes mellitus are given. Different values of risk were noted when using doses from different types of radiation. There was no significant increase in the risk of disease per dose unit (ERR / Sv).
Conclusion: With the aging of the cohort of liquidators, an increase in the incidence of T2DM was noted in both men and women. The results obtained on the assessment of the radiation risk of T2DM at this stage are taken as preliminary, since the use of radiation risk in the development of radiation safety regulations requires a total dose from all types of exposure (professional, emergency, medical, natural).
Keywords: diabetes, incidence, radiation, relative risk, overweight, Chernobyl accident, employees of the nuclear industry, sectoral register
For citation: Tukov AR, Shafransky IL, Prokhorova ON, Mikhailenko AM, Ziyatdinov MN. Diabetes Mellitus Incidence and the Risk of its Occurrence in Liquidators of the Chnpp Accident Consequences including Nuclear Industry Workers. Medical Radiology and Radiation Safety. 2023;68(6):60–66. (In Russian). DOI:10.33266/1024-6177-2023-68-6-60-66
References
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The work was carried out as part of the implementation of the State Order.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2023. Accepted for publication: 27.08.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 6
DOI:10.33266/1024-6177-2023-68-6-73-79
E.I. Matkevich1, A.N. Bashkov1, E.A. Ionova1, A.U. Veselkova1,V.S. Rudakov1,
O.V. Parinov1, V.V. Kapustin2
Modern Possibilities of Imaging Diagnosis Methods in Assessing the Severity of Fatty Hepatosis in Non-Alcoholic Fatty Liver Disease (Clinical Case)
1 A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
2 A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
Contact person: E.I. Matkevich, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To estimate the potential of imaging methods in the diagnosis of non-alcoholic fatty liver disease (NAFLD) based on the example of a clinical case.
Material and methods: A 42 years-old man with suspected of NAFLD, by the clinical and laboratory tests results, underwent a quantitative assessment of fatty hepatosis using radiodiagnosis imaging methods. We used US “liver protocol” with attenuation imaging technique (ATI), shear wave elastography (SWE), shear wave dispersion imaging (SWD), computed tomography (CT) with quantitative and qualitative assessment using the liver-spleen index (CTL-S); MRI with application that provides volumetric whole-liver fat fraction (FF) measurements by proton density (PDFF), on the basis of IDEAL IQ program. The morphological verification of liver biopsy was also performed.
Results: All imaging method used in this clinical case showed severe degree of fatty hepathosis, that correlated with biopsy of liver.
In repeated studies, on the background of treatment, the quantitative indicators of all imaging methods had a similar dynamics of reduction of the degree of fatty hepatosis.
Conclusion: The clinical case of verified acute steatohepatitis shows the possibilities of its diagnostics by means of the radiation modalities. We used US with ATI, SWE и SWD, CT with CTL-S, MRI with FF that demonstrated high diagnostic efficiency for determination fatty hepatosis and the possibility of its quantification. These technologies are suitable for widespread implementation into clinical practice providing good diagnostic accuracy. CT associated with higher doses of radiation is not considered to be the basic method of choice for diagnosing NAFLD, but still may provide a physician with necessary information to determine further treatment strategy.
Keywords: fatty hepathosis, ultrasound, CT, MRI, quantitative assessment
For citation: Matkevich EI, Bashkov AN, Ionova EA, Veselkova AU, Rudakov VS, Parinov OV, Kapustin VV. Modern Possibilities of Imaging Diagnosis Methods in Assessing the Severity of Fatty Hepatosis in Non-Alcoholic Fatty Liver Disease (Clinical Case). Medical Radiology and Radiation Safety. 2023;68(6):73–79. (In Russian). DOI:10.33266/1024-6177-2023-68-6-73-79
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2023. Accepted for publication: 27.08.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 6
DOI:10.33266/1024-6177-2023-68-6-67-72
Zh.V. Sheikh1, 2, 3, 4, S.N. Shvayko2, L.G. Leonova2, E.V. Tarachkova1,
E.I. Bogdanova1, E.S. Stepanchenko1
Cryptogenic Organizing Pneumonia (Clinical Case Report, Literature Review)
1 Russian Medical Academy of Continuing Professional Education, Moscow, Russia
2 S.P. Botkin City Clinical Hospital, Moscow, Russia
3 A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
4 P. Lumumba Russian Peoples̕ Frendship University, Moscow, Russia
Contact person: Zh.V. Sheikh, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Summary
Despite the widespread introduction of CT into clinical practice, the diagnosis of cryptogenic organizing pneumonia is still an urgent task of modern radiology. Radiological diagnosticians and clinicians have significant difficulties in diagnosis due to rather low frequency of this disease and nonspecific clinical manifestations. Cryptogenic organizing pneumonia is a disease which sharply worsens the quality of life in case of untimely diagnosis and belongs to the group of idiopathic interstitial pneumonias. The article is devoted to the clinical case of a patient with verified cryptogenic organizing pneumonia. CT of the chest organs, along with clinical data, plays a key role in the accurate diagnosis of organizing pneumonia.
Keywords: cryptogenic organizing pneumonia, organizing pneumonia, idiopathic interstitial pneumonia, computed tomography, “frosted glass”
For citation: Sheikh ZhV, Shvayko SN, Leonova LG, Tarachkova EV, Bogdanova EI, Stepanchenko ES. Cryptogenic Organizing Pneumonia (Clinical Case Report, Literature Review). Medical Radiology and Radiation Safety. 2023;68(6):67–72. (In Russian). DOI:10.33266/1024-6177-2023-68-6-67-72
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2023. Accepted for publication: 27.08.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 6
DOI:10.33266/1024-6177-2023-68-6-80-85
S.N. Prokhorov1, N.V. Kochergina1, 2, A.D. Ryzhkov1, 2,A.S. Krylov1, A.B. Bludov1
The Apparent Diffusion Coefficient in the Diagnosis of Metastatic Lesions of Skeletal Bones
1 N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia
2 Russian Medical Academy of Continuous Professional Education, Moscow, Russia
Contact person: Sergei Nikolaevich Prokhorov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Aim: To evaluate the possibilities of absolute and relative values of the apparent diffusion coefficient (ADC) in the diagnosis of metastatic lesions of skeletal bones.
Material and methods: The study included 12 patients with metastatic bone lesions, before any treatment was applied. The age of the patients ranged from 38 to 73 years, 3 men, 9 women. Among the morphological forms of tumors were presented: cancers of the breast (3), prostate (1) glands, colon (1), lung (2), body (1) and cervix (1) uterus, thyroid (1) and pancreas (2). The detected changes were classified on the basis of Bone scan, SPECT/CT and standard MRI. The ADC values of unchanged bone marrow (n=360), divided by anatomical zones, metastatic foci (n=117), as well as benign changes of various nature (n=19) were analyzed. The ratio of the ADC values of each of the metastatic and benign focal formations to the normal values for each of the localizations was calculated.
Results: Unchanged bone marrow, depending on anatomical localization (cervical, thoracic, lumbar spine, pelvic bones, shoulder blades, collarbones, sternum, ribs, proximal humerus and femur bones) from the point of view of ADC, showed statistically significant heterogeneity. Statistical analysis has shown that there is no connection between the groups of ADC indicators in the foci of metastatic lesions, combined depending on the anatomical localization. With a similar comparison, but by belonging to the primary tumor, an even greater intergroup difference was found. ADC values in the foci of metastatic lesions turned out to be dependent on the morphological type of the primary tumor and significantly differ both from metastases of other morphological affiliation and from normal red bone marrow parameters. The use of relative values allowed to increase the specificity from 15 to 19 %.
Conclusion: This study showed that knowledge of the range of reference ADC values for unchanged red bone marrow and anomalies of various genesis is important in differential diagnosis. The differentiation of the skeleton into separate anatomical zones probably makes it possible to increase the effectiveness of the isolated application of the technique when it comes to absolute values. The morphological affiliation of metastatic foci is important in the formation of ADC values, rather than the bone marrow microenvironment, which is also supported by the low efficiency of the use of relative values.
Keywords: bone metastases, MRI, apparent diffusion coefficient, SPECT/CT, bone scan
For citation: Prokhorov SN, Kochergina NV, Ryzhkov AD, Krylov AS, Bludov AB. The Apparent Diffusion Coefficient in the Diagnosis of Metastatic Lesions of Skeletal Bones. Medical Radiology and Radiation Safety. 2023;68(6):80–85. (In Russian). DOI:10.33266/1024-6177-2023-68-6-80-85
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2023. Accepted for publication: 27.08.2023.