JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 5
DOI:10.33266/1024-6177-2023-68-5-5-10
S.A. Abdullaev1, 4, D.V. Saleeva1, M.V. Dushenko1, 2,
N.F. Raeva1, А.I. Abdullaeva1, G.D. Zasukhina1, 3, A.N. Osipov1, 2
Protective Properties of Compound Aicar in Vivo Exposed to Radiation
1 A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
2 N.N. Semenov Federal Research Center for Chemical Physics, Moscow, Russia
3 N.I. Vavilov Institute of General Genetics, Moscow, Russia
4 Institute of Theoretical and Experimental Biophysics, Pushchino, Russia
Contact person: S.A. Abdullaev, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To study the effect of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) on the survival rate of mice and proportion of polychromatophilic erythrocytes (PCE) in the bone marrow cells with micronuclei (MN), as well as post-irradiation urinary excretion of cell-free nuclear DNA (cf-nDNA) and mitochondrial DNA (cf-mtDNA) in rats.
Material and methods: Male Balb/c mice aged 2 months and Fisher-344 male rats aged 3 months were used. To determine the survival rate of mice, X-irradiation was performed at a dose of 8 Gy, and to analysis the proportion of PCE in the bone marrow cells with MN, at a dose of 2 Gy. Rats were X-irradiated at a dose of 5 Gy. AICAR was administered to animals intraperitoneally at a dose of 400 mg/kg. The drug was administered 30 min before and 20 min after irradiation of the animals. The DNA content was measured by real-time PCR.
Results: The results of the study showed that the introduction of AICAR causes a statistically significant increase in the survival rate of irradiated animals. The greatest effect was shown in the group of mice treated with AICAR 20 min after their irradiation at a lethal dose. The introduction of AICAR before irradiation reduces the proportion of PCE with MN by 30 %, and after irradiation ‒ by 70 %, in comparison to the control. AICAR promoted enhanced urinary excretion of cf-nDNA and cf-mtDNA fragments in rats after irradiation.
Conclusion: The results show that AICAR acts as a radiomitigation effector and promotes active DNA excretion of damaged cell from animal tissues in the post-radiation period.
Keywords: X-rays, AICAR, survival rate, micronuclei, cell-free DNA in the urine, rats, mice
For citation: Abdullaev SA, Saleeva DV, Dushenko MV, Raeva NF, Abdullaeva АI, Zasukhina GD, Osipov AN. Protective Properties of Compound Aicar in Vivo Exposed to Radiation. Medical Radiology and Radiation Safety. 2023;68(5):5–10. (In Russian). DOI:10.33266/1024-6177-2023-68-5-5-10
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The work was carried out on the topic of the A.I. Burnazyan Federal State Budgetary Research Center «Technology-3» (state task
No. 123011300105-3).
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.04.2023. Accepted for publication: 27.05.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 5
DOI:10.33266/1024-6177-2023-68-5-11-18
E.Yu. Moskaleva1, O.V. Vysotskaya1, E.S. Zhorova2, D.A. Shaposhnikova1,
V.P. Saprykin3, I.V. Cheshigin1, O.D. Smirnova1, A.S. Zhirnik1
Late Effects of γ, n-Irradiation of Mice: Shortening of Telomeres and Tumors Development
1 National Research Center “Kurchatov Institute”, Moscow, Russia
2 A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
3 Moscow Institute of Physics and Technology, Dolgoprudny, Russia
Contact person: E.Yu. Moskaleva, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. , This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To investigate the telomere length (TL) of bone marrow and thymus cells as a marker of replicative aging late after the prolonged γ, n-irradiation of mice at low and moderate doses and analysis of the appearance of tumors by the end of the experiment − after
14 months.
Material and methods: C57Bl/6 and CBA mice were irradiated at doses of 10–500 mGy at the OR-M facility using Pu-Be radionuclide sources at a total absorbed dose rate of neutrons and gamma rays of 2.13 mGy/h, 75 % of which – 1.57 mGy/h – accounted for neutrons with an average energy of 3.5 MeV. Absolute TL in bone marrow and thymus cells was determined using real-time PCR 2 months and 1 year
2 months after irradiation, and the mean TL was calculated. Tumors found during the mice organs examination after autopsy were subjected to histological examination.
Results: It was shown that the TL in bone marrow and thymus cells of control CВA mice was 2 times higher than the TL observed in C57Bl/6 mice. Prolonged γ, n-irradiation of C57Bl/6 mice led to a dose-dependent decrease in TL in bone marrow cells 14 months after exposure, which was statistically significant at doses of 100 and 500 mGy. A decreased TL in the thymus was found only at a dose of 500 mGy. During this period, TL in bone marrow cells of CBA mice was reduced in dose-independent manner, starting from as low as 10 mGy, but no statistically significant decrease in TL was found in the thymus. The results obtained indicate the acceleration of replicative senescence of bone marrow cells in mice in the long term period after γ,n-irradiation already at low doses, and in thymus cells only at a dose of 500 mGy. Twenty-four hours after irradiation at doses of 100 and 500 mGy the number of leukocytes in mice of both lines was reduced, which was recovered in C57Bl/6 mice after a week, and in CBA mice – after two weeks. In 14 months after γ, n-irradiation, the appearance of tumors was found in mice of both studied lines: in CBA mice, lung adenocarcinoma at a dose of 50 mGy (in 1 out of 10) and uterine carcinosarcoma at a dose of 500 mGy (in 1 out of 10); in C57Bl/6 mice, keratinizing squamous cell carcinoma of the uterus at a dose of 500 mGy (2 out of 10) was seen in the absence of tumors in control mice. Histological examination of the liver of CBA mice after γ, n-irradiation at a dose of 500 mGy revealed deep dystrophic changes, the causes of which are not clear.
Conclusion: The results obtained indicate a high biological hazard of prolonged γ, n-irradiation at doses above 10 mGy, since after irradiation at this dose, an acceleration of replicative senescence of bone marrow cells in the long-term period was found, and the possibility of tumor formation increases after irradiation at a dose of 50 mGy and higher.
Keywords: γ, n-irradiation, telomere length, bone marrow, thymus, late effects, prolonged exposure, neutrons, low doses, mice
For citation: Moskaleva EYu, Vysotskaya OV, Zhorova ES, Shaposhnikova DA, Saprykin VP, Cheshigin IV, Smirnova OD, Zhirnik AS. Late Effects of γ, n-Irradiation of Mice: Shortening of Telomeres and Tumors Development. Medical Radiology and Radiation Safety. 2023;68(5):11–18.
(In Russian). DOI:10.33266/1024-6177-2023-68-5-11-18
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. SIC «Kurchatov Institute».
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.04.2023. Accepted for publication: 27.05.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 5
DOI:10.33266/1024-6177-2023-68-5-28-33
N.K. Shandala, I.V. Gushchina, A.V. Titov, I.S. Belskikh, V.А. Seregin,
T.A. Doroneva, D.V. Isaev, V.G. Starinskiy, A.A. Shitova
Radiation Situation Around Commissioning Mine No. 6
of Pjsc ‘Priargunskiy Mining and Chemical Production Association’
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: I.V. Gushсhina, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Study of the radioecological situation around mine No. 6 of PJSC ‘Priargunsky Industrial Mining and Chemical Association’ named after E.P. Slavskiy" before commissioning.
Material and Methods: During the radiation survey, to measure the ambient dose equivalent rate, the pedestrian gamma survey method was used using the portable spectrometric complex MKS-01A ‘Multirad-M’ (Russia) and the dosimeter-radiometer MKS-AT6101s (Belarus). To study the specific activity of radionuclides in the soil, samples were taken in accordance with GOST 17.4.3.01-2017. The activity of gamma-emitting radionuclides was measured on a stationary gamma spectrometer manufactured by Canberra (USA). The activity of 210Po and 210Pb was measured on the radiometric system UMF-2000 (Russia) after their radiochemical extraction from samples. Dose assessment of exposure to biological objects was made using dose coefficients established in ICRP Publication 136, considering recommendations R52.18.820-2015.
Results: The results of the study showed that the ambient dose equivalent rate of gamma radiation varied in a wide range from 0.1 to 4.9 µSv/h. The average value in the background areas is 0.14±0.02 µSv/h. The specific activity of natural radionuclides outside the rock dumps, except for 40K, in some areas exceeds the background values up to 10 times. The ecological risk for the considered terrestrial biological objects (grass, shrub, soil worm and mouse-like rodents) does not exceed 10‒2.
Conclusion: There are areas on the territory with traces of anthropogenic activity, which led to man-made radiation contamination. The highest levels of ambient dose equivalent of gamma radiation occur near rock dumps. The rest of the territory has local areas with radioactive contamination. Doses of exposure to biological objects don’t have a significant effect on the incidence, reproduction, and life expectancy of terrestrial biological objects.
Keywords: radioecological survey, mine, the specific activity, bioobject, gamma radiation, natural radionuclides
For citation: Shandala NK, Gushchina IV, Titov AV, Belskikh IS, Seregin VА, Doroneva TA, Isaev DV, Starinskiy VG, Shitova AA. Radiation Situation Around Commissioning Mine No. 6 of Pjsc ‘Priargunskiy Mining and Chemical Production Association’. Medical Radiology and Radiation Safety. 2023;68(5):28–33. (In Russian). DOI:10.33266/1024-6177-2023-68-5-28-33
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. Financing of the work was carried out under State Contract No. 10.002.19.2 with the Federal Biomedical Agency as part of the implementation of the Federal Target Program "Ensuring Nuclear and Radiation Safety for 2016-2020 and for the period up to 2030".
Contribution. N.K. Shandala ‒ development of the concept and design of the study, writing the text of the article. Yu.V. Gushchina ‒ writing and scientific editing of the text of the article. A.V. Titov ‒ development of the concept and design of the study, writing the text of the article.
Yu.S. Belskikh ‒ conducting field research, statistical data processing.
V.A. Seregin ‒ collecting material, statistical data processing. T.A. Dorone-
va ‒ performing laboratory experiments. D.V. Isaev ‒ conducting field research, statistical data processing. V.G. Starinsky ‒ collecting material, statistical data processing. A.A. Shitova ‒ performing laboratory experiments.
Article received: 20.04.2023. Accepted for publication: 27.05.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 5
DOI:10.33266/1024-6177-2023-68-5-19-27
V.V. Vostrotin
Integration of Icrp Oir Models Into the iDose 2 Dosimetry System
Southern Urals Biophysics Institute, Ozyorsk, Russia
Contact person: V.V. Vostrotin, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Introduction: The iDose 2 dosimetry system is a tool for assessing the doses of internal irradiation of workers under the current individual dosimetry control (IDC). In this system, according to a series of measurements of the activity of radionuclides in biological objects (including those not exceeding the detection limit of the measurement technique) and information on contact times and types of compounds, estimates of the committed effective dose equivalent (CEDE) of internal irradiation, as well as their uncertainties, are made based on the Bayesian approach. It is possible to integrate practically any biokinetic models of the behavior of radionuclides in the human body, presented in the form of a system of ordinary differential equations (ODEs) with constant transition coefficients between compartments, into the iDose 2 dosimetry system without changing the source code.
Purpose: Integration of new combined biokinetic models for the list of radionuclides: H-3, Sr-90, Cs-137, Pu-238, Pu-239 and Am-241 from Publications 100, 130, 134, 137 and 141 of the ICRP (conventionally called the series Occupational Intakes of Radionuclides (OIR)), for ingestion and inhalation routes of intake with AMAD = 1 and 5 microns.
Material and methods: For each variant of the biokinetic model, the functions of retention/removal of radionuclides were found through the eigenvectors and eigenvalues of the matrix describing the ODE system.
Results: A total of 65 new biokinetic models and 180 functions of radionuclide retention/removal in the form of a sum of exponents were integrated and quality control was carried out.
Keywords: internal exposure, biokinetic model, individual dosimetry control, Occupational Intakes of Radionuclides (OIR), ICRP, dosimetry system iDose 2, integration of models
For citation: Vostrotin VV. Integration of Icrp Oir Models Into the iDose 2 Dosimetry System. Medical Radiology and Radiation Safety. 2023;68(5):19–27. (In Russian). DOI:10.33266/1024-6177-2023-68-5-19-27
References
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14. Vostrotin V.V., Zhdanov A.N., Efimov A.V. Approbation of the iDose 2 Computer Program in Relation to the Tasks of Individual Dosimetry Control (IDC) of Internal Irradiation of Personnel of FSUE PO “MAYAK” During Inhalation of Plutonium. ANRI. 2017;4:45-54 (In Russ.).
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The author declares no conflict of interest.
Financing. The work was carried out within the framework of the research project “Improving control methods and studying the peculiarities of the formation of internal radiation doses of the personnel of FSUE “PO “Mayak” and the population of adjacent territories”, cipher “Luch-22”, funded by the FMBA of Russia.
Contribution. Conceptual development, creation of R scripts, mathematical calculations and their quality control were carried out by one author.
Article received: 20.04.2023. Accepted for publication: 27.05.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 5
DOI:10.33266/1024-6177-2023-68-5-34-37
A.A. Kosenkov
When the Factor of Crystallized Intelligence
Can Be a Professionally “Undesirable” Personal Quality of Operators
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: A.A. Kosenkov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To discuss the case of oppositely directed influences of the indicators of crystallized and fluid intelligence in the decisive rule designed to predict the professional success of the nuclear power plants (NPPs) operators.
Material and methods: This paper analyzes the results of psychodiagnostic examinations of operators of main control rooms (MCR) of NPPs that functioned under normal conditions. All individuals were administered the J. Raven’s “Progressive matrices”, the Russian language adaptation of the Minnesota Multiphasic Personality Inventory (MMPI) and the Sixteen Personality Factor Questionnaire (16PF, form A). A cross-expert review using the ranking method revealed two groups of operators with relatively higher and lower levels of professional success. The method of canonical correlation analysis has been used to obtain the best linear discriminator for predicting the professional success of MCR operators based on indicators of psychodiagnostic tests.
Results: Based on the results of the expert assessment, two groups of operators with the highest and lowest professional success were identified. Decisive rule were obtained that make it possible to predict the professional success of operators based on a system of signs (values of the psychodiagnostic tests scales multiplied by coefficients) after the data processing using canonical correlation analysis. Unexpected result was that the high values of 16PF factor «B» turned out to be «undesirable» for the prediction of professional success, that is, these values increased the probability of assigning the operator to the group of the lowest successful specialists.
Conclusion: Factor «B» of 16PF was considered as a tool for assessing predominantly crystallized intelligence, and the Raven’s test – for the fluid one. At the same time, there are no methods that allow measuring these indicators in their purest form. Taking this fact into account, the author believes that the true role of factor B in the decisive rule did not reflect the undesirability of advanced crystallized intelligence among MCR operators. It is most likely that its opposition to the «desirable» indicator (the number of correctly solved tasks of the Raven’s test) made it possible to single out the role of fluid intelligence (or some of its lower-level aspects) as a professionally important quality for the particular operator activity.
Keywords: NPP operators, crystallized intelligence, fluid intelligence, psychodiagnostics, Raven’s test, 16PF, factor B, professional success prediction, canonical correlation analysis, expert evaluation
For citation: Kosenkov AA. When the Factor of Crystallized Intelligence Can Be a Professionally “Undesirable” Personal Quality of Operators. Medical Radiology and Radiation Safety. 2023;68(5):34–37. (In Russian). DOI:10.33266/1024-6177-2023-68-5-34-37
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The author declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with one participation of the authors.
Article received: 20.04.2023. Accepted for publication: 27.05.2023.