SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.

The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Issues journals

Medical Radiology and Radiation Safety. 2020. Vol. 65. No. 1. P. 5–12

V.A. Brunchukov, T.A. Astrelina, V.A. Nikitina, I.V. Kobzeva, Yu.B. Suchkova, D.Yu. Usupzhanova, A.A. Rastorgueva, T.V. Karaseva, T.V. Gordeev, O.A. Maxsimova, L.A. Naumova, S.V. Lischuk, E.A. Dubova, K.A. Pavlov, V.A. Brumberg, A.E. Makhova, E.E. Lomonosova, E.I. Dobrovolsskaya, I.M. Barabash, A.Yu. Bushmanov, A.S. Samoilov

Experimental Treatment of Radiation Skin Lesions with Mesenchymal Stem Cells and Their Conditioned Media

A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Purpose: To study the regeneration processes in the treatment of radiation skin lesions with the mesenchymal stem cells (MSC) derived from human gingiva and their conditional medium concentrate (CCM) during animal studies.

Material and methods: The study includes 80 white male Wistar rats weighing 210 ± 30 g at the age of 8–12 weeks, randomized into 4 groups (20 animals in each): control group (C), animal did not receive treatment; control with the introduction of the conditional medium concentrate (CCM) three times on days 1, 14 and 21; the introduction of MSC in a dose of 2 million cells per 1 kg three times on days 1, 14 and 21; the introduction of CCM in the estimated dose of 2 million cells per 1 kg three times on days 1, 14 and 21. Radiation burn simulation was performed (using on an X-ray unit at a dose of 110 Gy) and each animal was observed 17 times: at days 1, 7, 14, 21, 28, 35, 42, 49, 56, 63, 70, 77, 84, 91, 98, 105 and 112. Histological (stained with hematoxylin-eosin) and immunohistochemical (CD31, CD68, and VEGF) studies were performed. MSC was cultivated according to the standard procedure up to passages 3–5, the conditioned medium was collected and concentrated 10 times. The MSC immunophenotype (CD34, CD45, CD90, CD105, CD73, HLA-DR) and viability (7-ADD) were determined using flow cytometry.

Results: Under the assessment of the animal skin on the day 7 in the CCM group, the area was significantly larger compared to the C, MSC, CM groups (р ≤ 0.05). In the CM group on the day 14 the area of the open wound surface and ulcers from day 28 to day 42 was significantly less, compared with the C, MSC and CCM groups (р ≤ 0.05). In group C, from 42 to 77 days of observation, an increase in the area of skin ulcers was observed compared with the CM and CCM groups (р ≤ 0.05). On the day 112, healing of skin ulcers in the CM group was observed in 40 %, in the MSC group in 60 %, and only in 20 % of animals in the CCM group, and in the C group it was not registered. Expression of VEGF marker on endothelial cells and stromal cells was observed in groups C and CM on day 28 and in groups MSCs and CCM on day 112. On the 28th day in the MSC group, the average number of vessels (CD31) in the field of view was 6.0, and on day 112 it was 12.75, р ≤ 0.05, in the CCM group – 19.10 and 28.6, respectively, р ≤ 0.05. An increase in the number of macrophages (CD68) was found in group C from 28 to 112 days (11.6 and 24.73, р ≤ 0.05), and in the CM group the decrease was 22.1 and 13.07, respectively, р ≤ 0.05.

Conclusion: Thus, all used treatment modes of radiation skin lesions, including 3-fold administration of CM, MSC and CCM at a dose of 2 million cells per 1 kg, were effective and resulted in a reduction in the damage area, accelerated ulcer healing, and improvement of the regenerative processes. In addition, the use of MSCs led to the improvement of inflammatory processes’ vascularization and reduction in the radiation skin lesions.

Key words: mesenchymal stem cells, radiation skin lesions, conditioned medium, cellular technologies, X-rays, skin

For citation: Brunchukov VA, Astrelina TA, Nikitina VA, Kobzeva IV, Suchkova YuB, Usupzhanova DYu, Rastorgueva AA, Karaseva TV, Gordeev TV, Maxsimova OA, Naumova LA, Lischuk SV, Dubova EA, Pavlov KA, Brumberg VA, Makhova AE, Lomonosova EE, Dobrovolsskaya EI, Barabash IM, Bushmanov AYu, Samoilov AS. Experimental Treatment of Radiation Skin Lesions with Mesenchymal Stem Cells and Their Conditioned Media. Medical Radiology and Radiation Safety. 2020;65(1):5-0. (In Russ.).

DOI: 10.12737/1024-6177-2020-65-1-5-12

Список литературы / References

  1. Радиационная медицина. Руководство для врачей-исследователей и организаторов здравоохранения. Под ред. Л.А. Ильина. М.: ИздАТ. 2001;(2):432 [Radiation Medicine. A Guide for Medical Researchers and Health Care Organizers. Ed. LA Ilyin. Moscow: Izdat. 2001;(2):432 (In Russ.)].
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PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The study was financially supported by the Federal Target Program “Ensuring Nuclear and Radiation Safety for 2016–2020. and for the period until 2030”. A series of publications is planned based on the results of the studies.

Contribution: Article was prepared with equal participation of the authors.

Compliance with the rules of bioethics. The study was performed in accordance with the ethical standards for the treatment of animals adopted by the European Convention for the protection of vertebrates used for research and other scientific purposes.

Article received: 12.10.2018. Accepted for publication: 11.12.2019

Medical Radiology and Radiation Safety. 2020. Vol. 65. No. 1. P.13–16

S.S. Somov

Determination of Radiation Exposure for Patients with Dental X-Ray Studies

Center of Hygiene and Epidemiology in the Samara Region, Samara, Russia
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Purpose: Improving the quality of radiation assessment of patients of the medical institution of the dental profile using the calculated values of effective doses.

Material and methods: Using the RED-2018 and ORTO-2018 programs, the values of effective patient exposure doses for 29 medical organizations of the dental profile were calculated. The obtained values of the effective dose were compared with the values specified in the methodological recommendations MP 0100 / 1659-07-26 of February 16, 2007 “Filling of forms of federal state statistical observation 3-DOZ”.

Results: The analysis showed that the doses obtained using the RED-2018 and ORTO-2018 computer programs, respectively, are 21 and 14 times lower than the doses indicated in the methodological recommendations MP 0100 / 1659-07-26.

Conclusion: It is shown that the developed computer programs can be applied by a dentist practicing physician who performs an x-ray examination in order to automatically and reliably determine the patient’s dose when performing x-ray-mathematical studies in accordance with the guidelines of MU 2.6.1.2944-11 “Monitoring effective doses of patients during x-ray examinations” also used in the preparation of radiation hygienic passports of organizations and statistical form 3-DOZ. The indication of the actually calculated values of the effective dose of the patient, rather than repeatedly overestimated averages, will reduce the level of radiophobia in society.

Key words: absorbed radiation dose, dose determination, dose per procedure, X-ray diagnostic, dentistry

For citation: Somov SS. Determination of Radiation Exposure for Patients with Dental X-Ray Studies. Medical Radiology and Radiation Safety. 2020;65(1):13-6. (In Russ.).

DOI: 10.12737/1024-6177-2020-65-1-13-16

Список литературы / References

  1. UNSCEAR. Sources and Effects of Ionising Radiation. UNSCEAR 2008 Report to the General Assembly with Scientific Annexes. Volume I, New York, UN, 2010. 683 с.
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  6. Свидетельство о государственной регистрации программы для ЭВМ № 2018613383 «Программа для расчета эффективной дозы облучения пациентов РЭД-2018» (дата государственной регистрации в Реестре программ для ЭВМ 13 марта 2018 г.) [Certificate of state registration of computer program No. 2018613383 «Program for calculating the effective dose of radiation to patients RED-2018» (date of state registration in the Register of computer programs on March 13, 2018) (In Russ.)].
  7. Свидетельство о государственной регистрации программы для ЭВМ № 2018616170 «Программа для расчета эффективной дозы облучения пациентов при рентгенологических стоматологических исследованиях ОРТО-2018» (дата государственной регистрации в Реестре программ для ЭВМ 24 мая 2018 г.) [Certificate of state registration of computer program No. 2018616170 «Program for calculating the effective dose of radiation of patients with dental x-ray studies ORTO-2018» (date of state registration in the Register of computer programs May 24, 2018) (In Russ.)].

PDF (RUS) Full-text article (in Russian)

ORCID авторов/ ORCID authors’
С.С. Сомов / S.S. Somov https://orcid.org/0000-0002-9307-5815

Conflict of interest. The author declares no conflict of interest.

Financing. The study had no sponsorship.

Article received: 15.01.2019. Accepted for publication: 11.12.2019

Medical Radiology and Radiation Safety. 2020. Vol. 65. No. 1. P. 22–26

A.S. Samoylov, Yu.G. Grigoriev

Brain Tumors and Cell EMF Radiobiological Criteria for Assessment Hazardous Population

A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia.
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Over the past ten years, the possibility of developing long-term consequences, in particular brain cancer in mobile phone users, has been actively discussed among the world scientific community. A number of international organizations still have the view that there is no absolute evidence for this. However, the International Agency for Research on Cancer (IARC) of the World Health Organization (WHO) issued an official press release No. 208 of May 31, 2011, which classified radio frequency electromagnetic fields as possibly carcinogenic to the public (Group 2B), which is associated with the use of a mobile phone. This decision was based on the increased risk of developing glioma brain cancer, high malignancy brain cancer.
The IARC decision was preceded by a very long period of scientific confrontation. However, Russian radiobiologists predicted the possibility of developing brain tumors, auditory and vestibular analyzers.

Two classical experiments conducted in the USA (2016) and Italy (2018) – total irradiation of animals for two years or throughout their life from the perinatal period to their natural death, strengthened the opinion of most scientists about the possibility of developing a tumor process with prolonged exposure to RF EMF.

The article discusses the risks of developing brain cancer in users of mobile phones in the early stages of the development of cellular communications. No corresponding correlation was obtained. Further, the results of epidemiological studies obtained in a number of countries (USA, Sweden, Great Britain, Finland) were analyzed during the period of mass use of cellular communications by all segments of the population, including children.

Until now, studies have not been conducted by the international scientific community to justify standards, taking into account the local effects of cellular EMF on the user’s brain. There is no corresponding scientific base. In our opinion, the population is at high risk. We consider it necessary to inform the population about the possible danger of developing a brain tumor. There are serious reasons to strengthen preventive measures aimed at reducing the electromagnetic effect on the population.

Key words: radio-frequency electromagnetic fields, mobile phones, carcinogenic factor, brain tumors

For citation: Samoylov AS, Grigoriev YuG. Brain Tumors and Cell EMF Radiobiological Criteria for Assessment Hazardous Population. Medical Radiology and Radiation Safety. 2020;65(1):22-6. (In Russ.).

DOI: 10.12737/1024-6177-2020-65-1-22-26

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PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 05.11.2019. Accepted for publication: 11.12.2019

Medical Radiology and Radiation Safety. 2020. Vol. 65. No. 1. P. 17–21

A.R. Tukov1, O.N. Prohorova1, Y.V. Orlov1, T.G. Talalaeva2, E.M. Markova2, A.S. Balkanov2, T.G. Bushmanova2

Health Assessment of the Liquidators of the Consequences of the Chernobyl Accident – Workers of the Nuclear Industry of Russia and Residents of the Moscow Region

1. A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia.
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ;
2. M.F. Vladimirsky Moscow Regional Research and Clinical Institute, Moscow, Russia

Abstract

Purpose: A comparative analysis of the health of the liquidators of the consequences of the Chernobyl accident, employees of enterprises and enterprises of the nuclear industry, and residents of the Moscow region.

Material and methods: The information bases of the Industrial Register of Persons Exposed to Radiation from the Chernobyl Accident and the Register of the Liquidators of the Consequences of the Chernobyl NPP Residents of the Moscow Region were used in the work. The development of the material was carried out according to the total morbidity and mortality rates of men + women in 2017 by disease classes (ICD-10). Statistical processing of the material was carried out in the Excel system; morbidity, mortality, their error, indicator structure (%), ratio indicator and reliability of the difference in indicators were calculated (p = 0.05 %).

Results: The results of the study showed that the incidence of some diseases is higher among the liquidators of the consequences of the Chernobyl accident – residents of the Moscow region: incidence of diseases of the skin and subcutaneous tissue (ratio 2.0), urogenital system (ratio 1.7). There was a higher mortality from diseases of the digestive system among the liquidators of the consequences of the Chernobyl accident – residents of the Moscow region (ratio 1.8).

Conclusion: The difference in the health indicators of the studied cohorts can be explained by the difference in their age structure and the difference in dispensary observation. The need for further observation of this cohort of individuals to increase the power of the study is shown.

Key words: radiation accident, Chernobyl nuclear power plant, liquidators, morbidity, mortality, nuclear industry workers, residents of the Moscow region

For citation: Tukov AR, Prohorova ON, Orlov YuV, Talalaeva TG, Markova EM, Balkanov AS, Bushmanova TG. Health Assessment of the Liquidators of the Consequences of the Chernobyl Accident – Workers of the Nuclear Industry of Russia and Residents of the Moscow Region. Medical Radiology and Radiation Safety. 2020;65(1):17-21. (In Russ.).

DOI: 10.12737/1024-6177-2020-65-1-17-21

Список литературы / References

  1. Богова ВС, Махонько МН, Шелехова ТВ, Шкробова НВ, Зайцева МР. Опыт наблюдения за состоянием здоровья ликвидаторов последствий аварии на Чернобыльской АЭС. Bulletin of Medical Internet Conferences. 2012;2(11):656. [Bogova VS, Maxon’ko MN, Shelexova TV, Shkrobova NV, Zajceva MR. The experience of monitoring the health of liquidators of the consequences of the Chernobyl accident. Bulletin of Medical Internet Conferences. 2012;2(11):656 (In Russ.)].
  2. Баранова ОВ, Королева ТМ, Шубик ВМ. Некоторые показатели здоровья ликвидаторов Чернобыльской аварии (отдалённые последствия). Радиационная гигиена. 2012;5(2):20-5. [Baranova OV, Koroleva TM, Shubik VM. Some indicators of health of liquidators of Chernobyl accident (long-term consequences). Radiation Hygiene. 2012;5(2):20-5. (In Russ.)].
  3. Состояние здоровья ликвидаторов аварии на Чернобыльской АЭС. https://www.progettohumus. it/wp-content/uploads/2018/05/Novara1.pdf (Обращение 07.10.2019). [The state of health of the liquidators of the Chernobyl accident. https://www.progettohumus. it/wp-content/uploads/2018/05/Novara1.pdf (Accessed 07.10.2019). (In Russ.)].
  4. Эпидемиологический анализ состояния здоровья участников ликвидации последствий аварии на Чернобыльской АЭС, поживающих на территории Томской области. – Томск, 1999. http://www.biometrica.tomsk.ru/ftp/medicine/chernobyl.html. (Обращение 07.10.2019). [Epidemiological analysis of the health status of participants in the liquidation of the consequences of the Chernobyl accident, living in the Tomsk region. Tomsk, 1999. http://www.biometrica.tomsk.ru/ftp/medicine/chernobyl.html. (Accessed 07.10.2019). (In Russ.)].
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PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 06.11.2019. Accepted for publication: 11.12.2019

Medical Radiology and Radiation Safety. 2020. Vol. 65. No. 1. P.27–36

A.S. Krylov1, A.D. Ryzhkov1, S.V. Shiryaev1, M.O. Goncharov1, M.A. Krylova2, D.A. Komanovskaya1, M.E. Bilik1, S.M. Kaspshik1, E.M. Mikhailova1, E.E. Stanyakina1, A.G. Zhukov3

The Value of 99mTc-MIBI SPECT/CT Imaging in Evaluation of Head and Neck Cancer in Children

1. N.N. Blokhin National Medical Research Center, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
2. Children’s City Polyclinic No. 11 of the Moscow City Health Department, Moscow, Russia
3. Clinical Hospital No. 52 Department of health of Moscow, Moscow, Russia

Abstract

Introduction: Head and neck cancers is a group of cancers that can vary in their histological form and localization. This disease has a high social significance thus it require well-timed and delicate approach, especially in children. We can improve the accuracy of diagnostic methods by using new algorithms and technologies. In this article we reveal the first experience of implementing 99mTc-MIBI SPECT/CT imaging for evaluation of head and neck cancer in children and introduce it as a routine method in Russia.

Purpose: Improve the diagnostic accuracy of head and neck cancer imagining in children by practical application of hybrid SPECT/CT method. Determine diagnostic value of planar scintigraphy and 99mTc-MIBI SPECT/CT of head and neck cancer in children.

Material and methods: This study was performed as a prospective clinical study. Between January 2017 and December 2017, 53 patients which met the inclusion criteria were examined. The inclusion criteria were patients with histologically proven malignancy, age 1–18, weight more than 10 kg, up to date CT or MRI scans (less than two weeks passed from scanning), for initial patients a tumor findings (more than 20 mm in the largest scale). We concluded 61 whole body planar scintigraphy followed by head and neck 99mTc-MIBI SPECT/CT examinations. 10 patients were examined twice, 1 patient was undergoing for this procedure for three times. Initial patients – 23, dynamic – 30. We performed scanning using a hybrid SPECT/CT after 15 minutes 99mTc-MIBI was injected. First stage was standard whole-body planar scintigraphy, second stage SPECT/CT (head and neck).

Results: We evaluated diagnostic accuracy of planar scintigraphy and 99mTc-MIBI SPECT/CT.
Planar scintigraphy sensitivity, specificity, NPV and PPV were 68.8, 96.6, 73.7, 95.7 %. SPECT/CT – 87.5, 96.6, 87.5, 96.6 %.
The verification method was histological examination or follow-up imagining (CT or MRI) during a 12 month period. Additional imagining using hybrid SPECT/CT method allows us to increase sensitivity and NPV of isotope scanning.
Most of false-negative results were obtained after planar scintigraphy, it can be related with image interpretation difficulties caused by equivocal image, especially, in patients during therapy. Six of such patients were correctly diagnosed with SPECT/CT and we revealed the presence of active tumor tissue.
With CT we additionally detected destruction of skull bones in 10 patients.

Conclusion: 1. Diagnostic accuracy of scintigraphy with 99mTc-MIBI is high: Sens. – 68.8 %. 2. We can increase diagnostic accuracy using hybrid methods, and so it plays an important role in final diagnosis: Sens. – 87.5 %, Spec. – 96.6 %. 3. SPECT/CT additionally detected destruction of skull bones even with negative scintigraphy results. 4. A strict clinical reasoning is needed in each individual case. 5. A further evaluation of the diagnostic capabilities of 99mTc-MIBI SPECT/CT in a larger number of patients appears justified.

Key words: SPECT/CT, 99mTc-MIBI, neck and head cancer, oncopediatry

For citation: Krylov AS, Ryzhkov AD, Shiryaev SV, Goncharov MO, Krylova MA, Komanovskaya DA, Bilik ME, Kaspshik SM, Mikhailova EM, Stanyakina EE, Zhukov AG. The Value of 99mTc-MIBI SPECT/CT Imaging in Evaluation of Head and Neck Cancer in Children. Medical Radiology and Radiation Safety. 2020;65(1):27-36. (In Russ.).

DOI: 10.12737/1024-6177-2020-65-1-27-36

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PDF (RUS) Full-text article (in Russian)


Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Informed consent. Parents of patients signed an informed consent for their children to participate in the study.

Article received: 30.10.2019. Accepted for publication: 11.12.2019

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