JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2014. Vol. 59. No. 6. P. 43-48
RADIATION THERAPY
S.I. Tkachev, P.V. Bulychkin, A.V. Berdnik, S.V. Medvedev, A.V. Zavistovsky, R.A. Gutnik, I.P. Yghunovich, U.B. Bykova, I.N. Kurganova, G.I. Hagverdieva
Hypofractionated Salvage Radiation Therapy for Patients with Recurrence Prostate Cancer after Radical Prostatectomy
N.N.Blokhin Russian Cancer Research Center of RAMS. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Creation, implementation and clinical evaluation of hypofractionation salvage radiation therapy (SRT) in patients with recurrent prostate cancer after radical prostatectomy.
Material and methods: There has been created a new scheme of hypofractionation SRT using simultaneous integrated boost for patients with biochemical and clinical recurrence of prostate cancer after radical prostatectomy. There have been evaluated and compared 40 patients who were treated by two methods of radiation therapy (classical fractionation and hypofractionation).
Results: the new scheme of hypofractionation SRT reduces equivalent uniform dose of the rectum and bladder compare classical fractionation SRT. The early biochemical response rates were consistent with expectations from conventional fractionation. Additional follow-up is required to better document the biochemical control. But these results suggest that hypofractionation is a well-tolerated approach for SRT.
Key words: prostate cancer, recurrence, salvage radiation therapy, hypofractionation, simultaneous integrated boost
Medical Radiology and Radiation Safety. 2014. Vol. 59. No. 6. P. 34-42
RADIATION EPIDEMIOLOGY
A.P. Biryukov, E.V. Vasil’ev, S.M. Dumansky, L.N. Belyikh
Information-Analytical Support for Radiation-Epidemiological Research Activities
Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To create the center of storage and data processing (CSDP) for providing information-analytical support of radiation-epidemiological research activities in FSBE Burnasyan FMBC of the FMBA of Russia
Results: It is formulated conceptual principles of forming, functioning and developing CSDP. It is defined that the most appropriate structure of the information-analytical database for CSDP is hybrid model consisting two models – EAV (Entity–Attribute–Value) and classical relationship model. Universal user-interface with remote access was developed for biomedical data entering, processing and analyzing. Radiation-epidemiological available data was integrated into CSDP. This gives an opportunity for researchers who do not know programming skills to use in their work the Business Intelligence (BI) such as On-line Analytic Processing (OLAP) and Data Mining which allow from available information to receive new data and make timely forecasts of development radiation-epidemiological processes. The use of disclosed methodology is shown on the example of OLAP-cube for studying co morbidity of main diseases associated with ionizing radiation
Conclusion: Created prototype CSDP can be recommended not only for research institutes associated with radiation-epidemiology, but also other organizations practicing in their work with large arrays of biomedical information.
Key words: business intelligence, OLAP, EAV, radiation-epidemiological research activities, Center of storage and data processing, Data warehouse
Medical Radiology and Radiation Safety. 2014. Vol. 59. No. 6. P. 18-23
RADIATION SAFETY
A.K. Guskova, M.V. Konchalovske, L.R. Kolganova
Characteristic of Technological Exposure as a Base for Adequate Planning of Research in Radiobiology and Radiation Medicine
Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Definition of man made sources is presented in dynamics starting from the time of ionizing radiation discovery. Change of radiation safety standards is shown by different periods. Circle of individuals involved in contact with man made irradiation is described in dependence on condition of work or residence. Possibilities of quantities evaluation of safety standards keeping are shown. It is characteristic that not only standards are decreased to practically safe level but possibility of their keeping is achieved. That makes actual the role of non-radiation factors. Necessity of significant changes in planning of radiobiological and radiation medicine researches become evident. Study of input of non-radiation factors is very important. The favorable dynamic in exposure levels on territories contaminated previously demand review of their categorizations. Necessity of adequate information on the radiation risk estimation is important as a significant psychological factor.
Key words: man made exposure, doses’ dynamic, main periods, safety standards, actual doses, addressee of information, minimum of information to everybody
Medical Radiology and Radiation Safety. 2014. Vol. 59. No. 6. P. 24-33
RADIATION MEDICINE
T.V. Azizova1, G.V. Zhuntova1, M.B. Moseeva1, E.S. Grigoryeva1, M.V. Bannikova1, Z.D. Belyaeva1, E.V. Bragin1, R. G. E. Haylock2, N. Hunter2
Risk of chronic bronchitis Incidence in the cohort of Mayak PA Nuclear Workers
1. Southern Urals Biophysics Institute of the FMBA of Russia, Ozyorsk, Chelyabinsk region. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Public Health of England, Chilton, United Kingdom
ABSTRACT
Purpose: To assess risk of chronic bronchitis incidence (CB) in Mayak workers cohort accounting for radiation (total external gamma-rays, internal alpha-radiation from incorporated plutonium) and non-radiation factors.
Material and methods: Mayak workers cohort consists of 12210 workers, employed at radiochemical or plutonium production plant from 1948 to 1958. The analysis included 1175 CB cases verified retrospectively based on medical records. Mean total absorbed dose from external gamma-rays to lung (± standard deviation, SD) for the entire follow-up was 0.7±0.9 Gy in males and 0.5±0.7 Gy in females; mean total absorbed dose from internal alpha-radiation to lung was 0.2±0.9 Gy in males and 0.6±2.9 Gy in females. Poisson regression methods were applied to assess relative risk (RR) and 95 % confidence interval (95 % CI) using the AMFIT module of EPICURE. Excess relative risk (ERR/Gy) estimates were calculated using linear dose-response.
Results: Occupational exposure was found to affect CB incidence in Mayak workers. The analysis adjusted for non-radiation factors including smoking has shown statistically significant increase in RR of CB incidence at total absorbed dose from internal alpha-radiation to lung more than 0.1 Gy; ERR/Gy was 1.11 (0.43–2.20)/Gy. External gamma irradiation has shown to affect less distinct: ERR/Gy was 0.14 (0.01–0.32)/Gy of total absorbed gamma-dose to lung, however, categorical analysis shown no statistically significant increase in RR. CB incidence risk among Mayak workers, as well as, in general population increased with attained age and was associated with smoking. Steep increase in CB incidence among Mayak workers before 1960 is to be explained further. Radiation risk estimates for CB incidence are to be clarified further using multivariate analysis with the extended follow-up period, quantitative smoking characteristics and characteristics of industrial aerosols.
Key words: chronic bronchitis, smoking, external gamma-irradiation, internal alpha-irradiation, Mayak PA
Medical Radiology and Radiation Safety. 2014. Vol. 59. No. 6. P. 5-17
RADIATION SAFETY
F.S. Ambesi-Impiombato1, A.A. Ivanov2,3,4, A. Mancini5, O.V. Belov4, A. Borrelli5, A.G. Molokanov6, T.M. Bulynina2,3, S.V. Vorozhtsova2,3, A.N. Abrosimova2,3, E.A. Krasavin4
Effect of Recombinant Manganese Superoxide Dismutase (rMnSOD) on the Hematologic Status in Mice Irradiated by Protons
1. Department of Medical and Biological Sciences, University of Udine, Udine, Italy; 2. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 3. A.I. Burnazyan Federal Medical and Biophysical Center of FMBA, Moscow, Russia; 4. Laboratory of Radiation Biology, Joint Institute for Nuclear Research, Dubna, Russia; 5. Molecular Biology and Viral Oncology Unit, Department of Experimental Oncology, “Istituto Nazionale Tumori “ Fondazione G. Pascale” — IRCCS, Naples, Italy; 6. Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, Dubna, Russia
ABSTRACT
Purpose: To study therapeutic properties of the human recombinant Manganese Superoxide Dismutase (rMnSOD) in mice exposed to the proton radiation.
Material and methods: Using the model of sublethal whole-body irradiation with protons available at Phasotron of the Joint Institute for Nuclear Research (Dubna, Russia), we reconstructed the bone-marrow form of the acute radiation syndrome in mice to test the therapeutic effect of rMnSOD. Male C57Bl/6 SPF mice with the average weight of 24 g were exposed to 171 MeV proton beam at the dose of 4 Gy and then subcutaneously treated with either rMnSOD or physiological solution.
Results: After irradiation, the daily subcutaneous treatment with rMnSOD for 6 days, has provided a statistically significant acceleration of the recovery of thymus and spleen mass and of the number of leukocytes in mice peripheral blood. In contrast mock-treated, irradiated control mice did not demonstrate these positive effects at day seven after exposure. The number of nucleated cells in the bone marrow of irradiated mice has even exceeded its basal level in the control group seven days after irradiation. The rMnSOD-treated group has thus demonstrated a significant hyper restoration of their normal characteristic.
Conclusion: The results on the state of organs of the immune system and hemopoiesis indicate a significant therapeutic effect of rMnSOD in treating the acute radiation disease induced by a sublethal dose of proton irradiation.
Key words: superoxidedismutase, rMnSOD, proton radiation, acute radiation syndrome, hematopoiesis, experimental therapy