Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 2. P. 5-8

RADIATION BIOLOGY

K.V. Kotenko, B.B. Moroz, Yu.B. Deshevoy, T.A. Nasonova, O.A. Dobrynina, V.G. Lebedev, A.V. Lirshikova, I.I. Eremin

Syngenic Multipotent Mesenchymal Stromal Cells in the Treatment of Persisted Radiation Skin Ulcers in the Experiment

A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: The effectiveness of syngenic multipotent mesenchymal stromal cells (MMSC) in treatment of persisted radiation skin ulcers caused by relatively soft x-ray was studied.

Material and methods: Experiments were carried out on rats by the inbreed strain Wistar-Kyoto. Rats had been irradiated locally in lumbar-iliac region using x-ray machine RAP 100-110 with the dose of 110 Gy (30 kV tube voltage, current 6.1 ma, thick Al filter 0.1 mm). Dose rate is 173 Gy/min. 27 rats (from 40 being irradiated) with expanded radiation skin ulcers of the were selected on day 84 after exposure to radiation. This group of animals were divided into three groups (in accordance with the dimensions and clinical course of ulcers) Two groups of rats have been treated with transplantation of MMSC isolated from bone marrow and developed in vitro: once (in 85 days) or twice(on 85 and 93 days). MMSC (1.7×106 cells per injection) was injected under the skin around the radiation ulcer. The third group was the control.

Results: The double imposition of syngenic MMSC stimulated healing of persisted radiation ulcers, that became clear from 93 to 111 days after exposure.

Conclusion: The findings suggest that singenic MMSC can be effective in the treatment of persisted radiation skin ulcers.

Key words: multipotent mesenchymal stromal cells, X-ray, radiation skin ulcers

REFERENCES

1. Radiatsionnaya meditsina. Rukovodstvo dlya vrachei-issledovatelei i organizatorov zdravookhraneniya. In L.A. Il'ina (ed.). Moscow: Publ. AT. 2001. Vol. 2. 432 p. (In Russ.).
2. Bushmanov A.Yu., Nadezhina N.M., Nugis V.Yu., Galstyan I.A. Mestnye luchevye porazheniya kozhi cheloveka: vozmozhnosti biologicheskoi indikatsii dozy (analiticheskii obzor). Medical Radiology and Radiation Safety. 2005. Vol. 50. No. 1. P. 37-47. (In Russ.).
3. Selidovkin G.D. Meditsinskaya pomoshch' pri radiatsionnoi avarii s istochnikom tseziya-137 v Brazilii (1987). V kn. «Meditsinskie aspekty avarii na Chernobyl'skoi atomnoi stantsii». Kiev: Zdorov'e. 1988. P. 180-185. (In Russ.).
4. Moroz B.B., Onishchenko N.A., Lebedev V.G. et. al. Vliyanie mul'tipotentnykh mezenkhimal'nykh stromal'nykh kletok kostnogo mozga na techenie mestnykh luchevykh porazhenii u krys posle lokal'nogo β-oblucheniya. Radiats. biologiya. Radioekologiya. 2009. Vol. 49. No. 6. P. 688-693. (In Russ.).
5. Kotenko K.V., Moroz B.B., Nadezhina N.M. et. al. Transplantatsiya mezenkhimal'nykh kletok pri lechenii luchevykh porazhenii kozhi. Patol. fiziologiya i eksper. terapiya. 2011. No. 1. P. 2-7. (In Russ.).
6. Kotenko K.V., Eremin I.I., Moroz B.B. et. al. Kletochnye tekhnologii v lechenii radiatsionnykh ozhogov: opyt FMBTs im. A.I. Burnazyana. Kletochnaya transplantologiya i tkanevaya inzheneriya. 2012. Vol. 7. No. 2. P. 97-102. (In Russ.).
7. Kotenko K.V., Moroz B.B., Nasonova T.A. et. al. Eksperimental'naya model' tyazhelykh mestnykh luchevykh porazhenii kozhi posle deistviya rentgenovskogo izlucheniya. Patol. fiziologiya i eksper. terapiya. 2011. No. 4. P. 121-123. (In Russ.).
8. Chertkov I.L., Gurevich O.A. Stvolovaya krovetvornaya kletka i ee mikrookruzhenie. Moscow: Meditsina. 1984. 238 p. (In Russ.).
9. Clark R.A.F., Nielsen L.D., Welch M.P., McPherson J. Collagen matrices attenuate the collagen-synthetic response of cultured fibroblasts to TGF-b. J. Cell. Sci. 1995. Vol. 108. P. 1251-1261.
10. Klein G. The extracellular matrix of the hematopoietic micro­environment. Experientia. 1995. Vol. 51. P. 914-926.
11. Prockop D.J. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science. 1997. Vol. 276. P. 71-74.
12. Pittenger M.F., Mackay A.M., Beck S.C. et al. Multilineage potential of adult human mesenchymal stem cells. Science.1999. Vol. 284. No. 2. P. 143-147.
13. Reese J.S., Koc O.N., Geson S.L. Human mesenchymal stem cells provide stromal support for efficient CD 34+ transduction. J. Hematother. Stem Cell Res., 1999. Vol. 8. P. 515-523.
14. Conget P.A., Minguell J.J. Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells. J. Cell Physiol. 1999. Vol. 181. P. 67-73.
15. Cheng L., Qasba P., Vanguri P. et al. Human mesenchymal stem cells support megakaryocyte and proplatelet formation from CD 34+ hematopoietic progenitor cells. J. Cell Physiol. 2000. Vol. 184. P. 58-69.
16. Minguell J.J., Erices A., Conget P. Mesenchymal stem cells. Exp. Biol. Med. 2001. Vol. 226. No. 6. P. 507-520.

For citation: Kotenko KV, Moroz BB, Deshevoy Yu.B, Nasonova TA, Dobrynina OA, Lebedev VG, Lirshikova AV, Eremin II. Syngenic Multipotent Mesenchymal Stromal Cells in the Treatment of Persisted Radiation Skin Ulcers in the Experiment. Medical Radiology and Radiation Safety. 2015;60(2):5-8. Russian.

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Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 3. P. 61-64

RADIATION THERAPY

V.V. Velikaya^1,2, L.I. Musabaeva^1,2, A.N. Aleinik², O.V. Gribova^1,2, Zh.A. Startseva^1,2, K.A. Simonov^1,2, V.A. Lisin^1,2

Use of Ozone Therapy in Patients with Recurrent Breast Cancer after Neutron and Neutron-Photon Therapy

1. Tomsk Cancer Research Institute, Tomsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. National Research Tomsk Polytechnic University, Tomsk, Russia

ABSTRACT

Purpose: To present cases of use of developed method of ozone therapy in patients with radiation injury of normal tissues after neutron and neutron-photon therapy.

Material and methods: Four patients with radiation-induced damage to the skin after neutron and neutron-photon radiation therapy delivered to the area of breast cancer local recurrence were examined. The method of ozone therapy (RF patent number 2,521,371 on 04/30/14). for the treatment of radiation damage after neutron and neutron-photon radiation was developed together with the Department of Applied Physics of Tomsk Polytechnic University.

Results: Ozone therapy was well tolerated in patients with radiation-induced skin injuries. In three cases ozone therapy resulted in decrease in purulent discharge, flattening of ulcer’s edges, appearance of granulation tissue and restoration of healthy tissue’s sensitivity. In the fourth case complete ulcer healing was observed.

Conclusion: The method of ozone therapy devised for the treatment of patients with radiation ulcer caused by neutron and neutron-photon therapy showed very positive effect.

Key words: breast cancer recurrence, neutron therapy, radiation-induced reactions and damages, ozone therapy

REFERENCES

1. Alyasova A.V., Kontorshchikova K.N., Shakhov B.E. Ozonovye tekhnologii v lechenii zlokachestvennykh opukholei. Publ. Nizhegorodskoi gosudarstvennoi meditsinskoi akademii. 2006. 204 p. (In. Russ.).
2. Titova V.A., Shipilova A.N., Kreinina Yu.M. et al. Sistemnaya i lokal'naya ozonoterapiya v profilaktike oslozhnenii, vyzvannykh mnogokomponentnym lecheniem zlokachestvennykh opukholei. MMedical Radiology and Radiation Safety. 2007. Vol. 52. No. 4. P. 47-52. (In. Russ.).
3. Musabaeva L.I., Lisin V.A., Zhogina Zh.A., Velikaya V.V. Neitronnaya i neitronno-fotonnaya terapiya v lechenii mestno-rasprostranennykh form raka molochnoi zhelezy i mestnykh retsidivov. Prakticheskaya meditsina. 2009. No. 4 (36). P. 45-46. (In. Russ.).
4. Gribova O.V., Musabaeva L.I., Choinzonov E.L., Lisin V.A. Neitronno-fotonnaya terapiya v kombinirovannom i luchevom lechenii bol'nykh s prognosticheski neblagopriyatnym rakom shchitovidnoi zhelezy. Med. fizika. 2009. No. 2. P. 41-46. (In. Russ.).
5. Tuzikov S.A., Musabaeva L.I., Zhogina Zh.A. Sluchai odnomomentnoi plastiki molochnoi zhelezy posle predoperatsionnogo kursa neitronnoi terapii u bol'noi rakom molochnoi zhelezy. Medical Radiology and Radiation Safety. 2002. Vol. 47. No. 3. P. 45-47. (In. Russ.).
6. Lisin V.A. Dozimetricheskoe komp'yuternoe planirovanie terapii zlokachestvennykh opukholei puchkom bystrykh neitronov tsiklotrona U-120. Med. radiologiya. 1991. Vol. 36. No. 1. P. 26-28. (In. Russ.).
7. Lisin V.A. Dozimetricheskoe planirovanie gamma-neitronnoi terapii zlokachestvennykh opukholei s ispol'zovaniem tsiklotrona U-120. MMedical Radiology and Radiation Safety. 1994. Vol. 39. No. 5. P. 53-57. (In. Russ.).
8. Lisin V.A. Metod rascheta raspredeleniya pogloshchennoi dozy puchka bystrykh neitronov tsiklotrona U-120 v biologicheskoi tkani. Meditsinskaya radiologiya. 1990. Vol. 35. No. 1. P. 45-47. (In. Russ.).
9. Zyryanov B.N., Evtushenko V.A., Kitsmanyuk Z.D. Nizko­intensivnaya lazernaya terapiya v onkologii. Tomsk: STT. 1998. 336 p. (In. Russ.).
10. Zyryanov B.N., Musabaeva L.I., Udalyi I.F. Sposob lecheniya luchevogo epidermatita. Avt. svid. No. 1768181. 1992. (In. Russ.).
11. Velikaya V.V., Musabaeva L.I., Aleinik A.N., Simonov K.A., Startseva Zh.A. Sposob lecheniya luchevykh povrezhdenii kozhi III-IV stepeni na polyakh oblucheniya posle neitronnoi terapii u bol'nykh mestnymi retsidivami raka molochnoi zhelezy. Patent RF No. 2521371 ot 30.04.2014. (In. Russ.).
12. Musabaeva L.I., Velikaya V.V., Zhogina Zh.A., Velichko S.A. Risk luchevykh povrezhdenii normal'nykh tkanei pri neitronnoi i neitronno-fotonnoi terapii mestnykh retsidivov raka molochnoi zhelezy. Vestnik Rossiiskoi voenno-meditsinskoi akademii. 2008. No. 3 (23). Suppl. 1. P. 182. (In. Russ.).

For citation: Velikaya VV, Musabaeva LI, Aleinik AN, Gribova OV, Startseva ZhА, Simonov КА, Lisin VA. Use of Ozone Therapy in Patients with Recurrent Breast Cancer after Neutron and Neutron-Photon Therapy. Medical Radiology and Radiation Safety. 2015;60(3):61-4. Russian.

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Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 3. P. 65-78

REVIEW

V.S. Kalistratova, I.K. Belyaev, E.S. Zhorova, I.M. Parfenova, G.S. Tischenko

Prophylaxis of Radiation and Chemical Carcinogenesis Using Vitamin A and Its Precursor Beta-Carotene (Experimental and Clinical Studies)

A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Objective: To summarize our own and literature data on the anti-cancer effect of carotenoids obtained in experiments on laboratory animals and clinical studies.

Content: The mechanism of the antitumor effect of vitamin A and beta-carotene, prevention and treatment of chemical and radiation carcinogenesis, long-term consequences for external whole-body irradiation and incorporation of radionuclides (¹³⁷Cs, HTO, ¹³¹I, ²³⁸Pu, ⁹⁰Sr).

Conclusions: It was found that experimental and clinical positive antitumor effects when used carotenoids in the case of chemical and radiation carcinogenesis (increased life expectancy, the latent period and the incidence of some types of tumors) require additional research.

Key words: carcinogenesis, prevention, radiation, chemical factor, laboratory animals, experimental studies, clinical studies, retinol, beta-carotene

REFERENCES

1. Zhuravlev V.F. Vliyanie vitamina A, retinoidov i β-karotina na kantserogenez. V kn. «Metabolizm i biologicheskoe deistvie radionuklidov pri oral'nom postuplenii v organizm». In V.S. Kalistratovoi (ed.). Moscow. 1989. P. 228-237. (In Russ.).
2. Vilenchik M.M. et al. Radiozashchitnoe deistvie prirodnykh karotinsoderzhashchikh preparatov: issledovanie karotina na belykh krysakh. Radiobiologiya. 1988. Vol. 28. No. 4. P. 542-544. (In Russ.).
3. Belyaev I.K., Zhorova E.S., Zalikin G.A. et al. Problemy modifikatsii beta karotinom radiatsionnogo kantserogeneza v eksperimente. V sb. «Problemy normirovaniya ioniziruyushchikh izluchenii v usloviyakh vozdeistviya modifitsiruyushchikh faktorov». Moscow. 1991. P. 142-151. (In Russ.).
4. Lemberg V., Kirillova Ye., Rogacheva S. et al. Prophylactic radioprotective effect of beta carotene. In «Problems of Setting up Standards for Ionizing Radiations with Modifying Factors Present». In Buldakov, V. Kalistratova (eds.). Moscow. 1991. P. 127-130.
5. Morozkina T.S. Rol' vitaminov E i C v razvitii zlokachestvennogo protsessa. Eksperim. onkologiya. 1986. No. 3. P. 3-10. (In Russ.).
6. Bukin Yu.V. Vitaminy i beta karotin v profilaktike zlokachestvennykh novoobrazovanii (itogi i perspektivy). Vopr. Pitaniya. 1993. No. 4. P. 912. (In Russ.).
7. Sanders G.L., Mahaffer I.A. Action of vitamin C on pulmonary cancerogenesis from inhaleted ²³⁹PuO₂. Health Phys. 1983. Vol. 45. No. 3. P. 794-798.
8. Kalistratova V.S., Belyaev I.K., Nisimov P.G. Profilaktika otdalennykh posledstvii, vyzvannykh inkorporirovannymi radionuklidami, pri pomoshchi vitaminov, ikh sinteticheskikh proizvodnykh i provitaminov. Tez. dokl. Vtorogo Mezhdunarod. simpoziuma «Pitanie i zdorov'e: biologicheski aktivnye dobavki k pishche». Moscow. 1996. P. 57-59. (In Russ.).
9. Kalistratova V.S. Vliyanie modifitsiruyushchikh faktorov na luchevoi kantserogenez. V kn. «Metabolizm i biologicheskoe deistvie radionuklidov pri oral'nom postuplenii v organizm». In V.S. Kalistratovoi (ed.). Moscow: MZ SSSR, In-t biofiziki. 1989. P. 219-228. (In Russ.).
10. Seifter E., Returra Y., Padaver I. Morbidity and Mortility Redution by Supplemental vitamin A or b-carotene in CBA Mice Given Total-body β-radiation. INCI. 1984. Vol. 75. No. 5. P. 1167-1177.
11. Trol'kis V.V. Eksperimental'nye puti prodleniya zhizni. Leningrad. 1988. 247 p. (In Russ.).
12. Belyaev I., Zhorova Ye., Ilyin L. Modification of late effects of incorporated strontium-90 with synthetic beta-carotene. In: Proceedings of a Congress on Radiobiology, Kiev. 20-25 September 1993. Pushino. 1993. P. 101-102.
13. Shashkina M.Ya., Shashkin N.P., Sergeev A.V. Karotinoidy kak osnova dlya sozdaniya lechebno-profilakticheskikh sredstv. Ross. Bioterap. journal. 2009. No. 4. P. 91-98. (In Russ.).
14. Korostylev S.A. Farmakologiya i mekhanizm antikantserogennogo deistviya karotinoidov. Avtoreferat diss. dokt. med. nauk. Moscow. 2002. 42 p. (In Russ.).
15. King M.M., Ml. Cay P. Modulation of tumor incidence and mechanismus of inhibition of mammary carcinogenesis by dietary antioxidants. Cancer Res. 1983. No. 5. P. 2485-2490.
16. Bolieva L.Z. Eksperimental'no-klinicheskoe obosnovanie primeneniya mikronutrientov i nesteroidnykh protivovospolitel'nykh preparatov v profilaktike zlokachestvennykh novoobrazovanii. Diss. dokt. med. nauk. Moscow. 2005. 248 p. (In Russ.).
17. Korostelev S.A., Sherenesheva N.I. Immunomoduliruyushchaya i antikantserogennaya aktivnost' karotinoidov. Voprosy med. khimii. 1992. Vol. 4. P. 42-45. (In Russ.).
18. Heywood R., Ralmer A. K., Iregson R. et al. The toxicity of beta-carotene. Toxicology. 1985. Vol. 36. No. 2-3. P. 91-100.
19. Petrunyaka V.V. Sravnitel'noe raspredelenie i rol' karotinoidov i vitamina A v tkanyakh zhivotnykh. J. evolyuts. biol. fiziol. 1979. Vol. 15. Ed. I. P. 97-103. (In Russ.).
20. Karnaukhov V.N. Funktsii karotinoidov v kletkakh zhivotnykh. Moscow. 1973. 48 p. (In Russ.).
21. Kondrusev A.I., Spirichev V.B., Chertkov K.S., Rymanenko T.V. Vitaminy i ioniziruyushchaya radiatsiya. farm. journal. 1990. No. 1. Part. 1. P. 4-12. (In Russ.).
22. Kuzin A.M., Vilenchik M.M. Problema sinergizma v radiatsionnom kantserogeneze i vozmozhnye puti snizheniya kantserogennogo riska. Pushchino. 1985, 36 p. (In Russ.).
23. Lidak M.Yu., Pletsityi K.D. Vitamin A i sinteticheskie retinoidy v immunologii i onkologii. Riga. 1984. 127 p. (In Russ.).
24. Rumbesht V.N., Polyak A.I., Nikolaeva N.I., Rumbesht L.M. Vliyanie kompleksa zhirorastvorimykh vitaminov na razvitie indutsirovannykh opukholei i nekotorye pokazateli immunologicheskoi reaktivnosti organizma. Eksperim. onkol. 1983. Vol. 5. No. 3. P. 43-45. (In Russ.).
25. Wald N., Boreham J., Hayward G.I. et al. Plasma retinol β-carotene and vitamin E levels in relation to the future risk of breast cancer. Brit. J. Cancer. 1984. Vol. 49. No. 3. P. 321-324.
26. Bukin Yu.V., Pozdnyakov S.P. Regressiya limfosarkomy Plissa u krys i nekotorye biokhimicheskie pokazateli v usloviyakh gipoavitaminoza A. Byul. eksperim. biol. i med. 1984. Vol. 97. No. 7. P. 65-68. (In Russ.).
27. Villani C. et al. Correluziini tru vitaminu o neoplasie ginecologii he. Pat e clin istete ginecol. 1983. Vol. 11. No. 6. P. 26-33.
28. Baglei E.A., Danko M.I., Grinevich Yu.P. et al. Modifikatsiya kantserogeneza antioksidantami i preparatami polinasyshchennykh zhirnykh kislot. Bioantioksidanty, Chernogolovka. 1983. P. 64-65. (In Russ.).
29. Kondrusev A.I., Spirichev V.B., Chertkov K.S., Rymanenko T.V. Vitaminy i ioniziruyushchaya radiatsiya. farm. journal. 1990. No. 2. P. 11-12. (In Russ.).
30. Nozhenko A.A. 1960 (quotation by 29 (bibliography)). (In Russ.).
31. Ershoff B., Greenberg. Quoted by Pospishil Ya., Pouchkova P., Polivkova I., Gloushkova D. Radiatsiya i gemostaz. In Baludy V.P. (ed.). Moscow. 1986. 160 p.
32. Hunt T. 1969 (quotation by 31 (bibliography)).
33. Bean J. 1944 (quotation by 31 (bibliography)).
34. Belyaev I.K., Zhuravlev V.F., Stepanov S.V., Zaraiskii A.V. Radiozashchitnaya effektivnost' karotinila pri vneshnem i vnutrennem ostrom obluchenii. Radiobiologiya. 1992. Vol. 32. No. 1. P. 121-125. (In Russ.).
35. Levenson S. Nutrition factor in the Induction. Maintenance of Malignancy. New York. 1983. P. 169.
36. Kalistratova V.S., Ivanov L.A., Pomerantseva M.D. et al. Otsenka toksichnosti i biologicheskogo deistviya naibolee znachimykh radionuklidov: ¹³¹I, ¹³⁷Cs, ⁹⁰Sr, ²³⁹ V kn. «Radioaktivnoe zagryaznenie okruzhayushchei sredy i zdorov'e naseleniya». In Vasilenko I.Ya. (ed.). Moscow. Meditsina. 2004. P. 155-163. (In Russ.).
37. Belyaev I.K., Zaraiskii A.V., Vakulova L.A. et al. Profilaktika beta karotinom radiatsionnykh (⁹⁰Sr) porazhenii gonad. V kn. «Problemy normirovaniya ioniziruyushchikh izluchenii v usloviyakh vozdeistviya modifitsiruyushchikh faktorov». In Buldakova L.A., Kalistratovoi V.S. (eds.). Moscow. 1991. P. 151-159. (In Russ.).
38. Kalistratova V.S., Kalistratov G.V., Ivanov A.A., Nisimov P.G. Sostoyanie problemy profilaktiki otdalennykh posledstvii, vyzvannykh inkorporirovannymi radionuklidami. Mater. 3-go S"ezda po radiatsionnym issledovaniyam. Moscow 1997. P. 442-443. (In Russ.).
39. Kalistratova V.S., Zhorova E.S., Belyaev I.K., Parfenova I.M. Problemy uskoreniya vyvedeniya radioaktivnykh veshchestv iz organizma. Medical Radiology and Radiation Safety. 2012. Vol. 57. No. 1. P. 5-16. (In Russ.).

For citation: Kalistratova VS, Belyaev IK, Zhorova ES, Parfenova IM, Tischenko GS. Prophylaxis of Radiation and Chemical Carcinogenesis Using Vitamin A and It`s Precursor Beta-Carotene (Experimental and Clinical Studies). Medical Radiology and Radiation Safety. 2015;60(3):65-78. Russian.

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Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 3. P. 58-60

RADIATION MEDICINE

A.K. Guskova

The Health of People Working at Nuclear Energy Facilities over the
Last 20-25 Years and also Using Radiation Sources in Different Branches of National Economy. The Main Difficulties in Estimation of the Mentioned Cohort and the Reasons for Incorrect Data Interpretation

A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia

ABSTRACT

The results of 20-25 years of observations on the state of health of large numbers of people will be evaluated. It will be estimated the real levels and effects of radiation also with more higher than normal doses. It is difficult to find adequate control group, but it is of interest to compare the health status of this group with other cohorts, working in enterprises generate energy in other ways. This is particularly important because these places are often used for employment of persons whose work with radiation sources to the accepted rules is prohibited. It remains unclear what extent the prognostic criteria for evaluation of the health status confirm pricing real changes after different periods from the beginning of radiation exposure. It is clear that the impact of the multiple non-radiation factors and aging of workers (from 20-22 to 45-50 years) is underestimated

Key words: norms of ionizing radiation, safe levels of radiation, personnel’s health, risk factors, sources of unfavorable influences, the prognosis of the consequences

REFERENCES

1. Torubarov F.S., Zvereva Z.F. Nevrologicheskie aspekty ostroi luchevoi bolezni cheloveka (klinicheskie nablyudeniya). Rukovodstvo dlya nevrologov, profpatologov, spetsialistov v oblasti eksperimental'noi meditsiny, prepodavatelei profil'nykh vuzov. In A.K. Gus'kovoi (ed.). Moscow: FGU FMBTs im. A.I. Burnazyana FMBA Rossii. 2009. 207 p. (In Russ.).

For citation: Guskova AK. The Health of People Working at Nuclear Energy Facilities over the Last 20-25 Years and also Using Radiation Sources in Different Branches of National Economy. The Main Difficulties in Estimation of the Mentioned Cohort and the Reasons for Incorrect Data Interpretation. Medical Radiology and Radiation Safety. 2015;60(3):50-60. Russian.

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