SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.

The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Issues journals

Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 1. P. 54-61

RADIATION PHYSICS, TECHNOLOGY AND DOSIMETRY

L.Ya. Klepper

Formation Optimum Doses Fields in Interstitial Radiotherapy as the Problem of the Covering of the Target by Circles of Identical Radius

Central Economic Mathematical Institute of RAS, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

The purpose of work consists in description of the problem of optimum sources accommodation in a target at interstitial radiotherapy of malignant tumor by methods of the «Parisian grid» and methods of optimum sources accommodation which are reduced to problems of an optimum covering of a target by identical circles of the minimal radius. Connection between two methods is tracked. It is shown, that particular decisions can be equivalent to the «Parisian grid» method. Examples of the problem decision and the analysis of the decisions received are presented.

Key words: interstitial radiotherapy, optimum distribution of intrastats

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  10. Klepper L.Ya., Ushkova V.L. Optimal'noe raspredeleniya sistemy parallel'nykh intrastatov pri vnutritkanevoi luchevoi terapii (svoistvo kvazi-invariantnosti). Med. fizika. 2011. No. 3. P. 5-13.
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  13. Klepper L.Ya., Ushkova V.L. Optimal'naya i «Parizhskaya sistema» razmeshcheniya istochnikov v vnutritkanevoi luchevoi terapii zlokachestvennykh opukholei. Med. fizika. 2008. No. 3. P. 29-34.
  14. Saati T. Tselochislennye metody optimizatsii i svyazannye s nimi ekstremal'nye problemy. Moscow: Mir. 1973. 213 p.
  15. Klepper L.Ya., Antipina N.A. Opredelenie veroyatnosti izlecheniya opukholevogo zabolevaniya pri vnutritkanevoi luchevoi terapii zlokachestvennykh novoobrazovanii. Med. fizika. 2006. No. 4. P. 30-41.
  16. «Bebig». Novye i usovershenstvovannye meditsinskie tekhnologii. Tekhnologiya vnutritkanevoi luchevoi terapii zakrytymi istochnikami I-125 lokalizovannogo raka predstatel'noi zhelezy. Brakhiterapiya». OOO «Bebig». 2006. 20 p.

For citation: Klepper LYa. Formation Optimum Doses Fields in Interstitial Radiotherapy as the Problem of the Covering of the Target by Circles of Identical Radius. Medical Radiology and Radiation Safety. 2015;60(1):54-61. Russian.

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 1. P. 45-53

REVIEW

V.Y. Kovtun1, V.D. Gladkih1, Y.A. Davidovuch1, E.S. Zhorova2, V.V. Ogorodnikova1, I.K. Belyaev2, V.I. Krasnjuk2

Drug Formulation of the Ca-DTPA and Zn-DTPA

1. Federal State Establishment Science and Engineering Сenter «Pharmzashchita» FMBA of Russia, Khimki, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia

ABSTRACT

Purpose: To analyze modern approaches to using of therapeutic forms of DTPA (Ca-DTPA and a Zn-DTPA) for enhance the elimination of transuranium elements and decrease the dose formation of internal exposure.

Materials and methods: The content-analysis of publications related to development, pharmacokinetics and practical using of chelating compounds.

Results: Among the complexons used for prevention and treatment of radionuclide incorporation in the developed countries (the USA, the European community, Japan, China) for medical using allowed Ca-DTPA and Zn-DTPA as inhalations and injection solutions. In Russia Ca-DTPA only is allowed. The comparative characteristic of properties Ca-DTPA and Zn-DTPA testifies to basic uniformity of their biological effect. At the same time Zn-DTPA is characterized by less expressed toxicity and selectivity of action concerning nuclides. Hundreds of patients have been treated with Zn-DTPA; its efficiency, safety and smaller toxicity were shown. In Russia this compound isn’t allowed for medical use. It is necessary to make the maximum efforts for correction of such situation.

Conclusions: Considering features of biological effect of Ca-DTPA and Zn-DTPA the expedient scheme of treatment can be proposed: first Ca-DTPA, second Zn-DTPA. This scheme increases efficiency and reduces negative manifestations of prolonged using of Ca-DTPA in the monotherapy mode.

Key words: chelate, drug formulation, pentacinum, zinkacinum, internally deposited transuranic elements, drug for removing

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For citation: Kovtun VY, Gladkih VD, Davidovuch YA, Zhorova ES, Ogorodnikova VV, Belyaev IK, Krasnjuk VI. Drug Formulation of the Ca-DTPA and Zn-DTPA. Medical Radiology and Radiation Safety. 2015;60(1):45-53. Russian.

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 1. P. 33-38

RADIATION THERAPY

O.P. Trofimova, O.I. Cheban, Z.P. Mikhina, S.V. Medvedev, Ju.I. Prjamikova, N.P. Schipilina, E.V. Timoshkina, E.V. Poddubskaya, A.A. Maklakova, N.V. Vekova, O.C. Zaichenko, A.V. Berdnik, Ju.V. Bikova, M.P. Baranova, I.P. Kovalenko, L.E. Rotobelskaya, S.I. Tkachev

Cardiovascular Complications in Patients with Breast Cancer After Breast-Conserving Treatment

N.N.Blokhin Russian Cancer research center, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: To evaluate the radiation dose on the heart in patients with left-sided localization of breast cancer receiving radiation therapy after breast-concerving treatment on the free breath and breath-hold at a deep breath.

Material and methods: The study included 113 patients with verified breast cancer T1-2N0-1M0 st. with left-sided localization of tumors who were treated in the N.N. Blokhin Russian Cancer Research Center in 2012-2013. Patients were treated with radical organ resection followed by radiation therapy. Radiation therapy (RT) on the free breath was carried out in 53 patients and on breath-hold at deep breaths in 60 patients. RT - 5 times per week dose 2 Gy per day to a total dose of 50 Gy. Radiation dose distribution in under risk organs was assessed for clinical radiotherapy planning parameters V25 Gy and Dmean to heart.

Results: The data presented show a significant reduction in the volume of the heart, which received a dose of 25 Gy - median performance V25 in RT sync breathing in comparison with the free breathing below the 82 % and the average dose of heart-median performance below the 65 %. The difference is not reliable because of the small number of observations.

Conclusion: The RT with breath holding on deep inhalation in patients with left-sided breast cancer localization reduces an average dose to the heart and the heart volume at the dose of 25 Gy. This allows to expect a further reduction in the incidence of cardio-vascular complications.

Key words: radiotherapy, breast cancer, cardiovascular complications

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For citation: Trofimova OP, Cheban OI, Mikhina ZP, Medvedev SV, Prjamikova JuI, Schipilina NP, Timoshkina EV, Poddubskaya EV, Maklakova AA, Vekova NV, Zaichenko OC, Berdnik AV, Bikova JuV, Baranova MP, Kovalenko IP, Rotobelskaya LE, Tkachev SI. Cardiovascular Complications in Patients with Breast Cancer after Breast-Conserving Treatment. Medical Radiology and Radiation Safety. 2015;60(1):33-8. Russian.

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Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 1. P. 39-44

RADIATION THERAPY

G.S. Zhamgaryan, L.I. Musabaeva, V.A. Lisin, Yu.I. Tyukalov

Combined Modality Treatment Including Intraoperative Electron and External Beam Radiation Therapies for Soft Tissue Sarcomas

Tomsk Cancer Research Institute, Tomsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: To study the efficiency of the combined modality treatment including intraoperative radiation therapy (IORT) and external radiotherapy for patients with soft tissue sarcomas.

Material and methods: Between 1991 and 2011, a total of 115 patients with soft tissue sarcomas of the trunk and extremities received combined modality IORT and external beam radiation therapy. There were 44 (38 %), male and 71 female (62 %) patients aged from 15 to 75 years (median age 47.6 ± 2.5 years). Primary sarcomas were diagnosed in 79 (69 %) patients and recurrent sarcomas in 36 (31 %). The study included patients with locally advanced stage II-III soft tissue sarcomas and most of them (52 %) had stage III disease.

Results: Acute and late radiation-induced damages were observed only in patients who underwent surgery with 20 Gy IORT. No radiation-induced complications were found in groups I and II. In these groups of patients who received the total radiation dose of 60-65 Gy, the 2-year disease-free survival rates were 76.2 ± 7.5 % and 76.0 ± 11.3 %, respectively.

Key words: combined modality treatment, soft tissue sarcomas, intraoperative radiation therapy, external beam radiotherapy

REFERENCES

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  4. Tyukalov Yu.I. Intraoperatsionnaya luchevaya terapiya v kombinirovannom lechenii sarkom myagkikh tkanei: Avtoreferat diss. kand. med. nauk. Tomsk. 1998. 22 p.
  5. Musabaeva L.I., Nechitailo M.N., Lisin V.A. Rezul'taty kombinirovannogo lecheniya s intraoperatsionnoi luchevoi terapiei i distantsionnoi gamma-terapiei zlokachestvennykh novoobrazovanii razlichnykh lokalizatsii. Medical Radiology and Radiation Safety. 2005. vol. 50. No. 2. P. 46-55.
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For citation: Galstyan IA, Nadejina NM, Levadnaya MG, Aksenenko AV. Ulcer-Cancer of the Skin as an Outcome of Local Radiation Injury. Medical Radiology and Radiation Safety. 2015;60(1):39-44. Russian.

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Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 1. P. 26-32

RADIATION BIOLOGY

I.A. Galstyan, N.M. Nadejina, M.G. Levadnaya, A.V. Aksenenko

Ulcer-Cancer of the Skin as an Outcome of Local Radiation Injury

Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: To estimate the frequency and risk factors for malignancy of late radiation ulcers as an outcome of the local radiation injuries (LRI).

Material and methods: 217 cases of long-term supervisions on the wound process and late consequences of LRI developed owing acute accidental radiation exposure were analyzed. Four clinical supervisions of skin-cancer are described in details. The review of literature findings on the matter is provided.

Results: Cancer emergence in the area of existing late radiation ulcer is rare outcome of LRI after acute exposure and it is slightly more often at chronic radiation exposure. In Burnazyan FMBC archive there are data about 4 cases (1.8 %) of a cancer in the long existing radiation ulcers development. The average duration of existence of a late radiation ulcer until its malignancy 21.8 ± 3.2 (15-29) years with the average duration of supervision of patients of this whole group about 20 years. Average age of the patients at the moment of development of a neoplasma 60.8 ± 4.9 (48-69) years. As the main localization of LRI at contacts with the isolated sources of ionizing radiation are hands, in 3 of 4 cases the cancer was revealed on hands. Other localizations LRI to data of literature are rarer. Only one the cancer ulcer was found on a forward surface of a hip. Choice method for treatment of cancer ulcer is an active surgery. At our patients recurrence of the tumor wasn’t observed yet.

Conclusions: Possible outcome of late radiation ulcer is an ulcer cancer development. Frequency of a malignancy in the long existing late radiation ulcer 1.8 % that according to literature doesn’t exceed the frequency of tumor development in long existing nonradiation ulcer. This similarity is testified nonspecific pathogenetic mechanism related with vascular disturbances and insufficient immunological control in the LRI. Undoubtedly, the role of almost continuous local use of medicines, including possessing an irritant action is significant as well. Performed plastic surgery in the field of LRI could prevent a malignancy of ulcers and, thereby, improves quality of life and the life forecast.

Key words: local radiation injury, outcomes, late radiation ulcer, cancer, neoplasm

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For citation: Galstyan IA, Nadejina NM, Levadnaya MG, Aksenenko AV. Ulcer-Cancer of the Skin as an Outcome of Local Radiation Injury. Medical Radiology and Radiation Safety. 2015;60(1):26-32. Russian.

PDF (RUS) Full-text article (in Russian)

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