SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.

The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Issues journals

Medical Radiology and Radiation Safety. 2017. Vol. 62. No. 2. P. 28-34

DOI: 10.12737/article_58f0b95734e699.63790534

Pu-239 Incorporation and Lifetime Reduction in Mayak PA Workers with Tumor and Non-Tumor Related Death

V.I. Tel’nov, F.D. Tretyakov, P.V. Okatenko

FSUE Southern Urals Biophysics Institute of FMBA of Russia. Ozyorsk, Chelyabinsk region, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

V.I. Telnov - PhD in Medicine, Senior Researcher, Deputy Director on Scientific Work; F.D. Tretyakov - PhD in Medicine, Senior Researcher, Head of Department of Radiation Safety; P.V. Okatenko - Head of the Laboratory of Radiation Epidemiology Unit

Abstract

Purpose: Assessment of the impact of Pu-239 incorporation on Mayak workers lifetime based on the analysis of mortality and age in death at tumor and non-tumor diseases taking into consideration the main and secondary radionuclide deposition organs.

Material and methods: The cohort of Mayak workers hired from 1948 to 1958 with known Pu-239 body burden was included into the analysis. The cohort comprised 3478 individuals including 2414 men (1739 deceased and 675 alive) and 1064 women (604 deceased and 460 alive). Depending on Pu-239 incorporation the lifetime as integral characteristic of the increased and premature mortality was assessed based on the analysis of the mortality and age of death in tumor and non-tumor pathology of the main and secondary deposition organs. Statistical analysis was performed using STATISTICA software.

Results: It was found that with the increase of Pu-239 incorporation in the organism of the deceased workers a decrease of lifetime occurred by 5.2 years in men and by 6.6 years in women, and after starting work - by 6.9 years in men and by 7.7 years in women. In the whole cohort the decrease of lifetime was less expressed - by 4.2 years in men and by 2.7 years in women, and after starting work - by 6.2 and by 3.0 years correspondingly. We found the increase of levels of mortality from tumors in males, mainly from malignant neoplasms of the lung and liver, which are organs of Pu-239 main deposition. For the first time the associated with Pu-239 incorporation decrease of age at death (premature mortality) was found in case of tumor and non-tumor pathology of main and secondary deposition organs both for males and females. At that, unlike increased mortality, premature mortality was registered at all studied causes of death as a significant shift or tendency.

Conclusion: The conclusion was made that increased and premature mortality are two relatively different processes leading to the reduction of lifetime of professional workers exposed to the incorporation of Pu-239.

Key words: cohort of Mayak PA workers, Pu-239, organs of main and non-main deposition, tumor and non-tumor causes of death, age at death, employment age, lifetime

REFERENCES

  1. Publikaciya 103 MKRZ: per. s angl. Pod obshchej red. M.F. Kiseleva i N.K. Shandaly. Moscow: Publ. OOO PKF «Alana». 2009. 344 p. (In Russ.).
  2. Cameron J.R. Longevity is the most appropriate measure of health effects of radiation. Radiology. 2003. Vol. 229. No. 1. P. 14-15.
  3. Morfeld P. Years of life due exposure: causal concepts and empirical shortcomings. Epidemiol. Perspect. Innovat. 2004. Vol. 1. No. 4. P. 1-19.
  4. Cologne J.B., Preston D.L. Longevity of atomic-bomb survivors. Lancet. 2000. Vol. 356. July 22. P. 303-311.
  5. Kendall G.M., Muirhead C.R. Moderate dose rate ionizing radiation increases longevity? Brit. J. Radiol. 2005. Vol. 78. No. 930. P. 573-574.
  6. Buldakov L.A., Lyubchanskij E.R., Moskalev Yu.I., Nifatov A.P. Problemy toksikologii plutoniya. Moscow: Atomizdat. 1969. 368 p. (In Russ.).
  7. Plutonij. Radiacionnaya bezopasnost’. In Il’ina L.A. (ed.). Moscow: Publ. AT. 2005. 416 p. (In Russ.).
  8. Tel’nov V.I., Tret’yakov F.D., Okatenko P.V. Poteryannye gody potencial’noj zhizni v kogorte rabotnikov PO «Mayak» 1948-1958 godov najma. Vopr. radiac. bezopasnosti. 2014. No. 3. P. 46-60. (In Russ.).
  9. Tel’nov V.I. Plutonij i sokrashchenie prodolzhitel’nosti zhizni u professional’nyh rabotnikov. Gigiena i sanitariya. 2015. Vol. 94. No. 3. P. 56-60. (In Russ.).
  10. Koshurnikova N.A., SHil’nikova N.S., Okatenko P.V. et al. Harakteristika kogorty rabochih atomnogo predpriyatiya PO «Mayak». Med. radiol. i radiac. bezopasnost’. 1998. Vol. 43. No. 6. P. 43-57.
  11. Vasilenko E.K., Miller S., Yakob P. Dozimetriya vneshnego oblucheniy No. 2. P. 52-58. (In Russ.).
  12. Khokhryakov V.V., Khokhryakov V.F., Suslova K.G. et al. Mayak Worker Dosimetry System 2008 (MWDS-2008): Assessment of internal dose from measurement results of plutonium activity in urine. Health Physics. 2013. Vol. 104. No. 4. Р. 366-378.
  13. Tret’yakov F.D., Koshurnikova N.A., Kreslov V.V. et al. Osnovnye pokazateli smertnosti naseleniya g. Ozerska za 50 let. Vopr. radiac. bezopasnosti. 2002. No. 1. P. 28-45. (In Russ.).
  14. Tablicy smertnosti naseleniya Rossii www.demoscope.ru/weekly/ssp/rus_ltmenu.php (accessed 22.09.2016). (In Russ.).
  15. Demograficheskij ezhegodnik Rossii, 2006: Stat. sb. Moscow: Rosstat. 2006. 561 p. (In Russ.).
  16. Demograficheskij ezhegodnik Rossii, 2014: Stat. sb. Moscow: Rosstat. 2014 http://www.gks.ru/bgd/regl/B14_16/Main.htm (accessed 30.09.2016). (In Russ.).
  17. Tel’nov V.I., Tihonova M.A. Vklad smertnosti i vozrasta smerti v dinamiku poteryannyh let potencial’noj zhizni u naseleniya Ural’skogo federal’nogo okruga i Rossijskoj Federacii. Instituty razvitiya demograficheskoj sistemy obshchestva: sbornik materialov V Ural’skogo demograficheskogo foruma s mezhdunarodnym uchastiem. Ekaterinburg: Institut ehkonomiki UrO RAN. 2014. P. 159-163. (In Russ.).
  18. Tel’nov V.I., Tret’yakov F.D., Okatenko P.V. Sinergizm inkorporacii plutoniya i tabakokureniya v sokrashchenii prodolzhitel’nosti zhizni pri rake legkih u rabotnikov atomnoj promyshlennosti. Metodologicheskie problemy izucheniya, ocenki i reglamentirovaniya himicheskogo zagryazneniya okruzhayushchej sredy i ego vliyaniya na zdorov’e naseleniya. Mat-ly plenuma Nauchnogo soveta Rossijskoj Federacii po ehkologii cheloveka i gigiene okruzhayushchej sredy. Moscow. 2015. P. 424-427. (In Russ.).
  19. Zöllner S., Sokolnikov M.E., Eidemüller M.Beyond Two-Stage Models for Lung Carcinogenesis in the Mayak Workers: Implications for Plutonium Risk. PLoS One. 2015. Vol. 10. No. 5. P. e0126238.
  20. Tel’nov V.I., Belinski S.A., Rusinova G.G. et al. Molekulyarnye markery raka legkogo u rabotnikov atomnoj promyshlennosti. Vopr. radiac. bezopasnosti. 2002. No. 4. P. 36-41. (In Russ.).
  21. Tokarskaya Z.B., Tel’nov V.I. Biohimicheskie issledovaniya pri ocenke sostoyaniya zdorov’ya rabotnikov PO «Mayak» v klinike Yuzhno-Ural’skogo instituta biofiziki. Vopr. radiac. bezopasnosti. 2003. Spec. vypusk. P. 53-63. (In Russ.).
  22. Prakticheskaya demografiya. In Rybakovskogo L.L. (ed.). Moscow: CSP. 2005. 280 p. (In Russ.).
  23. Yakovleva T.P. Ocenka vliyaniya uslovij truda na predstoyashchuyu prodolzhitel’nost’ zhizni rabotnikov. Uchenye zapiski Ross. gos. social. un-ta. 2009. No. 5. P. 15-20. (In Russ.).
  24. Diandini R., Takahashi K., Park E.K. et al. Potential years of life lost caused by asbestos-related diseases in the world. Amer. J. Ind. Med. 2013. Vol. 56. No. 9. P. 993-1000.

For citation: Telnov VI, Tretyakov FD, Okatenko PV. Pu-239 Incorporation and Lifetime Reduction in Mayak PA Workers with Tumor and Non-Tumor Related Death. Medical Radiology and Radiation Safety. 2017;62(2):28-34. Russian. DOI: 10.12737/article_58f0b95734e699.63790534

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2017. Vol. 62. No. 2. P. 66-70

DOI: 10.12737/article_58f0b957407525.06774674

Critical Issues Providing Radiation Safety at Radiation Accidents: Radiobiological, Medical Radiation and Organizational Providing Countermeasures against the Accident at the Chernobyl Nuclear Power Plant

L.M. Rozhdestvensky

A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

L.M. Rozhdestvensky - Head of Lab, Dr. Sci. Biol., Professor

Abstract

The goal of this article is to evaluate retrospectively to what extent were realized possibilities to decrease radiation injuries for different persons involved in the Chernobyl accident.

These possibilities were based on 3 blocks - radiobiological investigations (where radioprotectors’ preparation B and cystamine as drugs and iodine prophylaxis against thyroid radiation damage were developed), medical radiation experience in the acute radiation disease treatment and organization in reduction of radiation damages by means of civil defense patterns and local health authorities.

High quality treatment of 28 persons with very severe injuries (total-body gamma-irradiation and skin beta-irradiation) is commended. The main failures were non-use of preparation B at 28 accident liquidators and insufficient a decrease of radioiodine incorporation in the thyroid gland. It is connected with unpreparedness of civil defense patterns and local health authorities to a global accident.

The current state in fields of radiation safety in case of radiation accidents and incidents is analyzed.

Key words: radiation accident, acute radiation disease, combined radiation damage, acute radiation disease treatment, radioprotector, iodine prophylaxis, organization of events, regulatory guideline, accident at the Chernobyl NPP

REFERENCES

  1. Il’in L.A., Arhangel’skaya G.V., Konstantinov Yu.O., Lihtarev I.A. Radioaktivnyj jod v probleme radiacionnoj bezopasnosti. Moscow: Atomizdat. 1972. 270 p. (In Russ.).
  2. Instrukciya po diagnostike, medicinskoj sortirovke i lecheniyu ostryh radiacionnyh porazhenij. Ministerstvo zdravoohraneniya SSSR. Ministerstvo oborony SSSR. Moscow. 1978. 47 p. (In Russ.).
  3. Vremennaya instrukciya po ehkstrennoj profilaktike porazhenij radioaktivnym jodom. Sbornik normativnyh dokumentov po organizacii medicinskoj pomoshchi pri radiacionnyh avariyah. Moscow. 1986. P. 147-148 (In Russ.).
  4. Baranov A.E., Gus’kova A.K., Protasova T.G. Opyt lecheniya postradavshih pri avarii na Chernobyl’skoj AEHS i neposredstvennye iskhody zabolevaniya. Med. radiol. 1991. Vol. 36. No. 3. P. 29-32. (In Russ.)
  5. Baranov A.E. Allogeneic bone marrow transplantation after severe, uniform total-body irradiation. In: Advances in the Treatment of Radiation Injuries. Eds.: T.MacVittie, J.Weiss, D.Browne. Pergamon. 1996. P. 281-293.
  6. Barabanova A.V., Baranov A.E., Gus’kova.A.K. i soavt. Ostrye ehffekty oblucheniya cheloveka. Moscow: CNIIatominform. 1986. 79 p. (In Russ.).
  7. Selidovkin G.D. Okazanie medicinskoj pomoshchi v rannej faze razvitiya avarii na Chernobyl’skoj AEHS. Proschety i oshibki. Medicina katastrof. Spec. vypusk. 1996. P. 5-12. (In Russ.).
  8. Gus’kova A.K. Luchevoe porazhenie. Interv’yu s V. Gubarevym. Ezhenedel’nik «Tribuna». 18.04.2006. (In Russ.).
  9. Baranov A.E., Rozhdestvenskij L.M. Analiticheskij obzor skhem lecheniya ostroj luchevoj bolezni, ispol’zuemyh v ehksperimente i klinike. Radiac. biologiya. Radioehkologiya. 2008. Vol. 48. No. 3. P. 287-302. (In Russ.).
  10. Il’in L.A., Kryuchkov V.P., Osanov D.P., Pavlov D.A. Urovni oblucheniya uchastnikov likvidacii posledstvij Chernobyl’skoj avarii v 1986-1987 gg. i verifikaciya dozimetricheskih dannyh. Radiac. biologiya. Radioehkologiya. 1995. Vol. 35. No. 6. P. 803-828. (In Russ.).
  11. Vikipediya. Avariya na Chernobyl’skoj AEHS. (In Russ.)
  12. Rukovodstvo po organizacii medicinskoj pomoshchi pri radiacionnyh avariyah. Gus’kova A.K., Barabanova A.V., Drutman R.D., Moiseev A.A. Ministerstvo zdravoohraneniya SSSR. Moscow. 1986. 109 p. (In Russ.).
  13. Galstyan I.A. Sostoyanie zdorov’ya postradavshih v otdalennye sroki posle perenesennoj ostroj luchevoj bolezni. Avtoref. Diss. Dok. med. nauk. Moscow. 2011. 44 p. (In Russ.)
  14. Legeza V.I., Grebenyuk A.N., Zacepin V.V. Medicinskaya zashchita pri radiacionnyh avariyah: nekotorye itogi i uroki Chernobyl’skoj katastrofy. Radiac. biologiya. Radioehkologiya. 2011. Vol. 51. No. 1. P. 70-75. (In Russ.).
  15. Poverennyj A.M., Ryabuhin Yu.S., Cyb A.F. Veroyatnye prichiny zabolevanij shchitovidnoj zhelezy u postradavshih v rezul’tate Chernobyl’skoj avarii. Radiac. biologiya. Radioehkologiya. 1994. Vol. 34. No. 1. P. 8-15. (In Russ.).
  16. Poverennyj A.M., Shinkarkina A.P., Vinogradova Yu.E. et al. Radiac. biologiya. Radioehkologiya. 1996. Vol. 36. No. 4. P. 632-640. (In Russ.).
  17. Problema raka shchitovidnoj zhelezy v Rossii posle avarii na Chernobyl’skoj AEHS: ocenka radiacionnyh riskov, period nablyudeniya 1991-2008 gg. V sb.: «Medicinskie radiologicheskie posledstviya Chernobylya: prognoz i fakticheskie dannye spustya 30 let». Moscow: GEOS. 2015. P. 352-371. (In Russ.).
  18. Organizaciya sanitarno-gigienicheskih i lechebno-profilak­ticheskih meropriyatij pri radiacionnyh avariyah. Rukovodstvo. Moscow: FGU VCMK «Zashchita» Roszdrava. 2005. 524 p. (In Russ.).
  19. Grebenyuk A.N., Legeza V.I., Gladkih V.D. et al. Prakticheskoe rukovodstvo po ispol’zovaniyu medicinskih sredstv protivoradiacionnoj zashchity pri chrezvychajnyh situaciyah i obespechenie imi avarijnyh mediko-sanitarnyh formirovanij i regional’nyh avarijnyh centrov. Federal’noe mediko-biologicheskoe agentstvo. Moscow. 2015. 304 p. (In Russ.).
  20. Rozhdestvenskij L.M., Konchalovskij M.V., Baranov A.E. et al. Vozmozhnost’ primeneniya preparata Betalejkin (interlejkin-1β) dlya ehkstrennoj terapevticheskoj pomoshchi pri ostrom avarijnom obluchenii cheloveka. (In Russ.).
  21. Singh V.K., Newman V.L., Romain P.L. et al. Radiation countermeasure agents: an update (2011-2014). Expert Opin. Ther. Patents. 2014. Vol. 24. No. 11. P. 1229-1255. (In Russ.)

For citation: Rozhdestvensky LM. Critical Issues Providing Radiation Safety at Radiation Accidents: Radiobiological, Medical Radiation and Organizational Providing Countermeasures against the Accident at the Chernobyl Nuclear Power Plant. Medical Radiology and Radiation Safety. 2017;62(2):66-70. Russian. DOI: 10.12737/article_58f0b957407525.06774674

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2017. Vol. 62. No. 2. P. 39-46

DOI: 10.12737/article_58f0b9573b6b59.54629416

Cellular Connection and the Health of Children - Problem of the Third Millennium

Yu.G. Grigoriev1, A.S. Samoylov1, A.Yu. Bushmanov1, N.I. Khorseva2

1. A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. N.M. Emanuel Institute of Biochemical Physics, Moscow. Russia

Yu.G. Grigoriev - Professor Dr. Sci. Med., Deputy Chairman of the Scientific Council of Radiobiology RAS, President of Russian National Committee on Non-Ionizing Radiation Protection, Member of the WHO Advisory Committee on the international program “EMF and Health”; A.S. Samoylov - General Director of State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Dr. Sci. Med.; А.Yu. Bushmanov - First Deputy General Director of State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Dr. Sci. Med., Professor; N.I. Khorseva - PhD in Biol., Senior Researcher

Abstract

The article considers the problem of the influence of electromagnetic fields (EMF) of the mobile communication on the health of children and adolescents within the framework of the epidemiological and experimental studies.

All of the world population use mobile phones widely thus having strong and daily effect on the brain. There is no restriction on the use of mobile phones. Getting more advantages and convenience of the mobile communication, the population is trying not to hear the information about possible risks to their health, there is no element of self-restraint.

This process involves children aged 3-4 years. Pregnant women do not respect basic rules of protection from exposure to EMF of the mobile communication.

The data on the distribution of EMF RF energy absorbed in a child’s head during a mobile phone conversation are submitted. The original data on psychophysiological dysfunctions in children-users of mobile phones are discussed. We believe there is a risk of brain tumors. The estimation of the risk for children was made. Children are in the group of the risk. Special children standards for mobile EMF are therefore proposed.

Protecting children from exposure to EMF Cellular is one of the priorities of the third millennium.

Key words: the electromagnetic radiation of radio-frequency range, cell phones, children, the danger of the use of the mobile connection

REFERENCES

  1. Chernova S.A., Kuz’minskaya G.N. Sostoyanie nekotoryh pokazatelej gipofiz-gonadnoj i gipofiz-adrenalovoj sistemy pri dejstvii EHMP SVCH maloj intensivnosti. V kn.: Voprosy gigieny truda v radioehlektronnoj promyshlennosti. Moscow. 1979. P. 77-82. (In Russ.).
  2. Chernova S.A. Nekotorye ehndokrinno-biologicheskie aspekty pri vozdejstvii EHMP SVCH diapazona na molodyh i stareyushchih krys. Tez. dokl. Vsesoyuznyj simpozium. «Biologicheskoe dejstvie ehlektromagnitnyh polej». Pushchino. 1982. P. 30-31. (In Russ.).
  3. Kazyarin I.P., Shvajko I.I. Vozrastnaya chuvstvitel’nost’ organizma zhivotnogo k ehlektromagnitnym polyam sverhvysokih chastot // Gigiena i sanitariya. 1983. No. 3. P. 86-89. (In Russ.).
  4. Kazyarin I.P., Shvajko I.I. Sravnitel’naya harakteristika biologicheskogo dejstviya ehlektromagnitnyh polej sverhvysokoj i promyshlennoj chastoty. Gigiena i sanitariya. 1988. No. 7. P. 11-13. (In Russ.).
  5. Pol’ka N.S. Funkcional’noe sostoyanie razvivayushchegosya organizma, kak kriterij gigienicheskoj reglamentacii ehlektromagnitnogo polya 2750 MGc. Gigiena i sanitariya. 1989. No. 10. P. 36-39. (In Russ.).
  6. Navakatikyan M.A. Izmenenie aktivnosti uslovno-reflektornoj deyatel’nosti belyh krys v period hronicheskogo mikrovolnovogo oblucheniya i posle nego. Radiobiologiya. 1988. Vol. 28. No. 1. P. 121-125. (In Russ.).
  7. Navakatikyan M.A. Metodika izucheniya oboronitel’nyh uslovnyh refleksov aktivnogo izbeganiya . Zhurnal vysshej nervnoj deyatel’nosti. 1992. Vol. 42. No. 4. P. 12-18. (In Russ.).
  8. Pryahin E.A., Tryapicyna G.A., Andreev S.S. i soavt. Ocenka vliyaniya modulirovannogo ehlektromagnitnogo izlucheniya radiochastotnogo diapazona na kognitivnuyu funkciyu u krys raznogo vozrasta. Radiac. biologiya. Radioehkologiya. 2007. Vol. 47. No. 3. P. 339-344. (In Russ.).
  9. Salford L., Brun A., Eberhart J., Malmgren L., Persson B. Nerve cell damage in mammalian brain after exposure to microwaves from GSM mobile phone. Environ. Health Perspect. 2003. Vol. 111. No. 7. P. 881-883.
  10. Salford L., Brun A., Eberhardt J. et al. Microwaves emitted by mobile phones damage neurons in the rat brain, Proc. 3 rd Int. EMF seminar in China EMF and biological effects. Guilin (China). Oct. 2003. P. 33-34.
  11. Hardell L., Vild H., Carlberg M. et al. Cellular and cordless telephones and the association with brain tumors in different age group. Arch. Environ. Health. 2004. No. 59. P. 132-137.
  12. Lahkola A., Salminen T., Raitanen О. et al. Meningioma and mobile phone - a collaborative case-control study in five North European countries. Int. J. Epidemiol. 2008. Vol. 37. No. 6. P. 1304-1313.
  13. Hardell L., Carlberg M., Mild H. Epidemiological evidence for an association between use of wireless phones and tumor diseases. Pathophysiology. 2009. Vol. 16. No. 1. P. 113-122.
  14. Hardell L., Carlberg M., Söderqvist F., Mild H. Pooled analysis of case-control studies on acoustic neuroma diagnosed 1997-2003 and 2007-2009 and use of mobile and cordless phones. Int. J. Oncol. 2013. Vol. 43. No. 2. P. 1036-1044.
  15. IARC WHO. Classifies radiofrequency electromagnetic fields as possibly carcinogenic to humans. Press release No. 208. 31 May 2011. 3 p.
  16. Gittleman H. et al. Trends in central nervous system tumor incidence relative to other common cancers in adults, adolescents, and children in the United States, 2000 to 2010. Cancer. 2015. Vol. 121. No. 1. P. 102-112.
  17. Statistical Report: Primary brain and central nervous system tumors diagnosed in the United States in 2008-2012. Neuro Oncol. 2015. Oct.17. Suppl. 4.
  18. Ghandhi O., Kang G. Some present problems and a proposed experimental phantom for SAR compliant testing of cellular telephones at 835 and 1900 MHz. Phys. Med. Biol. 2002. Vol. 47. No. 5. P. 1501-1518.
  19. de Salles A., Bulla G., Rodriguez C. Electromagnetic absorption in the head of adults and children due to mobile phone operation close to the head. Electromagnet. Biol. Med. 2006. Vol. 25. No. 4. P. 349-360.
  20. Christ A., Gosselin M., Christopoulou M. et al. Age-dependent tissue-specific exposure of cell phone users. Phys. Med. Biol. 2010. Vol. 55. No. 7. P. 1767-1783.
  21. Gandhi P. d’Arsonval medal: address. Some bioelectromagnetics research at the University of Utah: acceptance speech on the occasion of receiving the d’Arsonval medal. Bioelectromagnetics. 1996. Vol. 17. No. 1. P. 3-9.
  22. Recommendations of a European Commission Expert Group. In.: Proc. Inter. Seminar on Biol. Effects of Non Thermal Pulsed and Amplitude Modulated RF Electromagnetic Fields and Related Health Risks. Munich, Germany. 1996. JCNIRP 3/97. P. 211-221.
  23. Rekomendacii naseleniyu Rossijskogo nacional’nogo komiteta po zashchite ot neioniziruyushchih izluchenij po ispol’zovaniyu sotovyh telefonov. Ezhegodnik RNKZNI (2002). Moscow. Publ. RUDN. 2003. P. 190-191. (In Russ.).
  24. Grigoriev Yu. Mobile phones and children: is precaution warranted? Bioelectromagnetics. 2004. Vol. 25. No. 5. P. 322-323. (In Russ.).
  25. Grigoriev O.A. Elektromagnitnye polya sotovyh telefonov i zdorov’e detej. Chto ozhidaet nashih detej v blizhajshej i dolgosrochnoj perspektive? Materialy mezhdunar. konferencii «Sotovaya svyaz’ i zdorov’e». Moscow. 20-29 sent. 2004. P. 12-65. (In Russ.).
  26. Grigoriev Yu.G. Elektromagnitnye polya sotovyh telefonov i zdorov’e detej i podrostkov (Situaciya, trebuyushchaya prinyatiya neotlozhnyh mer). Radiac. biologiya. Radioehkologiya. 2005. Vol. 45. No. 4. P. 442-450.
  27. Grigoriev Yu.G., Grigoriev O.A. Sotovaya svyaz’ i zdorov’e. Elektromagnitnaya obstanovka. Radiobiologicheskie i gigienicheskie problemy. Prognoz opasnosti. Moscow: Ekonomika. 2013. 567 p. (In Russ.).
  28. Medicinskij portal: http://bit.ly/17ZI5Mo (accessed 20.11.2013). (In Russ.).
  29. Novostnoj portal: Available from: http://www.rtbf.be/info/belgique/detail_gsm-potentiellement-cancerigene-les-jeunes-vont-etre-mieux-proteges?id=7934895 ( accessed 16.11.2013). (In Russ.).
  30. Medicinskij portal: Portables: l’Académie de médecine tempère les conclusions de l’Anses (accessed 15.11.2013). (In Russ.).
  31. Van den Bulck J. Adolescent use of mobile phones for calling and for sending text messages after lights out: results from a prospective cohort study with a one-year follow-up. Sleep. 2007. Vol. 30. No. 9. P. 1220-1223.
  32. Inyang I., Benke G., Dimitriadis C. et al. Predictors of mobile telephone use and exposure analysis in Australian adolescents. J. Paediatr. Child Health. 2010. Vol. 46, No. 5. P. 226-233.
  33. Inyang I., Benke G., McKenzie R. et al. A new method to determine laterality of mobile telephone use in adolescents. Occup. Environ. Med. 2010. Vol. 67. No. 8. P. 507-512.
  34. Chernenkov Yu. V., Gumenyuk O. I. Gigienicheskie aspekty izucheniya vliyaniya mobil’nyh telefonov i personal’nyh komp’yuterov na zdorov’e shkol’nikov. Gigiena i sanitariya. 2009. No. 3. P. 84-86. (In Russ.).
  35. Anttila P., Metsahonkala L., Sillanpaa M. Long-term trends in the incidence of headache in Finnish schoolchildren. Pediatrics. 2006. Vol. 117. P. 1197-1201.
  36. Kheifets L., Repacholi M. Sensitivity of children to electromagnetic fields // Pediatrics. 2005. Vol. 116. No. 4. P. 303-313.
  37. Sillanpaa M., Anttila P. Increasing prevalence of headache in 7-year-old schoolchildren // Headache. 1996. Vol. 36. No. 4. P. 466-470.
  38. Sudan M., Kheifets L., Arah O. et al. Prenatal and postnatal cell phone exposures and headaches in children. Open Pediatric Med. J. 2012. No. 2. P 146-152.
  39. Tomas J. Exposure to radio-frequency electromagnetic fields and behavioural problems in Bavarian children and adolescents. Eur. J. Epidemiol. 2010. Vol. 25. No. 2. P. 135-141.
  40. Rezk A., Abdulqawi K., Mustafa R. et al. Fetal and neonatal responses following maternal exposure to mobile phones. Saudi Med. J. 2008. Vol. 29. No. 2. P. 218-223.
  41. Divan H.A., Kheifets L., Obel C., Olsen J. Prenatal and postnatal exposure to cell phone use and behavioral problems in children. Epidemiology. 2008. Vol. 19. No. 4. P. 523-529.
  42. Grigoriev Yu.G. Vliyanie EHMP sotovogo telefona na kurinyj ehmbrion (k ocenke opasnosti po kriteriyu smertnosti. Radiac. biologiya. Radioehkologiya. 2003. Vol. 43. No. 5. P. 541-543. (In Russ.).
  43. Khorseva N.I., Grigoriev Yu.G., Gorbunova N.V. Psihofiziologicheskie pokazateli detej-pol’zovatelej mobil’noj svyaz’yu. Soobshchenie 1. Sovremennoe sostoyanie problemy. Radiacionnaya biologiya. Radioehkologiya. 2011. Vol. 51. No. 5. P. 611-616. (In Russ.).
  44. Khorseva N.I., Grigoriev Yu.G., Gorbunova N.V. Psihofiziologicheskie pokazateli detej-pol’zovatelej mobil’noj svyaz’yu. Soobshchenie 2. Rezul’taty chetyryohletnego monitoringa. Radiac. biologiya. Radioehkologiya. 2011. Vol. 51. No. 5. P. 617-623. (In Russ.).
  45. Khorseva N.I., Grigoriev Yu.G., Gorbunova N.V. Izmenenie parametrov prostoj sluho-motornoj reakcii detej-pol’zovatelej mobil’noj svyaz’yu: longityudnoe issledovanie. Radiac. biologiya. Radioehkologiya. 2012. Vol. 52. No. 3. P. 282-292. (In Russ.).
  46. Khorseva N.I., Grigoriev Yu.G., Gorbunova N.V. Izmenenie parametrov zritel’nogo analizatora detej-pol’zovatelej mobil’noj svyaz’yu: longityudnoe issledovanie. Radiac. biologiya. Radioehkologiya. 2014. Vol. 54. No. 1. P. 62-71. (In Russ.).
  47. Grigoriev Yu.G., Khorseva N.I. Mobil’naya svyaz’ i zdorov’e detej. Ocenka opasnosti primeneniya mobil’noj svyazi det’mi i podrostkami. Rekomendacii detyam i roditelyam. Moscow: Ekonomika. 2014. 230 p. (In Russ.).
  48. Grigoriev Yu.G., Grigoriev O.A. Mobil’naya svyaz’ i zdorov’e. Elektromagnitnaya obstanovka. Radiobiologicheskie i gigienicheskie problemy. Prognoz opasnosti. Moscow: Ekonomika. 2013. 565 p.(In Russ.).
  49. Panda N., Jain R., Bakshi J. et al. Disturbances in long-Term Mobile phone users. J. Otolaryngology-Head and Neck Surgery. 2010. Vol. 39. No. 1. P. 5-11.
  50. Calvente I., Pérez-Lobato R., Núñez M.I. et al. Does exposure to environmental radiofrequency electromagnetic fields cause cognitive and behavioral effects in 10-year-old boys?. Bioelectromagnetics. 2016. No. 37. P. 25-36.
  51. Grigoriev Yu.G., Grigoriev O.A. Mobil’naya svyaz’ i zdorov’e. Elektromagnitnaya obstanovka. Radiobiologicheskie i gigienicheskie problemy. Prognoz opasnosti. Moscow: Ekonomika. 2016. 2 ed. 574 p. (In Russ.).

For citation: Grigoriev YuG, Samoylov AS, Bushmanov AYu, Khorseva NI. Cellular Connection and the Health of Children - Problem of the Third Millennium. Medical Radiology and Radiation Safety. 2017;62(2):39-46. Russian. DOI: 10.12737/article_58f0b9573b6b59.54629416

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2017. Vol. 62. No. 2. P. 71-78

DOI: 10.12737/article_58f0b957500454.54839072

Successful Treatment of Recurrence of Rectal Cancer with Invasion of the Sacrum (Case Report)

Е.R. Musaev, S.I. Tkachev, D.V. Kuzmichev, A.V. Polynovskiy, A.O. Rasulov, V.F. Tsaryk, N.A. Kochura, E.A. Sushentcov, U.E. Suraeva

N.N.Blokhin Russian Cancer Research Center, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

E.R. Musaev - Dr. Sci. Med., Head of the Department of Vertebral Oncology; S.I. Tkachev - Dr. Sci. Med., Leading Researcher; D.V. Kuzmichev - PhD in Medicine, Senior Researcher; A.V. Polynovskiy - PhD in Medicine, Research Associate; A.O. Rasulov - Dr. Sci. Med., Head of the Department of Coloproctology; V.F. Tsaryuk - Dr. Sci. Med., Leading Research; N.A. Kochura - Doctor, Department of Anesthesiolody; E.А. Sushentcov - PhD in Medicine, Senior Researcher; J.E. Suraeva - PhD student

Abstract

Purpose: Recurrence of rectal cancer located in presacral area and having invasion in the bone structure, are the most difficult in clinical practice to diagnosis and treatment. The purpose of our observation is a demonstration of modern possibilities of preoperative chemoradiotherapy followed by high-tech surgery in treatment of the patient with recurrent rectal cancer with sacral invasion in a multidisciplinary clinic.

Material and methods: Article describes the case of successful treatment of patient with recurrent rectal cancer with sacral invasion, previously operated at another clinic without prior neoadjuvant therapy. At N.N.Blochin Russian Cancer Research Center patient was performed preoperative chemoradiotherapy 40 Gy in 4 Gy fractions with capecitabine 3500 mg/day per os on radiation days to achieve maximum tumor regression. In 8 weeks after the end of combined treatment, a control examination, according to which positive dynamics in the form of reducing the size of the tumor was identified. Taking into account the recurrent tumor with sacral invasion, the absence of distant metastases and severe concomitant comorbidity, the patient underwent high-tech surgery with recurrent tumor removal and high sacral resection (level S1) with plastic replacement of the defect with recto-abdominal flap. According to pathological examination of postoperative material in recurrent tumor was reached tumor regression grade II (Dworak).

At the time of publication of the article the patient after 43 months since the operation is observed without signs of recurrence and progression of disease, return to full social life without motor restrictions.

Conclusion: This case demonstrates the importance of preoperative chemoradiotherapy in patients with recurrent rectal cancer previously have not treated with neoadjuvant treatment. Sacral resections (including a high resection at the S1 level) with a recurrent tumor removal significantly increases the overall survival and life quality. If R0 resection can be achieved, it is possible to expect a better long-term result.

This type of operation is associated with a high number of intra - and postoperative complications and, therefore, must be performed in highly specialized centers by a multidisciplinary surgical team using modern possibilities of anesthesia and intensive care support.

Key words: recurrence, rectal cancer, invasion of the sacrum, resection of the sacrum, radiotherapy, preoperative chemoradiotherapy

REFERENCES

  1. Davydov M.I., Aksel’ E.M. Statistika zlokachestvennyh novoobrazovanij v Rossii i stranah SNG v 2014 g. (In Russ.).
  2. Harji D.P. et al. Surgery for recurrent rectal cancer: higher and wider?. Colorectal Dis. 2013. 15. No. 2. P. 139-145.
  3. Zhao J. et al. Patterns and prognosis of locally recurrent rectal cancer following multidisciplinary treatment. World J. Gastroenterol. 2012. Vol. 18. No. 47. P. 7015-7020.
  4. Hartley J.E. et al. Resection of locally recurrent colorectal cancer in the presence of distant metastases: can it be justified?. Ann. Surg. Oncol. 2003. Vol. 10. No. 3. P. 227-233.
  5. Bhangu A. et al. Comparison of long-term survival outcome of operative vs nonoperative management of recurrent rectal cancer. Colorectal Dis. 2013. Vol. 15. No. 2. P. 156-163.
  6. Pacelli F., Tortorelli A.P., Rosa F. et al. Locally recurrent rectal cancer: prognostic factors and long-term outcomes of multimodal therapy. Ann. Surg. Oncol. 2010. Vol. 17. No. 1. P. 152-162.
  7. Suzuki K. et al. Curative reoperations for locally recurrent rectal cancer. Dis. Colon. Rectum. 1996. Vol. 39. No. 7. P. 730-736.
  8. Yamada K., Ishizawa T., Niwa K. et al. Patterns of pelvic invasion are prognostic in the treatment of locally recurrent rectal cancer. Brit. J. Surg. 2001. Vol. 88. No. 7. P. 988-993.
  9. Wanebo H.J. et al. Pelvic resection of recurrent rectal cancer: technical considerations and outcomes. Dis. Colon. Rectum. 1999. Vol. 42. No. 11. P. 1438-1448.
  10. Moore H.G., Shoup M., Riedel E. et al. Colorectal cancer pelvic recurrences: determinants of resectability. Dis. Colon. Rectum. 2004. Vol. 47. No. 10. P. 1599-1606.
  11. Pilipshen S. Cancer of the rectum: local recurrence. In: Current Therapy in Colon and Rectal Surgery. Fazio V.W., ed. Toronto: Brian C. Decker. 1990. P. 137-149.
  12. Kusters M. et al. Radicality of resection and survival after multimodality treatment is influenced by subsite of locally recurrent rectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 2009. Vol. 75. No. 5. P. 1444-14496.
  13. Hocht S. et al. Pelvic sidewall involvement in recurrent rectal cancer. Int. J. Colorectal Dis. 2004. Vol. 19. No. 2. P. 108-113.
  14. Hruby G. et al. Sites of local recurrence after surgery, with or without chemotherapy, for rectal cancer: implications for radiotherapy field design. Int. J. Radiat. Oncol. Biol. Phys. 2003. Vol. 55. No. 1. P. 138-143.
  15. Kim T.H., Jeong S.Y., Choi D.H. et al. Lateral lymph node metastasis is a major cause of locoregional recurrence in rectal cancer treated with preoperative chemoradiotherapy and curative resection. Ann. Surg. Oncol. 2008. Vol. 15. No. 3. P. 729-737.
  16. Kusters M. et al. Patterns of local recurrence in rectal cancer: a single-center experience. Ann. Surg. Oncol. 2009. Vol. 16. No. 2. P. 289-296.
  17. Syk E., Torkzad M.R., Blomqvist L. et al. Radiological findings do not support lateral residual tumour as a major cause of local recurrence of rectal cancer. Brit. J. Surg. 2006. Vol. 93. No. 1. P. 113-119.
  18. Yu T.K., Bhosale P.R., Crane C.H. et al. Patterns of locoregional recurrence after surgery and radiotherapy or chemoradiation for rectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 2008. Vol. 71. No. 4. P. 1175-1180.
  19. Bosman S.J., Holman F.A., Nieuwenhuijzen G.A. et al. Feasibility of reirradiation in the treatment of locally recurrent rectal cancer. Brit. J. Surg. 2014. Vol. 101. No. 10. P. 1280-1289.
  20. Glimelius B. Recurrent rectal cancer. The pre-irradiated primary tumour: can more radiotherapy be given?. Colorectal Dis. 2003. Vol. 5. No. 5. P. 501-503.
  21. Valentini V., Morganti A.G., Gambacorta M.A. et al. Study Group for Therapies of Rectal Malignancies (STORM). Preoperative hyperfractionated chemoradiation for locally recurrent rectal cancer in patients previously irradiated to the pelvis: A multicentric phase II study. Int. J. Radiat. Oncol. Biol. Phys. 2006. Vol. 64. No. 4. P. 1129-1139.
  22. Miner T.J., Jaques D.P., Paty P.B, et al. Symptom control in patients with locally recurrent rectal cancer. Ann. Surg. Oncol. 2003. Vol. 10. No. 1. P. 72-79.
  23. Xiaodong Tang, Wei Guo, Rongli Yang, et al. Risk factors for blood loss during sacral tumor resection. Clin. Orthop. Relat. Res. 2009. Vol. 467. P. 1599-1604.
  24. Tomita K., Tsuchiya H. Total sacrectomy and reconstruction for huge sacral tumors. Spine (Phila Pa 1976). 1990. Vol. 15. No. 11. P. 1223-1227.
  25. Dahlin D.C., Cupps R.E., Johnson E.W. Jr. Giant-cell tumor: a study of 195 cases. Cancer. 1970. Vol. 25. No. 5. P. 1061-1070.
  26. Todd L.T. Jr, Yaszemski M.J., Currier B.L. et al. Bowel and bladder function after major sacral resection. Clin. Orthop. Relat. Res. 2002. Vol. 397. P. 36-39.
  27. Guo Y., Palmer J.L., Shen L. et al. Bowel and bladder continence, wound healing, and functional outcomes in patients who underwent sacrectomy. J. Neurosurg Spine. 2005. Vol. 3. No. 2. P. 106-110.
  28. Wanebo H.J., Marcove R.C. Abdominal sacral resection of locally recurrent rectal cancer. Ann. Surg. 1981. Vol. 194. No. 4. P. 458-470.
  29. Dozois E.J. Privitera A., Holubar S.D. et al. High sacrectomy for locally recurrent rectal cancer: Can long-term survival be achieved. J. Surg. Oncol. 2011. Vol. 103. No. 2. P. 105-109.

For citation: Musaev ER, Tkachev SI, Kuzmichev DV, Polynovskiy AV, Rasulov AO, Tsaryk VF, Kochura NA, Sushentcov EA, Suraeva UE. Successful Treatment of Recurrence of Rectal Cancer with Invasion of the Sacrum (Case Report). Medical Radiology and Radiation Safety. 2017;62(2):71-8. Russian. DOI: 10.12737/article_58f0b957500454.54839072

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2017. Vol. 62. No. 2. P. 5-12

DOI: 10.12737/article_58f0b9572d7131.31568909

Neuromediator Exchange Dynamics in Rats at Late Periods After Exposure to 60Co g-Rays

K.V. Belokopytova1,2, O.V. Belov1, V.N. Gaevsky1, V.B. Narkevich3, V.S. Kudrin3, E.A. Krasavin1, A.S. Bazyan4

1. Institute for Nuclear Research, Dubna, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Institute of Genetics, Physiology and Plant Protection of the Moldovan Academy of Sciences, Chisinau, Moldova; 3. FSBI Zakusov Institute of Pharmacology, Moscow, Russia; 4. Institute of Higher Nervous Activity and Neurophysiology of RAS, Moscow, Russia

K.V. Belokopytova - Junior Researcher; O.V. Belov - PhD in Biology, Head of Sector; V.N. Gaevsky - Leading Engineer; V.B. Narkevich - PhD in Medicine, Researcher; V.S. Kudrin - PhD in medicine, Head of Laboratory; E.A. Krasavin - Corr. Member RAS, Acad., D. Sc. Biol., Director of Laboratory; A.S. Bazyan - Prof., D. Sc. Biol., Head of Laboratory

Abstract

Purpose: Estimation of the 60Co γ-ray effect on the neuromediator exchange dynamics in the brain of rats of different age groups.

Material and methods: 20 male Sprague-Dawley rats with the weight of 190-210 g were used in the experiment. At the age of two months, animals were exposed to a single whole-body irradiation with 60Co γ-rays at the dose of 1 Gy. In 30 and 90 days after exposure, rats we killed by decapitation. The animals were tested at three and five months of age, respectively. The neuromediator exchange dynamics was estimated by measuring the concentrations of monoamines (dopamine, noradrenaline, and serotonin) and their metabolites in four brain regions including prefrontal cortex, hypothalamus, hippocampus, and striatum. The levels of substances were assessed using the high-performance liquid chromatography with electrochemical detection. The results of measurements were statistically analyzed with the one-way analysis of variance (ANOVA).

Results: Although the direct measurements seeking for changes at the same time points revealed a little effect of γ-rays on the monoamine metabolism, age-related dynamics of the neuromediator exchange was affected in many aspects. The most pronounced in alterations in the two-month monoamine exchange dynamics were observed in the prefrontal cortex, hypothalamus and hippocampus. It indicates the sensitivity of these brain structures to the action of γ-rays at doses about 1 Gy. In the prefrontal cortex, hippocampus and hypothalamus, radiation exposure affected dopamine and serotonin regulations in the manner that may indicate suppression of catecholamine degrading pathways dependent on monoamine oxidases A and B against the activation of metabolic processes associated with catechol-O-methyltransferase. The prefrontal cortex and hypothalamus additionally exhibited an accelerated decrease in levels of some neuromediators, as compared to the dynamics normally observed beyond the age of three months. At the same time, our study identified a resistance of striatal metabolic pathways to irradiation with γ-rays at the stated dose. A comparison of the obtained data with results of our previous experiments investigating the action of accelerated carbon ions confirmed our expectations that the effect of γ-rays on the dynamics of the neuromediator exchange is less pronounced than from heavy nuclei.

Conclusion: Made a hypothesis that, in the case of heavy ion exposure, more pronounced alterations in brain mediator systems lead to more intensive compensatory and regenerative processes in them. Consequently, it may change the normal dynamics of neuromediator exchange in the investigated post-irradiation periods and serve a reason not only for decrease but also for an abnormal increase in levels of monoamines and their metabolites after exposure. In general, results of the performed study contribute to understanding the neurotoxic effect of γ-rays in comparison with other radiation modalities that can potentially be useful for predicting late outcomes of cranial radiation therapy.

Key words: central nervous system, ionizing radiations, late effects, monoamines, metabolites

References

  1. Grigor'ev Yu.G., Ushakov I.B., Krasavin E.A. et al. Kosmicheskaya radiobiologiya za 55 let (k 50-letiyu GNC RF-IMBP RAN). Moscow: Ekonomika. 2013. 303 p. (In Russ.).
  2. Yin E., Nelson D.O., Coleman M.A. et al. Gene expression changes in mouse brain after exposure to low-dose ionizing radiation. Int. J. Radiat. Biol. 2003. Vol. 79. P. 759-775.
  3. Sanchez M.C., Benitez A., Ortloff L., Green L.M. Alterations in glutamate uptake in NT2-derived neurons and astrocytes after exposure to gamma radiation. Radiat. Res. 2009. Vol. 171. P. 41-52.
  4. Britten R.A., Davis L.K., Johnson A.M., et al. Low (20 cGy) doses of 1 GeV/u (56)Fe-particle radiation lead to a persistent reduction in the spatial learning ability of rats. Radiat. Res. 2012. Vol. 177. P. 146-151.
  5. Monje M.L., Mizumatsu S., Fike J.R., Palmer T.D. Irradiation induces neural precursor-cell dysfunction. Nat. Med. 2002. Vol. 8. P. 955-962.
  6. Mizumatsu S., Monje M.L., Morhardt D.R. et al. Extreme sensitivity of adult neurogenesis to low doses of x-irradiation. Cancer Res. 2003. Vol. 63. P. 4021-4027.
  7. Acharya M.M., Christie L.A., Lan M.L. et al. Human neural stem cell transplantation ameliorates radiation-induced cognitive dysfunction. Cancer Res. 2011. Vol. 71. P. 4834-4845.
  8. Cucinotta F.A., Alp M., Sulzman F.M., Wang M. Space radiation risks to the central nervous system. Life Sci. Space Res. 2014. Vol. 2. P. 54-69.
  9. Ballesteros-Zebadúa P., Chavarria A., Celis M.A. et al. Radiation-induced neuroinflammation and radiation somnolence syndrome. CNS Neurol. Disord. Drug Targets. 2012. Vol. 11. P. 937-949.
  10. Kyrkanides S., Moore A.H., Olschowka J.A. et al. Cyclo­oxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury. Mol. Brain Res. 2002. Vol. 104. P. 159-169.
  11. Moore A.H., Olschowka J.A., Williams J.P. et al. Regulation of prostaglandin E2 synthesis after brain irradiation. Int. J. Radiat. Oncol. Biol. Phys. 2005. Vol. 62. P. 267-272.
  12. Hwang S.Y., Jung J.S., Kim T.H. et al. Ionizing radiation induces astrocyte gliosis through microglia activation. Neurobiol. Dis. 2006. Vol. 3. P. 457-467.
  13. Grigor'ev A.I., Krasavin E.A., Ostrovskij M.A. K ocenke riska biologicheskogo dejstviya galakticheskih tyazhyolyh ionov v usloviyah mezhplanetnogo polyota. Ros. fiziol. zhurn. im. I.M. Sechenova. 2013. Vol. 99. No. 3. P. 273-280. (In Russ.).
  14. Parihar V.K., Allen B., Tran K.K. et al. What happens to your brain on the way to Mars. Sci. Adv. 2015. Vol. 1. No. 4. e1400256. P. 1-6.
  15. Schindler M.K., Forbes M.E., Robbins M.E. et al. Aging- dependent changes in the radiation response of the adult rat brain. Int. J. Radiat. Oncol. Biol. Phys. 2008. Vol. 70. P. 826-834.
  16. Casadesus G., Shukitt-Hale B., Stellwagen H.M. et al. Hippocampal neurogenesis and PSA-NCAM expression following exposure to 56Fe particles mimics that seen during aging in rats. Exp. Geront. 2005. Vol. 40. P. 249-254.
  17. Joseph J.A., Hunt W.A., Rabin B.M., Dalton T.K. Possible “accelerated striatal aging” induced by 56Fe heavy particle irradiation: Implications for manned space flights. Radiat. Res. 1992. Vol. 130. P. 88-93.
  18. Forbes M.E., Paitsel M., Bourland J.D., Riddle D.R. Early-delayed, radiation-induced cognitive deficits in adult rats are hetero­ge­neous and age-dependent. Radiat. Res. 2014. Vol. 182. P. 60-71.
  19. Belokopytova K.V., Belov O.V., Kudrin V.S. et al. Raspredelenie monoaminov i ih metabolitov v strukturah golovnogo mozga krys v pozdnie sroki posle oblucheniya ionami 12C. Nejrohimiya. 2015. Vol. 32. No. 3. P. 243-251. (In Russ.).
  20. Belokopytova K.V., Belov O.V., Kudrin V.S. et al. Dinamika obmena monoaminov v strukturah golovnogo mozga krys v pozdnie sroki posle oblucheniya uskorennymi ionami ugleroda. Nejrohimiya. 2016. Vol. 33. No. 2. P. 147-155. (In Russ.).
  21. Rabin B.M., Joseph J.A., Shukitt-Hale B., McEwen J. Effects of exposure to heavy particles on a behavior mediated by the dopa­minergic system. Adv. Space Res. 2000. Vol. 25. P. 2065-2074.
  22. Hunt W.A., Joseph J.A. Rabin B.M. Behavioral and neurochemical abnormalities after exposure to low doses of high-energy iron particles. Adv. Space Res. 1989. Vol. 9. P. 333-336.
  23. Savchenko O.V. Status and prospects of new clinical methods of cancer diagnostics and treatment based on particle and ion beams available at JINR. Soobshch. Ob"ed. in-ta yader. issled. Dubna: OIYAI. 1996. 40 p. (In Russ.).
  24. Vagner R., Zorin V.P., Jiroushek P. et. al. Fiziko-dozimetricheskie izmereniya na gamma-apparate ROKUS-M. Soobshch. Ob"ed. in-ta yader. issled. Dubna: OIYAI. 1987. 13 p. (In Russ.).
  25. Matveeva M.I., Shtemberg A.S., Timoshenko G.N. et. al. Vliyanie oblucheniya ionami ugleroda 12S na obmen monoaminov v nekotoryh strukturah mozga krys. Nejrohimiya. 2013. Vol. 30. No. 4. P. 343-348. (In Russ.).
  26. Burke S.N., Barnes C.A. Neural plasticity in the ageing brain. Nat. Rev. Neurosci. 2006. Vol. 7. P. 30-40.
  27. Enzinger C., Fazekas F., Matthews P.M. et al. Risk factors for progression of brain atrophy in aging. Neurology. 2005. Vol. 64. P. 1704-1711.
  28. Olesen P.J., Guo X., Gustafson D. et al. A population-based study on the influence of brain atrophy on 20-year survival after age 85. Neurology. 2011. Vol. 76. P. 879-886.
  29. Barnes C.A. Normal aging: regionally specific changes in hippocampal synaptic transmission. Trends Neurosci. 1994. Vol. 17. P. 13-18.
  30. McEntee W.J., Crook T.M. Cholinergic function in the aged brain: implications for the treatment of memory impairments associated with aging. Behav. Pharmacol. 1992. Vol. 3. P. 327-336.
  31. Lamberty Y., Gower A.J. Age-related changes in spontaneous behavior and learning in NMRI mice from middle to old age. Physiol. Behav. 1992. Vol. 51. P. 81-88.
  32. Rasmussen T., Schliemann T., Sorenson J.C. et al. Memory impaired aged rats: No loss of principal hippocampal and subicular neurons. Neurobiol. Aging. 1996. Vol. 17. P. 143-147.
  33. Miyagawa H., Hasegawa M., Fukuta T. et al. Dissociation of impairment between spatial memory, and motor function and emotional behavior in aged rats. Behav. Brain. Res. 1998. Vol. 91. P. 73-81.
  34. Miguez J.M., Aldegunde M., Paz-Valinas L. et al. Selective changes in the contents of noradrenaline, dopamine and serotonin in rat brain areas during aging. J. Neural Transm. 1999. Vol. 106. P. 1089-1098.
  35. Darbin O., Risso J.-J., Rostain J.-C. Pressure induces striatal serotonin and dopamine increases: a simultaneous analysis in free moving microdialysed rats. Neuroscience Lett. 1997. Vol. 238. P. 69-72.

For citation: Belokopytova KV, Belov OV, Gaevsky VN, Narkevich VB, Kudrin VS, Krasavin EA, Bazyan A.S. Neuromediator Exchange Dynamics in Rats at Late Periods after Exposure to 60Co y-Rays. Medical Radiology and Radiation Safety. 2017;62(2):5-12. Russian. DOI: 10.12737/article_58f0b9572d7131.31568909

PDF (RUS) Full-text article (in Russian)

  1. 2017-2-Bashkov-eng
  2. 2017-2-Abel-eng
  3. 2017-6-Larenkov-eng
  4. 2017-6-Hachirova-eng

Contact Information

 

46, Zhivopisnaya st., 123098, Moscow, Russia Phone: +7 (499) 190-95-51. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal location

Attendance

2759253
Today
Yesterday
This week
Last week
This month
Last month
For all time
1984
3035
17637
18409
66996
75709
2759253
Forecast today
2088

Your IP:216.73.216.228
Visitor Counter

© Журнал "Медицинская радиология и радиационная безопасность" 2020г.

Яндекс.Метрика

Наверх