SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.

The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Issues journals

Medical Radiology and Radiation Safety. 2021. Vol. 66. № 3. P. 68–75

Е.S. Sukhikh1,2, L.G. Sukhikh2, A.V. Vertinsky1,2, P.V. Izhevsky3, I.N. Sheino3,  V.V. Vertoukhova2

Analysis of the Physical and Radiobiological Equivalence of the Calculated
and Measured Dose Distributions for Prostate Stereotactic Radiotherapy

1Tomsk Regional Oncology Center, Tomsk, Russia

2National Research Tomsk Polytechnic University, Tomsk, Russia

3AI Burnasyan Federal Medical Biophysical Center Moscow, Russia

Contact person: Andrei Vladimirovich Vertinskii: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Purpose: Carrying out the analysis of the physical and radiobiological equivalence of dose distributions obtained during the planning of hypofractionated stereotactic radiation therapy of the prostate cancer and verification using a three-dimensional cylindrical dosimeter.

Material and Methods: Based on the anatomical data of twelve patients diagnosed with prostate carcinoma, stage T2N0M0 with low risk, plans were developed for stereotactic radiation therapy with volumetric modulates arc therapy (VMAT). The dose per fraction was 7,25 Gy for 5 fractions (total dose 36,25 Gy) with a normal photon energy of 10 MV. The developed plans were verified using a three-dimensional cylindrical ArcCHECK phantom. During the verification process, the three-dimensional dose distribution in the phantom was measured, based on which the values of the three-dimensional gamma index and the dose–volume histogram within each contoured anatomical structures were calculated with 3DVH software.

The gamma index value γ (3 %, 2 mm, GN) at a threshold equal to 20 % of the dose maximum of the plan and the percentage of coincidence of points at least 95 % was chosen as a criterion of physical convergence of the calculated and measured dose distribution according to the recommendations of AAPM TG-218. To analyze the radiobiological equivalence of the calculated and measured dose distribution, the local control probability (TCP) and normal tissue complication probability (NTCP) criteria were used based on the calculated and measured dose–volume histograms. Contours of the target (PTV) and the anterior wall of the rectum were used for the analysis. The approach based on the concept of equivalent uniform dose (EUD) by A. Niemierko was used to calculate the values of TCP/NTCP criteria.

Results: The results of physical convergence of plans for all patients on the contour of the whole body were higher than 95 % for the criteria γ (3 %, 2 mm, GN). The convergence along the PTV contour is in the range (75.5–95.2)%. The TCP and NTCP values obtained from the measured dose-volume histograms were higher than the planned values for all patients. It was found that the accelerator delivered a slightly higher dose to the PTV and the anterior wall of the rectum than originally planned.

Conclusion: The capabilities of modern dosimetric equipment allow us move to the verification of treatment plans based on the analysis of TCP / NTCP radiobiological equivalence, taking into account the individual characteristics of the patient and the capabilities of radiation therapy equipment. 

Key words: 3D gamma analysis, dose-volume histogram, tumor control probability, normal tissue complication probability

For citation: Sukhikh ЕS, Sukhikh LG, Vertinsky AV, Izhevsky PV, Sheino IN, Vertoukhova VV. Analysis of the Physical and Radiobiological Equivalence of the Calculated and Measured Dose Distributions for Prostate Stereotactic Radiotherapy. Medical Radiology and Radiation Safety. 2021;66(3):68-75.

DOI: 10.12737/1024-6177-2021-66-3-68-75

References

  1. Lo SS, Teh. BS, Lu JJ, et al. Stereotactic Body Radiation Therapy. Berlin Heidelberg, Springer-Verlag, 2012. 434 p. https://doi.org/10.1007/978-3-642-25605-9.
  2. Ezzell GA, Burmeister JW, Dogan N, et al. IMRT Commissioning: Multiple Institution Planning and Dosimetry Comparisons. A Report from AAPM Task Group 119. Med. Phys. 2019;36 (XI):5359–5373. 
  3. Smilowitz JB, Das IJ, Feygelman V, et al. AAPM Medical Physics Practice Guideline 5.a.: Commissioning and QA of Treatment Planning Dose Calculations— Megavoltage Photon and Electron Beams. J Appl Clin Med Phys. 2015,16(V):14-34. DOI: 10.1120/jacmp.v16i5.5768.
  4. Miftena M, Olch A, Mihailidis D. Tolerance Limits and Methodologies for IMRT Measurement-Based Verification QA: Recommendations of AAPM Task Group No.218. Med. Phys. 2018;45(IV):e53-83.
  5. Nelms BE, Opp D, Robinson J, et al. VMAT QA: Measurement-Guided 4D Dose Reconstruction on a Patient. Med. Phys. 2012;39(8):4228-4238.
  6. Olch AJ. Evaluation of the Accuracy of 3DVH Software Estimates of Dose to Virtual Ion Chamber and Film in Composite IMRT QA. Med. Phys. 2012;39(1):81-86. 
  7. Вертинский А.В., Сухих Е.С., Сухих Л.Г. Верификация терапевтических планов с объёмной модуляцией интенсивности излучения // Медицинская физика. 2018. Т.78. №2. Т. 78. С. 12-20  [Vertinskiy AV, Sukhikh ES, Sukhikh LG. Verification of Therapeutic Plans with Volume Modulation of Radiation Intensity. Medical Physics. 2015;78(2):12-21 (In Russian)].
  8. Gay HA, Niemierko A. A Free Program for Calculating EUD-based NTCP and TCP in External Beam Radiotherapy. Phys Med. 2007;23(3-4):115-25. DOI: 10.1016/j.ejmp.2007.07.001.
  9. Paudel NR, Narayanasamy G, Han EY, et al. Dosimetric and Radiobiological Comparison for Quality Assurance of IMRT and VMAT Plans. Radiation Oncology Physics. 2017;18(5):237-244. https://doi.org/10.1002/acm2.12145.
  10. Sumida I, Yamaguchi H, Kizaki H. Novell Radiological Gamma Index for Evaluation of 3-Dimentional Predicted Dose Distribution. Int J Radiat Oncol Biol Phys. 2015;92(4):779-86. DOI: 10.1016/j.ijrobp.2015.02.041.
  11. Sukhikh ES, Sukhikh LG, Taletsky AV, et al. Influence of SBRT Fractionation on TCP and NTCP Estimations for Prostate Cancer. Physica Medica. 2019;62:41–46. DOI: https://doi.org/10.1016/ j.ejmp.2019.04.017.
  12. Levegrün S, Jackson A, Zelefsky M, et al. Risk Group Dependence of Dose-Response for Biopsy Outcome after Three-Dimensional Conformal Radiation Therapy of Prostate Cancer. Radiother Oncol. 2002;63(1):11–26. https://doi.org/10.1016/ S0167-8140(02)00062-2.
  13. Dasu A, Dasu I. Prostate Alpha/Beta Revisited an Analysis of Clinical Results from 14168 Patients. Acta Oncol. 2012;51(8):963–74. https://doi.org/10.3109/0284186X.2012. 719635.
  14. Cheung R, Tucker SL, Lee AK, et al. Dose-Response Characterictics of Low- and Intermediate-Risk Prosate Cancer Treated with External Beam Radiotherapy. Int J Radiat Oncol Biol Phys. 2005;61(4):993-1002.
  15. Rana S, Cheng C, Zhao L, et al. Dosimetric and Radiobiological Impact of Intensity Modulated Proton Therapy and Rapidarc Planning for High-Risk Prostate Cancer with Seminal Vesicles. J Med Radiat Sci. 2017;64(1):18–24. https://doi.org/10.1002/ jmrs.175.
  16. Deasy J, Mayo C, Orton C. Treatment Planning Evaluation and Optimization should be Biologically and not Dose / Volume Based. Med Phys. 2015;42(6):2753-6. DOI: 10.1118/1.4916670

 PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 23.12.2020. 

Accepted for publication: 20.01.2021.

 

Medical Radiology and Radiation Safety. 2021. Vol. 66. № 3. С. 62-67

O.G. Kashirina, L.V. Timofeev, V.G. Likhvantseva

Radiation Protection of Personnel in Contact Radiation Therapy in Ophthalmology

A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia

Contact person: Kashirina O.G. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Purpose: To ensure radiation safety of medical staff personal protective equipment  (PPE).

Material and methods: In order to not make assumptions of possible protective materials optical distortion, estimated the dependence of light transmission in the wavelength range 330–660 nm leaded glass brands of TF-1 and TF-5, as well as the intensity of glow glasses when exposed to light and X-rays.

Results: We trace the degree of browning and the nature of the recovery of transparency of glass after irradiation. To determine the optimum thickness of lead glass for eyewear experimentally evaluated attenuation of X-rays with energy efficiency 30 and 80 keV. Lead equivalent values for lead glass, was determined so for Eeff ~ 20 keV at a multiplicity of weakening k = 10 lead glass brand TF-5 thickness 2.0 mm equivalent 0.8 mm Pb, etc. For the possible use of other additives in the window shows the curves of the attenuation of photon radiation radionuclide 241Am (20–60 кeV) filters from 9Be, 26Al, 56Fe, 64Cu, 99Mo, 112Cd, 184W, 207Pb

Conclusion: Possible  introduction of new dose limits for the lens of the eye can be successful only in case of both existing and newly developed PPE. To reduce the impact of domestic lead glass radiation can be used for staff in the form of screens and glasses.

Key words:оphthalmology, contact radiotherapy, personnel, personal protective equipment

For citation: Kashirina OG, Timofeev LV, Likhvantseva VG. Radiation Protection of Personnel in Contact Radiation Therapy in Ophthalmology. Medical Radiology and Radiation Safety 2021;66(3):62-67.

DOI: 10.12737/1024-6177-2021-66-3-62-67

References

  1. Statement on Tissue Reactions / Early and Late Effects of Radiation in Normal Tissues and Organs – Threshold Doses for Tissue Reactions in a Radiation Protection Context. ICRP Publication 118. Ann ICRP. 2012. V.42, No.1/2 (In Russian).
  2. Radiation Protection and Safety of Radiation Sources: International Basic IAEA Safety Standards. General Safety Requirements, Part 3. IAEA, Vienna. 2015 (In Russian).
  3. SanPiN 2.6.1. 2523-09. Radiation Safety Standards NRB-99/2009: 2009 (In Russian).
  4. Methodical Instructions MU 2.6.1.16-2002. Control of Equivalent Doses of Photon and Beta Radiation in the Skin and Lens of the eye. 2002. 42 p. (In Russian).
  5. Methodical Instructions MU 2.6.5.037-2016. Control of Equivalent Doses of Photon and Beta Radiation in the Skin and lens of the Eye. 2016 (In Russian).
  6. Radiation medicine. Ed by of R Ilyin LA. Published V.2. 2001 (In Russia).
  7. Kryuchkov VP, Kochetkov OA, Timofeev LV, et al.  The Accident at Chernobyl: Radiation Doses of Participants of Liquidation of Consequences of the Accident. Moscow Publ. 2011 (In Russian).
  8. Kozlov VF Reference Book on Radiation Safety. Moscow Publ. 2011. 227 p. (In Russian).
  9. Rubtsov VI, Klochkov VN, Trebuchyn AB, et al.   Control of Radiation Dose Equivalent Lens of the Eye and its Reduction.  ANRI. 2013. No.3 (In Russia).
  10. Brovkina AF, Timofeev LV et al.   The use of Isotopes in the Treatment of Eye Tumors. materials of Conf. "Radioactive Isotopes in Ophthalmology." Moscow Publ. 1973 (In Russian).
  11. Brovkina AF, Timofeev LV, et al. Beta-therapy of Tumors of the eye. Methodical Recommendation. Ministry of Health of the USSR.  Moscow Publ. 1998. 22 p. (In Russian).
  12. Budkina GP, Zarubei GD, Timofeev LV, et al. Medical Laboratory Testing of Ofthalmoplegical for Posterior Eye with the Radionuclides 90Sr + 90Y:a Report of Helmholtz's Institute. 1978 (In Russian).
  13. Ophthalmooncology. Ed. by Brovkina A F. Moscow, Moscow Publ. 2002 (In Russian).
  14. Timofeev LV, Semikova TS. Proposal for the Development and Implementation of Medical Products. Conclusion of the Ministry of health of the USSR on the Feasibility of Development. Protocol No. 6 dated 02.11.89 (In Russian).
  15. Timofeev LV, Bochkarev VV, Orlova TS, Shagaev VA.  Some Dosimetric Characteristics of Ofthalmoplegical for Radiation Therapy Unthrilling Tumors.  Materials of Int. Symp. Moscow Publ. 1986. 130 p. (In Russian).
  16. Linnik LF, Semikova TS, Timofeev LV. Experience of Using Ofthalmoplegical with Ruthenium-106+Rhodium-106. Materials of the All-Russian Scientific Conference "Methods of Obtaining and Using Therapeutic Radiation Sources." Moscow Publ. 1991 (In Russian).
  17. Timofeev LV, Bochkarev VV, Degtyarev SF Reduction of the Current of the Photoelectron Amplifier under the Influence of Gamma or x-ray Radiation.  Medical Radiology. 1970; 15; 9:73-7 (In Russian).
  18. Mikhailov LM, Arefieva ZS Tables for Calculation of Thickness of Protection from Lead Glasses from "Wide Beam" Rays.  Atomic Energy. 1962; 12; 1:58-62 (In Russian).

 PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 23.12.2020. 

Accepted for publication: 20.01.2021.

Medical Radiology and Radiation Safety. 2021. Vol. 66. № 3. P. 48–54

I.L. Bukhovets1, O.Ya. Vasiltseva1,2, Yu.B. Lishmanov1,2, I.N. Vorozhtsova1,3, A.G. Lavrov3, 
E.A. Ivanovskaya5, A.M. Cherniavskii2, W.Yu. Ussov1,2

Design and Clinical Evaluation of Pharmacologic Stress-Test with Dalargin
for SPECT Detection of Viable Myocardium in Patients after Myocardial Infarction

1 Cardiology Research Institute, Tomsk National Medical Research Center, Tomsk, Russia

2 E.N. Meshalkin National Medical Research Center, Novosibirsk, Russia  

3 National Research Tomsk Polytechnic University, Tomsk, Russia

4 Siberian State Medical University, Tomsk, Russia

5 Novosibirsk State Medical University, Novosibirsk, Russia

 Contact person: Wladimir Yurievich Ussov: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Purpose: To develop a functional stress-test with Dalargin used as a pharmacological stress agent and to study its diagnostic capabilities for quantifying the general and segmental systolic function of the left ventricle in patients with IHD using SPECT and echo methods.

Material and methods: The study comprised 29 male patients with CHD-angina of 2-3 functional classes, studied on 15–25 days (on average 20 ± 2.8 days) after a large-focal myocardial infarction. A fractional step-wise injection of Dalargin was performed with step doses as 0.1 mg / kg (1 ml up to a total of 8 ml, with intervals of 90 seconds, for a total of 12 minutes), in a supine position. After each dose of Dalargin, blood pressure, heart rate, ECG were recorded, and an echocardiographic assessment of hemodynamic parameters and local contractility was carried out. At the peak of the effect of dalargin, 99mTc-Tetrofosmin was administered intravenously (370 – 540 MBq), followed by chest SPECT.

Results: The optimal dose of dalargin for assessing the contractility of the LV was 0.3 mg/kg. From the data of myocardial perfusion SPECT, at dalargin test, the number of segments with normal regional blood supply increased statistically significantly from 56,0 % to 64,7 %, the number of hypoperfused segments decreased from 41.0% to 33.7% as compared to rest, and the number of non-perfused ones – from 3.0 % to 1.6 %. Spearman’s correlation coefficient between segmental contractility and local perfusion at the top dalargin inotropic effect was high and significant (R=0.67, p<0.01). The sensitivity and specificity of the pharmacological test with intravenous administration of dalargin for prediction of postoperative improvement of perfusion and contractility of the viable myocardium were: sensitivity 78.8 %, specificity 76.4 %, diagnostic accuracy 77.6 %.

Conclusion. The use of the agonist of the μ - and δ-opioid receptors dalargin as a pharmacological stress-agent at perfusion SPECT and Stress Echocardiography to assess the contractile reserve of a dysfunctional viable myocardium is informative and appropriate. In patients with IHD who have suffered a myocardial infarction and are referred to  myocardial revascularization, dalargin can be employed as an effective stress-agent for assessing the reserve of perfusion and contractility of dysfunctional left ventricular myocardium using perfusion  SPECT and echocardiography.

Key words: SPECT, myocardial blood flow, functional reserve, dalargin, dalargin functional test, heart ultrasound

For citation: Bukhovets IL, Vasiltseva OYa, Lishmanov YuB, Vorozhtsova IN, Lavrov AG, Ivanovskaya EA, Cherniavskii AM, Ussov WYu. Design and Clinical Evaluation of Pharmacologic Stress-Test with Dalargin for SPECT Detection of Viable Myocardium in Patients after Myocardial Infarction. Medical Radiology and Radiation Safety. 2021;66(3):48-54.

DOI: 10.12737/1024-6177-2021-66-3-48-54

References

  1. Maslov LN, Lishmanov YuB, Maryzhnaya NV. Opioidergic Component of Morpho-functional Changes in Myocardium in Stress and Adaptation. Tomsk, STT Publ., 2003. 237 p. (In Russian).
  2. Ussov WYu, Efimova IYu, Plotnikov MP, Karpov RS. Patterns of Cerebral Blood Flow Reactivity in Adenosine Stress-test in Patients with Carotid Stenosis, Evaluated with MRI and 99mTc-HMPAO SPECT Brain study. Vestnik Rentgenologii i Radiologii = Russ. J. Radiol. 2000;6:4-9 (In Russian).
  3. Aronov DM, Lupanov VP. Functional Tests in Cardiology. Moscow, Medpress-Inform, Publ., 2007 (In Russian).
  4. Borisenko VG, Gubareva EA, Kade AH. Myocardial Reactions to Ischemia. Therapeutic Archive. 2010;82;3:64-67 (In Russian).
  5. Bydanova SS, Kiryanova AN, Leshchinskii LA, Bydanov SA. Clinical Efficiency of Application of an Analogue of Endogenous Neuropeptides Dalargin in Complex Therapy of Acute Coronary Syndrome. Practical Medicine. 2004;1;6:22-23 (In Russian).
  6. Griffin B, Topol E. Cardiology. Moscow, Praktika, Publ., 2008 (In Russian).
  7. 7. Maslov LN, Naryzhnaya NV. Receptor Mechanisms and Signaling of Myocardial Protection Against Ischemic – Reperfusion Damage. Tomsk, University of Control Systems and Radioelectronics Publ., 2018. 352 p. (In Russian).
  8. Ansheles AA, Sergienko IB, Denisenko-Kankiya EI, Sergienko VB. Myocardial Perfusion SPECT and Coronary Angiography Results in Patients with Different Pre-Test Probability of Ishemic Heart Disease. Therapeutic Archive. 2020;92;4:30-36 (In Russian). DOI:10.26442/00403660.2020.04.000549.
  9. Migrino RQ, Xiaoguang Zhu, Pajewski N. Assessment of Segmental Myocardial Viability Using Regional 2-dimensional Strain Echocardiography. Journal of the American Society of Echocardiography. 2007;20;4:342-351. DOI:10.1016/j.echo. 2006.09.011.
  10. Dontsov AV. Possibilities of Dalargin in Treatmen of Patients Ischemic Heart Disease. Digest of New Medical Technologies. 2012;19;3:159-161 (In Russian).
  11. Lishmanov YuB, Makarova EV, Chernov VI, Vesnina JV, Babokin VE, Vorozhtsova IN, Bukhovets IL. I99Tl Reinjection Combined with SPECT Imaging in Myocardium Hibernation Diagnosis. Medical Radiology and Radiation Safety. 2005;50;1:62-67 (In Russian).
  12. Saidova MA. Current Methods of Detection of Viable Myocardium. Kardiologia. 2005;9: 47-54 (In Russian).
  13. Rosa S, Lauro C. The Clinical use of Stress Echocardiography in Ischemic Heart Disease. Cardiovascular Ultrasound. 2017;15:7. DOI 10.1186/s12947-017-0099-2.
  14. Vorozhtsova IN, Bukhovets IL, Bezlyak VV, Babokin VE, Lishmanov YuB. Prognostication of Hemodynamic Efficacy of Surgical Correction of Chronic Coronary Insufficiency Based on Stress test with Nitroglycerine. Cardiologia. 2003;6:23-27 (In Russian).
  15. Lishmanov YuB, Maslov LN. Ishemic Post-Conditioning of the Heart. Receptor Mechanisms and Possibilities of Clinical Applications. Cardiologia. 2010;6:68-74 (In Russian).
  16. Rybakova MK, Alekhin MN, Mit’kov VV. Echocardiohgraphy: Practical Guidebook in Ultrasound Diagnosis. Moscow, Vidar-M Publ., 2008. 544 p. (In Russian).
  17. Ross J. Myocardial Perfusion-Contraction Matching. Implications for Coronary Heart Disease and Hibernation. Circulation. 1991;83:1076-1083.

 PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Development of the concept and design of the study: Usov V.Yu., Bukhovets I.L., Vasiltseva O.Ya., Chernyavsky A.M., Lishmanov Yu.B.; Obtaining, analysis and scientific interpretation of data: Vasiltseva O.Ya., Bukhovets I.L., Lavrov A.G., Vorozhtsova I.N., Ivanovskaya E.A., Lishmanov Yu.B., Usov V.Yu.; Substantiation of the manuscript and verification critical intellectual content: Bukhovets I.L., Lavrov A.G., Vorozhtsova I.N., Chernyavsky A.M., Usov V.Yu.; Final approval of the manuscript for publication: Bukhovets I.L., Vasiltseva O.Ya., Lishmanov Yu.B., Chernyavsky A.M., Usov V.Yu.

Article received: 18.08.2020.

Accepted for publication: 19.01.2021

 

 

 

Medical Radiology and Radiation Safety. 2021. Vol. 66. № 3. С. 55–61

V.P. Zolotnitskaia1, I.V. Amosov1, O.P. Baranova1, A.P. Litvinov1, V.I. Amosov1,
A.A. Speranskaia1, V.A. Ratnikov2

SPECT with 67Ga Citrate in the Diagnosis of Systemic Sarcoidosis

1Academician I.P. Pavlov First St.-Petersburg State Medical University, St. Petersburg, Russia

2Sokolov Hospital № 122, St. Petersburg, Russia

Contact person: Valentina Petrovna Zolotnitskaia: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Purpose: To study the possibilities of using 67Ga-citrate in patients with systemic manifestations of sarcoidosis to identify foci of pathological accumulation of the drug and assess the degree of process activity.

Material and methods: Radionulide study with 67Ga-citrate was performed in 140 patients with respiratory sarcoidosis and suspected extrapulmonary localization. In addition, all patients underwent X-ray examination of the lungs, MSCT of the organs of the chest and abdominal cavity, SPECT of the lungs with radiopharmaceutical macroaggregates of albumin, ultrasound of the abdomen, pelvis, MRI of the head was performed in 16 patients with suspected neurosarcoidosis.

Results: Most patients (n = 125) showed changes in the lungs, manifested by a bright glow (yellow or purple) on the computer screen, which indicated a pronounced impaired function of lymphoid tissue. In 22 patients, the changes were recurrent. The results correlated with published data on damage to the nervous system (r = 0.96), musculoskeletal system (r = 0.97), parotid glands (r = 0.91), liver, spleen (r = 0.83) . At the same time, the results for eye damage (r = 0.23), ENT organs (r = 0.15), intestines (r = 0.48) were significantly different. In our study, no heart lesions were detected in any case.

Conclusions: The use of positive scintigraphy with Ga-67 citrate, taking into account the whole body scan and SPECT of areas of interest of interest (chest cavity, abdominal cavity, head, pelvis) is effective for the diagnosis of systemic sarcoidosis and in determining the activity of the process. The study is recommended to be performed 72 hours after intravenous administration of the drug.

The combination of CT, MRI and radionuclide studies allows you to obtain reliable information about the activity of the process, to identify the localization of increased metabolic activity, that is, the topography of active sarcoidosis.

Key words: sarcoidosis, 67Ga-citrate, SPECT

For citation: Zolotnitskaia VP, Amosov IV,.Baranova OP, Litvinov AP, Amosov VI, Speranskaia AA, Ratnikov VA. SPECT with 67Ga citrate in the diagnosis of systemic sarcoidosis. Medical Radiology and Radiation Safety. 2021;66(3):55-61.

DOI: 10.12737/1024-6177-2021-66-3-55-61

References

  1. Landi C, Carleo A, Cillis G, Rottoli P. Sarcoidosis: Proteomics and new Perspectives for Improving Personalized Medicine. Expert. Rev. Proteomics. 2018;15;10:829-835. DOI: 10.1080/14789450.2018.152 8148. 
  2. Vizel' AA, Vizel' IYu, Amirov NB Epidemiology of Sarcoidosis in the Russian Federation. Vestnik Sovremennoi Klinicheskoi Meditsiny. 2017;5:66-73 (In Russian) DOI: 10.20969/VSKM.2017.10(5). 66-73.
  3. Tikhonovich EL, Vezikova NN, Markelova OA, Malysheva I.E. Epidemiology, Clinical Features, Diagnosis and Treatment of Sarcoidosis in Karelia. Uchen. app. Petrozavod. State un-that. Ser. Natural and Technical Sciences. 2015;6;151:67-71 (In Russian).
  4. Elizabeth V, Arkema EV, Johan Grunewald J, Kullberg S, et al. Sarcoidosis Incidence and Prevalence: a Nationwide Register-based Assessment in Sweden. Eur. Respir. J. 2016;48:1545-1548.
  5. Baughman RP, Field S, Costabel U et al. Sarcoidosis in America. Analysis Based on Health Care Use. Ann Am Thorac Soc. 2016;13;8:1244-52. DOI: 10.1513/AnnalsATS.201511-760OC. 
  6. Fomin VV, Brovko MYu. Kalashnikov MV, Sholomova VI, Rozina TP, Akulkina LA, Pershina AE, Yanakaeva ASh, Nekrasova TP. Damage to the Liver with Sarcoidosis. Therapeutic Archive. 2019;04:4-12 (In Russian). DOI: 10.26442/00403660.2019.04. 000179
  7. Ungprasert P, Matteson EL Neurosarcoidosis. Rheum. Dis. Clin. North Am. 2017;43;4:593-606. Epub 2017. Aug. 23.  DOI: 10.1016/j.rdc.2017.06.008.
  8. Ibitoye RT, Wilkins A, Scolding NJ Neurosarcoidosis: a Clinical Approach to Diagnosis and Management  J. Neurol. 2017;264;5:1023-1028. DOI: 10.1007/s00415-016-8336-4.
  9. Vizel' AA, Amirov NB. Sarcoidosis and Organ Damage in the Digestive System. Vestnik Sovremennoi Klinicheskoi Meditsiny. 2010;1:43-50 (In Russian).
  10. Valeyre D, Prasse A, Nunes H, Uzunhan Y, Brillet PY, Müller-Quernheim J. Sarcoidosis. Lancet. 2014;383;9923:1155-67. DOI: 10.1016 /S0140-6736(13)60680-7 
  11. Lebedeva MV, Popova EN, Ponomarev AB, et al. Extrapulmonary Manifestations of Sarcoidosis. Vrach. 2011;3:43-5 (In Russian).
  12. El Sayed F, Torbey G, Youssef H, Chababi M. Childhood Sarcoidosis: Diagnostic Issues. Dermatol. Online J. 2013. V.19, No.10. P.20037
  13. Lishmanov YuB, Chernov VI. Radionuclide Diagnostics for Medical Practitioners. Tomsk.: STT, 2004. 394 p. (In Russian).
  14. Gezer N, Başara I, Altay C, Harman M, Rocher L, Karabulut N, Seçil M. Abdominal Sarcoidosis: Cross-Sectional Imaging Findings. Diagn Interv Radiol. 2015. V.21, No.2. P.111-7. DOI: 10.5152/ dir.2014.14210
  15. Chapman MN, Fujita A, Sung EK, Siegel C. Nadgir RN, Saito N, Sakai O. Sarcoidosis in the Head and Neck: an Illustrative Review of Clinical Presentations and Imaging Findings  AJR Am. J. Roentgenol. 2017. V.208, No.1. P.66-75. DOI: 10.2214/ AJR.16.16058.
  16. Heinle R, Chang C. Diagnostic Criteria for Sarcoidosis. Autoimmun Rev. 2014. V.13, No.5. P.383-387. DOI: 10.1016/j.autrev.2014. 01.035
  17. Aratfni T, Narabayashy I, Komori N, et al. Usefulness of Tc-99mMIBI SPECT in Predicting Multidrug Gene Expression Levels in Non-Small Cell Lung Cancer a Preliminary. Ann Nucl. Med. 2001;15;4:313-319.
  18. Korchagina EO. Results of Clinical and Radionuclide Studies in Patients with Respiratory Sarcoidosis. Ukrainian Medical Almanac. 2009;12;2:85-87 (In Russian).
  19. Videnovic, Ivanov J, Vucinic Mihailovic V, Artiko V, et al. Responsiveness of FDG PET/CT to Treatment of Patients with Active Chronic Sarcoidosis. Clin. Nucl. Med. 2013;38;7:516-521.
  20. Zaitsev AA, Antipushina DN, Sivokozov IV. Practical Possibilities of PET / CT in Assessing the Activity and Prevalence of Sarcoidosis. Pulmonology. 2013;6:119-122 (In Russian).

 PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 23.12.2020. 

Accepted for publication: 20.01.2021. 

Medical Radiology and Radiation Safety. 2021. Vol. 66. № 3. P. 40–47

G.P. Frolov1, K.N. Melkova2, T.I. Gimadova1, E.I. Klimenko1

Historical Aspects and Practice of the Use of Total Therapeutic Human Exposure

1A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia

2ALC Kompas Zdorovya, Moscow, Russia

Contact person: Gennady Pavlovich Frolov: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

The article discusses the historical experience of introducing into practice the clinic of the State Research Center Institute of Biophysics, Ministry of Health of the USSR, the method of irradiation of the whole patient's body on a device containing 137 Cs at a dose of 10–12 Gy before bone marrow transplantation. To ensure the safety of the total therapeutic irradiation method (TTI, total body irradiation – TBI in the world literature), as well as to maintain the specified irradiation parameters, a dose control system was used using thermoluminescent dosimeters (TLD) attached to the patient's body at each irradiation fraction to correct the total dose to the last fraction. In addition to the therapeutic procedure, the TTO model was used to study aspects of verification of emergency exposure and other issues of supporting cases of acute radiation disease. The practical part of the article illustrates the method of radiation dose control using TLD at 22 points when changing the TTI (TBI) technique to a linear accelerator for radiotherapy 6 MeV to perform the procedure with a more preferable dose rate and reduce the patient's exposure time for a fraction of radiation at a dose of 2 Gy for 40 to 20 minutes. The article presents the parameters of the irradiation according to the method and the data obtained on the basis of TLD during the irradiation of the patient according to the modified method. The correspondence of the radiation dose, as well as the irregularity of the irradiation to the specified parameters (less than 10 %), as well as the effectiveness of the use of lung protection with dose reduction from 12 to 8 Gy, is shown. The specified measurements using TLD should be carried out when changing the method at the first actual application, especially in the absence of preliminary phantom measurements. A clear understanding of the principles of radiation therapy in the case of TTI (TBI) is an invaluable experience of doctors, which is used in the treatment of rare cases of acute radiation sickness as a result of emergency (uncontrolled) exposure, both at radiation-hazardous enterprises and with known calculation errors in planning therapeutic radiation.

Key words:radiation therapy, total body irradiation, thermoluminescent dosimeter, bone marrow transplant, equipment for irradiation of the human body, radiation dose control, exposure in a radiation accident.

For citation: Frolov GP, Melkova KN, Gimadova TI, Klimenko EI. Historical Aspects and Practice of the Use of Total Therapeutic Human Exposure. Medical Radiology and Radiation Safety 2021;66(3):40-47.

DOI: 10.12737/1024-6177-2021-66-4-40-47

References

  1. Wheldon TE The Radiological Basis of Total Body Irradiation. Br. J Radiol. 1997;70:1204-1207.
  2. Tae HK, Faiz MK, Galvin JM A Report of the Work Party: Comparison of Total Body Irradiation Techniques for Bone Marrow Transplantation. Int. J Radiol. Oncol. Biol. Phys. 1980;6:779-83.
  3. Bortin MM. A Compendium of Reported Human Bone Marrow Transplants. Transplantation. 1970;9(6):571-83.
  4. Melkova KN, Gorbunova NV, Chernyavskaya TZ, et al. Total Body Irradiation for Bone Marrow Trasplantation. Journal of Clinical Oncohematology. 2012;5(2):96-116 (In Russian).
  5. Gorlachev GE, Trofimova OP, Zaychenko OS, Krylova TA, Gutnik RA, Yazhgunovich IP. Rules and Technique in Total Body Irradiation. Journal of Medical Physics. 2018;1:17-18 (In Russian).
  6. Bochvar IA, Gimadova TI, Keirim-Markus IB, Kushnerev AYa, Yakubik VV. IKS Method of Dosimentry. Мoscow, Atomizdat Publ., 1977. 222 p. (In Russian).
  7. Nugis V.Yu. Medical Radiology. 1986;(9):30-35 (In Russian).

 PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 23.12.2020. 

Accepted for publication: 20.01.2021. 

 

 
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  2. 29-34_Ilyin_Fazylova_eng
  3. 19-28_Frolov_Salenko_eng
  4. 13-18_Metlyaeva_Lartsev_eng

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