Medical Radiology and Radiation Safety. 2021. Vol. 66. № 4. P. 86–88

Analysis of the Results of Psychophysiological Examinations of Personnel of Nuclear Facilities

M.Yu. Kalinina, A.S. Kretov, A.N. Tsarev, M.A. Soloreva, E.A. Denisova

A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia

Contact person: Andrey Sergeevich Kretov: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

The link between the health level of an employee and his professional reliability is currently obvious and does not require additional proof. The implementation of measures aimed at reducing the risks of developing emergency situations due to the fault of the human factor at nuclear facilities is an important element of the radiation protection system.

In order to achieve the above goals of the organization in accordance with Federal Law No. 170-FZ of 21.11.1995, the performance of certain types of work in the field of atomic energy use requires special permits from Rostechnadzor. A prerequisite for obtaining such a permit for a specialist is the absence of psychophysiological contraindications based on the results of a psychophysiological examination.

In this study, the analysis of the results of psychophysiological examinations (hereinafter referred to as PPhE) of employees of atomic energy facilities, carried out by specialists of the A.I. Burnasyan Federal Medical Biophysical Centre in 2020.

Key words: workers, psychophysiological examinations, psychophysiological contraindications, radiation safety, nuclear facilities, nuclear industry

For citation: Kalinina MYu, Kretov AS, Tsarev AN, Soloreva MA, Denisova EA. Analysis of the Results of Psychophysiological Examinations of Personnel of Nuclear Facilities. Medical Radiology and Radiation Safety. 2021;66(4):86-88.

DOI: 10.12737/1024-6177-2021-66-4-86-88

References

1. Bobrov A.F. Рrevention of technological emergency situations: information technology to develop criteria for anthropo genic risks estimation. Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2019. N 2. P. 5–16. DOI 10.25016/2541-7487-2019-0-2-05-16 (In Russian).

2. Bushmanov A.Yu., Kretov A.S., Shcheblanov V.Y., Bobrov A.F., Kretova E.Y. The System of Organization the Obligatory Medical Surveys of Employees of Nuclear Facilities at the Current Stage. Medical Radiology and Radiation Safety. 2014;59(4):9-17. (In Russian). 

 PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 16.02.2021. 

Accepted for publication: 20.04.2021. 

Medical Radiology and Radiation Safety. 2021. Vol. 66. № 3. С. 76–81

A.V. Polynovskiy¹, D.V. Kuzmichev¹, Z.Z. Mammadli¹, M.V. Chernich², J.E. Suraeva¹,
J.M. Madjarov¹, A.A. Aniskin¹, E.S. Kolobanova¹

Successful Case of Treatment the Patient with Synchronous Rectal 
and Sigmoid Cancers and Synchronous Lung Metastasis

¹N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia

²PET-Technology, Podolsk, Moscow Region, Russia

Contact person: Andrey Vladimirovich Polynovskiy: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Colorectal cancers (CRC) takes the leading position in the incidence of morbidity and mortality worldwide. Metastatic CRC in the primary diagnosis ranges from 15 to 35 %. Lung metastasis are the most frequent extraperitoneal manifestation of the metastatic process. Such patients are relatively rare and there are no clear recommendations for their treatment tactics to date. This clinical case describes a successful strategy of using preoperative prolonged chemoradiotherapy on a primary tumor and stereotactic irradiation of lung metastasis, with courses of chemotherapy, with further radical laparoscopic operation, in a patient with disseminated primary multiple rectal cancer, synchronous sigmoid colon cancer and 2 metastatic focuses in both lungs.

Key words:rectal cancer, metastatic, lung metastasis, stereotactic body radiotherapy, ablative radiation therapy, chemoradiotherapy

For citation: Polynovskiy A.V., Kuzmichev D.V., Mammadli Z.Z., Chernich M.V., Suraeva  J.E., Madjarov J.M., Aniskin A.A., Kolobanova E.S. Successful Case of Treatment the Patient with Synchronous Rectal and Sigmoid Cancers and Synchronous Lung Metastasis.  Medical Radiology and Radiation Safety. 2021;66(3):76-81.

DOI: 10.12737/1024-6177-2021-66-3-76-81

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 PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 17.03.2021. 

Accepted for publication: 17.03.2021.

 

Medical Radiology and Radiation Safety. 2021. Vol. 66. № 4. P. 89–100

To the Question About Pharmacological Protection During Irradiation
in Non-infecting Doses: Maybe, Necessary?
Part 1.
General Overview of Medical-tactical and Phenomenological Aspects

A.V. Ivanchenko¹, V.A. Basharin², I.S. Drachev¹, A.B. Seleznev¹, A.Yu. Bushmanov³

¹Scientific Research Testing Institute of Military Medicine, St. Petersburg, Russia.

²S.M. Kirov Military Medical Academy, St. Petersburg, Russia.

³A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia

Contact person: Alexander Viktorovich Ivanchenko, This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: Review of modern concepts of the biological effect of ionizing radiation in medium doses on a living organism and the consequences of radiation in order to assess the need for the use of drugs suitable for the purpose of modifying the effects; stimulation of discussion on the issue under consideration.

Results: The conditions of origin and the list of possible radiation effects from irradiation at medium doses of the 0.1–1 Gy range were assessed, the scale and phenomenology of the consequences were assessed as a subject of modification by antiradiation agents.

Conclusions: Pharmacological support (use of PLC) under conditions of short-term and prolonged irradiation with a low dose rate and in the dose range of 0.2–1 Gy seems to be necessary due to the reality of deterministic effects when the dose limits are exceeded (partly at the premorbid or preclinical level, with pronounced psychogenic reactions – components of the final state), as well as with the possibility of stochastic effects in excess of spontaneous ones, although, according to approximate estimates, with an insignificant frequency.

Key words: irradiation, average doses, antiradiation agents, disputable use

For citation: Ivanchenko A.V., Basharin V.A., Drachev I.S., Seleznev A.B., Bushmanov A.Yu. To the Question About Pharmacological Protection During Irradiation in Non-infecting Doses: Maybe, Necessary? Part 1.Ggeneral Overview of Medical-Tactical and Phenomenological Aspects. Medical Radiology and Radiation Safety. 2021;66(4):89-100.

DOI: 10.12737/1024-6177-2021-66-4-89-100

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Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 16.02.2021. 

Accepted for publication: 20.04.2021. 

Medical Radiology and Radiation Safety. 2021. Vol. 66. № 3. P. 68–75

Е.S. Sukhikh^1,2, L.G. Sukhikh², A.V. Vertinsky^1,2, P.V. Izhevsky³, I.N. Sheino³,  V.V. Vertoukhova²

Analysis of the Physical and Radiobiological Equivalence of the Calculated
and Measured Dose Distributions for Prostate Stereotactic Radiotherapy

¹Tomsk Regional Oncology Center, Tomsk, Russia

²National Research Tomsk Polytechnic University, Tomsk, Russia

³AI Burnasyan Federal Medical Biophysical Center Moscow, Russia

Contact person: Andrei Vladimirovich Vertinskii: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Purpose: Carrying out the analysis of the physical and radiobiological equivalence of dose distributions obtained during the planning of hypofractionated stereotactic radiation therapy of the prostate cancer and verification using a three-dimensional cylindrical dosimeter.

Material and Methods: Based on the anatomical data of twelve patients diagnosed with prostate carcinoma, stage T2N0M0 with low risk, plans were developed for stereotactic radiation therapy with volumetric modulates arc therapy (VMAT). The dose per fraction was 7,25 Gy for 5 fractions (total dose 36,25 Gy) with a normal photon energy of 10 MV. The developed plans were verified using a three-dimensional cylindrical ArcCHECK phantom. During the verification process, the three-dimensional dose distribution in the phantom was measured, based on which the values of the three-dimensional gamma index and the dose–volume histogram within each contoured anatomical structures were calculated with 3DVH software.

The gamma index value γ (3 %, 2 mm, GN) at a threshold equal to 20 % of the dose maximum of the plan and the percentage of coincidence of points at least 95 % was chosen as a criterion of physical convergence of the calculated and measured dose distribution according to the recommendations of AAPM TG-218. To analyze the radiobiological equivalence of the calculated and measured dose distribution, the local control probability (TCP) and normal tissue complication probability (NTCP) criteria were used based on the calculated and measured dose–volume histograms. Contours of the target (PTV) and the anterior wall of the rectum were used for the analysis. The approach based on the concept of equivalent uniform dose (EUD) by A. Niemierko was used to calculate the values of TCP/NTCP criteria.

Results: The results of physical convergence of plans for all patients on the contour of the whole body were higher than 95 % for the criteria γ (3 %, 2 mm, GN). The convergence along the PTV contour is in the range (75.5–95.2)%. The TCP and NTCP values obtained from the measured dose-volume histograms were higher than the planned values for all patients. It was found that the accelerator delivered a slightly higher dose to the PTV and the anterior wall of the rectum than originally planned.

Conclusion: The capabilities of modern dosimetric equipment allow us move to the verification of treatment plans based on the analysis of TCP / NTCP radiobiological equivalence, taking into account the individual characteristics of the patient and the capabilities of radiation therapy equipment. 

Key words: 3D gamma analysis, dose-volume histogram, tumor control probability, normal tissue complication probability

For citation: Sukhikh ЕS, Sukhikh LG, Vertinsky AV, Izhevsky PV, Sheino IN, Vertoukhova VV. Analysis of the Physical and Radiobiological Equivalence of the Calculated and Measured Dose Distributions for Prostate Stereotactic Radiotherapy. Medical Radiology and Radiation Safety. 2021;66(3):68-75.

DOI: 10.12737/1024-6177-2021-66-3-68-75

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Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 23.12.2020. 

Accepted for publication: 20.01.2021.