JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2012. Vol. 57. No. 5. P. 5-10
RADIATION BIOLOGY
K.V. Kotenko1, I.K. Belyaev1, Yu.P. Buzulukov2, А.Yu. Bushmanov1, V.F. Demin2, I.V. Gmoshinski3, E.S. Zhorova1, V.S. Kalistratova1, N.S. Marchenkov2, P.G. Nisimov1, R.V. Raspopov3, V.Yu. Soloviev1
Experimental Research of Zinc Oxide-labeled Nanoparticles Biokinetics in Rats’ Organism after Single Oral Administration by Labeled Atoms Technology
1. Burnasyan Federal Medical Biophysical Center (FMBC) of Federal Medical Biological Agency, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Russian Research Center Kurchatov Institute, Moscow, Russia; 3. Institute of Nutrition of RAMS, Moscow, Russia
Abstract
Purpose: To make quantitative assessment of zinc oxide-labeled nanoparticles’ biokinetics in laboratory animals’ (rats’) organism after single oral administration.
Material and methods: Suspension of zinc oxide nanoparticles with 30 nmmedian diameter was used as source material. Before the injection nanoparticles were irradiated to thermal neutron beam, so that part of the atoms was activated with formation of radioactive nucleus of 65Zn with half-life of 234.8 days. Four groups of animals were used in the experiment (3 male Wistar rats with average body weight of ~ 170 g in each group). According to number of animals used in the experiment, the suspension of nanoparticles was divided into 12 parts of 0.5 mL each. Animals were sacrificed at hours 4, 24, 72 and 120 after administration; then organs of the sacrificed animals including brain, heart, lung, liver, spleen, pancreas, kidneys, testicle, also remained carcass, blood, excrement and urine were analyzed. Changes of organs’ activity were recorded on low-background gamma-ray spectrometer.
Results: Biokinetic parameters of Vistar rat-males are evaluated after single oral administration of zinc oxide nanoparticles. Maximum content of nanoparticles was observed in 24-72 hours after oral administration. 65Zn mass distribution in rats’ organs at maximum point decreases according to the following sequence: liver®kidneys®spleen ®pancreas®heart®blood®brain.
Conclusion: 1. Technology of producing new type of product - labeled nanoparticles by means of irradiating them with thermal neutrons of nuclear reactor is elaborated. 2. It is proved that there is a possibility to do research of nanoparticles’ biokinetics in the laboratory animal organisms using labeled atoms technology. 3. 65Zn activity records in the rats’ brain (near 0.06 % of administered activity) proves that nanoparticles can mount blood brain barrier.
Key words: nanoparticles, zinc oxide, radioactive label, experiment, rats, biokinetics, blood brain barrier
REFERENCES
- Soloviev V.Yu. Problem of providing safety of nanotechnology, human health products produced by means of nanotechnology and safety of life environment. Internat. Forum on Natotechnologies, 3-5.12.2008. Moscow. 2008. Vol. 2. P. 286-288.
- Hagens W.I., Oomen A.G., de Jong W.H. et. al. What do we (need to) know about the kinetic properties of nanoparticles in the body? Regul. Toxicol. Pharmacol. 2007. Vol. 49. No. 3. Р. 217-229.
- Li S.D., Huang L. Pharmacokinetics and biodistribution of nanoparticles. Mol. Pharm. 2008. Vol. 5. No. 4. Р. 496-504.
- Tang J., Xiong L., Wang S. et. al. Distribution, translocation and accumulation of silver nanoparticles in rats. J. Nanosci. Nanotechnol. 2009. Vol. 9. No. 8. Р. 4924-4932.
- De Jong W.H., Hagens W.I., Krystek P. еt. аl. Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials. 2008. Vol. 29. No. 12. Р. 1912-1919.
- Zhu M.-T., Feng W.-Y., Wang Y. et. al. Particokinetics and extrapulmonary translocation of intratracheally instilled ferric oxide nanoparticles in rats and the potential health risk assessment. Toxicol. Sci. 2009. Vol. 107. No. 2. Р. 342-351.
- Raspopov R.V., Buzulukov Yu.P., Marchenkov N.S. et. al. Research of zinc oxide nanoparticles’ bioavailability by radioactive tracer method. Nutrition questions. 2010. Vol. 79. No. 6. P. 14-18.
- Richness of the Nano-World. Photo-Report from the Depths of Matter. Ed. by Yu.D. Tretyakov. Moscow: BINOM. BKL Publishers. 2010. 171 p.
For citation: Kotenko KV, Belyaev IK, Buzulukov YuP, Bushmanov АYu, Demin VF, Gmoshinski IV, Zhorova ES, Kalistratova VS, Marchenkov NS, Nisimov PG, Raspopov RV, Soloviev VYu. Experimental Research of Zinc Oxide-labeled Nanoparticles Biokinetics in Rats’ Organism after Single Oral dministration by Labeled Atoms Technology. Medical Radiology and Radiation Safety. 2012;57(5):5-10.
PDF (ENG) Full-text article (in Inglish)Medical Radiology and Radiation Safety. 2012. Vol. 57. No. 6. P. 74-77
REVIEW
A.K. Guskova
German Specialists in Soviet Atomic Project
Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
The paper is devoted to the analysis of publications on the work of German specialists in the USSR Atomic Project (1945-1956). The operations done by groups composed of different staff members are analysed. Staff members from East Germany previously involved in biophysics and dosimetry subjects were invited. The work was also elaborated by the USSR citizens who have worked in the USSR and Germany during the wartime and were sentenced to prison term thereafter. The laboratory personnel have also included voluntary hired specialists and persons with legally limited social rights (Volga river catchment residents with German origin). Main goals and tasks of work are described for four laboratories responsible for research in the areas of radioactive waste, environment releases of nuclear facilities and for studies on radiation protection of human and environment. Most active operations were done in Laboratory B (town of Sungul, Urals). Detailed information on personnel selection principles and managerial measures is provided for these comprehensively staffed teams. The work results of these teams are compared to those obtained by correspondent routinely organized laboratories and facilities in the USSR. This paper publication is related to present efforts under the program of bilateral activities between Germany and Russia.
Key words: Soviet atomic project, German specialists, collaboration history
Medical Radiology and Radiation Safety. 2012. Vol. 57. No. 6. P. 58-67
NUCLEAR MEDICINE
I.S. Romanov, A.A. Odjarova, D.B. Udintsov, Y.V. Vishnevskaya, M.I. Nechushkin, L.P. Yakovleva, V.I. Sokorutov, K.D. Ilkaev
Identification of Sentinel Lymph Nodes in Squamous Cell Carcinoma of the Oral Cavity by Lymphoscintigraphy
N.N. Blokhin Russian Cancer Research Center of RAMS, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: To satisfy that lymphoscintigraphy prior the operation and the intraoperative method gamma-probe using provide to detect the sentinel nodes. Because the pathomorphological status of the sentinel node can evidently reflect presence or absence of the occult metastatic spread in the head and neck lymph groups in patients suffering of squamous cell carcinoma of the oral cavity with clinically (cN0) - negative lymph node occult regional metastases status.
Material and methods: There were 45 patients included in our study with oral cancer, their representative status of the neck lymph nodes was considered as clinically negative (cN0). Before 24 - hours prior the operation, these patients have been undergone the peritumoral injection with radiopharmaceutical agent, known as NANOCIS 99mTc traced and then the lymphoscintigraphy of the neck lymph nodes has being performed. During the operation the precise localization of the sentinel node was additionally explored by the gamma-probe Neo 2000 R, and followed by the sentinel node alone removing. The next stage was the primary tumor incision and functional neck dissection on levels I-V was performed due to standards. The removed species were studied by the pathologist in routine way.
Results: It was possible to reveal the sentinel nodes presence in all patients of the group. Occult metastatic lymph node spread was appeared in 33.3 % patients. The most often level for the metastases location was the subdigastrical (IIA) -in about 60 % The most remote localization of the metastatic spread was the lower jugular group lymph nodes (level IV) - 6.7 %. False-negative results were mentioned in 4.4 % cases. It means that there were no any metastases in sentinel nodes but there was detected the presence of metastatic spread at some point in some others parts of the neck tissue. The accuracy was 95 %, the sensitivity was 87 % and the negative predictive value was - 94 %, respectively.
Conclusions: The method of the lymphoscintigraphy prior the operation and the intraoperative method of the gamma-probe using give an opportunity to detect the sentinel nodes evidently in a case of squamous cell carcinoma of the oral cavity. The patomorphological status of the sentinel nodes, which being removed during the operation, can objectively assess the metastatic spread to the regional lymph nodes
Key words: sentinel lymph nodes, oral cancer, lymphoscintigraphy
Medical Radiology and Radiation Safety. 2012. Vol. 57. No. 6. P. 68-73
NUCLEAR MEDICINE
T.N. Sharypova, S.L. Timerbaeva
Features of SPECT Visualization of Brain for Functional Changes Estimation in the Focal Distention Patients
Research Center of Neurology of RAMS, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose:To estimate features and specific SPECT visualizations into Brodmann`s Maps in patients with cervical distention (CD).
Material and method: 16 patients with CD and 7 controls studied with SPECT (e.cam Siemens) after intravenous injection with 700 MBk 99mTc-teoxim (analog HMPAO). For analysis of results the program “Neurogam” with standardized perfusion middle maps was used.
Results: Different variants of the image cerebral perfusion by criterions hyper- or hypo-perfusion into Brodmann’s Maps have been obtained: in the group CD - increase cerebral perfusion into 1-3, 4, 6 and 40 at 81 % into right brain and 75 % into left brain; the control group - normal perfusion into 1-3, 4, 6, 5, 7, 39, 40 (U-criterion of Mann-Whitney p < 0. 001).
Conclusions: Maps of brain perfusion reflect microcirculation and functional deviations in Brodmann`s Maps 1-3, 4, 6, 5, 7, 39, 40 of CD patients in comparison with the control group.
Key words: SPECT, brain, focal dystonia, brodmann’s maps
Medical Radiology and Radiation Safety. 2012. Vol. 57. No. 6. P. 51-57
RADIATION THERAPY
E.V. Klisho, I.V. Kondakova, Е.L. Choinzonov, D.А. Shishkin, S.Yu. Chizhevskaya
Relation of the Level of Matrix Metalloproteinases and Their Tissue Inhibitors in Blood Serum to the Radiation Therapy Efficiency of Patients with Squamous Cell Head and Neck Cancer
Cancer Research Institute, SB of RAMS, Tomsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: To study of the levels of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in blood serum of patients with squamous cell head and neck carcinoma for identification of molecular markers and to create the mathematical model for predicting tumor response to radiotherapy.
Material and methods: Serum MMP and TIMP levels were determined by ELISA (enzyme-linked immunosorbent assay).
Results and conclusions: In patients with squamous cell head and neck carcinoma, serum TIMP-1 (133.54 ± 9.50 ng/mL) and TIMP-2 (88.39 ± 15.25 ng/mL) levels were significantly lower in the group of patients with complete tumor response to radiotherapy than those in patients without any response (193.24 ± 22.68 and 125.94 ± 4.80 ng/mL, respectively, р <0.01). Mathematical models for predicting response to radiotherapy were devised. Serum levels of TIMP-1, TIMP-2 and MMP-2 before the treatment and the primary tumor size were the most important predictors of radiotherapy response. The sensitivity, specificity and diagnostic accuracy of the discriminant model were 96 %, 75 % and 89 %, respectively.
Key words: squamous cell head and neck carcinomas, molecular markers, efficacy of radiotherapy, matrix metalloproteinases, tissue inhibitors