JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 5
DOI:10.33266/1024-6177-2024-69-5-104-108
P.A. Lushnikova1, 2, Ya.N. Sutygina1, 2, E.S. Sukhikh2, 3, Zh.A. Startseva3,
A.A. Polyakov1
Possibilities of Modern Radiation Therapy for Locally Advanced Endometrial Cancer
1 Tomsk Regional Oncology Center, Tomsk, Russia
2 National Research Tomsk Polytechnic University, Tomsk, Russia
3 Tomsk National Research Medical Center, Tomsk, Russia
Contact person: P.A. Lushnikova, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Analysis of radical radiotherapy efficacy (combination of remote irradiation with simultaneous dose escalation to the tumor focus and subsequent intracavitary component) in a patient diagnosed with stage III endometrial cancer when surgical treatment is impossible. Assessment of the dynamics of the underlying disease and adverse events. The purpose of the study is to analyze the effectiveness of radical radiation therapy in a patient diagnosed with stage III endometrial cancer when surgical treatment is impossible.
Material and methods: We present a clinical case of a patient with inoperable stage III endometrial cancer (histologic variant-highly differentiated adenocarcinoma) with metastasis to the lower third of the vagina. The first stage was a course of remote radiotherapy on a linear gas pedal VarianTrueBeamSTx on the uterus, vagina, paravaginal tissues, pelvic lymph nodes up to a total dose of 50 Gy and simultaneous dose intensification on the area of tumor focus in the lower third of the vagina up to a total dose of 62.5 Gy. The method of dose administration was rotational radiotherapy with intensity modulation of photon radiation (Volume-modulated arc therapy ‒ VMAT).
The second stage was a course of intracavitary (contact, brachytherapy) radiotherapy on MultiSource HDR device with 60Co ionizing radiation source. A gynecological two-channel applicator was used during treatment. The plan of each treatment session was developed based on CT images on the SagiPlan planning station. Intracavitary radiation therapy mode – single dose of 6 Gy, 4 fractions were performed.
The effect of radiation therapy was assessed by MRI of pelvic organs with intravenous contrasting immediately after treatment and further at intervals of every 3 months.We present a clinical case of a 71 year old female patient diagnosed with stage III endometrial cancer (well-differentiated adenocarcinoma), with adenocarcinoma metastasis to the lower 1/3 of the vagina. Planning of radiotherapy and radiation therapy in a patient with inoperable endometrial cancer with simultaneous escalation of the dose of ionizing radiation to the area of metastasis in the vagina during the remote component and subsequent intracavitary boost to the uterine area. Study of the results of radiation therapy.
Results: After treatment, MRI data showed complete regression of the tumor nidus in the vagina and reduction of the nidus in the uterine body (more 50 %). Long-term control of the tumor process in the patient, confirmed by clinical and radiological studies (MRI of the pelvic organs), was also achieved.The capabilities of modern radiation therapy make it possible to carry out radical treatment of patients with endometrial cancer in clinical cases when it is necessary to increase the dose of ionizing radiation to a separate tumor focus, without exceeding the tolerable levels of radiation exposure to risk organs. This approach makes it possible to achieve remission in real clinical practice.
Conclusion: The capabilities of modern radiation therapy allow radical treatment of patients with inoperable endometrial cancer in clinical cases when it is necessary to increase the dose of ionizing radiation to a separate tumor focus without exceeding tolerance levels of radiation loads on risk organs. This approach makes it possible to achieve remission in real clinical practice.
Keywords: endometrial cancer, radiation therapy, dose escalation, intensity modulated radiation therapy, dosimetric planning, linear accelerator
For citation: Lushnikova PA, Sutygina YaN, Sukhikh ES, Startseva ZhA, Polyakov AA. Possibilities of Modern Radiation Therapy for Locally Advanced Endometrial Cancer. Medical Radiology and Radiation Safety. 2024;69(5):104–108. (In Russian). DOI:10.33266/1024-6177-2024-69-5-104-108
References
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.05.2024. Accepted for publication: 25.06.2024.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 5
DOI:10.33266/1024-6177-2024-69-5-109-113
D.V. Ivanov1, 2, D.R. Baytimirov2, S.F. Konev2, E.E. Aladova3
Using of Cotton Fabric and Fiber as Objects of Retrospective EPR Dosimetry
1 M.N. Mikheev Institute of Metal Physics, Ekaterinburg, Russia
2 First President of Russia B.N. Yeltsin Ural Federal University, Ekaterinburg, Russia
3 Southern Urals Biophysics Institute of FMBA of Russia, Ozersk, Chelyabinsk region, Russia
Contact person: D.V. Ivanov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Testing samples of cotton materials for their use as objects of recovery of accumulated dose by EPR dosimetry.
Material and methods: Samples of cotton fabric and fabrics of mixed composition – lab coats, casual clothing items – shirts and jeans, as well as protective masks and respirators were irradiated using a linear electron accelerator model UELR-10-10C2 in the dose range from several Gy to 16 kGy. EPR spectra were recorded using the Bruker Elexsys-II E580 X-band EPR spectrometer with a SuperHighQ cylindrical resonator.
Results: It was found that ionizing radiation induces free radicals in materials with triplet EPR signal, the most intense line of which has g = 2.019 and a linewidth 6 G. There was no or negligible native signal in uncolored fabrics. The radiation-induced EPR signal decayed exponentially with average half-life time of 62 hours.
Conclusion: Clothing materials based on cotton fabrics, as well as materials of protective medical masks, have shown themselves suitable for use as an object of retrospective EPR dosimetry.
Keywords: retrospective dosimetry, solid state dosimetry, electronic paramagnetic resonance, radiation defects, emergency exposure, clothing materials
For citation: Ivanov DV, Baytimirov DR, Konev SF, Aladova EE. Using of Cotton Fabric and Fiber as Objects of Retrospective EPR Dosimetry. Medical Radiology and Radiation Safety. 2024;69(5):109–113. (In Russian). DOI:10.33266/1024-6177-2024-69-5-109-113
References
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3. Frantz S., Hubner A., Wendland O., Roduner E. Effect of Humidity on the Supramolecular Structure of Cotton, Studied by Quantitative Spin Probing. J Phys Chem. 2005;109;23:11572-9.
4. Herve M.L., Trompier F., Tikunov D.D., Amouroux V., Clairand I. Study of Materials for Mixed Field Dosimetry by EPR Spectroscopy. Radiat Prot Dosim. 2006;120:205-9.
5. Jiao L., Takada J., Endo S., Tanaka K., Zhang W., Ivannikov A., Hoshi M. Effects of Sunlight Exposure on the Human Tooth Enamel ESR Spectra Used for Dose Reconstruction. J. Radiat. Res. Tokyo Publ., 2007;48;1:21–29.
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7. Kleshenko E.D. Reconstruction of Personal Doses and its Distribution on the Body Surface of Persons Suffered by Accidental Irradiation by the EPR Method. Proceedings of the 10th International Congress of the International Radiation Association. 2000. Hiroshima Publ., 14-19 May. URL: www2000.irpa.net/pub/pr/index.html
8. Liidja G., Past J., Puskar J., Lippmaa E. Paramagnetic Resonance in Tooth Enamel Created by Ultra-Violet Light. Appl. Radiat. Isot. 1996;47:785–788.
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The work was financing by Federal Medical and Biological Agency within the framework of the Federal Target Program “Ensuring nuclear and radiation safety for 2016-2020 and for the period up to 2030” as well as by Ministry of Education and Science of the Russian Federation within the framework of the state assignment.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.05.2024. Accepted for publication: 25.06.2024.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 5
DOI:10.33266/1024-6177-2024-69-5-119-120
I.V. Ivanov1, T.A. Nasonova2
In Memory of Professor Natalia Georgievna Darenskaya
(on the 100th Anniversary of Her Birth on 12/16/1924-11/17/2008)
1 State Research and Testing Institute of Military Medicine, St. Petersburg, Russia
2 A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
For citation: Ivanov IV, Nasonova TA. In Memory of Professor Natalia Georgievna Darenskaya (on the 100th Anniversary of Her Birth on 12/16/1924-11/17/2008). Medical Radiology and Radiation Safety. 2024;69(5):119–120. (In Russian). DOI:10.33266/1024-6177-2024-69-5-119-120
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.05.2024. Accepted for publication: 25.06.2024.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 5
DOI:10.33266/1024-6177-2024-69-5-114-118
I.V. Ivanov1, 2
Academician I.B. Ushakov and his Contribution to General and Space Radiobiology (on the 70th Anniversary of his Birth)
1 State Scientific Research Taste Institute of Military Medicine, Saint-Petersburg, Russia
2 Sechenov First Moscow State Medical University, Moscow, Russia
Contact person: I.V. Ivanov, e-mail:
This email address is being protected from spambots. You need JavaScript enabled to view it.
For citation: Ivanov IV. Academician I.B. Ushakov and his Contribution to General and Space Radiobiology (оn the 70th Anniversary of his Birth). Medical Radiology and Radiation Safety. 2024;69(5):114–118. (In Russian). DOI:10.33266/1024-6177-2024-69-5-114-118
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The author declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. The article was prepared with one participation.
Article received: 20.05.2024. Accepted for publication: 25.06.2024.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 4
DOI:10.33266/1024-6177-2024-69-4-5-12
E.V. Plotnikov1, 2, 3, M.V. Belousov1, 2, A.G. Drozd1, K.S. Brazovsky1,
M.S. Larkina1, 2, E.S. Sukhikh1, A.A. Artamonov4, I.V. Lomov1, V.I. Chernov1, 5
Study of Radiosensitising Properties of Lithium Ascorbate under Neutron Irradiation in Tumour Growth Models
1 National Research Tomsk Polytechnic University, Tomsk, Russia
2 Siberian State Medical University, Tomsk, Russia
3 Mental Health Research Institute of the Tomsk National Research Medical Center, Tomsk, Russia
4 Institute of Biomedical Problems, Moscow, Russia
5 Cancer Research Institute, Tomsk National Research Medical Center, Tomsk, Russia
Contact person: E.V. Plotnikov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Background: Radiosensitivity of tumour cells is a serious problem in the treatment of oncological diseases, which, along with the dama-
ging effect of irradiation on healthy tissues, significantly limit the possibilities of radiation therapy; therefore, an important task of modern oncopharmacology is the search and study of new radiosensitizing compounds. The main objective of this study was to investigate the radiosensitising effect of lithium ascorbate in vitro and in vivo under neutron radiation exposure.
Material and methods: Evaluation of biological effect in vitro was performed on cell culture of tumour line HCT-116 (human colorectal cancer). To develop a model of tumour growth in vivo, SPF-nude immunodeficient mice (line Nu/j) were used. In vivo xenografts were formed by subcutaneous injection of cell suspension of HCT-116 cell line at a concentration of 2 million cells per 100 µl. The drug was administered to animals before irradiation by intraperitoneal injection in physiological solution at the rate of 2.4 mM/kg of animal weight. Neutron irradiation of cells was performed on cyclotron P-7M, by neutron flux with average energy of 7.5 MeV in the range of absorbed doses of 0.5‒1.5 Gy. Local irradiation of mice tumours was performed once at a dose of 1.5 Gy on a cyclotron with the same flux parameters. Cell viability was assessed by MTT test. Tumour growth parameters were assessed by measuring the sizes of xenografts and calculating the average volume, tumour doubling time and animal life span.
Results: Enhancement of cytotoxic effect with combined application of radiation exposure and lithium ascorbate in vitro and in vivo was shown. A dose-dependent decrease in cancer cell viability was found when lithium ascorbate was used at a concentration of 0.1‒0.3 mM in combination with neutron irradiation. It was shown that the average tumour volume decreased by more than 50 % in comparison with the control, the xenografts growth rate slowed down to 72 %, and the median life expectancy of experimental animals increased by 86 % when lithium ascorbate and neutron irradiation were combined. Mechanisms of radiosensitising effect by induction of oxidative stress were proposed.
Conclusion: The use of lithium ascorbate results in a more pronounced therapeutic effect of neutron radiation exposure in cellular and animal models of tumour growth.
Keywords: lithium ascorbate, radiosensitization, tumor growth models, colorectal cancer, HCT-116 cells, neutron, cytotoxicity, apoptosis
For citation: Plotnikov EV, Belousov MV, Drozd AG, Brazovsky KS, Larkina MS, Sukhikh ES, Artamonov AA, Lomov IV, Cher-
nov VI.Study of Radiosensitising Properties of Lithium Ascorbate under Neutron Irradiation in Tumour Growth Models. Medical Radiology and Radiation Safety. 2024;69(4):5–12. (In Russian). DOI:10.33266/1024-6177-2024-69-4-5-12
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Conflict of interest. The authors declare no conflict of interest.
Financing. The study was carried out within the framework of the Priority 2030 project.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.03.2024. Accepted for publication: 25.04.2024.