JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 5
DOI:10.33266/1024-6177-2024-69-5-59-65
A.I. Kotikova, V.S. Nikiforov, E.A. Blinova, A.V. Akleyev
Assessment of T-Regulatory Cell Population and Foxp3 Gene Expression in Chronically Exposed Residents of the Urals Region
Urals Research Center for Radiation Medicine, Chelyabinsk, Russia
Chelyabinsk State University, Chelyabinsk, Russia
Contact person: Alisa Igorevna Kotikova, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: To conduct a pilot study on the quantity of regulatory T-cells (Treg) in the peripheral blood and to assess transcriptional activity of FOXP3 gene in chronically exposed persons.
Material and methods: The study included 77 participants who were divided into two groups: exposed people – 45 individuals, with an average accumulated dose to red bone marrow (RBM) of 641.21±80.41 mGy, and a comparison group – 32 individuals, with an average accumulated RBM dose of 20.38±2.51 mGy. The study on the assessment of FOXP3 gene expression was conducted on 298 individuals: the irradiated group consisted of 163 individuals with an average accumulated dose to RBM of 702±43.10 mGy; the comparison group included 135 individuals with an average accumulated dose to RBM of 17.30±1.40 mGy. The study groups did not differ significantly by age, sex and ethnicity. Quantitative assessment of regulatory T-cells in the peripheral blood was performed using flow cytometry method by the presence of T-helper markers CD3 and CD4, high expression of marker CD25 and low expression of marker CD127. Thus, the phenotype of T-regulatory lymphocytes was described as CD3+CD4+CD25highCD127low. The relative mRNA content of the FOXP3 gene was assessed by PCR-RT.
Results: More than 70 years after the onset of chronic radiation, no statistically significant changes in the pool of regulatory T-cells were detected in the exposed persons: the content of absolute and relative amount of Treg did not differ statistically significantly between the studied groups (p=0.91 and p=0.29, respectively); no statistically significant relationship of Treg indices with the accumulated doses to RBM and thymus and peripheral lymphoid organs were found. No statistically significant differences in FOXP3 gene mRNA expression were found between exposed individuals and the comparison group. A linear positive dependence of FOXP3 gene mRNA expression on the relative number of regulatory T-cells was shown (p=0.007).
Keywords: chronic exposure, regulatory T cells, immunity, gene expression, FOXP3
For citation: Kotikova AI, Nikiforov VS, Blinova EA, Akleyev AV. Assessment of T-Regulatory Cell Population and Foxp3 Gene Expression in Chronically Exposed Residents of the Urals Region. Medical Radiology and Radiation Safety. 2024;69(5):59–65. (In Russian). DOI:10.33266/1024-6177-2024-69-5-59-65
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The work was carried out as part of the: «Study on the effect of chronic radiation exposure on the state of the human T-cell immune system».
Contribution. Kotikova AI ‒ laboratory research, statistical processing, article authoring; Nikiforov VS – laboratory research, statistical processing, article authoring; Blinova EA ‒ article authoring; Akleyev AV ‒ development of the research concept, scientific supervision, article authoring.
Article received: 20.05.2024. Accepted for publication: 25.06.2024.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 5
DOI:10.33266/1024-6177-2024-69-5-66-74
E.A. Kodintseva1, A.А. Akleyev2
Prospects and Methods for Studying the Proliferative Capacity
of the Human Peripheral Blood Lymphocyte Subpopulations in Radiation Medicine
1 Urals Research Center for Radiation Medicine, Chelyabinsk, Russia
1 Southern-Urals State Medical University, Chelyabinsk, Russia
Contact person: E.A. Kodintseva, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
CONTENT
Introduction
1. Proliferation of peripheral blood lymphocytes as an integrative indicator of the functional activity of ICS in normal and pathological conditions.
2. Features of proliferative activity of peripheral blood lymphocytes under the action of AI.
3. Methodological approaches to the quantitative determination of proliferating cells in human peripheral blood lymphocyte subpopulations.
Conclusion
Keywords: chronic radiation exposure, the Techa River, peripheral blood lymphocytes, proliferative activity, individual radiosensiti-
vity, late effects of radiation exposure
For citation: Kodintseva EA, Akleyev AА. Prospects and Methods for Studying the Proliferative Capacity of the Human Peripheral Blood Lymphocyte Subpopulations in Radiation Medicine. Medical Radiology and Radiation Safety. 2024;69(5):66–74. (In Russian). DOI:10.33266/1024-6177-2024-69-5-66-74
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. This study was carried out within the framework of the state assignment of the FMBA of Russia: “Evaluation of the medical and biological effects of chronic radiation exposure and mechanisms of their development to improve the methods for early detection of exposure effects” (Immunohematopoiesis-24)”.
Contribution. All authors confirm that their authorship meets the international ICMJE criteria. Kodintseva Е. А. ‒ conceived and designed the study, prepared the first draft of the article, read and approved the final version before publication. Akleуev А. А. ‒ conceived and designed the study, scientific editing, read and approved the final version before publication.
Article received: 20.05.2024. Accepted for publication: 25.06.2024.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 5
DOI:10.33266/1024-6177-2024-69-5-87-94
S.Yu. Chekin, S.V. Karpenko, M.A. Maksioutov, P.V. Kascheeva,
A.M. Korelo, N.V. Shchukina, E.V. Kochergina, O.E. Lashkova, N.S. Zelenskaya
Assessment of Radiation Risks of Mortality from Circulatory System Diseases in the Cohort of Liquidators of the Consequences of the Accident at the Chernobyl Nuclear Power Plant, Considering the Influence of Other Diseases Identified During the Observation Period
A.F. Tsyb Medical Radiological Research Center, Obninsk, Russia
Contact person: S.Yu. Chekin, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To assess the radiation risk of mortality from circulatory system diseases (CSD) in the cohort of liquidators of the consequences of the Chernobyl accident, considering the impact of other diseases detected in them during the observation period.
Material and methods: Radiation risks of mortality from CSD were studied in the cohort of liquidators of the consequences of the Chernobyl accident observed in the National Radiation and Epidemiological Register (NRER) system from 1986 to 2022. The studied deaths are included in the codes I00–I99 of the International Statistical Classification of Diseases of the 10th Revision (ICD-10). Among the 89,594 members of the studied cohort, 16,780 deaths from CSD were identified. Mean age at the beginning of exposure was 34 years, the average absorbed dose of external gamma exposure of the whole body was 0.133 Gy, the maximum dose was 1.5 Gy, the average duration of exposure was 2.6 months. To analyze the dependence of the radiation risk of mortality from CSD on the presence of other diseases in them, regression models of excess relative risk (ERR) and nonparametric relative risk (RR) estimates in dose groups were used.
Results: The average estimate of the excess relative risk ratio ERR/Gy=0.53 for the entire cohort, which is quantitatively comparable to the previously obtained estimate of ERR/Gy=0.74 for mortality from solid malignancies in the same cohort. The assessment of the radiation risk of mortality from CSD in the cohort of liquidators of the consequences of the Chernobyl accident depends on the presence of diseases from other categories identified in them during the observation period. Diseases of respiratory (J00-J99) and digestive organs (K00–K93) are radiation-competing risk factors for death from CSD. The risk group for radiation-related mortality from CSD with an estimate of ERR/Gy=1.22 consists of relatively healthy liquidators without respiratory and digestive diseases. Nonparametric estimates of relative radiation risk (RR) confirm the correctness of the linear non-threshold model of radiation risk of mortality of liquidators from CSD, regardless of the degree of multimorbidity of their health status.
Conclusions: The practical dose thresholds for mortality of liquidators from CSD depend on their health status and are in the range of 0.01–0.21 Gy, which is significantly less than the currently accepted ICRP level of 0.5 Gy. The determination of such thresholds does not mean that there is no effect of radiation at doses below the threshold doses. Further accumulation of radiation and epidemiological data in the NRER system will allow for the analysis of radiation risks considering multimorbidity, more detailed by diagnosis.
Keywords: radiation risk, liquidators, National Radiation and Epidemiological Register, diseases of the circulatory system, relative risk, linear non-threshold model, multiplicative model, excess relative risk
For citation: Chekin SYu, Karpenko SV, Maksioutov MA, Kascheeva PV, Korelo AM, Shchukina NV, Kochergina EV, Lashkova OE,
Zelenskaya NS. Assessment of Radiation Risks of Mortality from Circulatory System Diseases in the Cohort of Liquidators of the Consequences of the Accident at the Chernobyl Nuclear Power Plant, Considering the Influence of Other Diseases Identified During the Observation Period. Medical Radiology and Radiation Safety. 2024;69(5):87–94. (In Russian). DOI:10.33266/1024-6177-2024-69-5-87-94
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.05.2024. Accepted for publication: 25.06.2024.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 5
DOI:10.33266/1024-6177-2024-69-5-75-86
A.N. Koterov, L.N. Ushenkova, I.G. Dibirgadzhiev, T.M. Bulanova
Comparison of the Total Mortality Risk for Nuclear Workers, Uranium Miners and other Occupations with the Risk of Passive Smoking (Meta-Analysis)
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: Alexey N. Koterov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Despite thousands of studies and about 150 meta-analyses for the effects of second hand smoking (SHS) on the mortality risks from individual diseases for mortality from all causes there are two orders of magnitude less work and only one meta-analysis Lv X. et al, 2015.
Based on a selected sample of works (search in MEDLINE, PubMed, Cochrane Library, Elibrary, Google and reference lists of sources) on all cause mortality due to SHS for exposure to adults (18 publications; 1984–2014), a systematic review, combined analysis and meta-analysis of the appropriate risk (Relative Risk, RR; odds ratio, OR and Hazard Ratio, HR), the value of which was 1.14 (95 % confidence intervals: 1.10, 1.19). This value according to the gradation of risks (R. Monson, 1980, 1990) is ‘indeterminable’, but when compared with the risks of mortality from occupational factors, it is very significant.
By searching through these systems, as well as in the supported database, a selection of meta- and pooled analyzes on the Standardized Mortality Ratio (SMR) for all causes with reference to various kinds of activity, including harmful/dangerous trades was collected. For a number of professions, their own meta-analyses have previously been performed.
Of the 20 employment types considered, only five (25 %) were comparable in risk to or slightly higher than the SHS total mortality index
(in increasing magnitude of risk: coal miners, dust exposure, asbestos exposure, beta-naphthylamine, and asbestos cement production). For 70 % of rhazardous/harmful occupations reviewed, the risk of death was statistically significantly lower than from SHS (pilots, nuclear workers, physicians, wood processing, cotton textile production, acrylonitrile exposure, military, rubber production, chemical industry, organic solvent production, drivers, working with plant protection chemicals, exposure to Hg, Cd, Pb, Cu and uranium miners). Only for a few professions was the ‘Healthy Worker Effect’ possible: pilots, the nuclear workers, the military and, less expectedly, drivers and physicians.
Thus, the risk of death from SHS is higher than the risk for most hazardous/harmful occupations, including the nuclear industry and uranium mines. This indicates, on the one hand, the special danger of SHS and the need to strengthen measures to limit smoking, including at enterprises subordinate to the FMBA of Russia. On the other hand, the fact that for most hazardous occupations the mortality risks are now lower or comparable to the risks from SHS may reflect the high level of occupational safety and health and progress in its organization.
The importance and public-social significance of this study, which complements and corrects the earlier meta-analysis of the SHS effect
(Lv X. et al, 2015), is that the risk index of overall mortality, all causes, was used, that is, the final index, in contrast from the risks of mortality from individual pathologies or situations.
Keywords: passive smoking, meta-analyses, standardized mortality ratio, risks of mortality from all causes, harmful and hazardous types of employment
For citation: Koterov AN, Ushenkova LN, Dibirgadzhiev IG, Bulanova TM. Comparison of the Total Mortality Risk for Nuclear Workers, Uranium Miners and other Occupations with the Risk of Passive Smoking (Meta-Analysis). Medical Radiology and Radiation Safety. 2024;69(5):75–86. (In Russian). DOI:10.33266/1024-6177-2024-69-5-75-86
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.05.2024. Accepted for publication: 25.06.2024.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 5
DOI:10.33266/1024-6177-2024-69-5-95-103
W.Yu. Ussov1, M.L. Belyanin2, A.I. Bezlepkin3, O.Y. Borodin4,
S.M. Minin1, E. Kobelev1, Yu.B. Lishmanov2, A.M. Chernyavsky1,
N.L. Shimanovsky5
Preclinical Study of the Mn(II) Complex with Glucaric Acid
as an Oncotropic Paramagnetic Contrast Agent for MR Imaging of Malignant Tumors
1 E.N. Meshalkin National Medical Research Center, Novosibirsk, Russia
2 National Research Tomsk Polytechnic University, Tomsk, Russia
3 Aldan-Vet Veterinary Clinic LLC, Tomsk, Russia
4 Tomsk Regional Oncological Dispensary, Tomsk, Russia
5 N.I. Pirogov Russian National Research Medical University, Moscow, Russia
Contact person: W.Yu. Ussov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. , This email address is being protected from spambots. You need JavaScript enabled to view it.
Summary
Purpose: Since currently there are no selective drugs for paramagnetic contrast enhancement (PMC) in MRI in the oncology clinic as such, we tried to obtain a selective oncotropic paramagnetic contrast agent (PMCA) – Mn(II) manganese compound with glucaric acid (used in combination with 99mTc for breast cancer (breast cancer), and to evaluate on the basis of animal studies the possibility of using Mn(II)-glucarate (Glucaromang) as an oncotropic PMCA in breast cancer.
Material and methods: The synthesis of glucaric acid was carried out by a modified method by oxidation of D-glucose with strong nitric acid. A solution of D-glucaric acid was used to produce manganese glucarate by combining with manganese oxide or carbonate with an excess of glucarate in solution, since one manganese atom forms a complex with two glucaric acid molecules.
The injection solution of the obtained Mn(II)-glucarate was adjusted to pH = 6.4–7.2 and sterilized by microfiltration through Millipore filters with a pore size of 0.22 μm. The toxicity indices LD10, LD50, LD90 (ml/kg) were determined in laboratory white mice. An in vivo MRI study of the tumor accumulation of Mn(II)-glucarate was performed in veterinary patients – cats (n = 9) with diagnosed breast cancer, who underwent body MRI to clarify the diagnosis and assess the extent of breast cancer, and 4 cats with malignant tumors of the neck and submandibular region (salivary glands). Scanning was performed using Toshiba Titan Vantage (Canon Medical) and Magnetom Open (Siemens Medical), with subsequent processing by Radiant (https://www.radiantviewer.com ).
Results: In the injection solution of Mn(II)-glucarate 0.5 M, free manganese was absent in detectable amounts, the excess of glucaric acid (has an antineoproliferative effect) was up to 2–2.5 %. Osmolality 1550±39 mOsmol/(kg H2O), viscosity 2.85±0.15 MPa·s, at 37 °C. When stored for 6 months, there was no release of manganese from the complex. The thermodynamic stability constant was 17.6–17.9. For the injection drug «Mn(II)-glucarate, 0.5M, aqueous solution”, the mortality rates for single administration in mice were, respectively: LD10 = 6.8 ± 5.0 ml/kg, LD50=15.1 ± 4.7 ml/kg, LD90=37.5 ± 23.8 ml/kg . When administered Mn(II)-glucarate as laboratory mice and cats with breast cancer did not show significant changes in the blood pattern and any side effects. The drug accumulated intensively in the primary tumor and metastases. The index of enhancement for T1-WI was 1.78 ± 0.082 (p < 0.02) for the primary tumor and 1.49 ± 0.09 (p < 0.05) for lymphogenic metastases.
Conclusion: Mn-glucarate is an original paramagnetic contrast agent, highly stable, non-toxic, providing in vivo intensive MRI imaging of tumor structures, in particular in breast cancer.
Keywords: magnetic resonance imaging, paramagnetic contrast enhancement, Mn(II)-glucarate, Glucaromang, breast cancer, mice, cats
For citation: Ussov WYu, Belyanin ML, Bezlepkin AI, Borodin OY, Minin SM, Kobelev E, Lishmanov YuB, Chernyavsky AM, Shimanovsky NL. Preclinical Study of the Mn(II) Complex with Glucaric Acid as an Oncotropic Paramagnetic Contrast Agent for MR Imaging of Malignant Tumors. Medical Radiology and Radiation Safety. 2024;69(5):95–103. (In Russian). DOI:10.33266/1024-6177-2024-69-5-95-103
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.05.2024. Accepted for publication: 25.06.2024.