JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 5
DOI:10.33266/1024-6177-2024-69-5-95-103
W.Yu. Ussov1, M.L. Belyanin2, A.I. Bezlepkin3, O.Y. Borodin4,
S.M. Minin1, E. Kobelev1, Yu.B. Lishmanov2, A.M. Chernyavsky1,
N.L. Shimanovsky5
Preclinical Study of the Mn(II) Complex with Glucaric Acid
as an Oncotropic Paramagnetic Contrast Agent for MR Imaging of Malignant Tumors
1 E.N. Meshalkin National Medical Research Center, Novosibirsk, Russia
2 National Research Tomsk Polytechnic University, Tomsk, Russia
3 Aldan-Vet Veterinary Clinic LLC, Tomsk, Russia
4 Tomsk Regional Oncological Dispensary, Tomsk, Russia
5 N.I. Pirogov Russian National Research Medical University, Moscow, Russia
Contact person: W.Yu. Ussov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. , This email address is being protected from spambots. You need JavaScript enabled to view it.
Summary
Purpose: Since currently there are no selective drugs for paramagnetic contrast enhancement (PMC) in MRI in the oncology clinic as such, we tried to obtain a selective oncotropic paramagnetic contrast agent (PMCA) – Mn(II) manganese compound with glucaric acid (used in combination with 99mTc for breast cancer (breast cancer), and to evaluate on the basis of animal studies the possibility of using Mn(II)-glucarate (Glucaromang) as an oncotropic PMCA in breast cancer.
Material and methods: The synthesis of glucaric acid was carried out by a modified method by oxidation of D-glucose with strong nitric acid. A solution of D-glucaric acid was used to produce manganese glucarate by combining with manganese oxide or carbonate with an excess of glucarate in solution, since one manganese atom forms a complex with two glucaric acid molecules.
The injection solution of the obtained Mn(II)-glucarate was adjusted to pH = 6.4–7.2 and sterilized by microfiltration through Millipore filters with a pore size of 0.22 μm. The toxicity indices LD10, LD50, LD90 (ml/kg) were determined in laboratory white mice. An in vivo MRI study of the tumor accumulation of Mn(II)-glucarate was performed in veterinary patients – cats (n = 9) with diagnosed breast cancer, who underwent body MRI to clarify the diagnosis and assess the extent of breast cancer, and 4 cats with malignant tumors of the neck and submandibular region (salivary glands). Scanning was performed using Toshiba Titan Vantage (Canon Medical) and Magnetom Open (Siemens Medical), with subsequent processing by Radiant (https://www.radiantviewer.com ).
Results: In the injection solution of Mn(II)-glucarate 0.5 M, free manganese was absent in detectable amounts, the excess of glucaric acid (has an antineoproliferative effect) was up to 2–2.5 %. Osmolality 1550±39 mOsmol/(kg H2O), viscosity 2.85±0.15 MPa·s, at 37 °C. When stored for 6 months, there was no release of manganese from the complex. The thermodynamic stability constant was 17.6–17.9. For the injection drug «Mn(II)-glucarate, 0.5M, aqueous solution”, the mortality rates for single administration in mice were, respectively: LD10 = 6.8 ± 5.0 ml/kg, LD50=15.1 ± 4.7 ml/kg, LD90=37.5 ± 23.8 ml/kg . When administered Mn(II)-glucarate as laboratory mice and cats with breast cancer did not show significant changes in the blood pattern and any side effects. The drug accumulated intensively in the primary tumor and metastases. The index of enhancement for T1-WI was 1.78 ± 0.082 (p < 0.02) for the primary tumor and 1.49 ± 0.09 (p < 0.05) for lymphogenic metastases.
Conclusion: Mn-glucarate is an original paramagnetic contrast agent, highly stable, non-toxic, providing in vivo intensive MRI imaging of tumor structures, in particular in breast cancer.
Keywords: magnetic resonance imaging, paramagnetic contrast enhancement, Mn(II)-glucarate, Glucaromang, breast cancer, mice, cats
For citation: Ussov WYu, Belyanin ML, Bezlepkin AI, Borodin OY, Minin SM, Kobelev E, Lishmanov YuB, Chernyavsky AM, Shimanovsky NL. Preclinical Study of the Mn(II) Complex with Glucaric Acid as an Oncotropic Paramagnetic Contrast Agent for MR Imaging of Malignant Tumors. Medical Radiology and Radiation Safety. 2024;69(5):95–103. (In Russian). DOI:10.33266/1024-6177-2024-69-5-95-103
References
1. Tulupov AA, Korostyshevskaya AM, Savelov AA, Stankevich YuA, Bogomyakova OB, Vasilkiv LM, Petrovskiy ED, Zhuravleva KV, Sagdeev RZ. Magnetic Resonance in the Assessment of Circulation and Mass Transfer in Humans. Izvestiya Akademii Nauk. Seriya Khimicheskaya = Proceedings of the Academy of Sciences. The Chemical Series. 2021;(12):2266-2277 (In Russ.). EDN FGDYRD.
2. Karmazanovskiy GG, Shimanovskiy NL. Kontrastnyye Sredstva dlya Luchevoy Diagnostiki = Contrast Agents for Radiation Diagnostics: a Guide. Moscow, GEOTAR-Media Publ., 2022. 672 p. (In Russ.). ISBN 978-5-9704-6604-9. doi:10.33029/9704-6604-9-CARD2-2022-1-672. EDN JRSNYO.
3. Shimanovsky NL. Assessment of Morphological Changes and Function of the Hepatobiliary System Using Gadoxetic Acid (Primovist). Annaly Khirurgicheskoy Gepatologii = Annals of Surgical Hepatology. 2014;19(2):42–48 (In Russ.). EDN SFGUVJ.
4. Sosedova LM, Titov EA, Novikov MA, Fokina VA, Rukavishnikov VS. Assessment of Toxic Effects of Magnetically Contrasting Diagnostic Gadolinium-Containing Nanocomposite. Gigiyena i Sanitariya = Hygiene and Sanitation. 2019; 98(10):1161-1165 (In Russ.). https://doi.org/10.18821/0016-9900-2019-98-10-1161-1165. EDN SUZSNS.
5. Skalny AV. Evaluation and Correction of Elemental Status of the Population as a Perspective Direction of National Healthcare and Environmental Monitoring. Mikroelementy v Meditsine = Microelements in Medicine. 2018;19(1):5-13 (In Russ.). https://doi.org/10.19112/2413-6174-2018-19-1-5-13. EDN XODDRR.
6. Usov WYu, Belyanin ML, Kodina GE, Afanasyev SA, Bezlepkin AI, Gulyaev VM, Shimanovsky N L. Myocardial MRI Using Paramagnetic Contrast Enhancement with Manganese – Metoxyisobutylisonitryle (Mn-MIBI) in Animals. Meditsinskaya Vizualizatsiya = Medical Visualization. 2016;20(1):31-38 (In Russ.). EDN VWOIHH.
7. Belyanin ML, Borodin OYu, Novozheeva TP, Pod’yablonskiy AS, Belousov MV, Subbotina OA, Usov WYu, Shimanovskiy NL. Study of Organ Hepatic Uptake of a New Hepatotropic Paramagnetic Contrast Manganese (II) Complex with 2-(2-Carboxymethyl-(4-Hexa-decyloxyphenyl-Carbamoyl-Methyl)-Aminoethyl)-Aminoethyl-(4-Hexadecyl-Oxyphenyl-Carbamoyl Methyl)-Aminoacetic Acid (Mn-DTPA-GDOF) in Vivo in Some Experimental Models of Liver Damage in Rats. Khimiko-Farmatsevticheskiy Zhurnal = Parmaceutical Chemistry Journal. 2024;58(1):7-34 (In Russ.). https://doi.org/10.30906/0023-1134-2024-58-1-27-34. EDN NPBGCP.
8. Usov W.Yu., Filimonov V.D., Belyanin M.L., Bezlepkin A.I., Luchich M.A., Kovalenko A.Yu., Rogovskaya Yu.V., Shimanovskiy N.L. Synthesis, Quantum Chemistry Analysis and Pre-Clinical in Vivo Evalution of Magnetic Resonance Imaging Abilities of Paramagnetic Manganese Complex with 2,3-Dimercaptosuccinate (Succimang). Meditsinskaya Vizualizatsiya = Medical Visualization. 2019;(3):133-143 (In Russ.). https://doi.org/10.24835/1607-0763-2019-3-133-143. EDN QIQKZD.
9. Santra A, Kumar R, Sharma P. Use of 99mTechnetium-Glucoheptonate as a Tracer for Brain Tumor Imaging: an Overview of its Strengths and Pitfalls. Indian J Nucl Med. 2015;30(1):1-8. https://doi.org/10.4103/0972-3919.147525.
10. Metody Khimii Uglevodov = Methods of Carbohydrate Chemistry. Ed.by N.K. Kochetkov. Moscow, Mir Publ., 1967. 221 p. (In Russ.).
11. Zhdanov Yu A, Dorofeenko G N, Korolchenko G A, Bogdanova GV. Praktikum po Khimii Uglevodov = Practicum on the Chemistry of Carbohydrates. Moscow, Rosvuzizdat Publ., 1963. 276 p. (In Russ.).
12. Korenman IM. Photometric Analysis. Fotometricheskiy Analiz. Metody Opredeleniya Organicheskikh Soyedineniy = Methods for the Determination of Organic Compounds. Moscow, Khimiya Publ., 1975. P. 173, 180 (In Russ.).
13. Petkov CI, Flecknell P, Murphy K, Basso MA, Mitchell AS, Hartig R, Thompson-Iritani S. Unified Ethical Principles and an Animal Research ‘Helsinki’ Declaration as Foundations for International Collaboration. Curr Res Neurobiol. 2022;3:100060. https://doi.org/ 10.1016/j.crneur.2022.100060.
14. Patent No. 2328294 C1. Russian Federation. IPC A61K 33/04, A61K 31/07, A61K 31/191. Sredstvo dlya Profilaktiki Raka = Cancer Prevention Agent. No. 2006140723/15; application 20.11.2006; publ. 10.07.2008 by V.G.Bespalov, V.A.Alexandrov, L.V.Mironova, A.S.Petrov; applicant of the State Research Institute of Oncology named after Prof. N.N. Petrov of Roszdrav (In Russ.). EDN MVBTDI.
15. Alcantara D, Leal MP, García-Bocanegra I, García-Martín ML. Molecular Imaging of Breast Cancer: Present and Future Directions. Front. Chem. 2014;2:112. https://doi.org/ 10.3389/fchem.2014.00112.
16. Usov W.Yu, Belyanin M.L, Kovalenko A.Yu, Bezlepkin A.I, Filimonov V.D, Shimanovskiy N.L. Investigation of the Mn(II) Complex with Dimercaptosuccinic Acid as a Paramagnetic Agent for Contrast Enhancement in MR Tomography of Malignant Fibrous Epithelial Tumors in an Experiment. Rossiyskiy Elektronnyy Zhurnal Luchevoy Diagnostiki = Russian Electronic Journal of Radiology. 2017;7(4):108-116 (In Russ.). https://doi.org/ 10.21569/2222-7415-2017-7-4-108-116.
17. Usov WYu, Belyanin ML, Filimonov VD, Danilets MG, Milto IV, Vesnina ZhV, Zorkaltsev MA, Luchich MA, Shimanovskiy NL. Theoretical Basis and Experimental Study of The Mn(II) Complex with Hexametholpropyleneaminoxim as a Paramagnetic Contrast Agent for the Imaging of Malignant Tumors. Luchevaya Diagnostika i Terapiya = Diagnostic Radiology and Therapy. 2019;2(10):42-49 (In Russ.).
18. Usov WY, Belyanin ML, Borodin OY. Obtaining and Evaluating the Visualization Capabilities of a New National Oncotropic Agent Mn-Glucarate for Breast Cancer. Kongress Rossiyskogo Obshchestva Rentgenologov i Radiologov = Congress of the Russian Society of Radiologists and Radiologists. Collection of Abstracts, Moscow, 08-10 November, 2022. St. Petersburg, Chelovek i yego Zdorov’ye Publ., 2022. P. 222-223 (In Russ.). EDN ZLBBOI.
19. Willerson JT. Detection of Acute Myocardial Infarcts by Infarct-Avid Imaging. J Nucl Med. 1991;32(2):269-71.
20. Liu Z, Barrett HH, Stevenson GD, Kastis GA, Bettan M, Furenlid LR, Wilson DW, Pak KY. High-Resolution Imaging with 99mTc-Glucarate for Assessing Myocardial Injury in Rat Heart Models Exposed to Different Durations of Ischemia with Reperfusion. J Nucl Med. 2004;45(7):1251-1259.
21. Waxman AD, Tanacescu D, Siemsen JK, Wolfstein RS. Technetium-99m-Glucoheptonate as a Brain-Scanning Agent: Critical Comparison with Pertechnetate. J Nucl Med. 1976;17:345–348.
22. Houson H, Mdzinarishvili A, Gali H, Sidorov E, Awasthi V. PET Detection of Cerebral Necrosis Using an Infarct-Avid Agent 2-Deoxy-2-[18F]Fluoro-D-Glucaric Acid (FGA) in a Mouse Model of the Brain Stroke. Mol Imaging Biol. 2020;22(5):1353-1361. https://doi.org/10.1007/s11307-020-01513-9.
23. Belitskaya ED, Dmitrieva VA, Kozlov AN, Oleinikov VA, Zalygin AV. Radiopharmaceuticals for Oncology Nonspecific to Glucose (PET AND SPECT). Bioorganicheskaya Khimiya = Bioorganic Chemistry. 2023;49(6):575-590 (In Russ.). https://doi.org/10.31857/S0132342323060039.
24. Zhang D, Jin Q, Gao M, Jiang C, Ni Y, Zhang J. Untiring Pursuit for Glucarate-Based Molecular Imaging Probes. Mol Imaging Biol. 2021;23(3):310-322. doi: 10.1007/s11307-020-01564-y.
25. Cheng D., Rusckowski M., Wang Y.., Liu Y., Liu G., Liu X., Hnatowich D. A Brief Evaluation of Tumor Imaging in Mice with 99mTc-Glucarate Including a Comparison with 18F-FDG. Curr Radiopharm. 2011;4(1):5–9.
26. Santra A, Sharma P, Kumar R, Bal C, Kumar A, Julka PK, Malhotra A. Comparison of Glucoheptonate Single Photon Emission Computed Tomography and Contrast-Enhanced MRI in Detection of Recurrent Glioma. Nucl Med Commun. 2011;32(3):206-11. https://doi.org/ 10.1097/MNM.0b013e328341c3e9.
27. Khaw BA. The Current Role of Infarct Avid Imaging. Semin Nucl Med. 1999;29(3):259-70. https://doi.org/10.1016/s0001-2998(99)80014-2. PMID: 10433340.
28. Kustova TV, Danilova EA, Sinitsyn AM. Complex Compounds with Manganese Based on Derivatives of 3,5-Diamino-1,2,4-Triazole. Synthesis and Application Prospects. Zhidkiye Kristally i ikh Prakticheskoye Ispol’zovaniye = Liquid Crystals and Their Practical Use. 2020;20(2):35-44 (In Russ.). https://doi.org/10.18083/LCAppl.2020.2.35.
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.05.2024. Accepted for publication: 25.06.2024.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 5
DOI:10.33266/1024-6177-2024-69-5-104-108
P.A. Lushnikova1, 2, Ya.N. Sutygina1, 2, E.S. Sukhikh2, 3, Zh.A. Startseva3,
A.A. Polyakov1
Possibilities of Modern Radiation Therapy for Locally Advanced Endometrial Cancer
1 Tomsk Regional Oncology Center, Tomsk, Russia
2 National Research Tomsk Polytechnic University, Tomsk, Russia
3 Tomsk National Research Medical Center, Tomsk, Russia
Contact person: P.A. Lushnikova, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Analysis of radical radiotherapy efficacy (combination of remote irradiation with simultaneous dose escalation to the tumor focus and subsequent intracavitary component) in a patient diagnosed with stage III endometrial cancer when surgical treatment is impossible. Assessment of the dynamics of the underlying disease and adverse events. The purpose of the study is to analyze the effectiveness of radical radiation therapy in a patient diagnosed with stage III endometrial cancer when surgical treatment is impossible.
Material and methods: We present a clinical case of a patient with inoperable stage III endometrial cancer (histologic variant-highly differentiated adenocarcinoma) with metastasis to the lower third of the vagina. The first stage was a course of remote radiotherapy on a linear gas pedal VarianTrueBeamSTx on the uterus, vagina, paravaginal tissues, pelvic lymph nodes up to a total dose of 50 Gy and simultaneous dose intensification on the area of tumor focus in the lower third of the vagina up to a total dose of 62.5 Gy. The method of dose administration was rotational radiotherapy with intensity modulation of photon radiation (Volume-modulated arc therapy ‒ VMAT).
The second stage was a course of intracavitary (contact, brachytherapy) radiotherapy on MultiSource HDR device with 60Co ionizing radiation source. A gynecological two-channel applicator was used during treatment. The plan of each treatment session was developed based on CT images on the SagiPlan planning station. Intracavitary radiation therapy mode – single dose of 6 Gy, 4 fractions were performed.
The effect of radiation therapy was assessed by MRI of pelvic organs with intravenous contrasting immediately after treatment and further at intervals of every 3 months.We present a clinical case of a 71 year old female patient diagnosed with stage III endometrial cancer (well-differentiated adenocarcinoma), with adenocarcinoma metastasis to the lower 1/3 of the vagina. Planning of radiotherapy and radiation therapy in a patient with inoperable endometrial cancer with simultaneous escalation of the dose of ionizing radiation to the area of metastasis in the vagina during the remote component and subsequent intracavitary boost to the uterine area. Study of the results of radiation therapy.
Results: After treatment, MRI data showed complete regression of the tumor nidus in the vagina and reduction of the nidus in the uterine body (more 50 %). Long-term control of the tumor process in the patient, confirmed by clinical and radiological studies (MRI of the pelvic organs), was also achieved.The capabilities of modern radiation therapy make it possible to carry out radical treatment of patients with endometrial cancer in clinical cases when it is necessary to increase the dose of ionizing radiation to a separate tumor focus, without exceeding the tolerable levels of radiation exposure to risk organs. This approach makes it possible to achieve remission in real clinical practice.
Conclusion: The capabilities of modern radiation therapy allow radical treatment of patients with inoperable endometrial cancer in clinical cases when it is necessary to increase the dose of ionizing radiation to a separate tumor focus without exceeding tolerance levels of radiation loads on risk organs. This approach makes it possible to achieve remission in real clinical practice.
Keywords: endometrial cancer, radiation therapy, dose escalation, intensity modulated radiation therapy, dosimetric planning, linear accelerator
For citation: Lushnikova PA, Sutygina YaN, Sukhikh ES, Startseva ZhA, Polyakov AA. Possibilities of Modern Radiation Therapy for Locally Advanced Endometrial Cancer. Medical Radiology and Radiation Safety. 2024;69(5):104–108. (In Russian). DOI:10.33266/1024-6177-2024-69-5-104-108
References
1. Каприн А.Д., Старинский В.В., Шахзадова А.О. Злокачественные новообразования в России в 2021 году (заболеваемость и смертность). М., 2022. C.4-12. [Kaprin A.D., Starinsky V.V., Shakhzadova A.O. Zlokachestvennyye Novoobrazovaniya v Rossii v 2021 godu (Zabolevayemost’ i Smertnost’) = Malignant Neoplasms in Russia in 2021 (Morbidity and Mortality). Moscow Publ., 2022. P. 4-12 (In Russ.)].
2. Ашрафян Л.А., Тюляндина А.С., Берлев И.В., Кузнецов В.В., Шевчук А.С., Новикова Е.Г., Урманчеева А.Ф., Вереникина Е.В., Демидова Л.В., Антонова И.Б., Бабаева Н.А., Кравец О.А., Крикунова Л.И., Коломиец Л.А., Крейнина Ю.М., Мухтаруллина С.В., Ульрих Е.А., Хохлова С.В., Нечушкина В.М., Снеговой А.В., Трякин А.А., Герфанова Е.В. Рак тела матки и саркомы матки: Клинические рекомендации. M.: МЗ РФ, 2021. [Ashrafyan L.A., Tyulyandina A.S., Berlev I.V., Kuznetsov V.V., Shevchuk A.S., Novikova E.G., Urmancheeva A.F., Verenikina E.V., Demidova L.V., Antonova I.B., Babaeva N.A., Kravets O.A., Krikunova L.I., Kolomiets L.A., Kreinina Y.M., Mukhtarullina S.V., Ulrich E.A., Khokhlova S.V., Nechushkina V.M., Snegovoy A.V., Tryakin A.A., Gerfanova E.V. Rak Tela Matki i Sarkomy Matki: Klinicheskiye Rekomendatsii = Cancer of the Uterine Body and Uterine Sarcomas. Clinical Recommendations. Ministry of Health of the Russian Federation Publ., 2021 (In Russ.)].
3. Clinical Practice Guidelines in Oncology (NCCN Guidelines) Version 2.2024. March 6. 2024.
4. Wright J.L., Yom S.S., Awan M.J., Dawes S., Fischer-Valuck B., Kudner R., Mailhot Vega R., Rodrigues G. Standardizing Normal Tissue Contouring for Radiation Therapy Treatment Planning: an ASTRO Consensus Paper. Pract Radiat Oncol. 2019 Mar; 9;2:65-72.
5. Chargari C., Peignaux K., Escande A., Renard S., Lafond C., Petit A., Hannoun-Levi J.M., Durdux C., Haie-Meder C. Radiotherapy for Endometrial Cancer. Cancer Radiother. 2022 Feb-Apr; 26;1-2:309-314.
6. Schwarz J.K., Beriwal S., Esthappan J., Erickson B., Feltmate C., Fyles A., Gaffney D., Jones E., Klopp A., Small W. Jr., Thomadsen B., Yashar C., Viswanathan A. Consensus Statement for Brachytherapy for the Treatment of Medically Inoperable Endometrial Cancer. Brachytherapy. 2015 Sep-Oct;14;5:587-99.
7. Supakorn Pitakkarnkul, Saranya Chanpanitkitchot, and Siriwan Tangjitgamol. Management of Inoperable Endometrial Cancer. Obstet Gynecol Sci. 2022 Jul; 65;4:303–316.
8. Хансен Э.К. Лучевая терапия в онкологии / Пер. с англ. М.: ГЭОТАР-Медиа, 2014. 992 с. [Hansen E.K. Luchevaya Terapiya v Onkologii = Radiation Therapy in Oncology. Moscow, GEOTAR-Media Publ., 2014. 992 p. (In Russ.)].
9. eContour. URL: http://econtour.org/cases/3 (accessed date 31.07.2018).
10. American Society for Radiation Oncology (ASTRO). ASTRO Annual Meeting Abstracts. 2019. Retrieved from [insert link here, e.g., https://www.astro.org/]
11. International Commission on Radiation Units and Measurements. (2010). Prescribing, Recording, and Reporting Photon-Beam Intensity-Modulated Radiation Therapy (IMRT). ICRU Report 83. J. ICRU. 10(1).
12. Rovirosa А., Zhang Y., Tanderup K., Ascaso C., Chargari C., Van der Steen-Banasik E., Wojcieszek P., Stankiewicz M., Najjari-Jamal D., Hoskin P., Han K., Segedin B., Potter R., Van Limbergen E. Endometrial Task Group. Stages I-III Inoperable Endometrial Carcinoma: a Retrospective Analysis by the Gynaecological Cancer GEC-ESTRO Working Group of Patients Treated with External Beam Irradiation and 3D-Image Guided Brachytherapy. Cancers (Basel). 2023 Sep 27;15;19:4750.
13. Pгuetter R., Haie-Meder C., van Limbergen E., et al. Recommendations from Gynaecological (GYN) GEC ESTRO Working Group (II): Concepts and Terms in 3D Image-Based Treatment Planning in Cervix Cancer Brachytherapy – 3D Dose Volume Parameters and Aspects of 3D Imagebased Anatomy, Radiation Physics, Radiobiology. Radiother. Oncol. 2006;78:67–77.
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.05.2024. Accepted for publication: 25.06.2024.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 5
DOI:10.33266/1024-6177-2024-69-5-114-118
I.V. Ivanov1, 2
Academician I.B. Ushakov and his Contribution to General and Space Radiobiology (on the 70th Anniversary of his Birth)
1 State Scientific Research Taste Institute of Military Medicine, Saint-Petersburg, Russia
2 Sechenov First Moscow State Medical University, Moscow, Russia
Contact person: I.V. Ivanov, e-mail:
This email address is being protected from spambots. You need JavaScript enabled to view it.
For citation: Ivanov IV. Academician I.B. Ushakov and his Contribution to General and Space Radiobiology (оn the 70th Anniversary of his Birth). Medical Radiology and Radiation Safety. 2024;69(5):114–118. (In Russian). DOI:10.33266/1024-6177-2024-69-5-114-118
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The author declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. The article was prepared with one participation.
Article received: 20.05.2024. Accepted for publication: 25.06.2024.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 5
DOI:10.33266/1024-6177-2024-69-5-109-113
D.V. Ivanov1, 2, D.R. Baytimirov2, S.F. Konev2, E.E. Aladova3
Using of Cotton Fabric and Fiber as Objects of Retrospective EPR Dosimetry
1 M.N. Mikheev Institute of Metal Physics, Ekaterinburg, Russia
2 First President of Russia B.N. Yeltsin Ural Federal University, Ekaterinburg, Russia
3 Southern Urals Biophysics Institute of FMBA of Russia, Ozersk, Chelyabinsk region, Russia
Contact person: D.V. Ivanov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Testing samples of cotton materials for their use as objects of recovery of accumulated dose by EPR dosimetry.
Material and methods: Samples of cotton fabric and fabrics of mixed composition – lab coats, casual clothing items – shirts and jeans, as well as protective masks and respirators were irradiated using a linear electron accelerator model UELR-10-10C2 in the dose range from several Gy to 16 kGy. EPR spectra were recorded using the Bruker Elexsys-II E580 X-band EPR spectrometer with a SuperHighQ cylindrical resonator.
Results: It was found that ionizing radiation induces free radicals in materials with triplet EPR signal, the most intense line of which has g = 2.019 and a linewidth 6 G. There was no or negligible native signal in uncolored fabrics. The radiation-induced EPR signal decayed exponentially with average half-life time of 62 hours.
Conclusion: Clothing materials based on cotton fabrics, as well as materials of protective medical masks, have shown themselves suitable for use as an object of retrospective EPR dosimetry.
Keywords: retrospective dosimetry, solid state dosimetry, electronic paramagnetic resonance, radiation defects, emergency exposure, clothing materials
For citation: Ivanov DV, Baytimirov DR, Konev SF, Aladova EE. Using of Cotton Fabric and Fiber as Objects of Retrospective EPR Dosimetry. Medical Radiology and Radiation Safety. 2024;69(5):109–113. (In Russian). DOI:10.33266/1024-6177-2024-69-5-109-113
References
1. Иванов Д.В., Байтимиров Д.Р., Конев С.Ф., Аладова Е.Е., Василенко Е.К. Использование различных материалов для ЭПР дозиметрии в случаях аварийного облучения // Вопросы радиационной безопасности. 2018. Т.3, № 91. С.75-81 [Ivanov D.V., Baytimirov D.R., Konev S.F., Aladova E.E., Vasilenko E.K. The Use of Various Materials for EPR Dosimetry in Cases of Emergency Exposure. Voprosy Radiatsionnoy Bezopasnosti = Issues of Radiation Safety. 2018;3;91:75-81 (In Russ.)].
2. Barthe J., Kamenopoulou V., Cattoire B., Portal G. Dose Evaluation from Textile Fibers: a Post-Determination of Initial ESR Signal. Appl RadiatIsot. 1989;40:1029-83.
3. Frantz S., Hubner A., Wendland O., Roduner E. Effect of Humidity on the Supramolecular Structure of Cotton, Studied by Quantitative Spin Probing. J Phys Chem. 2005;109;23:11572-9.
4. Herve M.L., Trompier F., Tikunov D.D., Amouroux V., Clairand I. Study of Materials for Mixed Field Dosimetry by EPR Spectroscopy. Radiat Prot Dosim. 2006;120:205-9.
5. Jiao L., Takada J., Endo S., Tanaka K., Zhang W., Ivannikov A., Hoshi M. Effects of Sunlight Exposure on the Human Tooth Enamel ESR Spectra Used for Dose Reconstruction. J. Radiat. Res. Tokyo Publ., 2007;48;1:21–29.
6. Kamenopoulou V., Barthe J., Hickman C., Portal G. Accidental Gamma Irradiation Dosimetry Using Clothing. Radiat Prot Dosim. 1986;17:185-8.
7. Kleshenko E.D. Reconstruction of Personal Doses and its Distribution on the Body Surface of Persons Suffered by Accidental Irradiation by the EPR Method. Proceedings of the 10th International Congress of the International Radiation Association. 2000. Hiroshima Publ., 14-19 May. URL: www2000.irpa.net/pub/pr/index.html
8. Liidja G., Past J., Puskar J., Lippmaa E. Paramagnetic Resonance in Tooth Enamel Created by Ultra-Violet Light. Appl. Radiat. Isot. 1996;47:785–788.
9. Trompier F., Bassinet C., Wieser A., De Angelis C., Viscomi D., Fattibene P. Radiation-Induced Signals Analysed by EPR Spectrometry Applied to Fortuitous Dosimetry. Ann 1st Super Sanita. 2009;45;3:287-96.
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The work was financing by Federal Medical and Biological Agency within the framework of the Federal Target Program “Ensuring nuclear and radiation safety for 2016-2020 and for the period up to 2030” as well as by Ministry of Education and Science of the Russian Federation within the framework of the state assignment.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.05.2024. Accepted for publication: 25.06.2024.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 5
DOI:10.33266/1024-6177-2024-69-5-119-120
I.V. Ivanov1, T.A. Nasonova2
In Memory of Professor Natalia Georgievna Darenskaya
(on the 100th Anniversary of Her Birth on 12/16/1924-11/17/2008)
1 State Research and Testing Institute of Military Medicine, St. Petersburg, Russia
2 A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
For citation: Ivanov IV, Nasonova TA. In Memory of Professor Natalia Georgievna Darenskaya (on the 100th Anniversary of Her Birth on 12/16/1924-11/17/2008). Medical Radiology and Radiation Safety. 2024;69(5):119–120. (In Russian). DOI:10.33266/1024-6177-2024-69-5-119-120
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.05.2024. Accepted for publication: 25.06.2024.