Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 6. P. 34-41

RADIATI ON THERAPY

N.K. Voznesensky¹, N.V. Bogdanov¹, S.L. Dorohovich², Yu.G. Zabaryansky³, Yu.A. Kurachenko³, Eu.S. Matusevich¹, V.A. Levchenko², Yu.S. Mardynsky⁴, N.N. Voznesenskaya⁵

The Modeling of Temperat ure Fields in Vertebra Bone at Stabilizing Vertebroplasty*

* This article in Russian is published in the journal «Medical Radiology and Radiation Safety». 2015. Vol. 60. No. 4. P. 62-70.

1. Institute of Nuclear Power Engineering in National Research Nuclear University MEPhI, Obninsk, Russia; 2. Experimental research and methodological center “Simulation Systems Ltd”, Obninsk, Russia; 3. A.I. Leypunsky Institute for Physics and Power Engineering named after, Obninsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 4. A.F. Tsyb, Medical Radiological Research Centre, Obninsk, Russia; 5. City Clinical Hospital of FMBA, Obninsk, Russia

ABSTRACT

Purpose: To study the temperature fields caused by bone cement polymerization at the stabilizing vertebroplasty. To verify experimental data by thermohydraulic simulation. To modify program codes, applied in nuclear installations in order to adapt them to new object region.

Material and methods: Two groups of experiments involving the non-stationary temperature distribution measurements were done, namely, the cement polymerization: a) in the isolated cuvette; b) in a vertebra. For numerical modeling of experiments, the 3D nonstationary KANAL code applied in thermohydraulics of nuclear power plants is adapted.

Results: The satisfactory coherence of measured data and simulated ones is obtained for temperature distributions, the spatial and time-dependent as well. The most important is the closeness in experimental and simulating temperature maximum values at cement polymerization in a vertebra. The executed study grants the theoretical support of vertebroplasty in two aspects: a) by providing with the developed calculation techniques; b) by estimating the curative effect because of the bone tissue heating.

Key words: spinal metastases, vertebroplasty, temperature fields, experimental and simulating modeling, numerical simulation, curative effect

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For citation: Voznesensky NK, Bogdanov NV, Dorohovich SL, Zabaryansky YuG, Kurachenko YuA, Matusevich EuS, Levchenko VA, Mardynsky YuS, Voznesenskaya NN. The Modeling of Temperature Fields in Vertebra Bone at Stabilizing Vertebroplasty. Medical Radiology and Radiation Safety. 2015;60(6):34-41.

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Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 6. P. 15-19

RADIATION MEDICINE

T.A. Astrelina¹, A.Yu. Bushmanov¹, I.V. Kobzeva¹, A.V. Akleyev^2,3, G.P. Dimov², P.S. Eremin¹, A.S. Samoilov¹

Evaluation of Skin Fibroblasts Proliferation and Secretion from Patients with Chronic Radiation Exposure

1. A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Urals Research Center for Radiation Medicine, Chelyabinsk, Russia; 3. Chelyabinsk State University, Russia

ABSTRACT

Purpose: To investigate skin fibroblasts proliferation and activity in patients with chronic radiation exposure.

Material and methods: The study of skin fibroblasts bioptates from patients with chronic radiation exposure (19 samples, the mean age was 66.1 ± 7.6 years) and healthy donors (15 samples). Culturing of skin fibroblasts were performed by standard methods. The average dose accumulated during chronic radiation exposure of the soft tissue was 0.03 ± 0.03 Gy in the study group, and 0.53 ± 0.75 Gy of the bone marrow. Study of proliferative activity of skin fibroblasts was carried out by Delta Cell Index for the normalized time point with the slope of the curve in the exponential growth phase using cell analyzer xCELLigence. Investigation of the secretory activity of skin fibroblasts (concentration vascular endothelial growth factor (VEGF), interleukin 6 (IL-6), brain-derived neurotrophic factor (BDNF), fibroblast growth factor (FGF) in the cultural medium were determined by ELISA kits (R & D Systems, USA).

Results: It is found that the normalized cell index delta of skin fibroblasts was higher in the skin fibroblasts of patients compared with the healthy donors (189.91 ± 21,35 EU and 108.67 ± 4.25 EU, respectively, p = 0.04), that is, the decrease of proliferative activity in the patients compared to the control group. The secretory activity of skin fibroblasts is different: the concentration level of VEGF and BDNF was higher in the healthy donors compared with patients -174.22 ± 12.21 and 86.37 ± 6.81 pg/ml, p = 0.04; 80.10 ± 7.22 and 12.66 ± 2.35 pg/ml, p = 0.03, respectively. The concentration of IL-6 in the culture medium of the healthy donors is lower than in the patients (26.45 ± 5.16 and 116.68 ± 10.01 pg/ml, p = 0.03). It was found that there is the correlation between the dose of chronic radiation exposure and the fibroblasts secretion activity and proliferative potential.

Conclusion: The dose accumulated during chronic radiation exposure affects the proliferation and activity of skin fibroblasts. The dose accumulated during chronic radiation exposure correlates with biochemical markers.

Key words: proliferation, secretion, skin fibroblasts, chronic radiation Exposure

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For citation: Astrelina TA, Bushmanov AYu, Kobzeva IV, Akleyev AV, Dimov GP, Eremin PS, Samoilov AS. Evaluation of Skin Fibroblasts Proliferation and Secretion from Patients with Chronic Radiation Exposure. Medical Radiology and Radiation Safety. 2015;60(6):15-9. Russian.

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Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 6. P. 20-26

RADIATION EPIDEMIOLOGY

L.N. Belyh, A.P. Biryukov, E.V. Vasiliev, V.P. Nevzorov

Assessment of Lifetime Radiogenic Risk of Cancer Mortality and Morbidity

A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: To describe in detail the construction of additive models of lifetime radiation risk for cancer mortality and cancer incidence. The model is based on the assumption that the time of death is a continuous random variable that can be parameterized as a risk function.

Results: In this article the additivity of risks was proved. The authors defined a function of survival in conditions of radiation. A rigorous mathematical assessment of lifetime risk of radiation that causes death and disease was received.

Conclusion: The mathematical apparatus evaluating lifetime risk is versatile and may be useful for risk assessment of independent factors of a different nature. The results estimation of lifetime radiation risk structurally coincides with the estimations of experts from UNSCEAR.

Key words: lifetime radiation risk, additive models, mortality, morbidity

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For citation: Belyh LN, Biryukov AP, Vasiliev EV, Nevzorov VP. Assessment of Lifetime Radiogenic Risk of Cancer Mortality and Morbiditv. Medical Radiology and Radiation Safety. 2015;60(6):20-6. Russian.

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Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 6. P. 10-14

RADIATION SAFETY

N.K. Shandala¹, D.V. Isaev¹, T.I. Gimadova¹, S.M. Kiselev¹, M.P. Semenova¹, V.A. Seregin¹, A.V. Titov¹, S.B. Zolotukhina², L.A. Zhuravleva², E.A. Khohlova³

Current Radiation Situation in Krasnokamensk

1. A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Center for Hygiene and Epidemiology No.107 of FMBA, Krasnokamensk, Russia; 3. Inter-regional Management Center No.107 of FMBA, Krasnokamensk, Russia

ABSTRACT

Purpose: to obtain data on radiation exposure of natural radionuclides for Krasnokamensk inhabitants.

Materials and methods: For the purpose of the radiation survey in Krasnokamensk, we used methods of foot gamma shooting, gamma-spectrometric measurements of natural radionuclides in the environment using portable and stationary devices, radiochemical separation of radionuclides and its radiometric measurement.

Results: The survey was carried out in 2011–2013. The following data have been received: gamma dose rate at the area of the city and its neighborhood; specific activities of natural radionuclides in soil; specific activities of radionuclides in foodstuffs. Based on these data, radiation exposure for the inhabitants from natural radiation sources (external exposure, internal exposure due to ingestion of radionuclides via food) was assessed.

Conclusions: The level of intervention (which was established in NRS-99/2009) for drinking water has increased by the total number of natural radionuclides and ²²²Ra concentration in water. The average annual effective dose of the exposure of the inhabitants is 4.8 mSv. According to OSPORB-99/2010, the natural radiation exposure of the inhabitants of Krasnokamensk is somewhere at the boundary of acceptable and increased exposure.

Key words: natural radionuclides, gamma dose rate, inhabitants, radiation situation, average annual effective dose, specific activity

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For citation: Shandala NK, Isaev DV, Gimadova TI, Kiselev SM, Semenova MP, Seregin VA, Titov AV, Zolotukhina SB, Zhuravleva LA, Khohlova EA. Current Radiation Situation in Krasnokamensk. Medical Radiology and Radiation Safety. 2015;60(6):10-4. Russian.

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