SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.

The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Issues journals

Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 2. P. 79-82

MEDICAL PRACTICE ISSUE

G.V. Zhuntova1, T.V. Azizova1, A.V. Ephimov1, E.K. Vasilenko1, N.V. Sotnik1, N.N. Dudchenko2, I.A. Vologodskaya2, E.P. Phomin2

Medical Assistance After Plutonium Intake by a Worker Due to an Emergency Situation During Production Operations

1. Southern Urals Biophysics Institute of FMBA, Ozyorsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Central Medical Sanitary Department No. 71 of FMBA, Ozyorsk, Russia

ABSTRACT

We consider a case of 239Pu intake by a worker as a result of a production manufacturing unit rupture during repair operations. The worker received a contused wound of an index finger of his right hand and anterior abdominal wall contusion. The initial 239Pu burden in the areas of finger and abdominal skin injuries were 2000 and 40 kBq, respectively. The committed effective dose from internal radiation over 50 years (CED50) assuming the complete transfer of the measured 239Pu burden from original site of the intake into body fluids and eventual accumulation in main organs of deposition was 54 Sv. Radionuclide-contaminated tissues of the finger and the anterior abdominal wall were excised; however it became necessary to amputate the index finger of the right hand to avoid potentially harmful contamination. A dosimetry screening revealed that injured skin was not the only route by which 239Pu entered the worker’s body, but respiratory and digestive organs were also involved. The duration of chelation therapy (5 % pentacin solution) was 4 months. The final estimate of CED50 from internal radiation based on data on natural excretion of actinides was 25 ± 11 mSv. Thus, timely specialized medical assistance allowed avoiding significant transfer of 239Pu from the sites of original deposition to the worker’s body and decreasing the dose from internal alpha-radiation by a large factor.

Key words: plutonium intake, incident, pentacin

REFERENCES

  1. Plutonii. Radiatsionnaya bezopasnost'. Il'in L.A. (ed.). Moscow: IzdAT. 2005. 416 p. (In Russ.).
  2. International Commission on Radiological Protection (ICRP). Human respiratory tract model for radiological protection. ICRP Publication 66. Annals of the ICRP. Oxford. Pergamon Press. 1994. Vol. 24. No. 1-3. 482 p.
  3. International Commission on Radiological Protection (ICRP). Limits on intakes of radionuclides by workers. ICRP Publication 30. Part 1. Annals of the ICRP. Oxford. Pergamon Press. 1979. Vol. 2. No. 3/4. 84 p.
  4. International Commission on Radiological Protection (ICRP). Age dependent doses to members of the public from intake of radionuclides: ingestion dose coefficients. ICRP Publication 67. Part 2. Annals of the ICRP. Oxford: Pergamon Press. 1993. Vol. 23. No. 3/4. 450 p.
  5. National Council on Radiation Protection and Measurements (NCRP). Development of a biokinetic model for radionuclidecontaminated wounds and procedures for their assessment. dosimetry and treatment. NCRP Report No. 156. Bethesda. Maryland. NCRP. 2007. 411 p.
  6. United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR). Summary of Radiation Effects. New York. 2010.
  7. Sokolnikov M.E., Gilbert E.S., Preston D.L. et al. Lung. Liver and bone cancer mortality in Mayak workers. Int. J. Cancer. 2008. Vol. 123. No. 4. P. 905-911.
  8. International Atomic Energy Agency (IAEA). Cytogenetic Dosimetry: Applications in Preparedness for and Response to Radiation Emergencies. Vienna: IAEA. 2011. 247 p.
  9. Sotnik N.V., Azizova T.V., Osovets S.V. Strukturnye povrezhdeniya genoma u rabotnikov plutonievogo proizvodstva. Radiats. biologiya. Radioekologiya. 2011. Vol. 51. No. 2. P. 1-5. (In Russ.).
  10. Johansson M., Jin Y., Mandahl N. et al. Cytogenetic analysis of short-term cultured squamous cell carcinomas of the lung. Cancer Genetics and Cytogenetics. 1995. No. 81. P. 46-55.
  11. Durbin P.W., Kullgren B., Xu J., Raymond K.N. Development of decorporation agents for the actinides. Radiat. Protect. Dosim. Vol. 79, p. 433-443.
  12. Lloyd R.D., Boseman J.J., Taylor G.N. et al. Decorporation from beagles of a mixture of monomeric and particulate plutonium using Ca-DTPA and Zn-DTPA: dependence upon frequency of administration. Health Phys. 1978. Vol. 35. P. 217-227.
  13. Sotnik N.V., Osovets S.V., Scherthan H. et al. mFISH analysis of chromosome aberrations in workers occupationally exposed to mixed radiation. Rad. Environ. Biophys. 2014. Vol. 53. No. 2. P. 347-354.
  14. A proposed standard system of nomenclature of human mitotic chromosomes. Lancet. 1960. No. 7133. P. 1063-1065.
  15. Prikaz Minzdravsotsrazvitiya Rossii ot 12.04.2011 No. 302n (red. ot 15.05.2013) «Ob utverzhdenii perechnei vrednykh i (ili) opasnykh proizvodstvennykh faktorov i rabot, pri vypolnenii kotorykh provodyatsya obyazatel'nye predvaritel'nye i periodicheskie meditsinskie osmotry (obsledovaniya). i poryadka provedeniya obyazatel'nykh predvaritel'nykh i periodicheskikh meditsinskikh osmotrov (obsledovanii) rabotnikov. zanyatykh na tyazhelykh rabotakh i na rabotakh s vrednymi i (ili) opasnymi usloviyami truda». Minyust RF. 2011. No. 22111. (In Russ.).
  16. Normy radiatsionnoi bezopasnosti (NRB-99/2009): sanitarnye pravila i normativy SanPin 2.6.1.2523-09. (In Russ.).

For citation: Zhuntova GV, Azizova TV, Ephimov AV, Vasilenko EK, Sotnik NV, Dudchenko NN, Vologodskaya IA, Phomin EP. Medical Assistance after Plutonium Intake by a Worker due to an Emergency Situation during Production Operations. Medical Radiology and Radiation Safety. 2016;61(2):79-82. Russian.

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 2. P. 75-78

CHRONICLE

G.P. Sidorova1, D.A. Krylov2

Radioactive Elements in Coals and Their Combustion Products

1. Transbaikal State University, Chita, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. National Research Centre «Kurchatov Institute», Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Presents an extensive analytical material content of natural radionuclides (NRN) in coal of different fields, both domestic and foreign. Provides details on the study of radioactivity of coal and waste incineration on deposits of Transbaikalia. Not all Russian coal deposits contain rose-content NRN in progress, but it is necessary to determine at the time of exploration. If during exploration for coal deposits areas with high concentration of NRN are identified, the application of the proposed system of radiation monitoring at the stage of coal mining deposits will be reduced to a minimum the hit in the fuel cycle and the environment. Sources of pollution are thermal power plant air emissions, liquid effluents and solid waste left after burning coal - ash and slag.

Key words: coal, natural radionuclide’s uranium radioactivity, ash, slag, the specific activity of emissions

REFERENCES

  1. Kizil'shtein. L.Ya. Ugol' i radioaktivnost'. Khimiya i zhizn'. 2006. No. 2. P. 24-29. (In Russ.).
  2. Il'in L.A., Knizhnikov V.A., Knyazhev V.A. et al. Onkologicheskaya «tsena» teplovoi i atomnoi elektroenergii. Il'in L.A., Korenkov I.P. (eds.). Moscow. Meditsina. 2001. 240 p. (In Russ.).
  3. Yudovich Ya.E., Ketris M.P. Uran v uglyakh. Syktyvkar. Komi nauchnyi tsentr Uro RAN. 2001. 84 p. (In Russ.).
  4. Davydov M.G., Timonina Yu.A. Radiatsionnaya obstanovka v raione raspolozheniya GRES Rostovskoi oblasti. Teploenergetika. 2003. No. 12. P. 8-13. (In Russ.).
  5. Davydov M. G. Radioekologiya [Elektronnyi resurs]. Radioaktivnost' litosfery. (http://www.phys.rsu.ru./web/nudear/radiologie/fRE6.htm) (In Russ.).
  6. Ovseichuk V.A., Krylov D.A., Sidorova G.P. Radioaktivnye elementy v uglyakh i produktakh ikh szhiganiya. Atomnaya strategiya. 2013. No. 3. P. 12-14. (In Russ.).
  7. Arbuzov S.I., Ershov V.V., Potseluev A.A. Izuchenie poter' radioaktivnykh elementov pri ozolenii uglya i prognozirovanie ikh vybrosov v atmosferu. V sb. «Radioaktivnost' i radioaktivnye elementy v srede obitaniya cheloveka». Tomsk. Publ. TPU. 1996. P. 306-308. (In Russ.).
  8. Pavlov I.V. Radiatsionnaya opasnost' dlya naseleniya i proizvodstvennogo personala. svyazannaya s ekspluatatsiei ob"ektov toplivno-energeticheskogo kompleksa (materialy slushanii «Ob obespechenii radiatsionno-ekologicheskoi bezopasnosti v toplivno-energeticheskom komplekse Rossii», provedennykh 17 iyunya 1997 g. v Komitete po ekologii Gosudarstvennoi Dumy). Byull. Tsentra obshchest. inf-tsii po atomnoi energii. 1997. No. 9. P. 28-30. (In Russ.).
  9. Sukhanov R.A., Sidorova G.P. Problemy ispol'zovaniya uglei s povyshennoi radioaktivnost'yu. Gornyi zhurnal. 2009. No. 2. P. 43-45. (In Russ.).
  10. Sidorova G.P. Radiatsionno-gigienicheskoe kachestvo uglei Urtuiskogo mestorozhdeniya: ekologicheskie problemy i metody resheniya. Gornyi zhurnal. 2012. No. 8. P. 26-28. (In Russ.).
  11. Belyusenko N.A., Solov'yanov A.A. Printsipy programmnogo obespecheniya radiatsionno-ekologicheskoi bezopasnosti na ob"ektakh TEK Rossii. Bezopasnost' truda v promyshlennosti. 1996. No. 1. P. 30-34. (In Russ.).

For citation: Sidorova GP, Krylov DA. Radioactive Elements in Coals and their Combustion Productss. Medical Radiology and Radiation Safety. 2016;61(2):75-8. Russian.

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 2. P. 65-69

REVIEW

O.K. Kurpeshev1, N.Yu. Florovskaiya2

The Results of Palliative Treatment of Colorectal Cancer Metastases to the Liver by Thermoradiotherapy

1.A.F. Tsyb Medical Radiological Research Centre, Obninsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Murmansk Regional Oncology Center, Murmansk, Russia

ABSTRACT

Purpose: Studying of efficiency of thermoradiation therapy in palliative treatment of patients with metastasises (MTS) of a colorectal cancer (CRC) in a liver.

Material and methods: Thermoradiotherapy therapy (TRT), held on 23 patients with CRC to the liver mts. Comparison group was 28 patients who underwent only external beam radiotherapy (EBRT). Locoregional hyperthermia of the liver was performed by a capacitive method at a temperature of 41-44 °C MTS and duration of exposure of 40 to 90 min. The total tumor dose EBRT in total liver irradiation was 20-26 Gy, subtotal - 28-36 Gy. The results of treatment were assessed by direct effect and overall survival according to stage (st.) liver disease.

Results: In the control group immediate therapeutic effect was detected in 13 (46 %) patients in the study - 17 (74 %), p = 0.044. The tendency to a difference (p = 0,06-0,07) in overall survival between subgroups of patients was with 2 and 3 stage liver disease. Patients with 2 stage median survival after EBRT were 7 months., TRT - 9 months, 3 stage - 3 and 4 months respectively.

Conclusion: The findings suggest the need for further research of thermoradiotherapy for the palliative treatment of patients with colorectal cancer to the liver MTS.

Key words: hyperthermia, radiation therapy, colorectal cancer, metastases in the liver

REFERENCES

  1. Nasyrov A.R., Pirtskhalava T.L., Korovina Ya.V. Khimioterapiya patsientov s nerezektabel'nymi kolorektal'nymi metastazami v pechen': sistemnaya ili regionarnaya?. Voprosy onkologii. 2011. Vol. 57. No. 2. P. 192-198. (In Russ.).
  2. Rukovodstvo po khimioterapii opukholevykh zabolevanii. Perevodchikovoi N.I. (ed.). Moscow. Prakticheskaya meditsina. 2011. 511 p. (In Russ.).
  3. Kurpeshev O.K., Florovskaya N.Yu. Rezul'taty distantsionnoi luchevoi terapii metastazov kolorektal'nogo raka v pechen'. Medical Radiology and Radiation Safety. 2014. Vol. 59. No. 5. P. 32-36. (In Russ.).
  4. Kurpeshev O.K. Vozmozhnosti luchevoi terapii v palliativnom lechenii zlokachestvennykh opukholei pecheni. Medical Radiology and Radiation Safety. 2014. Vol. 59. No. 6. P. 49-53. (In Russ.).
  5. Yeo S-G., Kim D.Y., Kim T.H. Whole-liver radiotherapy for end-stage colorectal cancer patients with massive liver metastases and advanced hepatic dysfunction.Radiat. Oncol. 2010. Vol. 5. No. 97. DOI: 10.1186/1748-717X-5-97. Available from: http://www.ro-journal.com/content/5/1/97.
  6. Taranenko M.L. Luchevaya terapiya metastazov v pechen'. Mezhdun. med. zhurnal (Ukraina). 2006. Vol. 2. P. 111-114. (In Russ.).
  7. Ben-Josef E., Lawrence T.S. Radiotherapy for unresectable hepatic malignancies. Semin. Radiat. Oncol. 2005. Vol. 15. P. 273-278.
  8. Guha C., Kavanagh B.D. Hepatic radiation toxicity: avoidance and amelioration. Semin. Radiat. Oncol. 2011. Vol. 21. No. 4. P. 256-263.
  9. Ingold J.A., Reed G.B., Kaplan H.S., Bagshaw M.A. Radiation hepatitis. Am. J. Roentgenol. Radium Ther. Nucl. Med. 1965. Vol. 93. P. 200-208.
  10. Topkan E., Onal H.C., Yavuz M.N. Managing liver metastases with conformal radiation therapy. J. Support Oncol. 2008. Vol. 6. No. 1. P. 9-13, 15.
  11. Goloshchapov R.S., Kokov L.S., Vishnevskii V.A. et al. Regionarnaya arterial'naya khimioembolizatsiya i khimioimmunoembolizatsiya v kompleksnom lechenii raka tolstoi kishki s metastazami v pechen'. Khirurgiya. 2003. No. 7. P. 66-71. (In Russ.).
  12. Lee M.T., Kim J.J., Dinniwell R. et al. Phase I study of individualized stereotactic body radiotherapy of liver metastases. J. Clin. Oncol. 2009. Vol. 27. P. 1585-1591.
  13. Kurpeshev O.K., Lebedeva T.V., Svetitskii P.V. et al. Eksperimental'nye osnovy primeneniya gipertermii v onkologii. Rostov-na-Donu: NOK. 2005. 163 p. (In Russ.).
  14. Kurpeshev O.K., Tsyb A.F., Mardynskii Yu.S. et al. Lokal'naya gipertermiya v luchevoi terapii zlokachestvennykh opukholei (eksperimental'no-klinicheskoe issledovanie). Obninsk. GU MRNTs RAMN. 2007. 219 p. (In Russ.).
  15. Cvetitskii P.V. Ispol'zovanie tepla v lechenii zlokachestvennykh opukholei. Rostov-na-Donu. «Everest». 2001. 160 p. (In Russ.).
  16. Hildenbrandt B., Wust P., Ahles O. et al. The cellular and molecular basis of hyperthermia. Oncology/Hematology. Critical Rev. 2002. Vol. 43. P. 33-56.
  17. Van der Zee J., Vujaskovic Z., Kondo M., Sugahara T. The Kadota Fund International Forum 2004. Clinical group consensus. Int. J. Hypert. 2008. Vol. 24. No. 2. P. 111-122.
  18. Abe M., Hiraoka M., Takahashi M. et al. Multiinstutional studies on hyperthermia using an 8-MHz radiofrequency capacitive heating device (Thermotron RF-8) in combination with radiation for cancer therapy.Cancer. 1986. Vol. 58. P. 1589-1595.
  19. Nagata Y., Hiraoka M., Nishimura Y. et al. Clinical results of radiofrequency hyperthermia for malignant liver tumors.Int. J. Radiat. Oncol. Biol. Phys. 1997. Vol. 38. No. 2. P. 359-365.
  20. Hager E.D., Dziambor H., Hohmann D., Gallenbeck D. Deep hyperthermia with radiofrequencies in patients with liver metastases from colorectal cancer.Anticancer Res. 1999. Vol. 19. P. 3403-3408.
  21. Bengtsson G., Carlsson G., Häfström L., Jönsson P.E. Natural history of patients with untreated liver metastases. Amer. J. Surg. 1981. Vol. 141. No. 5. P. 586-589.
  22. Zolli M., Pisi P., Marchesini G. et al. A rapid method for the in vivo measurement of liver volume. Liver. 1989. Vol. 9. P. 159-163.
  23. Kurpeshev O.K., Osinskii S.P., Florovskaya N.Yu. et al. Prodolzhitel'nost' zhizni bol'nykh s metastazami kolorektal'nogo raka v pechen' posle nepolnykh kursov khimioterapii ili simptomaticheskogo lecheniya. Onkologiya. Kiev. 2013. Vol. 15. No. 4. P. 301-306. (In Russ.).
  24. Eisenhauer E.A., Therasse P., Bogaerts J. et al. New response evaluation criteria in solid tumours: Revised RECIST guideline (v. 1.1). Eur. J. Cancer. 2009. Vol. 45. P. 228-247.
  25. Kaplan E.L., Meier P. Nonparametric estimation from incomplete observations. J. Amer. Stat. Ass. 1958. Vol. 53. P. 457-481.

For citation: Kurpeshev OK, Florovskaiya NYu. The Results of Palliative Treatment of Colorectal Cancer Metastases to the Liver by Thermoradiotherapy. Medical Radiology and Radiation Safety. 2016;61(2):65-9. Russian.

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 2. P. 70-74

CHRONICLE

S.M. Kiselev

Evolution of Approaches of ICRP to the Regulations of Protection of the Population from Radon

A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

In late 2014, the International Commission on Radiological Protection issued a publication “Radiological Protection against Radon Exposure” (ICRP 126). An international expert team (France, Norway, Russia, Canada, Australia, Germany, Switzerland and China) was organized to prepare this document. With this document the Commission completed the cycle of modern recommendations on the radon issue, based on the analysis of current scientific evidence of the impact of the radioactive gas on human health. The paper presents the development of approaches of ICRP for regulating public radon exposure and also outlines modern approaches to the public protection against radon exposure in homes and at workplaces.

Key words: radon, ICRP, lung cancer, regulation, reference levels, national strategy, national action plan

REFERENCES

  1. Otsenka kantserogennykh riskov dlya cheloveka. Monografiya. Vol. 43. Mezhdunarodnoe agentstvo po issledovaniyu raka. 1988. (In Russ.).
  2. Rukovodstvo po radonu. VOZ. Zheneva. 2009. (In Russ.).
  3. Yakobi V. Istoriya radonovoi problemy v shakhtakh i zhilykh pomeshcheniya. Publikatsiya MKRZ 23(2). 1993. P. 39–45. (In Russ.).
  4. Radiologicheskaya zashchita v uranovykh i drugikh shakhtakh. Publikatsiya 24 MKRZ. 1977. (In Russ.).
  5. Predely ingalyatsionnogo postupleniya dochernikh produktov raspada radona dlya professional'nykh rabotnikov. Publikatsiya 32 MKRZ. 1981. Moscow. Energoatomizdat. 1984. (In Russ.).
  6. Printsipy normirovaniya oblucheniya naseleniya ot estestvennykh istochnikov ioniziruyushchikh izluchenii. Publikatsiya 39 MKRZ. Moscow. Energoatomizdat. 1986. (In Russ.).
  7. Radiologicheskaya zashchita rabochikh podzemnykh shakht. Publikatsiya 47 MKRZ. Moscow. Energoatomizdat. 1986. (In Russ.).
  8. Zashchita ot radona-222 v zhilykh zdaniyakh i na rabochikh mestakh. Publikatsiya 65 MKRZ. Moscow. Energoatomizdat. 1995. (In Russ.).
  9. Krisyuk E.M. Problema radona – vedushchaya problema obespecheniya radiatsionnoi bezopasnosti naseleniya. ANRI. 1996/97, No. 3(9), P. 13–16. (In Russ.).
  10. Optimizatsiya radiologicheskoi zashchity. Publikatsiya 101 MKRZ. 2006. (In Russ.).
  11. Publikatsiya 103 MKRZ 2007 g. Transl. from engl. In: Kiseleva M.F., Shandala N.K. (eds.). Moscow. Izd. OOO PKF «Alana». 2009. 312 p. (In Russ.).
  12. Istochniki i effekty ioniziruyushchego izlucheniya. Otchet NKDAR OON 2000. General'noi Assamblee OON s nauchnymi prilozheniyami. Vol. 1. Istochniki (chast' 1). Transl. from engl. In: Il'in L.A., Yarmonenko S.P. (eds.). Moscow. RADEKON. 2002. 308 p. (In Russ.).
  13. Publikatsiya 115 MKRZ 2010 g. Moscow. FMBTs im. A.I. Burnazyana FMBA Rossii. 2013. (In Russ.).
  14. Radiologicheskaya zashchita ot oblucheniya radonom. Publikatsiya 126 MKRZ. 2014. (In Russ.).

For citation: Kiselev SM. Evolution of Approaches of ICRP to the Regulations of Protection of the Population from Radon. Medical Radiology and Radiation Safety. 2016;61(2):70-4. Russian.

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 2. P. 58-64

RADIATION THERAPY

A.O. Rasulov, D.V. Kuzmichev, V.A. Aliev, Z.Z. Mamedli, S.S. Gordeyev, V.M. Kulushev, A.V. Polinovskiy, I.Sh. Tataev, J.M. Madyarov, A.V. Nazarenko, S.I. Tkachev, V.V. Glebovskaya, N.A. Kozlov

Neoadjuvant Chemoradiotherapy with Consolidation Chemotherapy in Complex Treatment of Locally Advanced Rectal Cancer

N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: To investigate preliminary results of neoadjuvant chemoradiotherapy followed by neoadjuvant chemotherapy in locallyadvanced rectal cancer patients.

Material and methods: Patients aged >18 with histologycally verified MRI-staged low and medium T3 (CRM+)–4N0–2M0 rectal cancer were included. In group A (21 patients) received a preoperative chemoradiation with GENUS 4 Gy 3 times a week, with regional lymph nodes of 32 Gy to the tumor of the rectum 40 Gy with capecitabine 850 mg/m2 bid per os followed by 2 cycles of XELOX. In group B (20 patients) received the same treatment without consolidating chemotherapy. Toxicity, tumor regression, downstaging and postoperative complications were analyzed.

Results: 40 patients completed treatment according to the protocol. The second XELOX chemotherapy was amended in 1 patient in group A due to cardiac toxicity. Grade 3 toxic events were observed in 2 (9.5 %) patients in group A and in 3 (15 %) patients in group B. No grade 4 toxic events were observed. The median follow-up was 10.8 months. No patients experienced disease progression during this period. Postoperative complications were observed in 17.7 % and in 15 % of the patients respectively. Complete response was observed in 9 (42.9 %) patients in group A. Among those, 4 were referred to watchful waiting and 5 were diagnosed with pathological complete response after surgery. In group B complete response was observed in 3 (15 %) patients.

Conclusions: Combined treatment with consolidating chemotherapy represents a promising strategy for rectal.

Key words: locally advanced rectal cancer, the complex treatment of rectal cancer, chemotherapy is consolidating, medical pathomorphosis

REFERENCES

  1. Ferlay J., Steliarova-Foucher E., Lortet-Tieulent J. et al. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. Eur. J. Cancer. 2013. Vol. 49. No. 6. P. 1374-1403.
  2. Stewart B.W., Wild C.P. IARC Nonserial Publication. 2014. 630 p.
  3. Давыдов М.И., Аксель Е.М. Статистика злокачественных новообразований в России и странах СНГ в 2009 г. Вестник РОНЦ им. Н.Н. Блохина РАМН. 2010. Т. 23. № 3.
  4. The Beyond TME Collaborative. Brit. J. Surg. 2013. Vol. 100. No. 8. P. 1009-1014.
  5. Bouzourene H., Bosman F.T., Seelentag W. et al. Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy. Cancer. 2002. Vol. 94. No. 4. P. 1121-1130.
  6. Braendengen M. Randomized phase III study comparing preoperative radiotherapy with chemoradiotherapy in nonresectable rectal cancer. J. Clin. 2008. Vol. 26. No. 22. P. 3687-3694.
  7. Bulow S., Jensen L.H., Altaf R. et al. National cohort study of long-course preoperative radiotherapy in primary fixed rectal cancer in Denmark. Colorectal Dis. 2010. P. 12.
  8. Eich H.T., Stepien A., Zimmermann C. et al. Neoadjuvant radiochemotherapy and surgery for advanced rectal cancer: prognostic significance of tumor regression. Strahlenther Onkol. Vol. 187. P. 225-230.
  9. Kapiteijn E., Marijnen C.A., Nagtegaal I.D. et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N. Engl. J. Med. 2001. Vol. 345. P. 638-646.
  10. Sanghera P., Wong D.W., McConkey C.C. et al. Chemoradiotherapy for rectal cancer: an updated analysis of factors affecting pathological response. Clin. (R. Coll. Radiol.) 2008. Vol. 20. No. 2. P. 176-183.
  11. Vestermark L.W., Jensen H.A. et al. High-dose radiotherapy (60 Gy) with oral UFT/folinic acid and escalating doses of oxaliplatin in patients with nonresectable locally advanced rectal cancer (LARC): a phase I trial. Acta Oncol. 2012. Vol. 51. No. 3. P. 311-317.
  12. Bosset J.F., Collette L., Calais G. et al. Chemotherapy with preoperative radiotherapy in rectal cancer. N. Engl. J. Med. 2006. Vol. 355. P. 1114-1123.
  13. Guckenberger M., Saur G., Wehner D. et al. Comparison of preoperative short-course radiotherapy and long-course radiochemotherapy for locally advanced rectal cancer. Strahlenther. 2012. Bd. 188. P. 551-557.
  14. Kim N.K., Baik S.H., Seong J.S. et al. Oncologic outcomes after neoadjuvant chemoradiation followed by curative resection with tumor-specific mesorectal excision for fixed locally advanced rectal cancer: Impact of postirradiated pathologic downstaging on local recurrence and survival. Ann Surg. 2006. Vol. 244. No. 6. P. 1024-1030.
  15. Peeters K.C., Marijnen C.A., Nagtegaal I.D. et al. The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann. 2007. Vol. 246. P. 693-701.
  16. Sauer R. Becker H. Hohenberger W et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N. Engl. J. Med., 2004. Vol. 351. P. 1731-1740.
  17. Videtic G.M., Fisher B.J., Perera F.E. et al. Preoperative radiation with concurrent 5-fluorouracil continuous infusion for locally advanced unresectable rectal cancer. Int. J. Radiat. Biol. Phys. 1998. Vol. 42. No. 2. P. 319-324.
  18. An X., Lin X., Wang F. et al. Short term results of neoadjuvant chemoradiotherapy with fluoropyrimidine alone or in combination with oxaliplatin in locally advanced rectal cancer: a meta analysis. Eur. J Cancer. 2013. Vol. 49. No. 4. P. 843-851.
  19. Bria E.G.R., Raftopoulos H. et al. Comparing two methods of meta-analysis in clinical research individual patient data-based (IPD) and literature-based abstracted data (AD) methods: analyzing five oncology issues involving more than 10.000 patients in randomized clinical trials (RCTs). J. Clin. Oncol. 2007. Vol. 25. Abstr. 6512.
  20. Gollins S.W., Myint S., Susnerwala S. et al. Preoperative downstaging chemoradiation with concurrent irinotecan and capecitabine in MRI-defined locally advanced rectal cancer: a phase I trial (NWCOG-2). Brit. J. Cancer. 2009. Vol. 101. No. 6. P. 924-34.
  21. Iles S., Gollins S., Susnerwala S. et al. Irinotecan+5- fluorouracil with concomitant pre-operative radiotherapy in locally advanced non-resectable rectal cancer: a phase I/II study. Brit. J. Cancer. 2008. Vol. 98. No. 7. P. 1210-1216.
  22. Levine E.L., Gollins S., Susnerwala S. et al. Phase II study of radiotherapy plus concurrent irinotecan (CPT-11) and infusional 5-fluorouracil (5FU) in the treatment of T3-T4 locally advanced inoperable rectalcancer. J. Clin. 2004. Vol. 22. P. 3612.
  23. Rodel C., Liersch T., Becker H. et al. Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial. Lancet Oncol. 2012. Vol. 13. P. 679-687.
  24. Roh M.S., Yothers G.A., O’Connell M.J. et al. The impact of capecitabine and oxaliplatin in the preoperative multimodality treatment in patients with carcinoma of the rectum. J. Clin. 2011. Vol. 2. No. 9. Abstr. 3503.
  25. Al-Gizawy S.M., Essa H.H., Ahmed B.M. Chemotherapy alone for patients with stage II/III rectal cancer undergoing radical surgery. Oncologist. 2015. Vol. 20. No. 7. P. 752-757.
  26. Arimoto A., Uehara K., Tsuzuki T. et al. Role of bevacizumab in neoadjuvant chemotherapy and its influence on microvessel density in rectal cancer. Int. J. Clin. 2015. Vol. 20. No. 5. P. 935-942.
  27. A., Weiser M. et al. Complete pathologic response in the primary of rectal or colon cancer treated with FOLFOX without radiation. J. Clin. Oncol., 2010. Vol. 28. No. 5. Abstr. 3649.
  28. Ishii Y., Hasegawa H. et al. Medium-term results of neoadjuvant systemic chemotherapy using irinotecan. 5-fluorouracil. and leucovorin in patients with locally advanced rectal cancer. Eur. J. Surg. 2010. Vol. 36. No. 11. P. 1061-1065.
  29. Schrag D., Weiser M.R., Goodman K.A. et al. Neoadjuvant chemotherapy without routine use of radiation therapy for patients with locally advanced rectal cancer: a pilot trial. J. Clin. 2014. Vol. 32. No. 6. P. 513-518.
  30. Schrag D., Weiser M. et al. Neoadjuvant FOLFOX-bev. without radiation. for locally advanced rectal cancer. J. Clin. Oncol. 2010. Vol. 28. P. 263. Abstr. 3511.
  31. Matsumoto T., Hasegawa S., Zaima M. et al. Outcomes of neoadjuvant chemotherapy without radiation for rectal cancer. United Eur. J. 2014. Vol. 2. No. 1. A132-A605.
  32. Jalil O., Claydon L., Arulampalam T. et al. Review of neoadjuvant chemotherapy alone in locally advanced rectal cancer. Gastrointest. 2014.
  33. Dworak O., Keilholz L., Hoffmann A. Pathological features of rectal cancer after preoperative radiochemotherapy. Int. J. Colorectal Dis. 1997. Vol. 12. P. 19-23
  34. Chua Y.J., Barbachano Y., Cunningham D. et al. Neoadjuvant capecitabine and oxaliplatin before chemoradiotherapy and total mesorectal excision in MRI-defined poor-risk rectal cancer: a phase 2 trial. Lancet Oncol. 2010. Vol. 11. P. 241-248.
  35. Gao Y.H., Zhang X., An X. et al. Oxaliplatin and capecitabine concomitant with neoadjuvant radiotherapy and extended to the resting period in high risk locally advanced rectal cancer. Strahlenther. 2014. Vol. 190. P. 158-164.
  36. Garcia-Aguilar J., Smith D.D., Avila K. et al. Optimal timing of surgery after chemoradiation for advanced rectal cancer: preliminary results of a multicenter, nonrandomized phase II prospective trial. Ann. 2011. Vol. 254. P. 97-102.
  37. Habr-Gama A., Perez R.O., Sabbaga J. et al. Increasing the rates of complete response to neoadjuvant chemoradiotherapy for distal rectal cancer: results of a prospective study using additional chemotherapy during the resting period. Dis. Rectum. 2009. Vol. 52. P. 1927-1934.
  38. Zampino M.G., Magni E., Leonardi M.C. et al. Capecitabine initially concomitant to radiotherapy then perioperatively administered in locally advanced rectal cancer. Int. J. Radiat. Biol. Phys. 2009. Vol. 75. P. 421-427.
  39. Borg C., André T., Mantion G. et al. Pathological response and safety of two neoadjuvant strategies with bevacizumab in MRI-defined locally advanced T3 resectable rectal cancer: a randomized. Noncomparative phase II study. Ann. Oncol. 2014. Vol. 25. No. 11. P. 2205-2210.
  40. Kennecke H., Berry S., Wong R. et al. Pre-operative bevacizumab, capecitabine, oxaliplatin and radiation among patients with locally advanced or low rectal cancer: a phase II trial. Eur. J. Cancer. 2012. Vol. 48. P. 37-45.
  41. Nogue M., Salud A., Vicente P. et al. Addition of bevacizumab to XELOX induction therapy plus concomitant capecitabine-based chemoradiotherapy in magnetic resonance imaging-defined poor prognosis locally advanced rectal cancer: the AVACROSS study. Oncologist. 2011. Vol. 16. P. 614-620.
  42. Landry J.C., Feng Y., Prabhu R.S. et al. Phase II Trial of Preoperative Radiation with concurrent capecitabine, oxaliplatin, and bevacizumab followed by surgery and postoperative 5-fluorouracil, leucovorin, oxaliplatin (FOLFOX), and bevacizumab in patients with locally advanced rectal cancer: 5-year clinical outcomes ECOG-ACRIN cancer research group E3204. Oncologist. 2015. Vol. 29. P. 106.
  43. Wang C.C., Liang J.T., Tsai C.L. et al. Neoadjuvant bevacizumab and chemoradiotherapy in locally advanced rectal cancer: early outcome and technical impact on toxicity. World J. Surg. 2014. Vol. 12. P. 329.
  44. Dellas K., Buller J., Görtz G.J. et al. Analysis of bevacizumab-based preoperative radiochemotherapy in patients with locally advanced rectal cancer on surgeryassociated spectrum of complications. Ann. Oncol. 2014. Vol. 21. No. 4. P. 1352-1360.
  45. Dellas K. Höhler T. Reese T. et al. Phase II trial of preoperative radiochemotherapy with concurrent bevacizumab, capecitabine and oxaliplatin in patients with locally advanced rectal cancer. Radiation Oncology. 15 April 2013. Vol. 8. Issue 1, 90.
  46. Fernandez-Martos C., Pericay C., Aparicio J. et al. Phase II, randomized study of concomitant chemoradiotherapy followed by surgery and adjuvant capecitabine plus oxaliplatin (CAPOX) compared with induction CAPOX followed by concomitant chemoradiotherapy and surgery in magnetic resonance imagingdefined, locally advanced rectal cancer: grupo cancer de recto 3 study. J. Clin. Oncol. 2010. Vol. 28. P. 859-865.

For citation: Rasulov AO, Kuzmichev DV, Aliev VA, Mamedli ZZ, Gordeyev SS, Kulushev VM, Polinovskiy AV, Tataev ISh, Madyarov JM, Nazarenko AV, Tkachev SI, Glebovskaya VV, Kozlov NA. Neoadjuvant Chemoradiotherapy with Consolidation Chemotherapy in Complex Treatment of Locally Advanced Rectal Cancer. Medical Radiology and Radiation Safety. 2016;61(2):58-64. Russian.

PDF (RUS) Полная версия статьи

  1. 2016-2-Bessonova-eng
  2. 2016-2-Khabarina-eng
  3. 2016-2-Varfolomeeva-eng
  4. 2016-2-Lyaginskaya-eng

Contact Information

 

46, Zhivopisnaya st., 123098, Moscow, Russia Phone: +7 (499) 190-95-51. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal location

Attendance

2762347
Today
Yesterday
This week
Last week
This month
Last month
For all time
2712
2366
20731
18409
70090
75709
2762347
Forecast today
5016

Your IP:216.73.216.1
Visitor Counter

© Журнал "Медицинская радиология и радиационная безопасность" 2020г.

Яндекс.Метрика

Наверх