SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.

The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Issues journals

Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 5. P. 5-11

RADIATION BIOLOGY

A.A. Ivanov1,2, I.E. Andrianova1, T.M. Bulynina1,2, O.V. Dorozhkina1,2, V.N. Mal’tsev1, N.M. Stavrakova1, G.A. Shal’nova1, A.Yu. Bushmanov1

The Pharmacological Effects of Melanin in the Irradiated Mice

1. A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Joint Institute for Nuclear Research, Dubna, Russia

ABSTRACT

Purpose: Investigation of the melanin efficiency administered to mice after irradiation at different doses.

Material and methods: The bone marrow form of the acute radiation syndrome in mice CD-1 was reconstructed by single or fractionated whole body irradiation with gamma- or X-rays. Phytomelanin water-soluble was given with water ad libitum from the first to the 30-th day after irradiation.

Results: It was shown that melanin was given after the acute exposure to ionizing radiation in doses 6.0-7.5 Gy decreased the lethal outcomes in all groups of mice. The survival melanin treated mice increased by 13-18 % as compared with control. After fractionated exposure (1 Gy daily, total dose 10 Gy) melanin produced 100 % therapeutic effect when the survival of control mice was 43.7 %. Melanin treated mice has demonstrated that body weight loss and the frequency test for bacteriuria were lower than in control. Moreover in mice which received melanin a more pronounced restoration motoric and searching activity had been observed.

Conclusion: According our experimental data melanin given “per os” after irradiation produced a marked therapeutic effect.

Key words: phytomelanin, X-rays and gamma-irradiation, single and fractionated, survival, bacteriuria, behavioral reactions, experimental therapy

REFERENCES

  1. Zherebin Yu.M., Bondarenko N.A., Makan S.Yu. et al. Farmakologicheskie svoistva melaninovykh pigmentov. Doklady AN USSR. 1984. No. 3. Seriya B. P. 64-67. (In Russ.).
  2. Ostrovskii M.A., Dontsov A.E. Fiziologicheskie funktsii melanina v organizme. Fiziologiya cheloveka. 1985. Vol. 11. No. 4. P. 670-678. (In Russ.)
  3. Kunwar A., Adhihary B., Jayakumar S. et al. Melanin a promising radioprotector: mechanisms of actions in mice model. Appl. Pharmacol. 2012. Vol. 264. No. 2. P. 202-211.
  4. Berdyshev G.D. O zashchitnom deistvii melanina pri obluchenii myshei. Radiobiologiya. 1964. Vol. 4. No. 4. P. 644-645. (In Russ.).
  5. Schweitzer A.D., Revskaya E., Chu P. et al. Melanincovered nanoparticles for protection of bone marrow during radiation therapy of cancer. Int. J. Radiat. Biol. Phys. 2010. Vol. 78. No. 5. P. 1494-1502.
  6. Ogarkov B.N., Samusenok L.V. Sposob polucheniya pigmenta-krasitelya iz rastitel'nogo syr'ya. Patent RU 2215761 S09861. 2003. (In Russ.).
  7. Ivanov A.A., Andrianova I.E., Mal'tsev V.N. et al. Farmakologicheskie svoistva fitomelanina. Meditsina ekstrem. situatsii. 2014. No. 4. P. 66-72. (In Russ.).
  8. Ivanov A.A., Shal'nova G.A., Mal'tsev V.N. et al. Bakteriuriya pri eksperimental'noi ostroi luchevoi bolezni. Medical Radiology and Radiation Safety. 2014. Vol. 59. No. 3. P. 12-15. (In Russ.).
  9. Buresh Ya., Bureshova O., Kh'yusten Dzh.P. Metodiki i osnovnye eksperimenty po izucheniyu mozga i povedeniya. Moscow: Vyssh. shk. 1991. 399 p. (In Russ.).
  10. Bushmanov A.Yu., Ivanov A.A., Andrianova I.E. et al. Protivoluchevye svoistva melanina. Saratovskii nauchno-med. zhurnal. 2014. Vol. 10. No. 4. P. 828-832. (In Russ.).
  11. Vasin M.V. Sredstva, povyshayushchie radiorezistentnost' organizma (sredstva «biologicheskoi zashchity»). V kn. «Radiatsionnaya meditsina». L.A. Il'ina (ed.). Moscow: IzdAT. 2004. Vol. 1. P. 756-761. (In Russ.).
  12. Ivanov A.A., Mal'tsev V.N. Immunnaya sistema. V kn.: «Radiatsionnaya meditsina». L.A. Il'ina (ed.). Moscow: IzdAT. 2004. Vol. 1. P. 327-348. (In Russ.).
  13. Petrov R.V. Immunologiya ostrogo luchevogo porazheniya. Moscow: Atomizdat. 1962. 267 p. (In Russ.).
  14. Borshchevskaya M.I., Vasil'eva S.M. Razvitie predstavlenii o biokhimii i farmakologii melaninovykh pigmentov. Voprosy med. khimii. 1999. Vol. 45, No. 1. P. 13-24. (In Russ.).
  15. Izmest'eva O.S., Dubovik B.V., Zhavoronkov L.P. Eksperimental'naya otsenka radiozashchitnogo deistviya melanina na somaticheskoe razvitie pri obluchenii v antenatal'nom periode ontogeneza. Radiats. biologiya. Radioekologiya. 2007. Vol. 47. No. 6. P. 684-689. (In Russ.).
  16. Ostrovskii M.A., Dontsov A.E. Fiziologicheskie funktsii melanina v organizme. Fiziologiya cheloveka. 1985. Vol. 11. No. 4. P. 670-678. (In Russ.).
  17. Zhukova N.A., Palyga G.F., Maksimenko A.A. Vliyanie poliinozinovoi politsitidilovoi kisloty (poly(i:c)) i dextran sulfate (DS) na radiorezistentnost' zhivotnykh. Radiatsiya i organizm. Obninsk. 1979. No. 3. P. 16-19. (In Russ.).
  18. Li Yuhuan. Radioprotective activity of Poly I: C. Clin. J. Radiol. Med. Protect. 1982. Vol. 2. No. 4. P. 31-33.
  19. Patсhen M.L., MacVittie T.J., Jackson W.E. Postirradiation glucan administration enhances the radioprotective effects of WR-2721. Radiat. Res. 1989. Vol. 117. P. 59-69.
  20. Andrianova I.E., Andrushchenko V.N., Vernigorova L.A., et al. Eksperimental'naya razrabotka i vnedrenie v praktiku kompleksa protivoluchevykh sredstv i sposoba lecheniya massovykh radiatsionnykh porazhenii. Meditsina ekstrem. situatsii. 1999. No. 2. P. 52-58. (In Russ.).
  21. Il'in L.A., Andrianova I.E., Glushkov V.A. Izuchenie zavisimosti radiozashchitnoi aktivnosti khitozana ot ego molekulyarnoi massy. Radiats. biologiya. Radioekologiya. 2004. Vol. 44. No. 2. P. 176-178. (In Russ.).
  22. El-Obeid A., Al-Harbi S., AL-Jomah N., Hassib A. Herbal melanin modulates tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) production. Phytomedicine. 2006. Vol. 13. No. 5. P. 324-333.
  23. Hamphreys E.R., Howells G.R. The effect of oral sodium alginate on the retention of radioactive barium in the rat. Contamin. Radionucleid. Osteotrop. et Radioprot. Soc. Franc. Radioprot. 5’eme Congr. Int. Grenoble. Montrouge. 1971. P. 593-598.
  24. Zhogolev K.D., Tsygan V.N., Nikitin V.Yu., Egorov V.N. Primenenie preparatov khitozana v kachestve biologicheski aktivnykh dobavok k pishche. Med. aspekty radiats. i khim. bezopasnosti. Materialy konferentsii. Saint Petersburg: VMA. 2001. P. 432-433. (In Russ.).
  25. Tarasenko G.A. Radioprotektornye i antitoksicheskie svoistva khitozana iz pantsirya kamchatskogo kraba po otnosheniyu 40K, 137S i 203Ng. Novye perspektivy v ispol'zovanii khitina i khitozana. Materialy 5-i konferentsii. Moscow: VNIROl. 1999. P. 197-198. (In Russ.).
  26. Senyuk O.F., Gorovoi L.F., Kovalev V.A. et al. Osobennosti i vozmozhnost' khimicheskoi modifikatsii povedencheskikh reaktsii v pripodnyatom krestoobraznom labirinte khronicheski obluchennykh myshei s razlichnoi geneticheski determinirovannoi radiochuvstvitel'nost'yu. Radiats. biologiya. Radioekologiya. 2013. Vol. 53. No. 2. P. 170-182. (In Russ.).

For citation: Ivanov AA, Andrianova IE, Bulynina TM, Dorozhkina OV, Mal’tsev VN, Stavrakova NM, Shal’nova GA, Bushmanov AYu. The Pharmacological Effects of Melanin in the Irradiated Mice. Medical Radiology and Radiation Safety. 2015;60(5):5-11. Russian.

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 6. P. 27-33

A.R. Tukov, A.P. Birukov, I.L. Shafransky, A.A. Fomin

Comparative Risk Analysis of Radiation-Epidemiological Studies of Liquidators of the Chernobyl Disaster Exposed to Different Types of Radiation

A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Material and methods: The study carried out with the use of the information on NPP workers participated in recovery operations at the Chernobyl NPP. For risk calculation, the dose of professional exposure and the dose received during operations in 30 km zone were used.

Results: It is shown that the influence on humans of different types of radiation results in different risk levels malignancies.

Conclusion: For correct cancer risk estimation, the total radiation dose should be used.

Key words: cancer risk, doses of different types of radiation, the total dose

REFERENCES

  1. Pierce D.A., Shimizu Y., Preston D.L. et al. Studies of the mortality of atomic bomb survivors. Report 12, Part I. Cancer: 1950-1990. Radiat. Res. 1996. Vol. 146. No. 1. P. 1-27.
  2. Pierce D. and Preston D.L. Radiation-related cancer risks at low doses among atomic bomb survivors. Radiat. Res. 2000. Vol. 154. No. 2. P. 178-186.
  3. Ivanov V.K., Tsyb A.F., Ivanov S.I. i soavt. Likvidatory Chernobyl'skoi katastrofy: radiatsionno-epidemiologicheskii analiz meditsinskikh posledstvii. Moscow: Galanis. 1999. 312 p. (In Russ.).
  4. Little M.P., Muirhead C.R. Evidence for curvilinearity in the cancer incidence dose-response in the Japanese atomic bomb survivors. J. Radiat. Biol. 1996. Vol. 70. No. 4. P. 83-94.
  5. Normy radiatsionnoi bezopasnosti (NRB-99): Gigienicheskie normativy. Moscow: Minzdrav Rossii. 1999. 116 p. (In Russ.).
  6. Cardis E., Vrijheid M., Blettner M. at al. Risk of cancer after low doses of ionising radiation: retrospective cohort study in 15 countries. 2005. Vol. 89. No. 9. P. 1-7.
  7. Otchet o prikladnoi nauchno-issledovatel'skoi rabote Obespechenie funktsionirovaniya «Federal'nogo banka dannykh individual'nykh doz oblucheniya personala organizatsii i naseleniya na territoriyakh, obsluzhivaemykh uchrezhdeniyami Federal'nogo mediko-biologicheskogo agentstva». Pod nauch. ruk. A.G. Tsov'yanova. Moscow: FMBTs im. A.I. Burnazyana FMBA Rossii. Ts-288. 2011. 188 p. (In Russ.).
  8. Tukov A.R., Biryukov A.P., Shafranskii I.L. Ispol'zovaniya dannykh o dozakh razlichnogo vida oblucheniya v radiatsionnoi epidemiologii. Medical Radiology and Radiation Safety. 2014. Vol. 59. No. 1. P. 43-49. (In Russ.).

For citation: Tukov AR, Birukov AP, Shafranskv IL, Fomin AA. Comparative Risk Analysis of Radiation-Epidemiological Studies of Liquidators of the Chernobyl Disaster Exposed to Different Types of Radiation. Medical Radiology and Radiation Safety. 2015;60(6):27-33. Russian.

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 6. P. 60-66

DISCUSSION

M.V. Osipov, M.E. Sokolnikov

Challenges in Carcinogenic Risk Assessment of Medical Radiation Exposure among Workers at a Nuclear Power Plant

Southern Urals Biophysics Institute of FMBA RF, Ozersk, Chelyabinsk Region, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: Explore an approach to the estimation of relative risk from medical radiation exposure and show a complex mechanism of causal relationship between exposure to medical radiation and the risk of cancer among Workers at a nuclear power plant.

Material and methods: The study has been carried out among Workers at the «Mayak» nuclear nuclear power plant. Nuclear workers underwent the combined exposure of chronic gamma and alpha ionizing radiation in a wide range of doses, and regular medical examination at the Central medical-sanitary unit of Ozersk. Information on vital status and cause of death was obtained from the Nuclear Personnel Register and the Oncological Register. The risk assessment was carried out on the basis of the excess relative risk model.

Results: The comparison of the coefficient of excess relative risk per unit dose obtained in the model for external professional and medical exposure showed that ERR per unit dose of medical radiation exposure (5.5 (95 % CI 0.3; 12.2) for solid cancers other than lung, liver and bone, is several times higher than one for occupational external gamma radiation exposure (0.13 (95 % CI 0.05; 0.2)). To a large extent, this is not due to a direct carcinogenic effect of medical radiation, but as a consequence of the effective detection of cancer by the X-ray.

Conclusion: The reason for bias in the estimation of excess relative risk of medical exposure is a reversed causal interaction between the analyzed factor and the effect. One of the possible solutions of to this problem is the risk of medical X-ray screening exposure (i.e. fluorography) analyses. Simple summation of doses of medical and occupational exposure to for calculating the risk is unacceptable due to the different mechanisms of accumulation of radiation dose.

Key words: medical exposure, absorbed dose, excess relative risk, medical radiation dose

REFERENCES

  1. ICRP Publication 105. Recommendations of the International Commission on Radiological Protection. Ann. ICRP. Vol. 37. No. 6, 2007.
  2. Publikatsiya 103 Mezhdunarodnoi komissii po radiatsionnoi zashchite (MKRZ). From engl. In M.F. Kiseleva i N.K. Shandaly (eds.). Moscow. 2009.
  3. Koshurnikova N.A., Shil'nikova N.S., Okatenko P.V. et al. Kharakteristika kogorty rabochikh atomnogo predpriyatiya PO «Mayak». Medical Radiology and Radiation Safety. 1998. Vol. 43. No. 6. P. 43-57.
  4. Koshurnikova N.A., Shil'nikova N.S., Okatenko P.V. et al. Kharakteristika kogorty rabochikh atomnogo predpriyatiya PO «Mayak» (chast' I). Voprosy radiats. bezopasnosti. 1998. No. 2. P. 46-55.
  5. Koshurnikova N.A., Shil'nikova N.S., Okatenko P.V. et al. Kharakteristika kogorty rabotnikov atomnogo predpriyatiya PO «Mayak» (chast' II). Voprosy radiatsionnoi bezopasnosti. 1998. No. 3. P. 48-58.
  6. Vasilenko E.K. Dozimetriya vneshnego oblucheniya rabotnikov PO «Mayak»: pribory, metody, rezul'taty. V sb.: «Istochniki i effekty oblucheniya ra-botnikov PO «Mayak» i naseleniya prozhivayushchego v zone vliyaniya predpriyatiya». In M.F. Kiseleva i S.A. Romanova (eds.). Chelyabinsk. 2009. Vol. 1. P. 51-100.
  7. Khokhryakov V.V., Khokhryakov V.F., Suslova K.G. et al. Mayak Worker Dosimetry System 2008 (MWDS-2008): Assessment of internal dose from measurement results of plutonium activity in urine. Health Phys. 2013. Vol. 104. No. 4. P. 366-378.
  8. Preston D. L. Epicure User’s Guide. USA. 330 p.
  9. Shilnikova N.S., Preston D.L., Ron E. et al. Cancer mortality risk among workers at the Mayak nuclear complex. Radiat. Res. 2003. Vol. 159. P. 787-798.
  10. Osipov M.V., Sokol'nikov M.E. Otsenka riska smertnosti ot zlokachestvennykh novoobrazovanii organov zheludochno-kishechnogo trakta u rabotnikov PO «Mayak». Voprosy radiatsionnoi bezopasnosti. 2014. No. 1. P. 76-83.
  11. Koshurnikova N.A., Gilbert E.S., Sokolnikov M.E. et al. Bone cancers in Mayak workers. Radiat. Res. 2000. Vol. 154. P. 154-237.
  12. Gilbert E.S., Koshurnikova N.A., Sokolnikov M. et al. Liver cancers in Mayak workers. Radiat. Res. 2000. Vol. 154. P. 246-252.
  13. Boice J.D. Jr. Paediatric CT and recent epidemiological studies. ICRP 2nd, Abu Dhabi. National Council on Radiation Protection and Measurements, Vanderbilt University. Oct. 24, 2013.
  14. Lebedev N.I., Osipov M.V., Fomin E.P. O sposobe snizheniya luchevoi nagruzki pri komp'yuternoi tomografii bryushnoi polosti. Medical Radiology and Radiation Safety. 2014. Vol. 59. No. 4. P. 48-52.
  15. Pearce M., Salotti J. et al. Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study. Lancet. 2012. Vol. 380. No. 9840. P. 499-505.
  16. Howe G.R. Lung cancer mortality between 1950 and 1987 after exposure to fractionated moderate-dose-rate ionizing radiation in the canadian fluoroscopy cohort study and the comparison with lung cancer mortality in the atomic bomb survivors study. Radiat. Res. 1995. Vol. 142. P. 295-304.

For citation: Osipov MV, Sokolnikov ME. Challenges in Carcinogenic Risk Assessment of Medical Radiation Exposure among Workers at a Nuclear Power Plant. Medical Radiology and Radiation Safety. 2015;60(6):60-6. Russian.

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 6. P. 76-79

MEDICAL PRACTICE ISSUE

A.Y. Bushmanov, A.S. Kretov

Ionizing Radiation Related Disease: Occupational Disease or Accident at Work – How to Distinguish?

A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

In accordance with the Labour Code of the Russian Federation and the Federal law dated 24.07.1998 No. 125-FZ, in the Russian Federation ionizing radiation that causes diseases associated with professional activities that give the an employee the right to receive compensation for injury of the caused harm to health, are divided into two groups: occupational diseases and industrial accidents. Unfortunately, a clear explanation to reasonably determine in what cases there is an occupational disease or an industrial accident is not given. This article offers an approach for clearly differentiating cases of occupational diseases due to exposure to ionizing radiation, and industrial accidents.

Key words: occupational disease, accident at work, ionizing radiation

REFERENCES

  1. «Trudovoi Kodeks Rossiiskoi Federatsii» ot 30.12.2001 No. 197-FZ.
  2. Federal'nyi zakon ot 24.07.1998 No. 125-FZ «Ob obyazatel'nom sotsial'nom strakhovanii ot neschastnykh sluchaev na proizvodstve i professional'nykh zabolevanii».
  3. Postanovlenie Pravitel'stva Rossiiskoi Federatsii ot 15.12.2000 No. 967 «Ob utverzhdenii Polozheniya o rassledovanii i uchete professional'nykh zabolevanii».
  4. Prikaz Minzdrava RF ot 28.05.2001 No. 176 «O sovershenstvovanii sistemy rassledovaniya i ucheta professional'nykh zabolevanii v Rossiiskoi Federatsii».
  5. Federal'nyi zakon ot 28.12.2013 No. 426-FZ «O spetsial'noi otsenke uslovii truda».
  6. R2.2.2006-05. Rukovodstvo po gigienicheskoi otsenke faktorov rabochei sredy i trudovogo protsessa. Kriterii i klassifikatsiya uslovii truda.
  7. Ozhegov S.I., Shvedova N.Yu. Tolkovyi slovar' russkogo yazyka. Moscow. 1992.

For citation: Bushmanov AY, Kretov AS. Ionizing Radiation Related Disease: Occupational Disease or Accident at Work - How to Distinguish?. Medical Radiology and Radiation Safety. 2015;60(6):76-9. Russian.

PDF (RUS) Full-text article (In Russian)

Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 6. P. 54-59

DISCUSSION

V.A. Lisin1,2

Some Approaches to the Definition of the Concept of “Radiotherapy Interval” in Radiation Therapy for Cancer<

1. Tomsk Cancer Research Institute, Tomsk, Russia; 2. National Research Tomsk Polytechnic University, Tomsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: To analyze the existing approaches to the definition of radiotherapy interval and to consider a more precise quantification of this concept.

Material and methods: Superficial tumors treated with X-rays and fast monoenergetic electrons were used as an example of estimation of a new approach to radiotherapy interval. The characteristics of the dose distributions for X-rays and fast monoenergetic electron beams generated by irradiating the superficial tumors were studied. Dependence of the radiotherapy interval on tumor size for X-rays and fast monoenergetic electron beam was determined by the calculation method. The algorithm for calculation corresponded to the new definition of radiotherapy interval.

Results: A new approach to the definition of radiotherapy interval removes uncertainty and contradictions that existed in the previous definition.

Key words: radiation therapy, radiotherapy interval, X-ray irradiation, fast electrons, dose distribution

REFERENCES

  1. Lindenbraten L.D., Lyass F.M. Meditsinskaya radiologiya. Moscow: Meditsina. 1979. 390 p.
  2. Yarmonenko S.P. Radiobiologiya cheloveka i zhivotnykh. Moscow: Vysshaya shkola. 1984. 375 p.
  3. Lisin V.A., Musabaeva L.I. Kolichestvennaya otsenka luchevykh reaktsii opukholei s uchetom ikh radiobiologicheskikh parametrov. Med. radiologiya. 1983. Vol. 28. No. 12. P. 30-34.
  4. Lisin V.A. Teoreticheskaya otsenka effektivnosti fraktsionirovannogo oblucheniya zlokachestvennykh opukholei bystrymi neitronami. Med. radiologiya. 1986. Vol. 31. No. 10. P. 13-18.
  5. Lisin V.A. Sposob optimizatsii fraktsionirovaniya dozy v luchevoi terapii zlokachestvennykh opukholei v ramkakh kontseptsii Ellisa. Med. radiologiya. 1984. Vol. 29. No. 12. P. 83-87.
  6. Ivanov V.I., Lystsov V.N. Osnovy mikrodozimetrii. Moscow: Atomizdat. 1979. 190 p.
  7. Pavlov A.S., Fadeeva M. A., Karyakina N. F. et al. Lineino-kvadratichnaya model' v raschetakh izoeffektivnykh doz, v otsenke protivoopukholevogo effekta i luchevykh oslozhnenii pri luchevoi terapii zlokachestvennykh opukholei. Posobie dlya vrachei. Moscow. 2005. 67 p.
  8. Lisin V.A. Otsenka predel'nodopustimoi odnokratnoi dozy pri intraoperatsionnoi luchevoi terapii. Med. fizika. 2006. No. 4. P. 18-23.
  9. Calvo F.A., Meirino R.M., Orecchia R. Intraoperatsionnaya luchevaya terapiya: obosnovanie metoda, tekhnicheskie aspekty, rezul'taty klinicheskogo primeneniya. Onkokhirurgiya. 2010. Vol. 2. No. 3. P. 73-82.
  10. Fotina I.E. Distantsionnaya radioterapiya. Tomsk: Publ. Tomskogo politekh. un-ta. 2010. 103 p.
  11. Yarmonenko S.P., Vainson A.A. Radiobiologiya cheloveka i zhivotnykh. Moscow: Vysshaya shkola. 2004. 510 p.
  12. Podlyashuk E.L., Ustinova V.F., Frolova A.V. Luchevaya terapiya na korotkodistantsionnom apparate. Metod. rekomendatsii. Moscow. 1986. 16 p.
  13. Emmanuel' N.M., Kavetskii R.E., Tarusov B.N., Sidorik E.P. Biofizika raka. Kiev. 1976. 293 p.
  14. Kholin V.V. Radiobiologicheskie osnovy luchevoi terapii zlokachestvennykh opukholei. Leningrad. 1979. 223 p.
  15. Ivanov V.K. Matematicheskoe modelirovanie i optimizatsiya luchevoi terapii opukholei. Moscow: Energoizdat. 1986. 145 p.
  16. Musabaeva L.I., Lisin V.A., Polishchuk P.F., Chakhlov V.L. Malogabaritnyi betatron dlya elektronnoi terapii poverkhnostnykh opukholei i ego aprobatsiya. Med. radiologiya. 1987. Vol. 32. No. 12. P. 43-47.
  17. Uskoriteli elektronov dlya luchevoi terapii. Gosudarstvennyi standart Soyuza SSR, GOST 4.490-89. Gosudarstvennyi Komitet SSSR po standartam. Moscow. 1989.
  18. Lisin V.A. Ustroistvo formirovaniya polei elektronnogo izlucheniya, Avtorskoe svidetel'stvo 1290938 ot 15 oktyabrya 1986 g.

For citation: Lisin VA. Some Approaches to the Definition of the Concept of "Radiotherapy Interval" in Radiation Therapy for Cancer. Medical Radiology and Radiation Safety. 2015;60(6):54-9. Russian.

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