Medical Radiology and Radiation Safety, 2016. Vol. 61. No. 2. P. 46-52

DIAGNOSTIC RADIOLODGY

N.V. Khabarina, E.V. Esin

Sonographic Syndromes of Osteochondral Changes of Medium and Small Joints of the Extremities with the Main Types of Arthropathy

Postgraduated Professional Education Institute of A.I. Burnasyan Federal Medical Biophisical Center, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: To determine the typical sonographic osteochondral manifestations of rheumatoid (ReA), reactive, gouty arthritis, osteoarthritis (OA), joint syndrome in systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), psoriatic arthropathy (PsA) of the early pathological process, trace its dynamics.

Material and methods: Arthrosonography was made for 540 patients with articular syndrome in the expert class machines. The basic structure of the ultrasonic symptoms of hyaline cartilage and underlying bone, their changes are specific for each type of nosology.

Results: The Change in joint cartilage plates installed in 75.4 % of cases. Echographic pattern of pathology consisted of varying the thickness of the cartilage disk, its echogenicity, texture, contour, presence or absence of additional education in the projection of hyaline tissue. The lack of pathology of the articular cartilage was observed in patients with ReA acute course (n = 70), the debut of gout (n = 8), patients with a short period of the disease SLE, SSc and PsA (n = 19, 16, 69 respectively), in OA young people with the period of the disease is not more than 2 years (n = 52). Bone changes were presented in two versions: as a symptom of hardening layer subchondral bone (9.9 %), symptoms of marginal bone growths (5.2 %). The sensitivity of ultrasound as a whole was 84.4 %, specificity - 83.1 %, accuracy - 83.8 %.

Conclusions: An analysis of the dynamics of the ultrasound picture in rheumatoid and reactive arthritis, osteoarthritis, gout, psoriatic arthropathy and articular syndrome in systemic lupus erythematosus and systemic sclerosis was a direct correlation between the activity of the pathological process, the duration of the disease, its stage of radiological and ultrasound appearances. Erozirovanie articular cartilage may identify within 2.8 months after the occurrence of a destructive arthritis, degenerative changes and microcrystalline inclusions in the thickness of cartilage - after 6.1 months.

Key words: arthropathy, cartilage, bone structure of the joint, ultrasound diagnostics

REFERENCES

1. Goncharov N.G. Sotsial'no-gigienicheskie aspekty invalidnosti, kliniko-funktsional'nye osobennosti. mediko-sotsial'naya ekspertiza i reabilitatsiya pri boleznyakh kostno-myshechnoi sistemy. Moscow. Avtoref. diss. dokt. med. nauk. 2001. 61 p. (In Russ.).
2. Chichasova N.V., Mendel' O.I., Nasonov E.L. Osteoartroz kak obshcheterapevticheskaya problema. Russkii med. zhurnal. 2010. Vol. 18. No. 11(275). P. 729-734. (In Russ.).
3. Nasonov E.L., Nasonova V.A. Revmatologiya: nauchnoe rukovodstvo. Moscow. GEOTAR-Media. 2008. 720 p. (In Russ.).
4. Nasonov E.L. Vnedrenie vysokikh meditsinskikh tekhnologii v revmatologii: problemy i resheniya. Nauchno-praktich. revmatologiya. 2008. No. 2. P. 4-5. (In Russ.).
5. Ivanova O.N., Sobolev Yu.A., Pyadova E.A. et al. Sravnitel'nyi analiz artrosonograficheskikh i rentgenologicheskikh izmenenii sustavov pri revmaticheskikh zabolevaniyakh. Nauchno-praktich. revmatologiya. 2013. No. 4. P. 11-15. (In Russ.).
6. Babaev M.V., Volkov G.P. Sravnitel'naya otsenka rentgenograficheskoi i ul'trazvukovoi diagnostiki degenerativnykh porazhenii kolennogo sustava. Sb. nauch. rabot III Rossiisk. nauch. foruma «Luchevaya diagnostika i luchevaya terapiya v klinike XXI veka. Radiologiya 2002». Moscow. 2002. P. 17-18. (In Russ.).
7. Karateev D.E., Aleksandrova E.N., Demidova N.V. et al. Antitsitrullinovye antitela i dannye magnitno-rezonansnoi tomografii sustavov kisti u bol'nykh rannim artritom. Ter. arkhiv. 2010. Vol. 80. No. 10. P. 72-77. (In Russ.).
8. Bryukhanov A.V., Fedorov V.V., Mikhal'kov D.F. Magnitno-rezonansnaya tomografiya v diagnostike osteoartritov krupnykh sustavov. med. zhurnal. 1998. Vol. 13. No. 1-2. P. 28-30. (In Russ.).
9. Sal'nikova T.S., Balabanova R.M. K voprosu o rannei diagnostike revmatoidnogo artrita. Nauchno-praktich. revmatologiya. 2009. No. 2. P. 7-10. (In Russ.).
10. Backhaus M., Kamradt T., Sandrock D. et al. Arthritis of the finger joints: a comprehensive approach comparing conventional radiography. Scintigraphy, ultrasound and contrast-enhanced magnetic resonance imaging. Arthritis & Rheumatism. 2009. Vol. 42. P. 1232-1245.
11. O’Connor P.J. US in early diagnosis and monitoring. ERR 2009. Book of Abstracts. Vienna. 2009. No. 19. Suppl. 1. P. 37.
12. Bianchi S., Martinoli C., Damiani S., Derchi L.E. High frequency US of the hand and wrist. Eur. Radiol. 2009. Vol. 9. No. 6. P. 16-17.
13. Cheremis N.A. Osobennosti diagnostiki revmatoidnogo artrita na rannei stadii. Moscow. Avtoref. dis. kand. med. nauk. 2005. 23 p. (In Russ.).
14. Karateev D.E., Luchikhina E.L. Rannyaya diagnostika revmatoidnogo artrita: problemy i resheniya. Ross. med. vesti. 2013. No. 4. P. 24-27. (In Russ.).
15. Ermak E.M., Kinzerskii A.Yu. Diagnostika rannikh stadii destruktsii sustavnogo khryashcha i ryada predartroznykh faktorov. Ul'trazvukovaya i funkts. diagnostika. 2002. No. 2. P. 297-298. (In Russ.).
16. Goekoop-Ruiterman Y.P.M., de Vries-Bouwstra J.K., Allaart C.F. et al. Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the best study). Arthritis & Rheumatism. 2005. Vol. 11. P. 3381-3390.
17. Kaposi P.N. The role of US angiography in rheumatological practice. Eur. 2009. Vol. 9. No. 6. P. 32-33.
18. Olivieri I., Barozzi L., Peierro A. et al. Dactylitis in patients with seronegative spondylarthropathy: assessment by ultrasonography and magnetic resonance imaging. Arthritis & Rheumatism. 2006. Vol. 39. No. 9. P. 1524-1528.
19. Ostergaard M., Ejbjerg B.J., Szkudlarek M. et al. Imaging in early rheumatoid arthritis: roles of magnetic resonance imaging. Ultrasonography, conventional radiography and computed tomography. Best Practice & Res. Clin. 2009. Vol. 19. No. 4. P. 91-116.
20. Scheel A.K., Herman K.-G.A., Ohrndorf S. et al. Prospective 7 year follow up imaging study comparing radiography. Ultrasonography, magnetic resonance imaging in rheumatoid arthritis finger joints. Ann. Rheumatis Diseases. 2006. Vol. 65. No. 7. P. 595-600.
21. Szkudlarek M., Klarlund M., Narvestad E. et al. Ultrasonography of the metacarpophalangeal and proximal interphalangeal joints in rheumatoid arthritis: a comparison with magnetic resonance imaging, conventional radiography and clinical examination. Arthritis Res. & Therapy. 2008. Vol. 143. No. 4. P. 572-579.
22. Perova T.B., Zavadovskaya V.D., Ekimova L.S. Ekhograficheskie priznaki revmatoidnogo porazheniya kolennykh sustavov. Sb. mater. Nevskogo radiolog. foruma «Iz budushchego v nastoyashchee». Petersburg. 2003. P. 104-105. (In Russ.).
23. Zavadovskaya V.D., Perova T.B., Khodashinskaya A.V., Saprykina E.V. Rol' ul'trazvukovogo issledovaniya v otsenke aktivnosti revmatoidnogo artrita. Vizualizatsiya v klinike. 2011. No. 17. P. 33-36. (In Russ.).
24. Mach E.S., Pushkova O.V. Ul'trazvukovaya kharakteristika artrita kolennogo sustava pri revmaticheskikh boleznyakh. Vizualizatsiya v klinike. 2009. No. 19. P. 18-22. (In Russ.).
25. Grassi W., Tittarelli E., Pirani O. et al. Ultrasound examination of metacarpophalangeal joints in rheumatoid arthritis. Scand. 2003. Vol. 22. No. 2. P. 243-247.
26. Rusakova M.S., Gritsman N.N., Speranskii A.I., Mirzoeva S.M. Dannye immunomorfologicheskogo issledovaniya sustavnogo khryashcha pri revmatoidnom artrite. V sb. nauch. trudov: «Sovremennye problemy patogeneza i terapii revmaticheskikh zabolevanii». Riga. 1985. No. 15. P. 62-65. (In Russ.).
27. Shostak N.A., Muradyants A.A., Loginova T.K., Timofeev V.T. Kliniko-immunologicheskie osobennosti rannego revmatoidnogo artrita. Nauchno-praktich. revmatologiya. 2011. No. 1. P. 15-17. (In Russ.).
28. Harland U., Sattler H. Ultraschallfibel Orthopadie. Traumatologie. Rheumatologie. Berlin. Heidelberg. New York. London. Springer Verlag. 2001. 33 p.
29. Erov N.K., Mairansaeva S.N. Voprosy diagnostiki mono- i oligoartritov razlichnoi etiologii. Voprosy revmatizma. 2012. No. 2. P. 41-44. (In Russ.).
30. Alsaarela E., Suramo I., Tervonen O. Evaluation of humeral head erosion in rheumatoid arthritis: A comparison of ultrasonography. MRI, computed tomography and plain radiography. Brit. J. Rheumatol. 2008. Vol. 37. P. 1152-1156.
31. Harris E.D. The bone and joint decade: a catalyst for progress. Arthritis & Rheumatism. 2011. Vol. 44. P. 1967-1970.
32. Khanna D., Ranganath V.K., Fitzgerald J. et al. Increased radiographic damage scores at the onset of seropositive rheumatoid arthritis in older patients are associated with osteoarthritis of the hands, but not with rapid progression of damage. Arthritis & Rheumatism. 2008. Vol. 24. No. 5. P. 2284-2292.
33. Dieppe P., Swan A. Identification of crystals in synovial fluid. Ann. Rheumatis Diseases. 2007. Vol. 58. P. 261-263.
34. Mach E.S., Pushkova O.V., Severinova M.V. Porazhenie sustavov pri podagre (po dannym artrosonografii). V sb. mater. IV s"ezda Rossiiskoi assotsiatsii spetsialistov ul'trazvukovoi diagnostiki v meditsine. Moscow. 2003. P. 275. (In Russ.).

For citation: Khabarina NV, Esin EV. Sonographic Syndromes of Osteochondral Changes of Medium and Small Joints of the Extremities with the Main Types of Arthropathy. Medical Radiology and Radiation Safety. 2016;61(2):46-52. Russian.

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 2. P. 30-38

RADIATION MEDICINE

Lyaginskya¹, I.M. Petoyan¹, V.A. Osipov¹, A.P. Ermalitskiy¹, S.M. Kiselev¹, S.V. Akhromeev¹, O.E. Kim²

State of Health of the Population Living in the Vicinity of the Enterprise for Radioactive Waste Management, FEC DalRAO

1. A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Medical Health Unit No.100 of FMBA, CTF Fokino, Primorsky Krai, Russia

ABSTRACT

Purpose: To study the state of health of the population of the town Fokino, living in the vicinity of the plant for the radiation waste management in the town Fokino.

Material and methods: A study of people’s state of health, including health assessment of adults, children and evaluation of reproductive health was carries out in the framework of radiationhygienic monitoring. to obtain the necessary information and estimations of the indices of health were used current forms of medical statistics: 7, 12, 19, 30, 31 and 32. All obtained materials were evaluated from the perspective of the available published average data to of the Russian Federation and Far-Eastern federal region in 2007-2011. Basic research was carried out during 2009-2013.

Conclusion: Analysis of the obtained data about state of the health of the population of the town Fokino, living in the vicinity of the plant for the radiation waste management in 2009-2013, showed that health conditions of the population according to the basic indicator (health assessment of adults, children and evaluation of reproductive health) corresponds to the average indicator of center regions of the Russian Federation.

Key words: population health, mortality, morbidity, reproductive health

REFERENCES

1. Federal'nyi zakon No. 3-FZ ot 09.01.1996. «O radiatsionnoi bezopasnosti naseleniya». (In Russ.).
2. Prikaz FMBA Rossii No. 1793 ot 30.12.2002. «Ob organizatsii sotsial'no-gigienicheskogo monitoringa na ob"ektakh i territoriyakh, obsluzhivaemykh FMBA Rossii». (In Russ.).
3. Metodicheskie ukazaniya «Ekspertnye i prognoznye otsenki sostoyaniya zdorov'ya naseleniya v raionakh razmeshcheniya atomnykh stantsii». MU 2.6.5.032-2014. 30 p. (In Russ.).
4. Shchepin O.P., Korotkikh R.V., Shchepin V.O., Medik V.A. Zdorov'e naseleniya - osnova razvitiya zdravookhraneniya. O.P. Shchepina (ed.). Natsional'nyi NII obshchestvennogo zdorov'ya RAMN. 2009. 376 p. (In Russ.).
5. Prokhorov B.B., Shmakov D.I. Perspektivy sotsial'no-ekonomicheskogo i mediko-demograficheskogo razvitiya Baikalo-Dal'nevostochnogo regiona do 2025 g. Sait regional'nye aspekty: Available from: http://www.ecfor.ru/pdf.php?id=books/sa2009/25. (accessed: 03.06.2015). (In Russ.).
6. Merkov A.M., Polyakov L.E. Sanitarnaya statistika (posobie dlya vrachei). Moscow: Meditsina. 1974. 384 p. (In Russ.).
7. Lyaginskaya A.M., Romanov V.V., Petoyan I.M. et al. Sostoyanie zdorov'ya naseleniya, prozhivayushchego vblizi Smolenskoi AES. Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 2. P. 25-26. (In Russ.).
8. Nauchnyi komitet OON po deistviyu atomnoi radiatsii. 37-ya sessiya NKDAR OON. Doklad Gene-ral'noi assamblee. Vena, 6-17 Jun. 1988. 33 p. (In Russ.).

For citation: Lyaginskya АМ, Petoyan IM, Osipov VA, Ermalitskiy AP, Kiselev SM, Akhromeev SV, Kim OE. State of Health of the Population Living in the Vicinity of the Enterprise for Radioactive Waste Management, FEC DalRAO. Medical Radiology and Radiation Safety. 2016;61(2):30-8. Russian.

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 2. C. 39-45

RADIATION MEDICINE

T.A. Varfolomeyeva¹, A.A. Akleyev^1,2, A.S. Mandrykina¹

The Characteristics of Homeostasis in Individuals Chronically Exposed to Radiation in the South Urals at Late Time After Exposure

1. Urals Research Center for Radiation Medicine, Chelyabinsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. , This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. South Ural State Medical University, Chelyabinsk, Russia

ABSTRACT

Purpose: To conduct a study on the characteristics of the quantitatively-cellular, functional and oxidation-reduction homeostasis of the blood system at late time after exposure in residents of the territories contaminated with radionuclides in the South Urals.

Material and methods: The study included a comprehensive analysis of the morpho-functional and oxidant-antioxidant status of the peripheral blood cells in residents of the Techa riverside villages all of whom was exposed to a prolonged non-uniform radiation with a broad dose range (4.7 Gy to the RBM ad maximum, up to 0.4 Gy to the organs of the peripheral immunopoiesis), and of whom the majority of whom had attained old or senile age. The approach used included up-to-date methods of laboratory diagnostics (multipleparameter method for carrying out blood analyses, integrated study of the immune system, assessment of the rates of the oxidative stress). The control group consisted of individuals residing either on uncontaminated territories or on territories with minimum levels of contamination (accumulated dose to the RBM was up to 0.06 Gy, the dose rate reached 0.001 Gy/year).

Results: The obtained data thus allowed us to draw a conclusion regarding the safety of the quantitative-cellular, functional and oxidation-reduction homeostasis of the blood system in persons exposed within the range of accumulative doses to RBM from 0.07 to 4.7 Gy (to the organs of the peripheral immunopoiesis up to 0.4 Gy) in spite of the long-term habitation on contaminated territories and the currently attained old age and senility. The following aberrations were observed only in particular blood indices: a reduced number of thrombosytes in 20.2 % of exposed persons and a tendency towards an increase in the number of CD95-positive lymphocytes may indirectly testify to some concealed injuries in the genome of the cells which representig the offspring of the pool of hematopoietic stem cells that had incurred damages during the period of maximum radiation exposures. No changes were observed in the indices characterizing the functional status of the immune cells and the components of the oxidant stress: the level of oxidants (malonedialdehyde (MDA), endogenous nitrite), and the principal enzyme of the antioxidant protection copper-zinc superoxide dismutase (Cu/Zn SOD) were at the level of equal-age control.

Key words: chronic radiation exposure, peripheral blood, cellular homeostasis, immune system, lipid peroxidation, Soth Urals, population

REFERENCES

1. Gorizontov P.D. Gomeostaz. Moscow: Meditsina. 1981. 576 p. (In Russ.).
2. Akleev A.V., Kiselev M.F. Mediko-biologicheskie i ekologicheskie posledstviya radioaktivnogo zagryazneniya r.Techa. Moscow: Medbioekstrem. 2001. 531 p. (In Russ.).
3. Akleev A.V., Varfolomeeva T.A., Krestinina L.Y., Dimov G.P. Hemopoiesis in residents of the Techa riverside villages after long-term low-dose rate radiation exposure. In: Radiation Exposure: Sources. Impacts and Reduction Strategies. Ed. by D. Balenovic. E. Stimac. New York: Nova Publishers. 2012. P. 75-112.
4. Akleev A.V., Varfolomeeva T.A. Dynamics of blood cell composition in residents of the Techa riverside villages. Acta Medica Nagasakiensia. 2007. Vol. 52. P. 19-28.
5. Alekseeva O.G., Vyalova N.A., Grebeneva A.A. i soavt. Dinamicheskoe nablyudenie za sostoyaniem zdorov'ya lyudei. podvergshikhsya deistviyu produktov deleniya urana. Byull. radiats. meditsiny. 1963. No. 1a. P. 47-52. (In Russ.).
6. Shvedov V.L., Akleev A.V. Radiobiologiya strontsiya-90. Chelyabinsk: UNPTs RM. 2001. 302 p. (In Russ.).
7. Blinova E.A., Veremeeva G.A., Akleyev A.V. Apoptosis of peripheral blood lymphocytes and mutations in the gene of the T-cell receptor in survivors of chronic radiation exposure. Health Phys. 2012. Vol. 103. No. 1. P. 58-60.
8. Frol'kis V.V. Starenie i biologicheskie vozmozhnosti organizma. Moscow: Nauka. 1975. 271 p. (In Russ.).
9. Degteva M.O., Shagina N.B., Vorobiova M.I. et al. Reevaluation of waterborne releases of radioactive materials from the «Mayak» production association into the Techa River in 1949-1951. Health Physics. 2012. Vol. 102. No. 1. P. 25-38.
10. Freidlin I.S. Metody izucheniya fagotsitiruyushchikh kletok pri otsenke immunnogo statusa cheloveka. Uchebnoe posobie. Leningrad. 1986. 37 p. (In Russ.).
11. Mayanskii A.N., Viksman M.K. Sposob otsenki funktsional'noi aktivnosti neitrofilov cheloveka po reaktsii vosstanovleniya nitrosinego tetrazoliya. Metod. Rekomendatsii. Kazan'. 1979. 11 p. (In Russ.).
12. Kamyshnikov V.S. Spravochnik po kliniko-biokhimicheskoi laboratornoi diagnostike. V 2 tt. Minsk. Belarus'. 2000. 207 p. (In Russ.).
13. Kozinets G.I., Sarycheva T.G., Dyagileva O.A. et al. Osobennosti kletochnogo sostava i issledovanie krovi pozhilykh lyudei. Labor. meditsina. 1998. No. 1. P. 34-42. (In Russ.).
14. Kozinets G.I., Novoderzhkina Yu.K. Stabil'nost' krovetvoreniya i ego adaptatsionnye vozmozhnosti. Klinich. labor. diagnostika. 1997. No. 5. P. 16. (In Russ.).
15. Korkushko O.V., Chebotarev D.F., Kalinovskaya E.G. Geriartriya v terapevticheskoi praktike. Kiev: Zdorov'e. 1993. 84 p. (In Russ.).
16. Peter M.E., Legembre P., Barnhart B.C. Does CD95 have tumor promoting activities?. Biochimica et Biophysica Acta. 2005. Vol. 1755. P. 25-36.
17. Men'shikova E.B., Lankin V.Z., Zenkov N.K. et al. Okislitel'nyi stress. Prooksidanty i antioksidanty. Moscow: Slovo. 2006. 556 p. (In Russ.).
18. Men'shikova E.B., Zenkov N.K. Okislitel'nyi stress pri vospalenii. Uspekhi sovremennoi biologii. 1997. Vol. 117. No. 2. P. 155-157. (In Russ.).

For citation: Varfolomeyeva TA, Akleyev AA, Mandrykina AS. The Characteristics of Homeostasis in Individuals Chronically Exposed to Radiation in the South Urals at Late Time after Exposure. Medical Radiology and Radiation Safety. 2016;61(2):39-45. Russian.

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 2. P. 25-29

RADIATION BIOLOGY

A.A. Wainson, V.V. Mescherikova, S.I. Tkachev

Radio-Thermomodifying Effects of Cisplatin, Gemzar and Paclitaxel on Tumor Cells in Vitro

N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: To study the modification of radiation, hyperthermic and radio-hyperthermic damage of tumor cells in vitro by chemotherapeutic agents – cisplatin, gemzar and paclitaxel.

Material and methods: SCC7 and V-79 cells in suspension were gamma-irradiated or treated with hyperthermia (42 °C, 30 min) in the presence of one of these compounds. The radio- or thermomodifying effects were estimated according to the decrease in cell clonogenicity of suppression of their growth.

Results: Щsplatin, 1μg/ml, itself decreased V-79 cell survival by 20 %. It increased the effect of gamma-radiation on clonogenicity with dose modification factor (DMF) ≈1.4, and had only additive effect for hyperthermic treatment (42 or 43 °C, 30 min), which itself decreased clonogenicity by 1.14 times. Gemzar (3 μg/ml) was tested on SCC7 cells, itself decreasing cell clonogenicity by 1.15 times. At this concentration gemzar substantially increased radiation damage, decreasing cell clonogenicity by 1.68 times. The DMF of hyperthermic treatment after radiation was only 1.07. The loss of cell clonogenicity in case of irradiation and following hyperthermia was increased by gemzar with DMF 1.8. The modifying effect of paclitaxel was studied also on SCC7 cells, but using suppression of cell growth as an end-point. At the concentration 0,068 μʠpaclitaxel diminished cell growth by 20 %, increased the effect of radiation with DMF = 1.3 and effect of hyperthermia by 10 %. Hyperthermic treatment (43 °C, 30 min) itself increased the effect of radiation with DMF=1.4. Due to its own effect on the cell growth and modification of radiosensitivity, the outcome of cell irradiation in the presence of paclitaxel was 1.58 times (DMF) larger than the effect of radiation alone.

Conclusion: These data demonstrates that the combined effect of radio-thermoradiotherapy and chemotherapy of tumors exceeds the additive effect of these three modalities. The largest modifying effect is shown by gemzar, and this corresponds to the data of other investigators. It is also essential to estimate the degree of chemotherapeutic radiothermotreatment’s modification for different normal tissues and cells.

Key words: v-79 and SCC7 cells, gamma-radiation, hyperthermia, cisplatin, gemzar, paclitaxel

REFERENCES

1. Dzhoiner M.S., van der Kogel' O. Osnovy klinicheskoi radiobiologii. Moscow. «Laboratoriya znanii». 2015. 600 p. (In Russ.).
2. Hall E. J., Giaccia A.J. Radiobiology for the Radiologist. Seventh Edition. Philadelphia, Wolters Kluwer/Lippincott Williams and Wilkins. 2012. 546 p.
3. Heijkoop S.T., van Doorn H.C., Stalpers L.J. et al. Results of concurrent chemotherapy and hyperthermia in patients with recurrent cervical cancer after previous chemoradiation. Int. J. Hyperthermia. 2014. Vol. 30. No. 1. P. 6–10.
4. Petryk A.A., Giustini A.J., Gottesman R.E. et al. Magnetic nanoparticle hyperthermia enhancement of cisplatin chemotherapy cancer treatment. Int. J. Hyperthermia. 2013. Vol. 29. No. 8. P. 845–851.
5. Schlaich F., Brons S., Haberer T. et al. Comparison of the effects of photon versus carbon ion irradiation when combined with chemotherapy in vitro. Radiat. Oncol. 2013. Vol. 8. P. 260–272.
6. El Shafie R.A., Habermehl D., Rieken S. et al. In vitro evaluation of photon and raster-scanned carbon ion radiotherapy in combination with gemcitabine in pancreatic cancer cell lines. J. Radiat. Res. 2013. Vol. 54. Suppl. 1. P. 113–119.
7. Vainson A.A., Meshcherikova V.V., Lavrova Yu.E., Mazokhin V.N. Effektivnost' oblucheniya i gipertermii pri odnovremennom i posledovatel'nom vozdeistvii na opukholevye kletki in vitro i perevivnye opukholi in vivo. Radiats. Biologiya. Radioekologiya. 2012. Vol. 52. No. 6. P. 510–516. (In Russ.).
8. Vainson A.A., Meshcherikova V.V. Metodika otsenki spetsificheskoi aktivnosti genno-inzhenernykh preparatov G-KSF, interferonov α, β i somatotropina in vitro. Rossiiskii bioterap. zh. 2012. Vol. 11. No. 3. P. 29–32. (In Russ.). (In Russ.).
9. Orth M., Lauber K., Niyazi M. et al. Current concepts in clinical radiation oncology. Environ. Biophys. 2014. Vol. 53. No. 1. P. 1–29. (In Russ.).
10. Gabikian P., Tyler B.M., Zhang I. et al. Radiosensitization of malignant gliomas following intracranial delivery of paclitaxel biodegradable polymer microspheres. J. Neurosurg. 2014. Vol. 120. No. 5. P. 1078–1085.

For citation: Wainson AA, Mescherikova VV, Tkachev SI. Radio-thermomodifying Effects of Cisplatin, Gemzar and Paclitaxel on Tumor Cells in vitro. Medical Radiology and Radiation Safety. 2016;61(2):25-9. Russian.

PDF (RUS) Full-text article (in Russian)