SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Issues journals

Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 4. P. 76-82

MEDICAL PRACTICE ISSUE

A.N. Bashkov1, Z.V. Sheykh2, E.A. Ionova1, S.A. Mirzoyants1, N.S. Drebushevskiy1, O.O. Grigor’eva1, A.P. Dunaev1

Unique Case of Giant Exophityc Solitary Liver Metastasis of Neuroendocrine Cancer of Small and Large Intestine

1. A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. S.P. Botkin City clinical hospital Moscow, Russia.

ABSTRACT

Purpose: To present a rare case of a giant solitary metastasis of the liver with exophytic growth pattern in a patient with neuroendocrine cancer of small intestine and colon, to demonstrate coordinated work of radiology department.

Material and methods: Computer tomography with bolus intravenous administration of 100 ml of contrast agent Ultravist-370 on multislice CT Aquilion 64; whole body scintigraphy on SPECT Philips with intravenous administration of 218.0 MBq 111In-octreotide.

Results: Яmputer tomography revealed a mass in the ileocecal region, which had features of carcinoid, and also a large exophytic solid mass in the left lobe of the liver observed since year 2011. The mass in the liver was solitary, with exophytic growth and heterogeneous structure, much more than the mass in the ileocecal region, maximal accumulate of the contrast agent at the venous phase; thus we thougth of the differential diagnosis between primary tumor and liver metastasis. It was recommended to perform 111In-octreotide SPECT in connection with suspected neuroendocrine cancer. The study has confirmed neuroendocrine nature of masses in the ileocecal region and liver, as well as the accumulation of a specific agent in the sigmoid colon, where was a colonoscopy found polyps. The histopathological study after surgery confirmed neuroendocrine cancer of the small and large intestine with liver metastasis.

Conclusion: 1. A rare case of a giant solitary metastasis of the liver with exophytic growth pattern in a patient with neuroendocrin cancer of small intestine and colon was presented. 2. Data from computer tomography and single photon emission tomography allow to make correct diagnosis at the stage of preoperative examination, despite the atypical signs of the solid mass in the liver.

Key words: neuroendocrine cancer, carcinoid, multidetector spiral computed tomography, single photon emission computed tomography, a solitary exophytic metastasis

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For citation: Bashkov AN, Sheykh ZV, Ionova EA, Mirzoyants SA, Drebushevskiy NS, Grigor'eva OO, Dunaev AP. Unique Case of Giant Exophityc Solitary Liver Metastasis of Neuroendocrine Cancer of Small and Large Intestine. 2014;61(4):76-82. Russian.

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 4. P. 68-75

REVIEW

I.A. Znamenskiy1,2, A.K. Kondakov1,2, V.V. Mil’kin1, D.Ju. Mosin1, A.V. Grechko1

Positron Emission Tomography with Oxygen-15 in Neurological Practice. Part 2. Clinical Application

1. Hospital for incurable patients -Scientific and Medical Rehabilitation Center, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. N.I. Pirogov Russian National Research Medical University, Moscow, Russia.

ABSTRACT

Purpose: To analyze clinical application of positron-emission tomography with radiopharmaceuticals based on oxygen-15 and to determine the field of its application.

Material and methods: The review of sources, selected from international bibliographic databases.

Results: It is shown that PET with radiopharmaceuticals based on oxygen-15 leads to deep exploration of pathophysiologic basis of a number of brain diseases, among which is ischemic stroke which occupies an important place. Furthermore, the review presents clinical application of PET for chronic cerebrovascular diseases and as a gold standard for validation of other neuroimaging modalities.

Conclusion: PET with radiopharmaceuticals based on oxygen-15 is the only one direct validated method of measurement of a number of quantities characterizing the perfusion and functional capacity of the brain. It may be used in the evaluation of penumbra, quality control of treatment for chronic cerebrovascular diseases and in research. Wide application of this method is prevented by a need of implementation of a large number of costly technical measures.

Key words: positron emission tomography, 15O, perfusion, brain, review

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For citation: Znamenskiy IA, Kondakov AK, Milkin VV, Mosin DJu, Grechko AV. Positron Emission Tomography with Oxygen-15 in Neurological Practice. Part 2. Clinical Application. Medical Radiology and Radiation Safety. 2016;61(4):68-75. Russian.

PDF (RUS) Full-text article (in Russian)

Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 4. P. 59-63

NUCLEAR MEDICINE

T.M. Geliashvili, A.V. Vazhenin, E.B. Vasil’eva, N.G. Afanas’eva

Experience of Use 18F-FDG PET/CT in Detecting Tumor Recurrence and Metastasis of Differentiated Thyroid Cancer

Chelyabinsk Regional Clinical Oncology Center, Chelyabinsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: To investigate the diagnostic accuracy and impact in patients management of the integrated 18F-FDG PET/CT modality in patients with differentiated thyroid cancer.

Material and methods: A retrospective review of patients who underwent PET/CT scans were performed. The study included patients with elevated thyroglobulin levels during the postoperative radioiodine ablation course or after completion of the combination treatment at follow-up of DTC.

Results: PET/CT was positive in 39 cases (64 %), 18 (46.1 %) of which was loco-regional recurrence, 12 (30.8 %) - distant metastases and the combination of loco-regional recurrence with distant metastases 9 (23.1 %). The negative result was obtained for 22 (36 %) PET/CT study (without pathology 7 (31.8 %), questionable results 15 (68.2 %)). Totally 27 (44.3 %) loco-regional recurrences diagnosed with PET / CT, and by 131I whole body scan (WBS) - 14 (23 %)). 15 surgical interventions for loco-regional recurrence were achieved. Diagnosis of recurrence in 13 cases (87 %) was proved historically. In 2 (13 %) patients we received a false-positive results of PET/CT. In 21 (34.4 %) of PET/CT study distant metastases were revealed (in the lungs and/or mediastinum - 14 (67 %), in bone 3 (14 %), a combination of several sites of distant metastases 4 (19 %)). In 11 of 14 cases (78.6 %) lung metastases were revealed exclusively in CT mode. Mediastinal lymph node metastases appeared all PET-positive 6 (100 %). Metastases in other organs were detected in 7 cases out of which all bone metastases were PET positive (6 cases); soft tissue metastases identified by CT mode in 1 case. By planar WBS detected distant metastases in 18 cases (29.5 %).

Conclusions: PET/CT showed higher sensitivity in the detection of the neck lymph nodes metastases (44.3 %) than WBS (23 %). With regard to detection of distant metastases, PET/CT and WBS showed similar sensitivity (34.5 % and 29.5 %, respectively). Through a combination of modes of PET with CT mode the sensitivity of PET/CT in detection of metastases in the lungs increases greatly.

Key words18: F-FDG PET/CT, differentiated thyroid cancer, whole body scan, loco-regional recurrence, distant metastases

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  10. Hooft L., Hoekstra O.S., Devillé W. et al. Diagnostic accuracy of 18F-fluorodeoxyglucose positron emission tomography in the follow-up of papillary or follicular thyroid cancer. J. Clin. Endocrinol. Metabolism. 2001. Vol. 86. No. 8. P. 3779-3786.
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For citation: Geliashvili TM, Vazhenin AV, Vasil'eva EB, Afanas'eva NG. Experience of Use 18F-FDG PET/CT in Detecting Tumor Recurrence and Metastasis of Differentiated Thyroid Cancer. Medical Radiology and Radiation Safety. 2016;61(4):59-63. Russian.

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Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 61. P. 64-67

NUCLEAR MEDICINE

Yu.V. Lysak1, B.Ya. Narkevich2,3, S.V. Shiryaev2, V.V. Krylov4

Mathematical Modeling of Liquid Radioactive Waste in Radionuclide Therapy

1. Moscow Engineering Physics Institute, Moscow, Russia; 2. N.N. Blokhin Russian Oncological Research Center, Moscow, Russia; 3. Institute of Medical Physics and Engineering, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 4. A.F. Tsyb Medical Radiological Research Center, Obninsk

ABSTRACT

Purpose: To determine the estimated capacity of the station cleaning in special units radionuclide therapy based on mathematical modeling of processes of accumulation and exposure to the collapse of liquid radioactive waste.

Material and methods: The simulation is based on solving a system of linear first order differential equations with constant coefficients under certain simplifying assumptions about these processes of accumulation and exposure. For specific numerical simulation results technical and clinical settings for typical units of radionuclide therapy were used.

Results: It is shown that only the presence of a vacuum in the unit special sewage radionuclide therapy ensures that the requirements of regulations on permissible discharge disintegrated liquid radioactive waste into the domestic sewage. Water consumption was hospitalized in “active” patient rooms should not exceed 50 liters / day for 1 person.

Conclusion: Mathematical modeling allows to objectify the processes of dealing with liquid radioactive waste in radionuclide therapy units of radiological clinics in Russia.

Key words: radionuclide therapy, liquid radioactive waste, cleaning station power, mathematical modeling

REFERENCES

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  7. Narkevich B.Ya., Shiryaev S.V., Krylov V.V. Povyshaet li novaya versiya OSPORB-99/2010 uroven' radiatsionnoi bezopasnosti v yadernoi meditsine? // Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 6. P. 5-9. (In Russ.). (In Russ.).
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For citation: Lysak YuV, Narkevich BYa, Shiryaev SV, Krylov VV. TMathematical Modeling of Liquid Radioactive Waste in Radionuclide Therapy. Medical Radiology and Radiation Safety. 2016;61(6):64-7. Russian.

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Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 4. P. 52-58

RADIATION EPIDEMIOLOGY

I.A. Martinenko1, M.E. Sokolnikov1, N.A. Koshurnikova1, Yu.G. Mokrov2, D.A. Beregich2

Risk Assessment of Thyroid Cancer Incidence Among Population Due to the Residence Close to Mayak PA

1. Southern Urals Biophysics Institute, Ozersk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Mayak PA, Ozersk, Russia

ABSTRACT

Purpose: Thyroid cancer incidence rates in the population residing as children in areas contaminated by radioactive gas-aerosol emissions during technological development at Mayak PA were assessed in the current epidemiological study.

Material and methods: The study was carried out in a cohort of 31,836 people residing in childhood in Ozersk during 1948-1962. In that period uncontrolled gas-aerosol emissions from chimneys of radiochemical plants took place. There were 60 thyroid cancer cases diagnosed and histologically verified in the study cohort. Standardized incidence rates (SIR) were estimated by the indirect standardization by age and sex with a 95 % confidence interval. Age- and sex-related thyroid cancer incidence rates in Russia and among the urban population of Chelyabinsk were chosen as a standard. Information on radiation exposure levels of thyroid for Ozersk residents of different ages was obtained on the basis of preliminary dose calculations for two scenarios of food consumption from different suppliers. Radiation excess relative risk per unit dose (ERR/Sv) was calculated with the us of a Poisson regression model implemented in Amfit module of the Epicure software.

Results: SIR of thyroid cancer in the cohort was 3.16 among men (1.68-5.06) and 2.07 (1.52-2.65) among women compared to the data of national statistics. Significant difference of thyroid cancer incidence in the cohort compared to the regional statistics was also found: SIR was 2.04 (1.08-3.26) among men and 1.59 (1.17-2.04) among women. ERR/Sv was -0.03 (p > 0.5), i.e. increase of thyroid cancer incidence in the study cohort is not associated with the obtained estimates of equivalent doses to the thyroid.

Conclusion: In the cohort of persons residing as children in Ozersk in the period of uncontrolled gas-aerosol emissions from the chimneys of radiochemical plants in 1948-1962, age- and sex-related thyroid cancer incidence rates and relative risk of thyroid cancer incidence in men and women significantly (2-3 times) exceeded those in the national and regional statistics. The correlation between dose and effect was not observed. It could be associated with using group doses due to lack of individual doses.

Key words: thyroid cancer incidence, Mayak PA, radiation risk, standardized incidence ratio

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For citation: Martinenk IA, Sokolnikov ME, Koshurnikova NA, Mokrov YuG, Beregich DA. Risk Assessment of Thyroid Cancer Incidence among Population Due to the Residence Close to Mayak PA. Medical Radiology and Radiation Safety. 2016;61(4):52-8. Russian.

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  1. 2016-4-Ohrimenko-eng
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