JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 2
DOI: 10.33266/1024-6177-2023-68-2-85-91
R.M. Takhauov1, 2, D.E. Kalinkin1, 2, A.P. Blinov1, G.V. Gorina1, O.V. Litvinova1, I.V. Milto1, 2
Dosimetric Characteristics of the Cohort of the Siberian Chemical Plant Personnel in the Period 1950–2010
1Seversk Biophysical Research Center, Seversk, Russia
2Siberian State Medical University, Tomsk, Russia
Contact person: I.V. Milto, e-mail:
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ABSTRACT
Purpose: To give a dosimetric characterization of the personnel of the Siberian Chemical Plant (SCP) subjected to prolonged technogenic occupational exposure to ionizing radiation (IR) in the period 1950–2010, as well as the cohort of the personnel of the SCP involved in working with uranium compounds.
Material and methods: SCP is one of the largest and oldest complexes of nuclear industry enterprises in the world, having experience in continuous dosimetric monitoring of personnel for more than 60 years. The database of the regional medical-dosimetric register of employees of the SCP (RMDR) contains information about all employees of the SCP for the entire history of the enterprise, including personal data of medical, dosimetric and professional nature of 65.350 employees of the SCP, of which more than 32.000 people were exposed to chronic technogenic occupational radiation in the range of low doses. The archive of the medical documentation of the Seversk Biophysical Research Center contains 55.569 medical histories of the employees of the SCP, 29.800 outpatient records and 11.953 autopsy protocols.
Results: Employees of the radiochemical, chemical-metallurgical, sublimate and separation industries of the SCP were subjected to combined (external and internal) irradiation, while the personnel of the reactor production were exposed exclusively to external irradiation. Auxiliary production workers were mainly exposed to non-radiation factors. Individual dosimetric control (IDC) of external exposure was carried out for all workers who were in the zone of exposure to external radiation sources. The average accumulated dose of external radiation for employees of the SCP was 28.3 mSv. IDC of internal irradiation was carried out for all workers employed at the production site, where the excess of the regulatory level of the concentration of radionuclides in the air of the working area was detected. The average value of the activity of radionuclides in the urine of SCP workers does not exceed 0.74 Bq. The life status has been clarified for 80.8 % of the employees of the SCP. About 3.500 employees of the agricultural complex have an IDC for internal irradiation from uranium based on the results of a biophysical examination. The life status is established for 75 % of employees of the uranium cohort.
Conclusion: For the first time, a dosimetric characteristic of a cohort of 65.350 workers of the SCP (21 % women) who started work in the period 1950–2010 was given. The cohort of the staff of the SCP is suitable for conducting epidemiological studies in order to establish the risks associated with the impact on the human body of technogenic occupational exposure to IR.
Keywords: occupational exposure, ionizing radiation, uranium, plutonium, dosimetric data
For citation: Takhauov RM, Kalinkin DE, Blinov AP, Gorina GV, Litvinova OV, Milto IV. Dosimetric Characteristics of the Cohort of the Siberian Chemical Plant Personnel in the Period 1950–2010. Medical Radiology and Radiation Safety. 2023;68(2):85–91. (In Russian). DOI: 10.33266/1024-6177-2023-68-2-85-91
References
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The research was carried out within the framework of the state task, the topic of research: «Assessment of the radiation situation and the state of health of the personnel of the Siberian Chemical Plant involved in working with uranium compounds.»
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.11.2022. Accepted for publication: 25.01.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 2
DOI: 10.33266/1024-6177-2023-68-2-92-94
B.E. Serebryakov
Recommendations for Amendments to the NRB-99/2009 and to the OSPORB-99/2010
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: B.E. Serebryakov, e-mail:
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ABSTRACT
Purpose: In Russia, the main regulatory documents on radiation safety are being adjusted: Radiation Safety Standards (NRB-99/2009) and Basic Sanitary Rules (OSPORB-99/2010). The purpose of the work is to remove and correct certain incorrect provisions of these documents.
Results: The disadvantages of NRB-99/2009 related to the values of the minimum significant activity and the minimum significant specific activity of radionuclides were identified and justified.
In OSPORB-99/2010, the inadmissibility of introducing minimally licensed activity of radionuclides in closed sources of ionizing radiation into Sanitary Rules was identified and justified. An unacceptably large amount of this activity can lead to overexposure of personnel and the public in incidents with these sources.
Conclusions: The following recommendations were made for the adjustment of NRB-99/2009 and OSPORB-99-2010:
– in NRB-99/2009, it is recommended to completely remove the minimally significant specific activities, and use the minimally significant activities in accordance with NRB-76/87.
– in OSPORB-99/2010, it is recommended to remove all provisions related to the minimum licensed activity of radionuclides in closed sources of ionizing radiation.
Key words: radiation safety, regulatory documents, minimally significant activity, minimally significant specific activity, closed sources of ionizing radiation
For citation: Serebryakov BE. Recommendations for Amendments to the NRB-99/2009 and to the OSPORB-99/2010. Medical Radiology and Radiation Safety. 2023;68(2):92–94. (In Russian). DOI: 10.33266/1024-6177-2023-68-2-92-94
References
1. SanPiN 2.6.1.2523 – 09 Radiation Safety Standards (NRB-99/2009) (In Russ.).
2. SP 2.6.1.2612-10 Basic Sanitary Rules for Radiation Safety (OSPORB-99/2010) (In Russ.).
3. Serebryakov B.Ye. About of the Necessary of Corrections of the NRB-99/2009 and OSPORB-99/2010. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost = Medical Radiology and Radiation Safety. 2020;65;3:27–30 (In Russ.).
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5. Serebryakov B.Ye. About of the Necessary the Review of the Government Decision of the Russian Federation from October 19, 2012 No. 1069. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost = Medical Radiology and Radiation Safety. 2021;66;2:83–88 (In Russ.).
6. Radiation Safety Standards NRB-76/87 and Basic Sanitary Rules for Working with Radioactive Substances and Other Sources of iONIZING Radiation OSP-72/86. Moscow Publ., 1988 (In Russ.).
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.11.2022. Accepted for publication: 25.01.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 2
DOI: 10.33266/1024-6177-2023-68-2-99-104
Leonid Andreevich Ilyin (on the Occasion of His 95th Birthday)
I.L. Efimova
A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia.
Contact person: Efimova Irina Leonidovna, e-mail:
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ABSTRACT
Full member of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor Leonid Andreevich Ilyin is a recognized world authority in the field of radiation medicine, biomedical and hygienic aspects of radiation protection. From 1968 to 2008 for 40 years – director and scientific director of the State Scientific Center of the Order of Lenin of the Institute of Biophysics. Since 2008 – Honorary President of the Federal State Budgetary Institution «State Research Center of the Russian Federation – A.I. Burnazyan Federal Medical Biophysical Center» (after the merger of the Institute of Biophysics and Clinical Hospital No. 6).
Thanks to the work of Academician Ilyin, his students and colleagues, highly effective drugs for the prevention and treatment of acute radiation injuries were created, tested and entered into domestic practice. Repeatedly took part as a supervisor in testing the developed drugs in field conditions. He is a veteran of special risk units. L.A. Ilyin is the first scientist in the world who developed and substantiated the forecast of the radiological consequences of the Chernobyl disaster, subsequently confirmed by leading foreign and domestic experts.
Keywords: biophysics, radiation safety, Chernobyl acsident, Ilyin
For citation: Efimova IL. Leonid Andreevich Ilyin (on the occasion of his 100th birthday). Medical Radiology and Radiation Safety. 2023;68(2):99-104. DOI: 10.33266/1024-6177-2022-67-4-99-104
PDF (RUS) Full-text article (in Russian)
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 2
DOI: 10.33266/1024-6177-2023-68-2-95-98
V.N. Klochkov, S.M. Shinkarev, O.A. Kochetkov, V.G. Barchukov, A.V. Simakov
To the Discussion on Amendments to Nrb-99/2009 and to Osporb-99/2010
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: Vladimir Nikolaevich Klochkov, e-mail:
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For citation: Klochkov VN, Shinkarev SM, Kochetkov OA, Barchukov VG, Simakov AV. To the Discussion on Amendments to Nrb-99/2009 and to Osporb-99/2010. Medical Radiology and Radiation Safety. 2023;68(2):95–98. (In Russian). DOI: 10.33266/1024-6177-2023-68-2-95-98
References
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2. Kochetkov O.A., Klochkov V.N., Panfilov A.P., Usoltsev V.Yu. Scientific and Methodological Support of Radiation Safety in the Organizations of the State Corporation “Rosatom” V.1. Metodicheskoye Obespecheniye Radiatsionnogo Kontrolya v Atomnoy Otrasli = Methodological Support of Radiation Monitoring in the Nuclear Industry. Moscow Publ., 2016. P. 24-40 (In Russ.).
3. Kochetkov O.A., Panfilov A.P., Usoltsev V.Yu., Klochkov V.N., Shinkarev S.M., Tsovyanov A.G., Simakov A.V. Radiation Hygiene and Safety of Nuclear Industry. Gigiyena i Sanitariya = Hygiene and Sanitation. 2017;69;9:868-874 (In Russ.).
4. Abramov Yu.V., Klochkov V.N., Kochetkov O.A., Simakov A.V., Nurlybayev K. Current Requirements to Establishment of the Radiation Monitoring System. Apparatura i Novosti Radiatsionnykh Izmereniy = ANRI. 2019;3:3-10 (In Russ.).
5. Simakov A.V., Abramov Yu.V. Radiation Safety Standards and Basic Health Rules for Radiation Safety: Proposal on the Development of New Versions. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost = Medical Radiology and Radiation Safety. 2019;64;5:15-19. DOI: 10.12737/1024-6177-2019-64-5-15-19 (In Russ.).
6. Shinkarev S.M., Kochetkov O.A., Klochkov V.N., Barchukov V.G. To Discussion on Amendments to the Federal Law as of 09.01.1996 No. 3-FZ «About Radiation Safety of the Public». Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost = Medical Radiology and Radiation Safety. 2020;65;3:77-78. DOI 10.12737/1024-6177-2020-65-3-77-78 (In Russ.).
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8. Kochetkov O.A., Klochkov V.N., Samoylov A.S., Shandala N.K, Barchukov V.G., Shinkarev S.M. General Principles of Legal, Standard and Methodical Regulation of Radiation Safety. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost = Medical Radiology and Radiation Safety. 2022;61;1:19–26. DOI: 10.12737/1024-6177-2022-67-1-19-26 (In Russ.).
9. Gubin A.T., Sakovich V.A. On Some Conceptual Issues of Changing the Federal Law «On Radiation Safety of the Population». Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost = Medical Radiology and Radiation Safety. 2020;65;6:83-84. DOI: 10.12737/1024-6177-2020-65-6-83-84 (In Russ.).
10. Serebryakov B.Ye. About of the Necessary of Corrections of the NRB-99/2009 and OSPORB-99/2010. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost = Medical Radiology and Radiation Safety. 2020;65;3:27-30. DOI: 10.12737/1024-6177-2020-65-3-27-30 (In Russ.).
11. Serebryakov B.Ye. On the Need to Revise Government Decree No. 1069 dated 10/19/2012. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost = Medical Radiology and Radiation Safety. 2021;66;2:83-88 (In Russ.).
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.11.2022. Accepted for publication: 25.01.2023.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 1
DOI: 10.33266/1024-6177-2023-68-1-5-14
V.A. Nikitina, T.A. Astrelina, V.Yu. Nugis, I.V. Kobzeva, E.E. Lomonosova,
Yu.B. Suchkova, T.F. Malivanova, V.A. Brunchukov, D.Yu. Usupzhanova,
V.A. Brumberg, A.A. Rastorgueva, E.I. Dobrovolskaya, T.V. Karaseva,
M.G. Kozlova, M.V. Pustovalova, A.K. Chigasova, N.Yu. Vorobyeva,
A.N. Osipov, A.S. Samoilov
Cytogenetic Analysis of the Cell Line of Multipotent Human Mesenchymal Stromal Cells during Long-Term Cultivation after Exposure to X-Ray Radiation at Low and Medium Doses
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: V.A. Nikitina, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To evaluate the frequency and spectrum of chromosome aberrations under X-Ray exposure at doses of 80, 250, and 1000 mGy in a human multipotent mesenchymal stromal cell (MMSC) cell line during long-term cultivation.
Material and methods: MMSCs were isolated from human gingival mucosa by an enzymatic method and cultured in a serum-free medium. The presence of surface antigens was determined using the method of flow cytometry. The ability of the cell line to differentiate in the osteogenic, adipogenic, and chondrogenic directions was studied using induction media. Authentication was performed by genotyping of polymorphic STR loci, cytogenetic analysis was performed by multicolor fluorescent in situ hybridization (mFISH). Irradiation was carried out on an X-ray biological unit RUB RUST-M1 (Russia) at a dose rate of 40 mGy/min, a voltage of 100 kV, and a current of 0.8 mA.
Results: At the first passage after irradiation, a statistically significant increase in the frequency of non-clonal CA compared with the control was recorded at a dose of 80, but not 250 and 1000 mGy. At the late stages of cultivation, the average frequency of breaks per chromosome in the group of non-irradiated cells did not differ from the values obtained after irradiation at doses of 80, 250, and 1000 mGy (p > 0.05). However, in MMSCs irradiated at a dose of 80 mGy, damage occurred more often in pairs of chromosomes 6 and 10, and at a dose of 1000 mGy, in a pair of chromosomes 9. A single irradiation of MMSCs in vitro did not affect the growth and progression of MMSCs characteristic of the studied primary cell line, of clonal cells with chromosome translocations and monosomy X, but led to an increase in the representation of a clone with tetrasomy 8. The total number of random clones with chromosome translocations that arose de novo increased after irradiation at a dose of 1000 mGy.
Conclusion: Minor fluctuations in the proportion of cells with non-clonal CA, depending on the dose received in the early stages after irradiation (passage 1–4), disappeared at the later stages of cultivation (passage 8–14). There were no differences in mean frequencies between irradiated and non-irradiated MMSCs, but after irradiation, damage to some chromosomes could occur more frequently than others. A single X-ray irradiation of MMSCs can promote the growth and progression of primary pathological cytogenetic clones, regardless of the dose received, as well as an increase in the total number of de novo cell clones with chromosomal translocations that have arisen. A single X-ray irradiation of MMSCs can promote the growth and progression of primary pathological cytogenetic clones, regardless of the dose received, as well as an increase in the total number of de novo cell clones with chromosomal translocations that have arisen.
Keywords: mesenchymal multipotent stromal cells, chromosome aberrations, mFISH, X -ray irradiation, low doses
For citation: Nikitina VA, Astrelina TA, Nugis VYu, Kobzeva IV, Lomonosova EE, Suchkova YuB, Malivanova TF, Brunchukov VA, Usupzhanova DYu, Brumberg VA, Rastorgueva AA, Dobrovolskaya EI, Karaseva TV, Kozlova MG, Pustovalova MV, Chigasova AK, Vorobyeva NYu, Osipov AN, Samoilov AS. Cytogenetic Analysis of the Cell Line of Multipotent Human Mesenchymal Stromal Cells during Long-Term Cultivation after Exposure to X-Ray Radiation at Low and Medium Doses. Medical Radiology and Radiation Safety. 2023;68(1):5–14. (In Russian). DOI: 10.33266/1024-6177-2023-68-1-5-14
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Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.09.2022. Accepted for publication: 25.11.2022.