JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 1
DOI: 10.33266/1024-6177-2023-68-1-92-100
S.M. Rodneva1, D.V. Guryev1,2
Tritium Dosimetry at the Cellular Level
1A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
2N.N. Semenov Federal Research Center for Chemical Physics, Moscow, Russia
Contact person: Sofya Mikhailovna Rodneva: e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
CONTENTS
Introduction
1. Tritium radioisotope and its energy spectrum
2. Methods for calculating doses from radiation of radionuclides
2.1 General equation for absorbed dose rate
2.2 Absorbed dose rate versus average energy
2.3 Formulas for calculating dose and S-values from radiation of radionuclides
2.4 Method of dose point nuclei
2.5 MIRD effective stopping power method
2.6 Geometric factor
3. Analysis of S-value calculations by various methods
3.1 Values of the CSDA range at low initial electron energies
3.2 Comparison of S-value calculations for low energy electrons
3.3 Comparison of tritium S-value calculations
4. Evaluation of S-value calculations in the absence of spherical symmetry
Conclusion
Keywords: radiation dosimetry, radionuclides, tritium, electrons, S-value, cell, mathematical model
For citation: Rodneva SM, Guryev DV. Tritium Dosimetry at the Cellular Level. Medical Radiology and Radiation Safety. 2023;68(1):92–100. (In Russian). DOI: 10.33266/1024-6177-2023-68-1-92-100
References
1. Shiragap A. Comment on Estimation Methods of Absorbed Dose Due to Tritium. Journal of Radiation Research. 1971;2;2:73-86. DOI: 10.1269/jrr.12.73.
2. Alloni D., Cutaia C., Mariotti L., Friedland W., Ottolenghi A. Modeling Dose Deposition and DNA Damage Due to Low-Energy β-Emitters. Radiat. Res. 2014;182:322-330. DOI: 10.1667/RR13664.1.
3. Klimanov V.A., Kramer-Ageyev Ye.A., Smirnov V.V. Dozimetriya Ioniziruyushchikh Izlucheniy = Dosimetry of Ionizing Radiation. Tutorial. Ed. Klimanov V.A. Moscow Publ., 2015. 740 p. (In Russ.).
4. Stabin M. Nuclear Medicine Dosimetry II. Phys. Med. Biol. 2006;51;1:187-202. DOI:10.1088/0031-9155/51/13/R12.
5. Berger M., Cloutier R., Edwards C., Snyder W. Beta-Ray Dosimetry Calculations with the Use of Point Kernels. Medical radionuclides: Radiation Dose and Effects. Washington, DC, US Atomic Energy Commission, 1970. P. 63-86.
6. Prestwich W., Nunes J., Kwok C.S. Beta Dose Point Kernels for Radionuclides of Potential Use in Radioimmunotherapy. J. Nucl. Med. 1989;51:1036-1046.
7. Simpkin D., Mackic T. EGS4 Monte Carlo Determination of the Beta Dose Kernel in Water. Med. Phys. 1990;17:179-186. DOI: 10.1118/1.596565.
8. Timofeyev L.V. Raschetnyye Metody Dozimetrii Beta-Izlucheniya = Calculated Methods of Beta Radiation Dosimetry. Moscow Publ., 2017. 240 p. (In Russ.).
9. Robertson J., Hughes W., Quastler H., Morowitz H. Intranuclear Irradiation with Tritium-Labeled Thymidine. Proc. 1st. Natl. Biophys. Conf. New Haven, Yale University Press, 1959. P. 278-283.
10. Goodheart C. Radiation Dose Calculation in Cells Containing Intranuclear Tritium. Rad. Res. 1961;15:767-773. DOI: 10.2307/3571113.
11. Saito M., Ishida M., Travis C. Dose-Modification Factor for Accumulated Dose to Cell Nucleus Due to Protein-Bound 3H. Health. Phys. 1989;56;6:869-874. DOI: 10.1097/00004032-198906000-00004.
12. Stepanenko V.F., YAskova YE.K., Belukha I.G., Petriyev V.M., Skvortsov V.G., Kolyzhenkov T.V., Petukhov A.D., Dubov D.V. The Calculation of Internal Irradiation of Nano-, Micro- and Macro-Biostructures by Electrons, Beta Particles and Quantum Radiation of Different Energy for the Development and Research of New Radiopharmaceuticals in Nuclear Medicine. Radiatsiya i Risk = Radiation and Risk. 2015;24;1:35-57 (In Russ.).
13. Howell R., Rao D., Sastry K. Macroscopic Dosimetry for Radioimmunotherapy: Nonuniform Activity Distributions in Solid Tumors. Med. Phys. 1989;16:66-74. DOI: 10.1118/1.596404.
14. Goddu S., Howell R., Rao D. Cellular Dosimetry: Absorbed Fractions for Monoenergetic Electron and Alpha Particle Sources and S-Values for Radionuclides Uniformly Distributed in Different Cell Compartments. J. Nucl. Med. 1994;35:303-316.
15. Goddu S., Howell R., Bouchet L., Bolch W., Rao D. Mird Cellular S Values: Self-Absorbed Dose Per Unit Cumulated Activity for Selected Radionuclides and Monoenergetic Electron and Alpha Particle Emitters Incorporated into Different Cell Compartments. Reston, VA, USA, Society of Nuclear Medicine, 1997.
16. Cole A. Absorption of 20-eV to 50.000-eV Electron Beams and Plastic. Radiat. Res. 1969;38:7-33.
17. Sastry K., Haydock C., Basha A., Rao D. Electron Dosimetry for Radioimmunotherapy: Optimal Electron Energy. Radial. Prot. Dosim. 1985;13:249-252. DOI: 10.1093/rpd/13.1-4.249.
18. Gardin I., Faraggi M., Hue E., Вок B. Modelling of the Relationship between Cell Dimensions and Mean Dose Delivered to the Cell Nucleus: Application to Five Radionuclides Used in Nuclear Medicine. Phys. Med. Biol. 1995;40:1001-1014. DOI: 10.1088/0031-9155/40/6/003.
19. International Commission on Radiation Units and Measurements. Linear Energy Transfer. ICRU Report 16. 1970.
20. International Commission on Radiation Units and Measurements. Stopping Powers for Electrons and Positrons. ICRU Report 37. 1984a.
21. International Commission on Radiation Units and Measurements. Key Data for Ionizing-Radiation Dosimetry: Measurement Standards and Applications. ICRU Report 90. 1996.
22. Siragusa M., Baioeco G., Fredericia P., Friedland W., Gser T., Ottolenghi A., et al. The COOLER Code: A Novel Analytical Approach to Calculate Subcellular Energy Deposition by Internal Electron Emitters. Radiat Res. 2017;188;2:204-220. DOI: 10.1667/RR14683.1.
23. Incerti S., Kyriakou I., Bernal M., Bordage M., Francis Z., Guatelli S., Geant4-DNA Example Applications for Track Structure Simulations in Liquid Water: a Report from the Geant4-DNA Project. Med Phys. 2018;45:722-739. DOI: 10.1002/mp.13048.
24. Berger M., Seltzer S. Tables of Energy Losses and Ranges of Electrons and Positrons. NASA SP-3012. 1964.
25. Akkerman A., Akkerman E. Characteristics of Electron Inelastic Interactions in Organic Compounds and Water over the Energy Range 20-10000 eV. Journal of Applied Physics. 1999;86;10:5809-5816. DOI: 10.1063/1.371597.
26. NCRP. Tritium and Other Radionuclide Labeled Organic Compounds Incorporated in Genetic Material. NCRP Report No. 63. Bethesda, National Council on Radiation Protection and Measurements, 1979.
27. Sefl M., Incerti S., Papamichacl G., Emfietzoglou D. Calculation of Cellular S-Values Using Geant4-DNA: The Effect of Cell Geometry. Appl. Radial. Isot. 2015;104:113-123. DOI: 10.1016/j.apradiso.2015.06.027.
28. Salim R., Taherparvar P. Monte Carlo Single-Cell Dosimetry Using Geant4-DNA: the Effects of Cell Nucleus Displacement and Rotation on Cellular S Values. Radial. Environ Biophys. 2019;58:353-371. DOI: 10.1007/s00411-019-00788-z.
29. Vaziri В., Wu H., Dhawan A., Du P., Howell R. MIRD Pamphlet No. 25: MIRDcell V2.0 Software Tool for Dosimetric Analysis of Biologic Response of Multicellular Populations. J. Nucl. Med. 2014;55:1557-1564. DOI: 10.2967/jnumed.113.131037.
30. Chao T., Wang C., Li J., Li C., Tung C. Cellular- and Micro-Dosimetry of Heterogeneously Distributed Tritium. Int. J. Radiat. Biol. 2011;88;1-2:151-157. DOI: 10.3109/09553002.2011.595876.
31. Siragusa M., Fredericia P., Jensen M., Groesser T. Radiobiological Effects of Tritiated Water Short-Term Exposure on V79 Clonogenic Cell Survival. Int. J. Radiat. Biol. 2018;94;2:157-165. DOI: 10.1080/09553002.2018.1419301.
32. Saito M., Ishida M., Streffer C., Molls M. Estimation of Absorbed Dose in Cell Nuclei Due to DNA-Bound 3H. Health Phys. 1985;48:465-473. DOI: 10.1097/00004032-198504000-00009.
33. Nettleton J., Lawson R. Cellular Dosimetry of Diagnostic Radionuclides for Spherical and Ellipsoidal Geometry. Phys. Med. Biol. 1996;41:1845-1854. DOI: 10.1088/0031-9155/41/9/018.
34. Falzone N., Fernandez-Varea J., Flux G., Vallis K. Monte Carlo Evaluation of Auger Electron-Emitting Theranostic Radionuclides. J. Nucl. Med. 2015;56:1441-1446. DOI: 10.2967/jnumed.114.153502.
35. Salim R., Taherparvar P. Cellular S Values in Spindle-Shaped Cells: a Dosimetry Study on more Realistic Cell Geometries Using Geant4-DNA Monte Carlo Simulation Toolkit. Annals of Nuclear Medicine. 2020;34:742-756. DOI:10.1007/s12149-020-01498-z.
36. Ulanovsky A., Pröhl G. A Practical Method for Assessment of Dose Conversion Coefficients for Aquatic Biota. Radiat. Environ. Biophys. 2006;45;3:203-214. DOI: 10.1007/s00411-006-0061-4.
37. Amato E., Lizio D., Baldari S. Absorbed Fractions for Electrons in Ellipsoidal Volumes. Phys. Med. Biol. 2011;56;2:357-365. DOI: 10.1088/0031-9155/56/2/005.
38. Sazykina T.G., Kryshev L.I. Model for Calculating Energy Absorption from Incorporated Emitters of Monoenergetic Electrons in Natural Biota. Radiatsiya i Risk = Radiation and Risk. 2021;30;21:113-122 (In Russ.).
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.09.2022. Accepted for publication: 25.11.2022.
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 6
DOI: 10.33266/1024-6177-2022-67-6-5-11
I.V. Kobzeva1, T.A. Astrelina1, V.A. Brunchukov1, V.A. Brumberg1, A.A. Rastorgueva1,
Yu.B. Suchkova1, D.Yu. Usupzhanova1, T.F. Malivanova1, V.A. Nikitina1, S.V. Lishchuk1,
E.A. Dubova1, K.A. Pavlov1, Ya.V. Tonkal1, O.F. Serova1,2, A.S. Samoilov1
Transplantation of Human Decellularized Amniotic Membrane in Local Radiation Injuries
1A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
2Moscow Regional Perinatal Center, Balashikha, Russia
Contact person: T.A. Astrelina, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Evaluation of the effectiveness of the use of human decellularized amniotic membrane, both as an independent covering material and as a cell-free matrix for syngeneic regenerative cells of adipose tissue (stromal-vascular fraction – SVF, adipose tissue ‒ AT) in local radiation injuries (LRI) IIIb-IV severity in laboratory animals.
Material and methods: 42 laboratory animals were studied. LRI modeling was carried out on an X-ray at a dose of 110 Gy. Animals were randomized randomly and divided into 6 groups depending on the type of treatment:
1st group (K) ‒ control group animals after irradiation did not receive specific treatment; the 2nd group (Gl) ‒ after irradiation, medical glue BF-6 was applied to the ulcer surface on the 21st day; 3rd group (Am) ‒ animals after irradiation on the ulcer surface was applied decellularized amniotic membrane, fixed with interrupted sutures on the 21st day; 4th group (Am-Gl) ‒ animals after irradiation on the ulcer surface was applied decellularized amniotic membrane, fixed with medical adhesive BF-6 for 21 days; 5th group (SVF-Gl) ‒ after irradiation, the SVF AT at a dose of 0.4×106 cells was applied to the ulcer surface after irradiation, followed by fixation with BF-6 medical glue for
21 days; the 6th group (Am-SVF) ‒ after irradiation, SVF AT was applied to the ulcer surface at a dose of 0.4×106 cells under the decellularized amniotic membrane, fixed with interrupted sutures on the 21st day.
Results: On the 112th day, complete healing of the ulcer was observed in 100 % of animals in the Am-Gl group, in 70 % in the Am and Gl groups. There was no complete healing of the ulcer in the SVF-CGl and Am-SVF groups. The greatest reduction in the area of the total altered skin from 21 to 112 days of the experiment was noted in the groups Gl-SVF (34.7 %), K (31.6 %), Am-SVF (30.7 %). In the Am-Gl and Am groups, a reduction in the area of the total altered skin was recorded by 24.6 % and 14.7 %, respectively. In the GL group, the reduction in the area of the total altered skin was the smallest, by only 13.5 %.
Conclusion: The use of a decellularized human amniotic membrane fixed with medical adhesive BF-6 can be considered as a promising method for the conservative treatment of LRI of the skin.
Keywords: local radiation injury, transplantation, decellularized human amniotic membrane, efficacy, rat
For citation: Kobzeva IV, Astrelina TA, Brunchukov VA, Brumberg VA, Rastorgueva AA, Suchkova YuB, Usupzhanova DYu, Malivanova TF, Nikitina VA, Lishchuk SV, Dubova EA, Pavlov KA, Tonkal YaV, Serova OF, Samoilov AS. Transplantation of Human Decellularized Amniotic Membrane in Local Radiation Injuries. Medical Radiology and Radiation Safety. 2022;67(6):5–11. (In Russian). DOI:10.33266/1024-6177-2022-67-6-5-11
References
1. Ilin L.A., Kirillov V.F., Korenkov I.P. Radiatsionnaya Gigiyena = Radiation Hygiene. A Textbook for Universities. Moscow, GEOTAR Media Publ., 2010 (In Russ.).
2. Fang Z., Chen P., Tang S., Chen A., Zhang C., Peng G., Li M., Chen X. Will Mesenchymal Stem Cells Be Future Directions for Treating Radiation-Induced Skin Injury? Stem. Cell. Res. Ther. 2021;12;12;1:179.
3. Higashi Y., Yusoff F.M., Kishimoto S., Maruhashi T. Regenerative Medicine for Radiation Emergencies. J. Radiat Res. 2021;5:62.
4. Vorobyeva N.Yu., Boyeva O.V., Osipov A.N., Bozhenko V.K. Radiation-Induced DNA Double-Strand Breaks and Dynamics of Apoptotic Death of Human Peripheral Blood Lymphocytes. Vestnik Rentgenologii i Radiologii = Journal of Radiology and Nuclear Medicine. 2008;4:6 (In Russ.).
5. Kim J.H., Jenrow K.A., Brown S.L. Mechanisms of Radiation-Induced Normal Tissue Toxicity and Implications for Future Clinical Trials. Radiat. Oncol. J. 2014;32;3:103-115.
6. Myung H., Jang H., Myung J.K., Lee C., Lee J., Kang J.H. Platelet-Rich Plasma Improves the Therapeutic Efficacy of Mesenchymal Stem Cells by Enhancing their Secretion of Angiogenic Factors in a Combined Radiation and Wound Injury Model. Exp. Dermatol. 2020;29:158-167.
7. Bray F.N., Simmons B.J., Wolfson A.H., Nouri K. Acute and Chronic Cutaneous Reactions to Ionizing Radiation Therapy. Dermatol. Ther. (Heidelb). 2016;6;2:185–206.
8. Ahmed E.A., Agay D., Schrock G., Drouet M., Meineke V., Scherthan H. Persistent DNA Damage after High Dose in Vivo Gamma Exposure of Minipig Skin. PLoS One. 2012;7;6:e39521.
9. Burnett L.R., Hughes R.T., Rejeski A.F., Moffatt L.T., Shupp J.W., Christy R.J., Winkfield K.M. Review of the Terminology Describing Ionizing Radiation-Induced Skin Injury: A Case for Standardization. Technol. Cancer. Res. Treat. 2021.
10. Yarnold J., Brotons M.C. Pathogenetic Mechanisms in Radiation Fibrosis. Radiother. Oncol. 2010;97;1:149-161.
11. Galstyan I.A., Nadezhina N.M. Local radiation injuries and their long-term consequences. Meditsina Truda i Promyshlennaya Ekologiya = Russian Journal of Occupational Health and Industrial Ecology. 2017;9:42-43
(In Russ.).
12. Brunchukov V., Astrelina T., Usupzhanova D., Rastorgueva A., Kobzeva I., Nikitina V., Lishchuk S., Dubova E., Pavlov K., Brumberg V. et al. Evaluation of the Effectiveness of Mesenchymal Stem Cells of the Placenta and Their Conditioned Medium in Local Radiation Injuries. Cells. 2020;29;9;12:2558
13. Sun J., Zhang Y., Song X., Zhu J., Zhu Q. The Healing Effects of Conditioned Medium Derived from Mesenchymal Stem Cells on Radiation-Induced Skin Wounds in Rats. Cell Transplant. 2019;28;1:105-115.
14. Chu C., Gao Y., Lan X., Lin J., Thomas A.M., Li S. Stem-Cell Therapy as a Potential Strategy for Radiation-Induced Brain Injury. Stem Cell Rev Rep. 2020;16;4:639-649.
15. Vyas K.S., Saba E.S., Tran N. Regenerative Properties of Autologous Fat Grafting in a Complicated Radiation-Induced Wound. Wounds. 2021;33;2:E20-E23.
16. Павлова О. Н., Гуленко О. Н., Девяткин А.А. Methods of Treatment and Prevention of Pterygium. Vestnik Meditsinskogo Instituta «REAVIZ». Reabilitatsiya, Vrach i Zdorovye = Bulletin of the Medical Institute “REAVIZ” (Rehabilitation, Doctor and Health). 2019;3:39 (In Russ.).
17. Silini A.R., Cargnoni A., Magatti M., Pianta S., Parolini O. The Long Path of Human Placenta, and Its Derivatives, in Regenerative Medicine. Front Bioeng Biotechnol. 2015;19;3:162.
18. Anselmo D.S., McGuire J.B., Love E., Vlahovic T. Application of Viable Cryopreserved Human Placental Membrane Grafts in the Treatment of Wounds of Diverse Etiologies: a Case Series. Wounds. 2018;30;3:57‐61.
19. Castellanos G., Bernab‐Garcia A., Moraleda J.M., Nicolas F.J. Amniotic Membrane Application for the Healing of Chronic Wounds and Ulcers. Placenta. 2017;59:146‐153.
20. Dhall S., Sathyamoorthy M., Kuang J.Q., et al. Properties of Viable Lyopreserved Amnion Are Equivalent to Viable Cryopreserved Amnion with the Convenience of Ambient Storage. PLoS ONE. 2018;13;10:e0204060.
21. Regulski M.J., Danilkovitch A., Saunders M.C. Management of a Chronic Radiation Necrosis Wound with Lyopreserved Placental Membrane Containing Viable Cells. Clin. Case Rep. 2019;28;7;3:456-460.
22. Kotenko K.V., Moroz B.B., Nasonova T.A., et al. Experimental Model of Severe Local Radiation Skin Lesions after Exposure to X-Rays. Patologicheskaya Fiziologiya i Eksperimentalnaya Terapiya = Pathological Physiology and Experimental Therapy. 2013;3:121–123 (In Russ.).
23. Samoylov A.S., Brumberg V.A. Sposob Polucheniya Beskletochnogo Matriksa Amnioticheskoy Membrany dlya Posleduyushchey Rekonstruktsii Defektov Tkaney = A Method for Obtaining a Cell-Free Matrix of the Amniotic Membrane for the Subsequent Reconstruction of Tissue Defects. Patent 2 751 353 C1 Russian Federation, IPC A61K35/50 A61L27/38 C12N5/73, No. 2020124830; Publ. 07.13.2021, Bull. No. 2 (In Russ.).
24. Bose B. Burn Wound Dressing with Human Amniotic Membrane. Ann. R. Coll. Surg. Engl. 1979;61:444‐447
25. Cornwell K.G., Landsman A., James K.S. Extracellular Matrix Biomaterials for Soft Tissue Repair. Clin. Podiatr. Med. Surg. 2009;26:507‐523.
26. John T. Human Amniotic Membrane Transplantation: Past, Present, and Future. Ophthalmol Clin. North. Am. 2003;16:43‐65.
27. Quinby J.W., Hoover H.C., Scheflan M., et al. Clinical Trials of Amniotic Membranes in Burn Wound Care. Plast. Reconstr. Surg. 1982;70:711‐717.
28. Sawhney C. Amniotic Membrane as a Biological Dressing in the Management of Burns. Burns. 1989;15:339‐342.
29. Diyarbakırlıoğlu M., Bağhaki S., Ercan A., et al. Effect of Fresh Human Amniotic Membrane on Radiation-Induced Wounds in a Murine Experimental Model. Eur. J. Plast. Surg. 2018;41:279–284.
30. Fernandez D. Cryopreserved Amniotic Membrane and Umbilical Cord for a Radiation-Induced Wound with Exposed Dura: a Case Report. J. Wound Care. 2019;1;28:S4-S8.
31. Lobo Gajiwala A., Sharma V. Use of Irradiated Amnion as a Biological Dressing in the Treatment of Radiation Induced Ulcers. Cell. Tissue. Bank. 2003;4;2-4:147-150.
32. Murphy S.V., Skardal A., Nelson R.A., Sunnon K., Reid T., Clouse C., Kock N.D., Jackson J., Soker S., Atala A. Amnion Membrane Hydrogel and Amnion Membrane Powder Accelerate Wound Healing in a Full Thickness Porcine Skin Wound Model. Stem. Cells Transl. Med. 2020;9;1:80-92.
33. Kakabadze Z., Chakhunashvili D., Gogilashvili K., Ediberidze K., Chakhunashvili K., Kalandarishvili K., Karalashvili L. Bone Marrow Stem Cell and Decellularized Human Amniotic Membrane for the Treatment of Nonhealing Wound After Radiation Therapy. Exp Clin Transplant. 2019;17;Suppl 1:92-98.
PDF (RUS) Full-text article (in Russian)
Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.
Финансирование. Исследование не имело спонсорской поддержки.
Участие авторов. Cтатья подготовлена с равным участием авторов.
Поступила: 20.07.2022. Принята к публикации: 25.09.2022.
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 6
DOI:10.33266/1024-6177-2022-67-6-19-23
A.Yu. Bushmanov, O.A. Kasymova, A.S. Kretov, M.A. Soloreva, E.A. Denisova
Results of Psychophysiological Examinations of Personnel of Nuclear Facilities
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: A.S. Kretov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
The relationship between the employee’s level of health and his professional reliability is currently obvious and does not require additional evidence. The implementation of measures aimed at reducing the risks of emergency situations caused by the human factor at nuclear energy facilities is an important element of the radiation protection system.
In order to achieve the above-mentioned goals of the organization, in accordance with Federal Law № 170-FZ of 21.11.1995, the performance of certain types of work in the field of atomic energy use requires special permits from Rostechnadzor. A prerequisite for obtaining such a permit for a specialist is the absence of psychophysiological contraindications based on the results of a psychophysiological examination.
This study analyzes the results of psychophysiological examinations of employees of nuclear energy facilities conducted by specialists of the State Research Center – A.I. Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency in 2020 and 2021.
Keywords: nuclear industry, workers, psychophysiological examinations, psychophysiological contraindications, radiation safety
For citation: Bushmanov AYu, Kasymova OA, Kretov AS, Soloreva MA, Denisova EA. Results of Psychophysiological Examinations of Personnel of Nuclear Facilities. Medical Radiology and Radiation Safety. 2022;67(6):19–23. (In Russian). DOI:10.33266/1024-6177-2022-67-6-19-23
References
1. Bobrov A.F. Prevention of Technological Emergency Situations: Information Technology to Develop Criteria for Anthropogenic Risks Estimation. Mediko-Biologicheskiye i Sotsialno-Psikhologicheskiye Problemy Bezopasnosti v Chrezvychaynykh Situatsiyakh = Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2019;2:5–16 (In Russ.).
2. Bushmanov A.Yu., Kretov A.S., Shcheblanov V.Yu., Bobrov A.F., Kretova Ye.Yu. The System of Organization the Obligatory Medical Surveys of Employees of Nuclear Facilities at the Current Stage. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost = Medical Radiology and Radiation Safety. 2014;59;4:9–17 (In Russ.).
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2022. Accepted for publication: 25.09.2022.
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 6
DOI: 10.33266/1024-6177-2022-67-6-12-18
A.A. Kosenkov, F.S. Torubarov, M.Yu. Kalinina, S.A. Afonin
Some Organizational and Methodological Aspects of Psycho-Physiological Support
of Functional Reliability of Russian Nuclear Workers
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: A.A. Kosenkov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To improve organizational and methodological approaches to psycho-physiological support of functional reliability of Russian nuclear workers.
Results: The authors’ position on a number of topical organizational and methodological issues of psycho-physiological support of functional reliability of nuclear workers is presented.
Measures aimed at optimizing the interaction of medical organizations of the FMBA of Russia and organizations of the Rosatom State Corporation in the preparation and conduct of psychophysiological examinations are proposed. The optimal solution to this problem, according to the authors, is the development of a joint regulatory document defining the rights and obligations of both parties by the FMBA of Russia and the State Corporation. The expediency of avoiding duplication in carrying out a number of diagnostic techniques after developing a mechanism for transferring test results from medical organizations of the FMBA of Russia to organizations of the Rosatom State Corporation is shown.
According to the authors, the following issues are to be improved: a) the existing diagnostic arsenal, taking into account new technological capabilities, and having in mind the fact that some important tests are easily available on the Internet; b) the content of methodological recommendations, which should describe in detail sensorimotor and other tests, allowing for a variety of their interpretations, to ensure the invariance of their computer implementations. Such measures will increase the diagnostic value of the tests used, as well as the comparability of the results obtained using various software and hardware complexes.
Authors also propose to reconsider the role of the Scientific and Technical Council of the State Corporation in improving the functional reliability of the personnel of the industry by integrating psycho-physiological and other areas related to human resources into the general research topics. Proposed actions:
a) to create a thematic scientific and technical council on human resource management and reduction of anthropogenic risks including specialists in psycho-physiological, psychological, medical, sanitary-hygienic, ergonomic and other aspects of ensuring the functional reliability of personnel, and to elect a scientific adviser of the council;
b) to include the development plan for the direction of ensuring the functional reliability of personnel in the new edition of the “Program of Innovative Development and Technological Upgrading of the Rosatom State Corporation for the Period up to 2030”;
c) to add the direction on improving the reliability of the human factor in the Unified Industry Thematic Plan of Research and Development Work of the Rosatom State Corporation;
d) to include the most important reports related to human resource management and reduction of anthropogenic risks in the plenary sessions of the conferences “Radiation Protection and Radiation Safety in Nuclear Technologies”.
Conclusion: The above proposals are aimed at improving the organizational and methodological aspects of the psycho-physiological direction in ensuring the functional reliability of nuclear workers. According to the authors, this direction should be part of the human resource management system and the reduction of anthropogenic risks in the nuclear industry. The research part of this system should be integrated into the activities of the Scientific and Technical Council of the Rosatom State Corporation and meet the requirements of a systematic approach.
Keywords: nuclear industry, safety, functional reliability, nuclear workers, professionally important qualities, anthropogenic risks, regulatory documents, psychophysiological laboratory
For citation: Kosenkov AA, Torubarov FS, Kalinina MYu, Afonin SA. Some Organizational and Methodological Aspects of Psycho-Physiological Support of Functional Reliability of Russian Nuclear Workers. Medical Radiology and Radiation Safety. 2022;67(6):12–18. (In Russian). DOI:10.33266/1024-6177-2022-67-6-12-18
References
1. Andryushina L.O., Chernetskaya Ye.D., Belykh T.V. Digitalization of Psychological Recruitment: Automated Psychophysiological Examination System. Psikhofiziologicheskoye Obespecheniye Professionalnoy Nadezhnosti Personala Predpriyatiy i Organizatsiy Atomnoy Otrasli = Psychophysiological Support of Professional Reliability of Personnel of Enterprises and Organizations of the Nuclear Industry. Proceedings of the IV Scientific and Practical Conference. Moscow, October 6-8, 2020. Moscow Publ., 2020. P. 13-19 (In Russ.).
2. Andryushina L.O., Chernetskaya Ye.D., Belykh T.V., Velichkovskiy B.B. Individual Predictors of Safety in Nuclear Power Plants Personnel. Psikhofiziologicheskoye Obespecheniye Professionalnoy Nadezhnosti Personala Predpriyatiy i Organizatsiy Atomnoy Otrasli = Psychophysiological Support of Professional Reliability of Personnel of Enterprises and Organizations of the Nuclear Industry. Proceedings of the IV Scientific and Practical Conference. Moscow, October 15-17, 2018. Moscow Publ. Moscow Publ., 2018. P. 47-61 (In Russ.).
3. Kalinina M.Yu., Andryushina L.O., Chernetskaya Ye.D., Belykh T.V. System of Psychophysiological Support of Professional Reliability of Personnel of Nuclear Power Plants. Psikhofiziologicheskoye Obespecheniye Professionalnoy Nadezhnosti Personala Predpriyatiy i Organizatsiy Atomnoy Otrasli = Psychophysiological Support of Professional Reliability of Personnel of Enterprises and Organizations of the Nuclear Industry. Proceedings of the III Scientific and Practical Conference. Moscow, October 15-17, 2018. Moscow Publ., 2018. P. 17-29 (In Russ.).
4. Abramova V.N. What Needs to be Changed based on Lessons Learned from Chernobyl. Human and Organizational Aspects of Assuring Nuclear Safety —Exploring 30 Years of Safety Culture // Proceedings of an International Conference. International Atomic Energy Agency, IAEA, Vienna, Austria, February 22–26, 2016. IAEA, 2019. P. 81-100.
5. Stern H., Becker T. Development of a Model for the Integration of Human Factors in Cyber-physical Production Systems. Procedia Manufacturing. 2017;9:151–158. DOI: https://doi.org/10.1016/j.promfg.2017.04.030.
6. Pacaux-Lemoine M.-P., Trentesaux D., Rey G.Z., Millot P. Designing Intelligent Manufacturing Systems through Human-Machine Cooperation Principles: A Human-Centered Approach. Computers & Industrial Engineering. 2017;111:581-595. DOI: https://dx.doi.org/10.1016/j.cie.2017.05.014.
7. Carvalho P.V.R., dos Santos I.L., Gomes J.O., Borges M.R.S., Guerlain S. Human Factors Approach for Evaluation and Redesign of Human–System Interfaces of a Nuclear Power Plant Simulator. Displays. 2008;29;3:273-284. DOI: https://doi.org/10.1016/j.displa.2007.08.010.
8. Kalinina M.Yu. Psychophysiological Provision of Professional Reliability of Personnel of Enterprises and Organizations of the Atomic Industry. Psikhofiziologicheskoye Obespecheniye Professionalnoy Nadezhnosti Personala Predpriyatiy i Organizatsiy Atomnoy Otrasli = Psychophysiological Support of Professional Reliability of Personnel of Enterprises and Organizations of the Nuclear Industry. Proceedings of the III Scientific and Practical Conference. Moscow, October 15-17, 2018. Moscow Publ., 2018. P. 13-16 (In Russ.).
9. International Atomic Energy Agency. IAEA Report on Human and Organizational Factors in Nuclear Safety in the Light of the Accident at the Fukushima Daiichi Nuclear Power Plant. Action Plan on Nuclear Safety Series. Vienna: IAEA, 2014.
10. Lee J.-W., Lee Y., Jang T., Kim D., Park, J. A Proposition of Human Factors Approaches to Reduce Human Errors in Nuclear Power Plants. Human Factors and Power Plants and HPRCT 13th Annual Meeting, 2007 IEEE 8th. IEEE, 2007. P. 16-22.
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2022. Accepted for publication: 25.09.2022.
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 6
DOI:10.33266/1024-6177-2022-67-6-24-29
A.A. Molokanov, N.P. Potsyapun, E.Yu. Maksimova
Application of New Icrp Recommendations on Dose Calculation
for Workers after Inhalation Intake of Uranium Radionuclides
A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: Andrey Alekseevich Molokanov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Harmonization and improvement of the system for regulating the internal radiation exposure of workers and the basic requirements for ensuring radiation safety, taking into account the application of new international requirements and recommendations.
Material and methods: A brief description of the procedure for calculating absorbed and equivalent doses in organs and tissues after the intake of radionuclides into the human body is presented, using the biokinetic and dosimetric models adopted in the new ICRP recommendations, as well as a discussion of the impact of these changes on the results of calculating dose coefficients for the case of inhalation intake of uranium-235 radionuclide.
Results: The effective dose values and equivalent doses to organs and tissues for workers were calculated depending on the time after a single inhalation intake of uranium-235 aerosol, according to new models [1–12] and according to previous ICRP models [15, 16]. The calculation of the effective dose according to the new models included calculations of equivalent doses for 14 main organs and tissues and 13 organs and tissues classified as “remainder tissues” as described in ICRP Publication 103 [3]. The committed effective dose was then calculated according to the new approach using the average of the equivalent doses for the reference adult male, HTM, and the reference adult female, HTF, as well as the tissue and organ weighting factors, WT, adopted in ICRP Publication 103. The values of the effective dose and equivalent doses on the red bone marrow, lungs and remainder tissues vs time in the range from several days to 18250 days (50 years) after a single inhalation intake of an aerosol of uranium-235 for standard value AMAD=5 µm and types of compounds F, M, S, F/M and M/S are presented according to new and previous ICRP models.
It is shown that the value of the dose coefficient for type F, calculated by new models, is 2.6 times (2.3E-07÷6.0E-07) less than that calculated by previous ICRP models, and the value of the dose coefficient for type F/M calculated by new models is 1.6 times (3.8E-07÷6.0E-07) less than the value of the dose coefficient for type F calculated by previous ICRP models. For uranium trioxide UO3, taking into account its transition from compound type M to F/M, the value of the dose coefficient for committed effective dose according to the updated model of the respiratory tract is 4.7 times (3.8E-07÷1.8E-06) less than the corresponding value for the previous model of the type M respiratory tract. The committed effective dose value for compound type M, calculated using the new models, is 1.4 times (1.3E-06÷1.8E-06) less than the same value calculated using the previous ICRP models. The value of the committed effective dose for type M/S compounds (which, according to the new model of the respiratory tract, include uranium oxide U3O8 and dioxide UO2), calculated according to new models, is 1.2 times (5.1E-06÷6.1E-06) less than the value calculated from previous ICRP models for type S compounds (which included U3O8 and UO2 in the previous respiratory tract model).
Conclusion: From the above data it follows that in case of the adoption of national radiation safety standards to new ICRP models, differences in the values of dose coefficients will result in a change of annual limits of intake (ALI) in the corresponding proportion for the types of uranium aerosol compounds noted above.
Keywords: uranium, inhalation intake, dose coefficient, internal exposure, biokinetic model, dosimetric model, absorbed dose, equivalent dose, organs and tissues, committed effective dose, new ICRP recommendations
For citation: Molokanov AA, Potsyapun NP, Maksimova EYu. Application of New Icrp Recommendations on Dose Calculation for Workers after Inhalation Intake of Uranium Radionuclides. Medical Radiology and Radiation Safety. 2022;67(6):24–29. (In Russian). DOI:10.33266/1024-6177-2022-67-6-24-29
References
1. ICRP. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP. 2002;32;3-4.
2. ICRP. Human Alimentary Tract Model for Radiological Protection. ICRP Publication 100. Ann. ICRP. 2006;36;1-2.
3. ICRP. The 2007 Recommendations of the International Commission on Radiological Protection. ICRP Publication 103. Ann. ICRP. 2007;37;2-4.
4. ICRP. Nuclear Decay Data for Dosimetric Calculations. ICRP Publication 107. Ann. ICRP. 2008;38;3.
5. ICRP. Adult Reference Computational Phantoms. ICRP Publication 110. Ann. ICRP. 2009;39;2.
6. ICRP. Occupational Intakes of Radionuclides: Part 1. ICRP Publication 130. Ann. ICRP. 2015;44;2.
7. ICRP. The ICRP computational framework for internal dose assessment for reference adults: specific absorbed fractions. ICRP Publication 133. Ann. ICRP. 2016;45;2:1–74.
8. ICRP. Occupational Intakes of Radionuclides: Part 2. ICRP Publication 134. Ann. ICRP. 2016;45;3/4:1–352.
9. ICRP. Occupational Intakes of Radionuclides: Part 3. ICRP Publication 137. Ann. ICRP. 2017;46;3/4.
10. ICRP. Occupational Intakes of radionuclides: Part 4. ICRP Publication 141. Ann. ICRP. 2019;48;2/3.
11. ICRP. Occupational Intakes of Radionuclides: Part 5. ICRP Publication 151. Ann. ICRP. 2022;51;1–2.
12. ICRP. Occupational Intakes of radionuclides: Electronic Annex of ICRP Publications 130, 134, 137, 141, 151. 2022.
13. ICRP. 1990 Recommendations of the International Commission on Radiological Protection. ICRP Publication 60. Ann. ICRP. 1991;21;1-3.
14. ICRP. Limits for Intakes of Radionuclides by Workers. ICRP Publication 30. Part 1. Ann. ICRP. 1979;2;3-4.
15. ICRP. Human Respiratory Tract Model for Radiological Protection. ICRP Publication 66. Ann. ICRP. 1994;24;1-3.
16. ICRP. Age-Dependent Doses to Members of the Public from Intake of Radionuclides. Part 2. Ingestion Dose Coefficients. ICRP Publication 67. Ann. ICRP. 1993;23;3-4.
17. Нормы радиационной безопасности НРБ-99/2009. Гигиенические нормативы СП 2.6.1.2523-09. М. 2009. 100 с. [Radiation Safety Standards NRB-99/2009. Hygienic Standards SP 2.6.1.2523-09. Moscow Publ., 2009. 100 p. (In Russ.)].
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study was carried out under the Federal Target Program, code “Radiometry-19.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2022. Accepted for publication: 25.09.2022.