JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 5
DOI: 10.33266/1024-6177-2022-67-5-10-17
A.S. Zhirnik, A.V. Rodina, Yu.P. Semochkina,
O.V. Vysotskaya, O.D. Smirnova, M.G. Ratushnyak,
E.Yu. Moskaleva
COGNITIVE DISTURBANCES AND THE STATE OF BRAIN GLIAL CELLS IN MICE EXPOSED TO FRACTIONATED WHOLE-BRAIN IRRADIATION
National Research Center Kurchatov Institute, Moscow, Russia
Contact person: A.S. Zhirnik, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To investigate the effect of fractionated whole-brain γ-irradiation at a cumulative dose of 20 Gy on cognitive functions, the state of brain glial cells and expression of multiple cytokines in mice 2 months after exposure.
Material and methods: Male C57Bl/6 mice were exposed to fractionated head γ-irradiation with 5 doses of 4 Gy. Two months after irradiation the behavior and cognitive functions of animals were assessed. After isolation of cells from mice brains the content of resting and activated microglia, microglial cells with M1- and M2-phenotype, astrocytes, proliferating cells were evaluated, and the hippocampal mRNA levels of pro- and anti-inflammatory cytokines (TNFα, IL-1β, IL-6, IL-4, TGFβ) were determined.
Results: It was shown that fractionated head γ-irradiation didn’t alter the locomotor activity and associative (context fear) memory, but reduced the episodic memory in novel object recognition test (discrimination index was 0.44 ± 0.08 и 0.02 ± 0.09 in control and irradiated groups, respectively) and spatial memory in Morris water maze (time in target quadrant was 46,8 ± 2,4 % and 37,4 ± 2,8 % in control and irradiated groups, respectively). Exposure of γ-radiation significantly reduced the brain contents of microglial cells (Iba1+) and astrocytes (GFAP+) with concurrent 2.5 times increase in proportion of activated microglia (from 2.0 ± 0.2 % in control to 4.9 ± 0.5 % in irradiated mice), changed the M1- / M2-microglia ratio and significantly decreased the number of proliferating cells (BrdU+) and proliferating microglial cells (BrdU+/Iba1+). An increase in mRNA level of pro-inflammatory cytokine TNFα, a decrease in mRNA level of anti-inflammatory cytokine TGFβ and concurrent increase in mRNA level of IL-4 were detected in hippocampus 2 months after irradiation.
Conclusion: We show that fractionated head γ-irradiation at a cumulative dose of 20 Gy reduces the episodic and spatial memory in mice 2 months after exposure. Cognitive dysfunctions detected are associated with neuroinflammation characterized by increasing proportion of activated brain microglia and altered hippocampal pro- and anti-inflammatory cytokine profile.
Keywords: brain, hippocampus, microglia, activated microglia, astrocytes, neuroinflammation, cytokines, gene expression, fractionated irradiation, cognitive function, mice
For citation: Zhirnik AS, Rodina AV, Semochkina YuP, Vysotskaya OV, Smirnova OD, Ratushnyak MG, Moskaleva EYu. Cognitive Disturbances and the State of Brain Glial Cells in Mice Exposed to Fractionated Whole-Brain Irradiation. Medical Radiology and Radiation Safety. 2022;67(5):10–17. (In Russian). DOI: 10.33266/1024-6177-2022-67-5-10-17
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. Research Center Kurchatov Institute.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.06.2022. Accepted for publication: 25.08.2022.
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 5
DOI: 10.33266/1024-6177-2022-67-5-18-23
V.P. Mamina
RADIOPROTECTIVE EFFECT OF THE ERACOND
ON SPERMATOGENESIS UNDER THE INFLUENCE OF A SINGLE EXTERNAL ACUTE γ-IRRADIATION
Institute of Plant and Animal Ecology, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia
Contact person: Vera Pavlovna Mamina, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: Experimental evaluation of the radioprotective effect of Erakond on spermatogenesis in BALB/c mice under external acute γ-irradiation.
Material and methods: Single external γ-irradiation of males at a dose of 1 Gy was carried out at the IGUR facility (137Cs, dose rate 0.85 Gy/min). Erakond was administered orally for 6 days followed by irradiation 2 weeks later. Violation of spermatogenesis and its correction by eracondas in irradiated animals was assessed by the morphofunctional state of the testes, spermatozoa and the reproductive function of males.
Results: In mice on days 16, 24, 48 after irradiation, the number of seminiferous tubules with destructive changes in the spermatogenic epithelium increases from 2.4 to 5.4; 10.2 8.3 % respectively. Erakond contributed to the reduction in the number of seminiferous tubules with destruction to 3.2; 5.1 and 3.5 % respectively.
On the 24th, 48th day after irradiation, the number of spermatozoa with an abnormal head increases from 2.8 to 4.8 and 4.5 %; and tail pathology from 4.2 to 8.2 and 7.5 %, respectively, the number of live spermatozoa decreases from 58.1 to 40.5 and 20.0 %, respectively. Erakond contributed to a decrease in the number of spermatozoa with an abnormal head to 3.0; 3.5 %, with tail pathology up to 6.1; 5.3 % and an increase in the number of live sperm up to 50.8; 35.5 % respectively.
In mice, on days 16, 24, and 48 after irradiation, the spermatogenea index decreased from 3.4 to 1.5; 0.9 and 2.1, respectively, Erakond contributed to an increase in the spermatogenesis index to 1.9; 2.1 and 2.9 respectively.
In mice after irradiation, pre-implantation death at the stages of mature spermatozoa, spermatids, spermatocytes and spermatogonia increased from 24.1 to 41.0; 39.8 and 44.7; 42.0 %, respectively, and post-implantation death at the stages of mature sperm, spermatids, spermatocytes from 16.9; up to 26.5; 27.1 and 38.4 % respectively. The number of live fetuses per female decreased from 5.8 to 3.0; 3.9 and 3.7 respectively. Erakond statistically significantly contributed to the reduction of pre-implantation death at the stages of mature sperm, spermatids, spermatocytes and spermatogonia to 35.6; 33.4; 37.5 and 34.1, respectively, and a decrease in post-implantation death at the stages of mature sperm, spermatids and spermatocytes to 21.6; 20.5 and 28.2 respectively.
Conclusion: The data obtained indicate the possible preventive use of Erakond as an effective dietary supplement for the correction of spermatogenesis disorders when exposed to ionizing radiation.
Keywords: external acute γ-irradiation, spermatogenesis, spermatozoa, testis, Еracond, mice
For citation: Mamina VP. Radioprotective Effect of the Eracond on Spermatogenesis under the Influence of a Single External Acute γ-Irradiation. Medical Radiology and Radiation Safety. 2022;67(5):18–23. (In Russian). DOI: 10.33266/1024-6177-2022-67-5-18-23
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.06.2022. Accepted for publication: 25.08.2022.
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 5
DOI: 10.33266/1024-6177-2022-67-5-33-40
A.N. Koterov1, A.A. Wainson2
CONJUNCTURAL APPROACH TO THE CONCEPT OF LOW DOSE RADIATION RANGE WITH LOW LET IN FOREIGN REVIEW SOURCES: NO CHANGES FOR 18 YEARS
1A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
2N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia
Contact person: Alexey N. Koterov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Dedicated to the memory of Professor S.P. Yarmonenko (1920–2011)
Abstract
The upper limit of low dose radiation with a low LET of 100 mGy, established in 2008 by international and internationally respected organizations UNSCEAR, ICRP, IAEA, NCRP (USA), BEIR (USA), DOE (USA), etc., is used by these organizations and programs at low doses (European MELODI and others) to date (documents 2019–2021). Researchers from Russia in the last decade adhere to this boundary quite strictly.
The conducted systematic review showed that leading foreign radiation epidemiologists from more than ten Western countries and Japan in their review publications for 2008–2022 (on the example of two themes: the rate mortality from diseases of the circulatory system and the rate of cataracts after irradiation – 54 sources in total) in 81 % of cases incorrectly (usually greatly overestimating) determine the limit of low dose radiation or do not mention it at all, although they consider the ‘effects of low doses’. In 41 % of review sources, the term ‘low dose’ or ‘low level’ was reflected in the title, but only 36 % of these had a correct definition of low doses.
Given the high international and national authority of the authors of the reviewed sources, the revealed incorrectness, apparently, cannot be accidental or be explained by lack of information (at least for the first authors). They are probably associated with unscientific reasons of a subjective and conjunctural nature, due to the desire to ‘prove’ the effects of low doses by any means, even by overestimating the value of their range, as it was decades ago.
Keywords: radiation with low LET, limit of low-dose, 100 mGy, foreign review sources, incorrect and missing definitions
For citation: Koterov AN, Wainson AA. Conjunctural Approach to the Concept of Low Dose Radiation Range with Low Let in Foreign Review Sources: no Changes for 18 Years. Medical Radiology and Radiation Safety. 2022;67(5):33–40. (In Russian). DOI: 10.33266/1024-6177-2022-67-5-33-40
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.06.2022. Accepted for publication: 25.08.2022.
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 5
DOI: 10.33266/1024-6177-2022-67-5-24-32
A.V. Akleyev1, 2,T.V. Azizova3, L.A. Karpikova4, S.M. Kiselev5,
D.V. Kononenko6, E.M. Melikhova7, V.V. Romanov8, S.A. Romanov3,
R.M. Takhauov9, 10, V.Yu. Usoltsev8, S.M. Shinkarev5
RESULTS OF THE 69th SESSION OF THE UNITED NATIONS SCIENTIFIC COMMITTEE ON THE EFFECTS OF THE ATOMIC RADIATION (UNSCEAR) (Vienna, 9‒13 May, 2022)
1Urals Research Center for Radiation Medicine, Chelyabinsk, Russia
2 Chelyabinsk State University, Chelyabinsk, Russia
3 Southern Urals Biophysics Institute, Ozyorsk, Russia
4 Federal Medical and Biological Agency, Moscow, Russia
5A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
6 P.V. Ramzaev Saint-Petersburg Research Institute of Radiation Hygiene, Saint-Petersburg, Russia
7Nuclear Safety Institute, Moscow, Russia
8State Atomic Energy Corporation “ROSATOM”, Moscow, Russia
9Seversk Biophysical Research Centre, Seversk, Russia
10Siberian State Medical University, Tomsk, Russia
Contact person: A.V. Akleyev, e-mail:
This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
The paper dwells upon the key outcomes of the 69-th Session of the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) which took place during 09-13 May 2022. The delegation of the Russian Federation took part in the Session in on-line format in the form of videoconferences. 153 experts from 31 UNSCEAR member-states as well as the representatives of 13 international organizations participated in the work of the Session. Within the framework of the meetings of the working group and subgroups the documents on the following projects were discussed: R.752 “Second primary cancer after radiotherapy”, R.753 “Epidemiological studies of radiation and cancer” and R.754 “Evaluation of public exposures to ionizing radiation from natural and other sources”. The Committee also discussed interim reports: (R.755 “Evaluation of diseases of the circulatory system from radiation exposure” and UNSCEAR/69/7 “Implementation of public information and outreach strategy for 2020–2024”), Reports of the Secretariat (R.756 “Strategy to improve collection, analysis and dissemination of data on radiation exposure (including considerations of the ad hoc working group on sources and exposure”,
UNSCEAR/69/8 “Implementation of the Committee’s Future Programme of Work (2020–2024), and proposals for 2025–2029 period, including consideration of the Committee’s ad hoc working group on effects and mechanisms” and UNSCEAR/69/9 “UNSCEAR use of radiation protection quantities and units”), and Report to the UN General Assembly.
Keywords: 69th UNSCEAR Session, occupational exposure, public exposure, dose
For citation: Akleyev AV, Azizova TV, Karpikova LA, Kiselev SM, Kononenko DV, Melikhova EM, Romanov VV, Romanov SA, Takhauov RM, Usoltsev VYu, Shinkarev SM. Results of the 69th Session of the United Nations Scientific Committee on the Effects of the Atomic Radiation (UNSCEAR) (Vienna, 9‒13 May, 2022). Medical Radiology and Radiation Safety. 2022;67(5):24–32. (In Russian). DOI: 10.33266/1024-6177-2022-67-5-24-32
References
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.06.2022. Accepted for publication: 25.08.2022.
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 5
DOI: 10.33266/1024-6177-2022-67-5-41-46
E.A. Kodintseva1, 2, A.А. Akleyev3
EFFECT OF CHRONIC EXPOSURE AND NON-RADIATION FACTORS ON THE INTRACELLULAR STAT3 CONCENTRATION
1Urals Research Center for Radiation Medicine, Chelyabinsk, Russia
2Chelyabinsk State University, Chelyabinsk, Russia
3Southern-Urals State Medical University of the RF Ministry of Public Health, Chelyabinsk, Russia
Contact person: Е.А. Kodintseva, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To evaluate the influence of radiation and non-radiation factors on the intracellular concentration of the transcription factor STAT3 in peripheral blood lymphocytes of chronically irradiated residents of the coastal villages of the Techa River in the long-term after the onset of irradiation.
Material and methods: The main group consisted of 50 people aged 67 to 84 years old with an average dose of irradiation of the red bone marrow of 727.9±79.1 mGy; thymus and peripheral lymphoid organs – 85.9±13.6 mGy. The comparison group included 25 people aged from 61 to 87 who were not exposed to accidents, whose distribution by sex and ethnicity corresponded to the composition of the main group. Peripheral blood lymphocyte lysates were normalized for total protein concentration prior to enzyme immunoassay.
Results: The median intracellular concentration of STAT3 was 167.6 (118.3–240.1) pg/ml in the main group and 147.0 (116.7–179.2) pg/ml in the control group.
Conclusion: The intracellular level of STAT3 did not differ significantly between chronically exposed and non-exposed individuals, as well as in people from different dose subgroups. Correlations between the concentration of STAT3 and dose characteristics, gender and ethnicity of the examined people were not found. In people with a red bone marrow dose of 0.85 Gy or more, STAT3 concentration correlated with age at the time of examination (SR= ‒0.67, p=0.01). In other dose subgroups, no correlation was found between the estimated indicator and the achieved age. The results are preliminary.
Keywords: chronic radiation exposure, the Techa River, transcription factor STAT3, intracellular concentration, peripheral blood lymphocytes
For citation: Kodintseva ЕА, Akleyev АА. Effect of Chronic Exposure and Non-Radiation Factors on the Intracellular STAT3 Concentration. Medical Radiology and Radiation Safety. 2022;67(5):41–46. (In Russian). DOI: 10.33266/1024-6177-2022-67-5-41-46
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.06.2022. Accepted for publication: 25.08.2022.