JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 4
Magnetic Resonance Imaging of Primary Extra-Axial Intracranial Tumors:
Diagnostic Problems and Prospects of Radiomics
А.V. Kapishnikov1, E.N. Surovcev1,2, Yu.D. Udalov3
1Samara State Medical University, Samara, Russia.
2Treatment and Diagnostic Center of the International Institute of Biological Systems named after Sergey Berezin, Tolyatti, Russia.
3Federal Scientific Clinical Center for Medical Radiology and Oncology, Dimitrovgrad, Russia.
Contact person: Kapishnikov Aleksandr Viktorovich: This email address is being protected from spambots. You need JavaScript enabled to view it.
CONTENTS
Introduction
MRI semiotics in the differential diagnosis of primary extra-axial intracranial tumors (PEIT)
Localization of the tumor and its relationship with the anatomical structures
Heterogeneity (heterogeneity) of the tumor
Tumor margins and peritumoral edema
Apparent diffusion coefficient (ADC)
Dural tail sign
Information technology for MRI analysis and radiomics
Radiomics in differential diagnosis of PEIT
Conclusion
Keywords: magnetic resonance imaging, primary extra-axial intracranial tumors, meningiomas, radiomics, information technology.
For citation: Kapishnikov АV, Surovcev EN, Udalov YuD. Magnetic Resonance Imaging of Primary Extra-Axial Intracranial Tumors: Diagnostic Problems and Prospects of Radiomics. Medical Radiology and Radiation Safety. 2022;67(4):49-56. DOI: 10.33266/1024-6177-2022-67-4-49-56
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The author declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors
Article received: 20.04.2022. Accepted for publication: 25.05.2022
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 4
X-ray Estimation of Structural-topographic Parameters of the Tempo-low Jaund
Joint After Orthognic Surgical Treatment of Dental Jaws with Condition
M.A. Mokhirev, O.S. Kaganova, V.N. Olesova, V.I. Ermolin, E.E. Olesov, A.A. Ilyin
A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia.
Contact person: Olesova Valentina Nikolaevna, This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Using the methods of radiation diagnostics, to trace in dynamics the structural and topographic state of the temporomandibular joint (TMJ) before and after orthognathic treatment of patients with air conditioning
Material and Methods: A CT analysis of the TMJ condition was carried out before and after orthodontic surgical removal of the dentofacial anomaly (skeletal form) with the effects of Candyline resorption. We used the method of Fadeev R.A. et al. to assess the TMJ parameters: height of the head of the lower jaw; anterior and posterior articular angle; the width of the joint space in the upper, anterior, posterior, mesial and lateral sections; maximum width of the head of the lower jaw; density of cortical and cancellous bones of the head of the lower jaw; height of the articular fossa; the length of the anterior slope of the articular fossa; angle of the anterior slope of the articular fossa; the length of the posterior slope of the articular fossa; angle of the posterior slope of the articular fossa.
Results: Comparison of CT parameters of TMJ before and after orthognathic treatment reveals a positive trend in remodeling of the articular process of the lower jaw after surgery, as evidenced by a noticeable increase in the width of the head of the lower jaw with a slight decrease in its height. The absence of compression in the bilaminar zone of the TMJ is recorded due to an increase in the width of the joint space in the posterior section, although the width of the joint space in the upper and anterior sections still does not correspond to normal values. The preservation of a lower density of the cortical and spongy layers of the articular head in comparison with the norm is apparently associated with continued adaptation to the new position of the articular processes and changed functional loads.
Conclusion: A comprehensive orthodontic and surgical approach to the elimination of dentoalveolar anomalies is effective and can be recommended in the treatment of patients with skeletal anomalies and condyloresorption, as it provides not only a significant improvement in facial aesthetic parameters, but also has a positive effect on the structural and topographic parameters of the temporomandibular joint.
Keywords: maxillofacial anomaly, temporomandibular joint, orthognathic surgery, computed tomography, condition dynamics
For citation: Mokhirev MA, Kaganova OS, Olesova VN, Ermolin VI, Olesov EE, Ilyin AA. X-ray Estimation of Structural-topographic Parameters of the Tempo-low Jaund Joint After Orthognic Surgical Treatment of Dental Jaws with Condition. Medical Radiology and Radiation Safety. 2022;67(4):57-61. DOI: 10.33266/1024-6177-2022-67-4-57-61
References
1. Shipika D.V. Sovershenstvovaniye Diagnostiki i Lecheniya Zabolevaniy VNCHS u Patsiyentov s Anomaliyami Prikusa = Improving the Diagnosis and Treatment of TMJ Diseases in Patients with Malocclusion. Extended abstract of candidate’s thesis in Medicine. Moscow Publ., 2012. 26 p. (In Russ.).
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The author declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors
Article received: 20.04.2022. Accepted for publication: 25.05.2022
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 4
Combined Treatment of Rectal Cancer Using Two-component Radiomodification with Neoadjuvant Radiation Therapy Together with a Chemotherapy
Yu.A. Barsukov1, S.I. Tkachev1, Z.Z. Mammadli1, V.A. Aliev1,
O.A. Vlasov2, N.D. Oltarzhevskaya3, M.A. Korovina3
1N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, Moscow, Russia
2Russian Scientific Center of Radiology and Nuclear Medicine, Ministry of Health of Russia, Moscow, Russia
3“Coletex” Ltd., Moscow, Russia
Contact person: Yu.A. Barsukov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: to evaluate the effectiveness of a “short” course of neoadjuvant radiation therapy using two radio modifiers with different mechanisms of radio-modulating action together with a drug therapy.
Material and methods: To increase the effectiveness of radiation therapy there was created a variant of combined treatment of patients with rectal cancer, using the concept of polyradiomodification. Two radio modifiers have been applied (local microwave hyperthermia and intrarectal Metronidazole administration as part of a polymer composition) together with neoadjuvant radiation therapy and oral administration of Capecitabine, followed by surgical intervention 4–6 weeks after the end of radiation therapy. For intrarectal delivery of Metronidazole to the tumor, a new medical device was created, which is a biopolymer composition in the form of a hydrogel with a Metronidazole substance physically immobilized in it (RF Patent No. 2007139304, 2007).
Results: The study included 520 patients, of whom 114 underwent a new variant of combined treatment with modulation of the effect of irradiation with two different radiomodifiers together with a drug therapy (group-1), 193 patients underwent only single-mode radiation therapy (group-2), and 213 patients underwent a combination of radiation therapy with local microwave hyperthermia (group-3). Toxic manifestations in group-1 was diagnosed in 38 (33,3 %) of 114 patients, general toxic manifestations of the III degree – in 13 (11,4 %) of 114. Postoperative complications in the group-1 was observed in 21 (18,4 %) of 114 patients, which was significantly less than in the group-2 and group-3, where they occurred in 78 (40,4 %) of 193 (p=0,0001) and in 78 (36,6 %) of 213 (p=0,0006). With a median follow-up of 54,6 months. relapses of cancer in the group-1 was not detected in any of 114 patients, which is significantly less than in the group-2, in which cancer relapses were diagnosed in 17 (8,8 %) of 193 patients (p=0,0011), and in the group-3, where they were detected in
10 (4,7 %) of 213 patients (p=0,0188). This made it possible to increase the number of sphincter-preserving operations performed in the group-1 to 84,2 %, which is significantly more compared to 53,4 % in the group-2 (p=0,00001) and 56,8 % in the group-3 (p=0,00001). It was also possible to significantly increase the rate of five-year relapse-free survival in the group-1 up to 82,9 % compared to 65,3 % at group-2 (p=0,01106) and 61,1 % at group-3 (p=0,00276).
Conclusion: The treatment option using polyradiomodification is effective in improving local antitumor control of the disease and increasing relapse-free survival rates compared to other combined treatment options.
Keywords: rectal cancer, combined treatment, radiomodifiers, therapeutic pathomorphosis, long-therm results
For citation: Barsukov YuA, Tkachev SI, Mammadli ZZ, Aliev VA, Vlasov OA, Oltarzhevskaya ND, Korovina MA. Combined Treatment of Rectal Cancer Using Two-component Radiomodification with Neoadjuvant Radiation Therapy Together with a Chemotherapy. Medical Radiology and Radiation Safety. 2022;67(4):69-73. (In Russian) DOI:10.33266/1024-6177-2022-67-4-69-73
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 17.01.2022. Accepted for publication: 15.03.2022.
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 4
Three-Color FISH Method: Translocations in Peripheral Blood Lymphocytes Cultures before and after Local Gamma Radiation for Breast Cancer
V.Yu. Nugis, T.A. Astrelina, V.A. Nikitina, M.G. Kozlova,
I.V. Kobzeva, E.E. Lomonosova, Yu.B. Suchkova,
D.Yu. Usupzhanova, V.A. Brunchukov, A.A. Rastorgueva,
T.F. Malivanova, V.A. Brumberg,T.V. Karaseva, E.S. Lyubaeva,
D.Yu. Bobrov, N.G. Stepanyants, M.Yu. Sukhova, A.S. Samoilov
A.I. Burnasyan Federal Medical Biophysical Center of FMBA of Russia, Moscow, Russia
Контактное лицо: Nugis V.Yu., E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Study of chromosomal aberration yields with a three-color FISH method in the peripheral blood lymphocyte cultures of patients with breast cancer before and after local irradiation.
Material and methods: Venous blood was obtained from 24 patients aged from 33 to 79 years which suffering from cancer of the left or right breast after the implementation of a sectoral or radical resection of an affected organ with subsequent local adjuvant distant radiation therapy (DRT) to the scar area. Also it could be preceded by adjuvant polychimotherapy (PCT). A linear accelerator of the Trilogy system based on the Clinac iX platform was used for local irradiation. SOD was installed at 50 Gy per 25 fractions (daily 2 Gy). venous blood sampling produced to PCT and/or DRT and after 1 and/or 3 months after irradiation. A set of DNA probes to 1, 4 and 12 pairs of chromosomes was used for three-color FISH staining.
Results: Levels of translocations, dicentrics and acentrics (per 100 cells) in peripheral blood lymphocyte cultures of patients up to DRT did not differ significantly with and without PCT and were amounted to average 0.63 ± 0.10; 0.10 ± 0.04 and 0.17 ± 0.06, respectively. The frequency of these chromosome rearrangements significantly increased after radiation therapy by an average of up to 4.62 ± 0.46; 1.48 ± 0.19 and 0.95 ± 0.14. The differences between 1 and 3 months of taking material after irradiation were absent. One of the patients, unlike the rest, was cytogenetically examined 11 years after a similar local irradiation, and the frequencies of translocations and dicentrics in her lymphocyte culture were 4.56 and 0.19 (per 100 cells), respectively, while they were varied from 1.63 to 10.00 for translocations and from 0.27 (0 in one patient) to 4.06 for dicentrics for other patients.
Conclusion: When using a three-color FISH method there was a significant increase in the frequencies of translocations, dicentrics and acentrics in peripheral blood lymphocyte cultures of patients after DRT of breast cancer. At the same time there were more translocations than dicentrics and, apparently, they remain at the initial level for a long time. The frequency of translocations per 1 cell with translocations in the peripheral blood lymphocyte cultures in most cases exceeds 1 after local DRT of the breast cancer. The correlation between average physical doses to the whole body and cytogenetical estimates in individual patients was statistically insignificant.
Keywords: peripheral blood lymphocytes culture, three-color FISH method, translocations, breast cancer, local gamma-irradiation
For citation: Nugis VYu, Astrelina TA, Nikitina VA, Kozlova MG, Kobzeva IV, Lomonosova EE, Suchkova YuB, Usupzhanova DYu, Brunchukov VA, Rastorgueva AA, Malivanova TF, Brumberg VA, Karaseva TV, Lyubaeva ES, Bobrov DYu, Stepanyants NG, Sukhova MYu, Samoilov AS. Three-Color FISH Method: Translocations in Peripheral Blood Lymphocytes Cultures before and after Local Gamma Radiation for Breast Cancer. Medical Radiology and Radiation Safety. 2022;67(4):62-68. DOI: 10.33266/1024-6177-2022-67-4-62-68
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Informed Consent
All patients signed an informed consent to participate in the study.
Article received: 11.04.2022. Accepted for publication: 11.05.2022
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 4
Peculiarities of Radionuclide Diagnosis of Signal Lymph Nodes in Patients of Breast Cancer with Using of Radiopharmaceutical Based on the Gamma-Aluminum Oxide Labeled with 99mTc
A.A. Medvedeva, V.I. Chernov, R.V. Zelchan, O.D. Bragina,
A.N. Rуbina, E.Iu. Garbukov, A.V. Doroshenko,
N.A. Tarabanovskaya
Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia
Contact person: Anna Alexandrovna Medvedeva, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To study the possibility of using [99mТс]-Al2O3 for the diagnosis of sentinel lymph nodes (SLN) in patients with breast cancer, to analyze the results obtained in comparison with a phytate colloid labeled with 99mTc.
Material and methods: The study included 86 patients with breast cancer. [99mTc]-phytate colloid (31 patients) and [99mТс]-Al2O3 (55 patients) were used as radiopharmaceutical.
Results: The optimal time interval between the injection of [99mТс]-Al2O3 and the acquisition of a scintigraphic image was determined to be 18-20 hours, when the maximum possible number of lymph nodes (LNs) with the most optimal level of radioactivity for their detection is visualized.
In the group of patients who were injected with [99mTc]-phytate colloid, SLN were visualized in 27 out of 31 patients, a total of 37 LNs were detected in this group. The median number of detected LNs in one patient was 1 [0–3], the intensity of accumulation of [99mTc]-phytate colloid according to single-photon emission computed tomography (SPECT) was 1.75% [0.5–4.3%], intraoperatively using gamma -probe – 2.95% [1.1–5.6%].
When [99mТс]-Al2O3 was used as radiopharmaceutical, SLNs were detected in 51 patients out of 55. In total, 111 LNs were detected in this group, the median number of detected LNs in one patient was 2 [0-6], the intensity of accumulation of [99mТс]-Al2O3 according to SPECT data – 6.1% [0.5–18.4%], intraoperatively – 7.2% [1.3–22.1%].
In the absence of radiopharmaceuticals accumulation in regional LNs (n=7 in total), 3 patients had total metastatic lesions of the SLN, in two of them other regional LNs were also affected by metastases.
Conclusion: A comparative analysis of the indices of two radiopharmaceuticals shows that studies with [99mТс]-Al2O3 are characterized by statistically significantly higher accumulation rates in the SLN compared with [99mTc]-phytate colloid. The number of detected LNs when using [99mТс]-Al2O3 was also higher than in the group with [99mTc]-phytate colloid. As a result, when [99mТс]-Al2O3 is used, the method is characterized by higher sensitivity in detecting SLN (94.5%).
Keywords: 99mТс, gamma alumina, sentinel lymph node, breast cancer
For citation: Medvedeva AA, Chernov VI, Zelchan RV, Bragina OD, Rуbina AN, Garbukov EIu, Doroshenko AV, Tarabanovskaya NA. Peculiarities of Radionuclide Diagnosis of Signal Lymph Nodes in Patients of Breast Cancer with Using of Radiopharmaceutical Based on the Gamma-Aluminum Oxide Labeled with 99mTc. Medical Radiology and Radiation Safety. 2022;67(4):74-79. DOI: 10.33266/1024-6177-2022-67-4-74-79
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 11.04.2022. Accepted for publication: 11.05.2022