JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 1
DOI: 10.33266/1024-6177-2023-68-1-5-14
V.A. Nikitina, T.A. Astrelina, V.Yu. Nugis, I.V. Kobzeva, E.E. Lomonosova,
Yu.B. Suchkova, T.F. Malivanova, V.A. Brunchukov, D.Yu. Usupzhanova,
V.A. Brumberg, A.A. Rastorgueva, E.I. Dobrovolskaya, T.V. Karaseva,
M.G. Kozlova, M.V. Pustovalova, A.K. Chigasova, N.Yu. Vorobyeva,
A.N. Osipov, A.S. Samoilov
Cytogenetic Analysis of the Cell Line of Multipotent Human Mesenchymal Stromal Cells during Long-Term Cultivation after Exposure to X-Ray Radiation at Low and Medium Doses
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: V.A. Nikitina, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To evaluate the frequency and spectrum of chromosome aberrations under X-Ray exposure at doses of 80, 250, and 1000 mGy in a human multipotent mesenchymal stromal cell (MMSC) cell line during long-term cultivation.
Material and methods: MMSCs were isolated from human gingival mucosa by an enzymatic method and cultured in a serum-free medium. The presence of surface antigens was determined using the method of flow cytometry. The ability of the cell line to differentiate in the osteogenic, adipogenic, and chondrogenic directions was studied using induction media. Authentication was performed by genotyping of polymorphic STR loci, cytogenetic analysis was performed by multicolor fluorescent in situ hybridization (mFISH). Irradiation was carried out on an X-ray biological unit RUB RUST-M1 (Russia) at a dose rate of 40 mGy/min, a voltage of 100 kV, and a current of 0.8 mA.
Results: At the first passage after irradiation, a statistically significant increase in the frequency of non-clonal CA compared with the control was recorded at a dose of 80, but not 250 and 1000 mGy. At the late stages of cultivation, the average frequency of breaks per chromosome in the group of non-irradiated cells did not differ from the values obtained after irradiation at doses of 80, 250, and 1000 mGy (p > 0.05). However, in MMSCs irradiated at a dose of 80 mGy, damage occurred more often in pairs of chromosomes 6 and 10, and at a dose of 1000 mGy, in a pair of chromosomes 9. A single irradiation of MMSCs in vitro did not affect the growth and progression of MMSCs characteristic of the studied primary cell line, of clonal cells with chromosome translocations and monosomy X, but led to an increase in the representation of a clone with tetrasomy 8. The total number of random clones with chromosome translocations that arose de novo increased after irradiation at a dose of 1000 mGy.
Conclusion: Minor fluctuations in the proportion of cells with non-clonal CA, depending on the dose received in the early stages after irradiation (passage 1–4), disappeared at the later stages of cultivation (passage 8–14). There were no differences in mean frequencies between irradiated and non-irradiated MMSCs, but after irradiation, damage to some chromosomes could occur more frequently than others. A single X-ray irradiation of MMSCs can promote the growth and progression of primary pathological cytogenetic clones, regardless of the dose received, as well as an increase in the total number of de novo cell clones with chromosomal translocations that have arisen. A single X-ray irradiation of MMSCs can promote the growth and progression of primary pathological cytogenetic clones, regardless of the dose received, as well as an increase in the total number of de novo cell clones with chromosomal translocations that have arisen.
Keywords: mesenchymal multipotent stromal cells, chromosome aberrations, mFISH, X -ray irradiation, low doses
For citation: Nikitina VA, Astrelina TA, Nugis VYu, Kobzeva IV, Lomonosova EE, Suchkova YuB, Malivanova TF, Brunchukov VA, Usupzhanova DYu, Brumberg VA, Rastorgueva AA, Dobrovolskaya EI, Karaseva TV, Kozlova MG, Pustovalova MV, Chigasova AK, Vorobyeva NYu, Osipov AN, Samoilov AS. Cytogenetic Analysis of the Cell Line of Multipotent Human Mesenchymal Stromal Cells during Long-Term Cultivation after Exposure to X-Ray Radiation at Low and Medium Doses. Medical Radiology and Radiation Safety. 2023;68(1):5–14. (In Russian). DOI: 10.33266/1024-6177-2023-68-1-5-14
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.09.2022. Accepted for publication: 25.11.2022.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 1
DOI: 10.33266/1024-6177-2023-68-1-15-18
D.V. Saleeva1, L.M. Rozhdestvensky1, N.F. Raeva1, E.S. Vorobeva1,
G.D. Zasukhina1,2
Mechanisms of Antitumor Activity of Low Doses of Radiation Associated with Activation of Cells’ Defense System
1A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
2Institute of General Genetics, Moscow, Russia
Contact person: D.V. Saleeva, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Background: The effects of ionizing radiation (IR) involve a highly orchestrated series of events in cells, including DNA damage and repair, cell death, and changes in the level of proliferation associated with the stage of the cell cycle. A large number of existing studies in literature have examined the activity of genes and their regulators in mammalian cells in response to high doses of ionizing radiation. Although there are many studies, the research in effect of low doses of ionizing radiation remains limited. Though much progress has been made in understanding the basic principles of effects of low doses radiation on individual components of biological systems, less is known about how low doses affect target molecules and regulate the cellular networks (e.g., activation of the immune system, genes and their regulators in the phenomenon of hormesis, the formation of an adaptive response). These observations determined the purpose of the work: to investigate the activity of genes and non-coding RNAs (long non-coding RNAs and microRNAs) in various organs of mice with transplanted Lewis carcinoma after low doses radiation.
Material and methods: 24 female mice C57Bl/6 were transplanted subcutaneously with Lewis carcinoma cells (105 cells in 0.2 ml of Hanks’ solution). Total 4-fold X-ray irradiation with an interval of 4 days at a dose of 0.075 Gy (0.85 Gy/min) was performed on the RUST M1 from 6 days after transplantation; the tumor size was measured daily. The mice were divided into the following groups: biocontrol, biocontrol+irradiation, tumor and tumor+irradiation. On the 19th day from the beginning of the experiment, the mice were euthanized. The expression profiles of mRNA genes, long non-coding RNAs and microRNAs controlling the response to radiation were determined in the bone marrow, thymus, spleen and tumor of mice.
Results: Fractionated low doses irradiation of mice with transplanted Lewis carcinoma caused a growth decrease of implanted tumour cells compared to the similar group without irradiation. At the same time, there was an activation of oncosuppressors, and a decrease in the activity of oncogenes in the thymus and spleen of mice with tumor and irradiation. In the tumor group, without irradiation, the number of activated oncogenes prevailed over the number of inactivated ones.
Conclusion: Thus, the low doses radiation exposure led to the activation of antitumor immunity in mice, which emerged in slowing tumor growth in animals and was represented in the induction of oncosuppressors and inhibition of oncogenes expression.
Keywords: low doses of radiation, Lewis carcinoma, non-coding RNA, oncogenes, oncosuppressors, mice
For citation: Saleeva DV, Rozhdestvensky LM, Raeva NF, Vorobeva ES, Zasukhina GD. Mechanisms of Antitumor Activity of Low Doses of Radiation Associated with Activation of Cells’ Defense System. Medical Radiology and Radiation Safety. 2023;68(1):15–18.
(In Russian). DOI: 10.33266/1024-6177-2023-68-1-15-18
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The work was carried out on the topic of the A.I. Burnazyan State Scientific Research Center «Technology-2» (state task No. 10.009.20.800) and on the topic of the N.I. Vavilov Institute of General Genetics of the Russian Academy of Sciences (state task No. 0112-2019-0002).
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.09.2022. Accepted for publication: 25.11.2022.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 1
DOI: 10.33266/1024-6177-2023-68-1-25-33
V.G. Barchukov, O.A. Kochetkov, V.N. Klochkov, N.A. Eremina, P.P. Surin,
A.A. Maximov, D.I. Kabanov, V.K. Velichko, N.A. Bogdanenko, Zh.I. Alsagaev
Distribution of Radiocarbon in the Environment
under Normal Conditions of Operating of Kurskaya Nuclear Power Plant
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: V.G. Barchukov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Introduction: 14C is one of the fifteen radionuclides that account for at least 99 % of the radiation dose to the critical group of the population from NPP emission sources. The continuous growth of the total capacity of operating NPPs leads to a significant increase in the amount of 14С emitted into the environment during NPP operation. Efficient capture and disposal of 14C, which has a half-life of 5760 years, is a very laborious undertaking. At the same time, due to the high mobility of this radionuclide, local foci of contamination with 14C can appear both near the NPP at a distance of 1–2 km from its ventilation pipe, and in soil and plants located at a distance of 20–30 km from the NPP due to the transfer of air masses. Therefore, the control of the formation of 14C during the operation of nuclear power plants, its content in emissions and discharges of nuclear power plants, as well as distribution in the environment is an urgent problem today.
Purpose: Analysis of the environmental pollution due to emissions and discharges of radiocarbon from the Kurskaya nuclear power plant.
Material and methods: During the research, a method being developed by specialists of the Laboratory for Radiation Safety of Personnel was used to determine the specific activity of 14C in soil and vegetation. To explore the 14C content in the air, the method of bubbling air through a TASC-HT-HTO-C-14 flow meter-sampler (Overhoff technology, USA) and the method of air conditioning through a Ballu BDH-15L air dryer (Ballu, Russia) were used. To prepare counting samples from selected soil and food samples, a method based on the combustion of selected samples in a Pyrolyser-6 Trio catalytic decomposition system was used. All prepared counting samples, including samples from surface water and biosubstrate of the personnel of the Kursk NPP and the population, were measured by liquid scintillation spectrometry on a Tri-Carb 3180 TR/SL alpha, beta spectrometer.
Results: On the basis of an integrated approach to assessing the content of 14C in air, water, soil and food, an analysis of the formation of environmental pollution due to emissions and discharges 14C from the Kurskaya NPP was carried out.
Conclusions: An increased content of the 14C radionuclide in soil samples, food products and vegetation in the area of the Kursk NPP with RBMK-1000 nuclear reactors is shown, both in comparison with the content of natural 14C and NPPs operating BN-600,800 and VVER-1000 nuclear reactors. The necessity of taking into account radiocarbon emissions from NPPs into the environment in the problem of optimizing the radiation protection of the population under the conditions of normal operation of NPPs is confirmed.
Keywords: radiocarbon, radiocarbon in soil, radiocarbon in vegetation, emission of radiocarbon, nuclear power plant
For citation: Barchukov VG, Kochetkov OA, Klochkov VN, Eremina NA, Surin PP, Maximov AA, Kabanov DI, Velichko VK, Bogdanenko NA, Alsagaev ZhI. Distribution of Radiocarbon in the Environment under Normal Conditions of Operating of Kurskaya Nuclear Power Plant. Medical Radiology and Radiation Safety. 2023;68(1):25–33. (In Russian). DOI: 10.33266/1024-6177-2023-68-1-25-33
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Research concept – Barchukov V.G., Kochetkov O.A.
Data collection and processing – Eremina A.A., Surin P.P., Alsagaev Zh.I., Valery G. Barchukov, Valerya K.Velichko, Dmitryi I. Kabanov.
Text writing and editing – Eremina N.A., Klochkov V.N., Aleksei A. Maximov, Natalya A.Bogdanenko.
Article received: 20.09.2022. Accepted for publication: 25.11.2022.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 1
DOI: 10.33266/1024-6177-2023-68-1-19-24
V.V. Petrova, P.A. Shulepov, T.D. Simagova, A.A. Petrov
The Concept of the Digital Twin of the Radiation and Nuclear Facilities’ Worker
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: V.V. Petrova, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Analysis of the possibilities of a predictive model for assessing the risks of pathology of the cardiovascular, cerebrovascular systems and psychophysiological state in workers of radiation and nuclear hazardous enterprises and industries as part of the development of the concept of a digital twin.
Material and methods: The study involved employees of one of the leading radiation and nuclear hazardous enterprises, who underwent periodic medical examinations at comprehensive medical health center of the A.I. Burnazyan Federal Medical and Biological Center in September–October 2022. In total 154 patients (115 men and 39 women) were questioned, examined, and analyzed medical records. Diagnostic criteria for risk factors and other pathological conditions and diseases that increase the likelihood of developing chronic non-communicable diseases were evaluated both in accordance with the orders of the Ministry of Health and using the AI-HIPPOCRAT digital prognostic model developed by the Computer Science and Management Federal Research Center.
Results: In accordance with the criteria specified in the orders of the Ministry of Health, it was revealed that high or very high risks of developing diseases such as heart attack, stroke, hypertension and depression are observed in 120 people (77.9 %), and according to the analysis in the AI-HIPPOCRAT system, these risks occur in 131 people (85.1 %).
Conclusion: As a result of the study, the capabilities of the AI-HIPPOCRATE system were analyzed and the following recommendations were given for its use by workers of radiation and nuclear hazardous enterprises and industries: to integrate the AI-HIPPOCRAT system into the medical information system used at the enterprise; to divide the presented risk factors into three groups: manageable (on which the doctor or patient can influence), conditionally manageable (which can be influenced by the use of drugs) and uncontrollable, which the doctor and the patient cannot manage (for example, gender, age, etc.); to raise the threshold for setting the risk of a particular disease to “high and above”.
Keywords: predictive model, digital twin, risk assessment, periodic medical examination, radiation and nuclear facilities, staff
For citation: Petrova VV, Shulepov PA, Simagova TD, Petrov AA.The Concept of the Digital Twin of the Radiation and Nuclear Facilities’ Worker. Medical Radiology and Radiation Safety. 2023;68(1):19–24. (In Russian). DOI: 10.33266/1024-6177-2023-68-1-19-24
References
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. FITZ IU RAS.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.09.2022. Accepted for publication: 25.11.2022.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 1
DOI: 10.33266/1024-6177-2023-68-1-34-40
I.A. Galstian, A.Yu. Bushmanov, M.V. Konchalovsky, V.Yu. Nugis,
N.A. Metlyaeva, F.S. Torubarov, V.V. Korenkov, A.A. Davtian, D.A. Dubovoy
Features of the Dynamics of the Peripheral Blood Lymphocytes
during the First Week in Combined Radiation-Mechanical Lesions
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: I.A. Galstian, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
For a long time, the attention of researchers studying combined radiation-mechanical injuries (CRMI) has been focused on the study of individual syndromes: mechanical trauma and acute radiation syndrome. To diagnose and assess the severity of each syndrome, tests used for isolated injuries are recommended. However, the results of tests based on counting the number of different peripheral blood cells in an initially healthy person and in an injured patient who has experienced severe bleeding will be different. Accordingly, the assessment of the severity of developing acute radiation disease these patients will differ.
The possibility of predicting the severity of developing radiation injury in CRMI using a lymphatic test during the first week after exposure is also being evaluated. In this report, based on the literature data, the dynamics of the absolute number of lymphocytes in patients with multiple mechanical injuries is considered.
The results of numerous clinical and experimental studies indicate that severe and multiple injuries, starting from the first hours and during the first week of observation, are characterized by instability of the number of lymphocytes in peripheral blood with significant absolute lymphopenia on the first day. It is shown that the depth of lymphopenia and the rate of recovery of the number of lymphocytes to normal values depends on the severity of the mechanical injury. In addition, the deepening of lymphopenia is also caused by urgent medical measures that are standard in the provision of medical care for severe trauma with blood loss: massive infusion therapy and the appointment of corticosteroids.
Thus, the use of a lymphocytic test in CRMI to assess the radiation dose without taking into account the significance of the trauma suffered will lead to a false prognosis of the degree of developing acute radiation damage, as well as to the lack of differentiation between the effects of radiation and non-radiation factors, and, consequently, to errors in patient management tactics.
Keywords: combined radiation-mechanical lesions, acute radiation sickness, biodosimetry, lymphocytes, lymphocyte test
For citation: Galstian IA, Bushmanov AYu, Konchalovsky MV, Nugis VYu, Metlyaeva NA, Torubarov FS, Korenkov VV, Davtian AA, Dubovoy DA. Features of the Dynamics of the Peripheral Blood Lymphocytes during the First Week in Combined Radiation-Mechanical Lesions. Medical Radiology and Radiation Safety. 2023;68(1):34–40. (In Russian). DOI: 10.33266/1024-6177-2023-68-1-34-40
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.09.2022. Accepted for publication: 25.11.2022.