JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Issues journals
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 2
Statistical Forecasting of 137Cs Accumulation
in Crop Production on Radioactively Contaminated Lands
S.I. Spiridonov, V.V. Ivanov, I.E. Titov
Russian Institute of Radiology and Agroecology, Obninsk, Russia
Contact person: S.I. Spiridonov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: the development of statistical models for forecasting the accumulation of 137Cs in crop production, model parameterisation and prognostic estimates for the territories of the Bryansk region contaminated with 137Cs because of the Chernobyl accident.
Material and methods: The use of a probabilistic approach for correct predictive assessments of the safety of agricultural products from radioactively contaminated agricultural lands has been substantiated. Analytical models were developed in the framework of a probabilistic approach to predict the risks of radioactive contamination of crop products, to assess the permissible levels of contamination of arable lands and the time of their natural remediation.
Results: Based on a statistical analysis of radioecological survey data, it was established that the 137Cs contamination density of the soil follows a lognormal distribution law with a high level of significance. For farms in the south-western districts of the Bryansk region, it was shown that, if the average values of 137Cs content in crop production corresponded to the established standard, the risks of its excess could reach 30 %. This is due to the variability of 137Cs soil contamination densities and migration parameters. The dependences of limiting soil contamination densities of 137Cs on the risk of exceeding the standards (RES) of the content of this radionuclide in products were presented. The time of natural rehabilitation of arable agricultural land with a given risk for products of 10 % can exceed 30 years.
Conclusion: The application of probabilistic methods to predict the consequences of 137Cs contamination of agricultural lands makes it possible to correct practical recommendations developed on the basis of a deterministic approach. The results of prognostic calculations are the basis for planning and evaluating the possibility of returning territories contaminated by 137Cs to economic use. The developed methodology and models can be used in the development of decision support systems for the remediation of agricultural lands exposed to radioactive fallout.
Keywords: radioactively contamination agricultural lands, crop production, statistical models, risk of exceeding the standard, lognormal distribution, the Bryansk region, south-western districts
For citation: Spiridonov SI, Ivanov VV, Titov IE. Statistical forecasting of 137Cs accumulation in crop production on radioactively contaminated lands. Medical Radiology and Radiation Safety. 2022;67(2):10-17. (In Russian) doi: 10.33266/1024-6177-2022-67-2-10-17
References
1.Panov A.V., Sanzharova N.I., Shubina O.A., Gordienko E.B., Titov I.E. Contamination of agricultural lands in Bryansk, Kaluga, Orel and Tula regions with 137Cs as a result of the Chernobyl accident: current status and prognosis. Radiatsiya i risk = Radiation and Risk. 2017;26;3:66-74. (In Russian).
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riy = Radioecological Consequences of the Chernobyl Accident: Biological Effects, Migration, Rehabilitation of Contaminated Areas. Moscow, RAN Publ., 2018. 278 p. (In Russian).
3.Shubina O.A., Titov I.YE., Krechetnikov V.V., Sanzharova S.I. Results of Complex Passportization of Agricultural Lands of South-Western Districts of the Bryansk Region Polluted by Radionuclides. Agrokhimicheskiy vestnik = Agrochemical Herald. 2017;3:35-39 (In Russian).
4.Krechetnikov V.V., Titov I.E., Shubina O.A., Prudnikov P.V. Assessment of current radioecological situation of agricultural landsin the Novozybkov district of the Bryansk region. Vestnik Bryanskoy Gosudarstvennoy Selskokhozyaystvennoy Akade-
mii = Bulletin of the Bryansk Agricultural Academy. 2017;62;4:25-30 (In Russian).
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11.Spiridonov C.I., Ivanov V.V. Probabilistic Assessment of Radionuclide Accumulation in Agricultural Products and Permissible Levels of Radioactive Contamination of Soils. Radiatsionnaya Biologiya. Radioekologiya = Radiation Biology. Radioecology. 2013;53;1:95-103 (In Russian).
12.Spiridonov C.I., Ivanov V.V. Statistical Prediction of Consequences of Radioactive Contamination of Pasture Agricultural Lands. Radiatsionnaya Biologiya. Radioekologiya = Radiation Biology. Radioecology. 2014;54;6:621-631 (In Russian).
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19.Yamamura K., Fujimura S., Ota T., Ishikawa T., Saito T., Arai Y., Shinano T. A Statistical Model for Estimating the Radiocesium Transfer Factor from Soil to Brown Rice Using the Soil Exchangeable Potassium Content. Journal of Environmental Radioactivity. 2018;195:114-125.
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21.Spiridonov S.I., Ivanov V.V., Titov I.E., Nushtaeva V.E. Radioecological Assessment of Forage Agricultural Land in the Southwestern Areas of the Bryansk Region Based on a Set of Statistical Models. Radiatsiya i Risk = Radiation and Risk. 2021;30;2:38-49 (In Russian).
22.Panov A.V., Prudnikov P.V., Titov I.E., Krechetnikov V.V., Ratnikov A.N., Shubina O.A. Radioecological Assessment of the Agricultural Lands and Products in South-West Districts of the Bryansk Region Contaminated by Radionuclides as the Result of the Chernobyl NPP Accident. Radiatsionnaya Gygiena = Radiation Hygiene. 2019;12;1:25-35 (In Russian).
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 30.11.2021. Accepted for publication: 30.03.2022.
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 2
Socio-Psychophysiological Assessment of Two Patients
with Local Radiation Injuries
N.A. Metlyaeva, A.Yu. Bushmanov, I.A. Galstyan, V.Yu. Nugis,
M.V. Konchalovsky, O.V. Shcherbatykh, F.S. Torubarov
A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: N.A. Metlyaeva, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: A socio-psychophysiological assessment of the adaptation of two patients with local radiation injuries (LRI) of the hands of severe and moderate severity and acute radiation sickness (ARS) of the 1st degree, according to the characteristics of their individual mental adaptation and the stages of the course of local radiation injuries (30 years of observation).
Material and methods: Psychophysiological examination was carried out on two patients, former border guards, who were injured on October 5, 1982 as a result of accidental contact with a source of gamma radiation (cesium – 137) while on duty while serving on the Iranian-Azerbaijani border in the ranks of the USSR army. They suffered grade I ARS with extremely uneven gamma irradiation in the form of local radiation injuries of the hands of varying severity. The assessment of the average dose to the whole body by the frequency of dicentrics in the cultures of peripheral blood lymphocytes in patient No. 1 and patient No. 2 is the same and amounts to 0.26 Gy. One of them, patient No. 1, had a local radiation injury of the left and right hand of the III degree of severity. In 1984 – 1985, he underwent amputation of the nail phalanges of the 1st and 2nd fingers of the left hand; in 2003, skin grafting was performed for late radiation ulcer of the 3rd fingers of the left hand. Patient No. 2 had grade III-IV LRI in both hands with severe and extremely severe sequelae of local radiation damage to both hands. Amputation stumps 1 – 5 fingers of the right and left hand. Rough cicatricial – atrophic changes in the skin of the left hand with a violation of its function. Condition after multiple surgical interventions, including autotransplantation of full-thickness flaps on vascular pedicles. Psychophysiological research was carried out in dynamics in 2001, 2003, 2008, 2009, 2011, 2013 using the automated software and methodological complex “Expert”, designed to study personal properties of a person, cognitive and intellectual characteristics of a person according to the MMPI method, the Cattell,s 16-Personality Factor Questionnaire (16PF), Raven’s Progressive Matrices test, sensorimotor reaction (SSR, СSR) and reaction to a moving object (RMO).
Results: According to MMPI data, both victims have a hyperthymic type of psychophysiological adaptation with varying degrees of severity. Patient No. 2 is a chronically hyperthymic personality with a significant increase in the profile on scale 9 and with a gradual increase in dynamics, which reflects the persistence of hyperthymic personality characteristics and causes an overstrain of mental adaptation, with an increase in the dynamics of the tendency to explain their difficulties and problems with somatic ill-being (1Hs). Characterological features were determined by high emotionality (factor A – 9.8 stan), sufficiently high intelligence (factor B – 7.3 stan), sufficient integration and sthenism of behavior, high dominance and freedom of behavior (factor F – 8.5 stan), due to a propensity for increased self-esteem, a high propensity to take risks (H – 9.3 stan), down-to-earth interests (factor M). Very high extroverted behavior (factor F2 –--- 9.9 stan). High rates of the Raven test and sensorimotor reactions. Thus, the personality profile of patient No. 2 has the form of a pronounced chronic hyperthymic personality, which determines the overstrain of mental adaptation, with manifestations of psychosomatic hypochondria.
Patient No. 1, according to the data of psychophysiological examination, revealed a hyperthymic personality type with a moderate increase in the dynamics of the profile on the ninth scale. The personality trait is also indicated by a high, growing in dynamics, indicator on the K scale, which determines behavior depending on social approval and concern for one’s social status. On the first three scales (1, 2, 3) there is a type of conversion V – this is a combination of unpleasant physical sensations with vegetative anxiety and with a predominance of demonstrative tendencies aimed at overcoming difficulties caused by the state of health (scales 1 and 3). The appearance in dynamics (2013) of a peak on scales 1 and 4 determines the insufficient ability to internalize the social norm, i.e. insufficient ability to perceive this norm as part of their own attitudes (combination of profile peaks on scales 4 and 9). The presence of profile peaks on the 7th scale and on the scales of the neurotic triad reflect the tendency towards various options for the implementation of asocial attitudes in a socially acceptable way, the desire to look in a favorable light (scale L). A sufficiently high intelligence and demonstrative behavior determine good adaptation to the environment with self-confidence, high social adaptability, and resilience in overcoming difficulties.
Conclusion: Psychophysiological assessment of personality and current mental state determined individual personality traits in two patients with hyperthymic type of psychophysiological adaptation of varying severity, who underwent ARS, severe and extremely severe local radiation injuries 30 years after the radiation incident, respectively.
A significant increase in the profile on the 9th scale in patient No. 2 was constantly detected, reflecting the persistence of the described personality traits characteristic of chronically hyperthymic individuals. A high level of hyperthymic activity causes him to overstrain his psychophysiological adaptation, with manifestations of psychosomatic hypochondria
A moderate increase in the profile on scale 9 and scale 3 characterized patient No. 1 as an optimistic, energetic and capable of high activity person, concerned about his social status (high values on the K scale). The appearance in the dynamics (2013) of a peak on the 1 (concern with the state of health) and 4 on the scale (emotional tension in direct behavior) determine the insufficient ability to internalize the social norm, i.e. insufficient ability to perceive this norm as part of one’s own attitudes (combination of profile peaks on scales 4
and 9). The presence of profile peaks on the 7th scale and the scales of the neurotic triad reflect the tendency for the implementation of asocial attitudes in a socially acceptable way.
Keywords: local radiation injuries, acute radiation sickness, criminal incident, military service, socio-psychophysiological assessment
For citation: Metlyaeva NA, Bushmanov AYu, Galstyan IA, Nugis VYu, Konchalovsky MV, Shcherbatykh OV, Torubarov FS. Socio-psychophysiological assessment of two patients with local radiation injuries to the hands. Medical Radiology and Radiation Safety. 2022;67(2):18-24. (In Russian) doi: 10.33266/1024-6177-2022-67-2-18-24
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 30.11.2021. Accepted for publication: 30.03.2022.
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 2
Problems of Scintigraphic Diagnosis of Inflammatory Heart Disease and Methods of Their Correction
I.N. Ilyushenkova, Zh.Zh. Anashbaev, E.V. Popov, S.I. Sazonova
Tomsk National Research Medical Center, Tomsk, Russia
Contact person: I.N. Ilyushenkova, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
The present review is devoted to the issues of topical diagnostics of inflammatory myocardial diseases, problems that arise at the stages of primary data collection, processing and interpretation of results, as well as ways to solve them. The paper describes the basic principles of indication of focal pathological inclusions of radiopharmaceuticals by single-photon emission computed tomography and current approaches used in world practice to eliminate motor and respiratory artifacts that affect the diagnostic effectiveness of molecular imaging. Literature search was performed using electronic bibliographic databases, such as PubMed, E-library, Medline, GoogleShcolar.
Keywords: inflammation, scintigraphy, motion correction, respiratory correction, SPECT/CT, myocarditis.
For citation: Ilyushenkova IN, Anashbaev ZhZh, Popov EV, Sazonova SI. Problems of scintigraphic diagnosis of inflammatory heart disease and methods of their correction. Medical Radiology and Radiation Safety. 2022;67(2):32-37. (In Russian) doi: 10.33266/1024-6177-2022-67-2-32-37
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 30.11.2021. Accepted for publication: 30.03.2022.
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 2
Risk of prostate cancer among Chernobyl clean-up workers,
1996-2018
А.I. Gorski1, М.А. Maksioutov1, K.A. Tumanov1, E.V. Kochergina1, V.K. Ivanov1, S.A. Ivanov1, A.D. Kaprin2
1 A.F. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre, Obninsk, Russia
2 National Medical Research Radiological Centre, Moscow, Russia
Contact person: A.I. Gorski, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: The paper deals with the occurrence of prostate cancer and mean survival time following a diagnosis of the disease among Chernobyl clean-up workers.
Material and methods: Clinical and dosimetry data accumulated at the National Radiation and Epidemiological Registry (NRER) during the period from 1996 over 2018 were used for the study. The study cohort consisted of 69,698 men. During the follow-up 742 prostate cancer cases were detected, all patients had radiation dose records, the disease stage was established in 628 patients. To assess radiation risk maximum likelihood approach was used. Mean survival time was evaluated with the use of the relationship between a disease prevalence and newly detected disease cases intensity in a stationary population (diseases intensity is equal to intensity of mortality from all causes).
Results: Excess relative risk of prostate cancer induction per 1 Gy was 0.74 (95 % CI: ‒0.31; 2.15) and it was statistically insignificant. Standardized incidence ratios between clean-up workers and male population of Russia within 95 % confidence limits do not differ from 1.0. Mean survival time after the disease diagnosis within the period from 1996 over 2018 was 3.5±1.3 years. The relationship between a survival time and a disease stage was estimated. Survival time for cases with 1–3 stages 3.3±2.9, 3.6±2.3, 4.3±2.7 years respectively. The less survival time for cases with stage 4 was 1.5±0.8 years. Mean mortality rate, i.e. the ratio of the number of clean-up workers died from prostate cancer to the total number of clean-up workers with diagnosed prostate cancer was 36.8 %, for stages 1–4 it was 20, 16, 37, 74 % respectively. Mean survival time in the groups with doses less than and higher than 150 mGy was 3.4±1.4 and 3.7±1.7, respectively. Presented data confirm the null hypothesis that there is no difference in survival times (p=0.20).
Conclusion: Increase in prostate cancer incidence becomes the social problem not only in Russia but in other countries as well. The paper presents results of comprehensive radiation epidemiological analysis of prostate cancer incidence in cleanup workers, who constitute the representative sample of the Russian male population. The dose ‒ prostate cancer incidence relationship for the follow-up period from 1996 over 2018 is not statistically significant, although the value of excess relative risk per dose unit is positive. It is not unthinkable that the absence of statistical significance is caused due to limited length of the follow-up period. But at the same time, the fact that observed the standardized incidence ratio is 1.0 and characteristics of two groups with doses ≥150 mGy are similar, speaks of the lack of a significant radiation effect. The obtained results of the analysis confirm our view of the necessity to continue the study.
Key words: prostate cancer, morbidity, Chernobyl clean-up workers (liquidators), National Radiation and Epidemiological Registry, radiation risk, average survival time after diagnosis, tumor stage
For citation: Gorski АI, Maksioutov МА, Tumanov KA, Kochergina EV, Ivanov VK, Ivano SA, Kaprin AD. Risk of prostate cancer among Chernobyl clean-up workers, 1996-2018. Medical Radiology and Radiation Safety. 2022;67(2):25-31. (In Russian)
doi: 10.33266/1024-6177-2022-67-2-25-31
References
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3. Ivanov V.K., Maksyutov M.A., Tumanov K.A., et al. 35-Year Experience in the Functioning of the National Radiation and Epidemiological Registry as a State Information System for Monitoring the Radiological Consequences of the Chernobyl Accident. Radiatsiya i risk = Radiation and Risk. 2021;30;1:7–39. (In Russian).
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5. Ivanov V.K., Gorskiy A.I., Kashcheev V.V., et al. Latent Period in Induction of Radiogenic Solid Tumors in the Cohort of Emergency Workers. Radiat. Environ. Biophys. 2009;48;3:247–252.
6. Gorskiy A.I., Kashcheev V.V., Tumanov K.A. Latent Period in Induction of Radiogenic Solid Tumors in the Cohort of Emergency Workers. Radiatsiya i risk = Radiation and Risk. 2008;17;2:30–38. (In Russian).
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 30.11.2021. Accepted for publication: 30.03.2022.
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 2
THE FIRST EXPERIENCE OF CLINICAL USE 99mTс-DARPinG3 FOR RADIONUCLIDE DIAGNOSIS OF BREAST CANCER WITH HER2/neu OVEREXPRESSION
O.D. Bragina1,2, V.I. Chernov1,2, S.M. Deyev2,4, A.G.Vorobyeva4, E.V. Konovalova3, A.M. Orlova2,4, A.A. Shulga4,
E.Yu. Garbukhov 1, R.V. Zelchan 1,2, A.A. Medvedeva1, V.M. Tolmachev4
1Tomsk National Research Medical Center of Cancer Research Institute, Tomsk, Russia
2 National Research Tomsk Polytechnic University, Tomsk, Russia
3Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
4 Uppsala University, Uppsala, Sweden
Contact person: O.D. Bragina, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To study the possibility of clinical use of the radiopharmaceutical 99mТс – DARPinG3 for the diagnosis of breast cancer with HER2 / neu overexpression in humans.
Material and methods: The clinical study was registered with ClinicalTrials.gov Identifier: NCT04277338 and approved by the Bioethical Committee of the Research Institute of Oncology of the Tomsk National Research Medical Center. The study included 9 breast cancer patients (T1-4N0-2M0-1) before systemic treatment: 5 – with HER2/neu overexpression; 4 – with negative expression. In all cases, a morphological and immunohistochemical study of the tumor biopsy material was carried out. The dosage of the DARPinG3 protein was 1000 μg; labeling was carried out according to the tricarbonyl technique. WholeBody scintigraphy and single-photon emission computed tomography were performed on an E.CAM 180 gamma camera from Siemens (Germany) at 2, 4, 6 and 24 hours after injection.
Results: The first clinical studies of 99mTc – DARPinG3 at a dosage of 1000 µg demonstrated the safety and the absence of toxic effects on patients with breast cancer. The radiopharmaceutical demonstrated rapid elimination from the bloodstream and an specific effective dose
(0.011 ± 0.001 mSv / MBq), comparable to results of other representatives of alternative scaffold proteins labeled with various isotopes. The highest accumulation of the labeled protein was observed in patients with HER2-positive breast tumors at 2 and 4 hours after injections
(p <0.05, Mann‒Whitney test).
Conclusion: The obtained results indicate that 99mTc-DARPinG3 is safe for clinical use in human and can be considered as a new additional method for diagnosing HER2-positive breast tumors.
Keywords: radionuclide diagnostics, scaffold proteins, DARPinG3, breast cancer, HER2/neu
For citation: Bragina OD, Chernov VI, Deyev SM, Vorobyeva AG, Konovalova EV, Orlova AM, Shulga AA, Garbu-
khov EYu, Zelchan RV, Medvedeva AA, Tolmachev VM. The first experience of clinical use 99mtc-darping3 for radionuclide diagnosis of breast cancer with her2/neu overexpression. Medical Radiology and Radiation Safety. 2022;67(2):38-42. (In Russian) doi: 10.33266/1024-6177-2022-67-2-38-42
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(In Ukr.).
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4. Bragina O.D., Chernov V.I., Zelchan R.V., Sinilkin I.IG., Medvedeva A.A., Larkina M.S. Alternative Scaffolds in Radionuclide Diagnosis of Malignancies. Byulleten Sibirskoy Meditsiny – Bulletin of Siberian Medicine. 2019;18;3:125-133 (In Russ.).
5. Shilova O.N., Deyev S.M. DARPins: Promising Scaffolds for Theranostics. Acta Nature. 2019;11;1:42-53 (In Russ.).
6. Bragina O.D., Larkina M.S., Stasyuk E.S., Chernov V.I., Yusubov M.S., Skuridin V.S., et. al. Development of Highly Specific Radiochemical Compounds Based on 99m Tc-Labeled Recombinant Molecules for Targeted Imaging of Cells Overexpressing Her-2/neu. Byulleten Sibirskoy Meditsiny – Bulletin of Siberian Medicine. 2017;16;3:25–33 (In Russ.).
7. Chernov V., Sinilkin I., Choynzonov E., et. al. Comparative Evaluation on 99mTc-Fitat Nanocolloids for Sentinel Lymph Nodes Visualisation in Patients with Cancer of Larynx and Hypopharynx. European Journal of Nuclear Medicine and Molecular Imaging. 2015;42;S1:704.
8. Vorobyeva A., Schulga A., Konovalova E., et. al. Optimal Composition and Position of Histidine-Containing Tags Improves Biodistribution of 99mTc-Labeled DARPin G3. Scientific Reports. 2019;9;1:9405.
9. Bragina O., Chernov V., Schulga A., et. al. Phase I Trial of 99mTc-(HE)3-G3, a DARPin-Based Probe for Imaging of HER2 Expression in Breast Cancer. Journal of Nuclear Medicine. 2021:Jnumed.121.262542. DOI: https://doi.org/10.2967/jnumed.121.262542.
10. Bragina O., Witting E., Garousi J., et. al. Phase I Study of 99mTc-ADAPT6, a Scaffold Protein-Based Probe for Visualization of HER2 Expression in Breast Cancer. Journal of Nuclear Medicine. 2021;62;4:493-499.
11. Bragina O.D., Chernov V.I., Garbukov E.Yu., et. al. Possibilities of Radionuclide Diagnostics of Her2-Positive Breast Cancer Using Technetium-99m-Labeled Target Molecules: the First Experience of Clinical Use. Byulleten sibirskoy meditsiny – Bulletin of Siberian Medicine. 2021;20;1:23-30 (In Russ.).
12. Bragina O.D., Chernov V.I., Tashireva L.A., Zelchan R.V., Medvedeva A.A., Lukina N.M., Goldberg V.E., Tolmachev V.M. Determination of the most Informative Prognostic Parameters for Assessing the Status of the Epidermal Growth Factor Receptor Her2/neu in the Primary Tumor in Breast Cancer Patients Using the Targeted Radiopharmaceutical «99mTс-ADAPT6». Voprosy onkologii – Problems of Oncology. 2021;67;3:368-373 (In Russ.).
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 30.11.2021. Accepted for publication: 30.03.2022.