SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Issues journals

Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 6. P. 25-49

RADIATION EPIDEMIOLOGY

A.N. Koterov, L.N. Ushenkova, A.P. Biryukov, V.V. Uyba

Risk of Thyroid Cancer After Exposure to 131I: Combined Analysis of Experimental and Epidemiological Data Over Seven Decades. Part 1. Actual Problems and Statement of Tasks for Series of Researches

A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

The first, goal­setting paper on analytical studies scheduled cycle on the question of the possible realistic thresholds for 131I carcinogenic effect to the thyroid gland was presented.

The problem of thyroid cancer in radiation epidemiology, radiation medicine and radiation risk of nuclear power plants assessments by people and the media was considered. The importance of this neoplasm in a purely scientific aspect was accented because the thyroid for some indicators is one of the most radiosensitive organs in terms of tumor formation (including the relative risk of cancer induction after irradiation). At the same time, the practical aspect of thyroid cancer does not seem to be relevant in connection with its low background level in the population and the low absolute risk of increased frequency of this tumor after radiation exposure. The bibliographic and bibliometric study of sources in PubMed for the period 1960-2015 revealed no special significance for the work on radiogenic thyroid cancer compared with radiogenic leukemia and two other important in radiation aspect solid tumors (breast and lung).

However, a similar study of documents of UNSCEAR (since the founding of the Committee), BEIR (BEIR­VII) and ICRP (Publication 99 and 103) showed a dramatic, statistically significant, permanent increase in the relevance of thyroid cancer (according to increase the number of references from 1964 to 2015) in contrast to the other neoplasm mentioned above. A similar pattern was found for the citation in 4 editions of the textbook «Radiation Biology of Human and Animals» (1977-2004). This proves the growth of relevance and popularity of thyroid cancer for the worldwide radiation epidemiology and radiobiology as the theme of discussion and risk assessment.

The view was expressed that on the basis of a common view on the reviews on radiobiology and radiation epidemiology of thyroid cancer after exposure to 131I for the entire study period (from the 1940s) to date there is no fullness and completeness in terms of the final risk assessments for all dose ranges; it is not clear the realistic schedule impact on any experiment or on the contingent of people (and whether it is in principle). Therefore concluded on the significance of the appropriate work cycle which provides observational studies and possibly combined analysis data (meta and/or pooled analysis) for the maximum total number of sources both in epidemiology and in radiation biology of 131I carcinogenic effects on the thyroid. Radiation biology studies are considered for determination of biological plausibility extent according to Hill causality criteria.

Key words: thyroid cancer, 131I, combined analysis of data, radiation biology, radiation epidemiology

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For citation: Koterov AN, Ushenkova LN, Biryukov AP, Uyba VV. Risk of Thyroid Cancer After Exposure to 131I: Combined Analysis of Experimental and Epidemiological Data Over Seven Decades. Part 1. Actual Problems and Statement of Tasks for Series of Researches. Medical Radiology and Radiation Safety. 2016;61(6):25-49. Russian.

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Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 6. P. 64-67

NUCLEAR MEDICINE

N.E. Kosykh1, S.Z. Savin1, T.P. Potapova2

The Use of Textural Analysis for Assessment of Differences Between Metastatic and Non-Metastatic Zones on Planar Bone Scintigrams

1. Computer Center of Far-Eastern Branch, Russian Academy of Sciences, Khabarovsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Far-Eastern State Medical University, Khabarovsk, Russia

Abstract

Purpose: Study of metastatic images’ textural characteristics on planar scintigrams of skeleton.

Material and methods: The study involves computer analysis program for automatic assessment of skeletal metastases which is based on image recognition principles and is capable of expert analysis. The program’s functionality includes skeleton image segmentation, calculation of textural, histogrammic and morphometric parameters, creation of learning sample, dividing segmented foci to pathological and non-pathological by means of classifying function based on support vector machine. The study is based on planar scintigraphy data assessment of 168 patients with disseminated breast cancer. Computer automated analysis was used to distinguish pathological (metastatic) from physiological (non-metastatic) radiopharmaceutical hyperfixation foci in which Haralick’s textural features were determined: autocorrelation, contrast, forth feature and heterogeneity. On anterior view scintigrams, in a segmented skeleton, 8 zones were selected: scull, accessory sinuses of the nose, spine, sternum, thorax, pelvis, large joints and long cortical bones. On posterior view scintigrams 6 zones were selected: scull, spine, thorax, large joints and long cortical bones. Weighted means were calculated for each zone. Derived values for pathological and non-pathological hyperfixation foci were paralleled with calculation of Students’ criteria.

Results: In most skeletal zones textural Haralick’s features prevail in pathological hyperfixation foci over similar values in physiological hyperfixation foci. Differences by all 5 features between pathological and physiological radiopharmaceutical hyperfixation foci on frontal scintigrams were found in sternal and pelvic zones. On posterior scintigrams they were found only in pelvic zones. Most commonly in pathological hyperfixation foci (both posterior and anterior scintigrams) prevalence of contrast was found in comparison with similar features of physiological hyperfixation foci.

Conclusion: Results of our research show possibility of Haralick’s textures application for differential diagnostics of metastatic and non-metastatic foci on planar bone scintigrams by means of computer automated analysis.

Key words: automated computer analysis, image recognition, planar scintigrams, hyperfixation zone, radiopharmaceutical, histograms, image brightness

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For citation: Kosykh NE, Savin SZ, Potapova TP. The Use of Textural Analysis for Assessment of Differences between Metastatic and Non-Metastatic Zones on Planar Bone Scintigrams. 2016;61(6):64-7. Russian.

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Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 6. P. 68-71

NUCLEAR MEDICINE

V.I. Chernov1,2, I.G. Sinilkin1,2, R.V. Zelchan1,2, A.A. Medvedeva1,2, A.Yu. Lyapunov1, O.D. Bragina1,2, N.V. Varlamova2, V.S. Skuridin2

Experimental Study of the Possibility of Using a New Radiopharmaceutical 99mТс-Al2O3 for Imaging Sentinel Lymph Nodes

1. Tomsk National Research Medical Center, Tomsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. National Research Tomsk Polytechnic University, Tomsk, Russia

Abstract

Purpose: A comparative study of the possibility of using the radiopharmaceutical 99mТс-Al2O3 and 99mTc-Nanocis for visualizing sentinel lymph nodes in the experiment.

Material and methods: The pharmacokinetics of radiopharmaceuticals 99mТс-Al2O3 and 99mTc -Nanocis studied on white rats. After 1, 2, 3, 5, and 24 hours after subcutaneous injections of radiopharmaceuticals in I (interdigital) web space of right hind limb of the activity of 30 MBq animals were decapitated, harvested organs subjected to radiometric examination, which is performed on the radiometer RIS-A1 Dosekalibrator. The possibility of using 99mТс-Al2O3 and 99mTc -Nanocis for sentinel lymph nodes visualization was performed on the CAM-E-180 (Siemens) gamma camera. In 1, 2, 3 and 24 hours after subcutaneous injections of drugs between the first and second fingers hind paw at activity 18-20 MBq scintigraphy was performed for anesthetized animals. According to the results of scintigraphic studies % accumulation of the drug in the inguinal lymph node was determined relative to the injection site.

Results: Radiometry of organs in rats showed that 99mТс-Al2O3 and 99mTc -Nanocis actively leave the injection site after subcutaneous injection. After 24 hours in the subcutaneous depot remained about half of the radiopharmaceutical activity. After 1 hour after administration of the average accumulation of 99mТс-Al2O3 in the inguinal lymph node was 8.6 %, the accumulation of 99mTc -Nanocis was significantly lower - 1,8 % (p < 0.05). The second hour of the study the average accumulation of 99mТс-Al2O3 exceeded 10 % and in a day gradually increased to 12.8 % in the lymph node. Accumulation of 99mTc -Nanocis after 2 hours reached 3.6 % and slightly fluctuated at this level up to 24 hours of the observation. Received through the thoracic duct into the blood radioactive tracers very actively accumulated in liver and spleen. Radiopharmaceuticals slightly accumulated in the heart, lungs and blood, which absorbed less than 1 % of the administered radioactivity.

Conclusions: Thus, the experimental study of a new domestic radiopharmaceutical 99mТс-Al2O3 showed that the nanocolloid several times more actively accumulates in the lymph nodes as compared to the imported analogue and its practical application will facilitate intraoperative identification of sentinel lymph nodes.

Key words: sentinel lymph nodes, radiopharmaceutical, tumor, colloid, 99mТс

REFERENCES

  1. Kanaev S.V., Novikov S.N., Zhukova L.A. et al. Ispol'zovanie dannykh radionuklidnoi vizuali-zatsii individual'nykh putei limfoottoka ot no-voobrazovanii molochnoi zhelezy dlya planirova-niya luchevoi terapii. Voprosy onkologii. 2011. Vol. 57. No. 5. P. 616-621. (In Russ.).
  2. Chernov V.I., Afanas'ev S.G., Sinilkin A.A. et al. Radionuklidnye metody issledovaniya v vyyav-lenii «storozhevykh» limfaticheskikh uzlov. Sib. onkol. zhurnal. 2008. Vol. 28. No. 4. P. 5-10. (In Russ.).
  3. Natsional'noe rukovodstvo po radionuklidnoi diagnostike. In: Lishmanova Yu.B., Chernova V.I. (eds.). Vol. 2. Tomsk: STT. 2010. 418 p. (In Russ.).
  4. Afanas'ev S.G., Avgustinovich A.V., Chernov V.I., Sinilkin I.G. Vozmozhnosti opredeleniya storozhevykh limfaticheskikh uzlov u bol'nykh rakom zheludka. Sib. onkol. zhurnal. Vol. 29. No. 4. P. 27-31. (In Russ.).
  5. Jimenez I.R., Roca M., Vega E. et al. Particle sizes of colloids to be used in sentinel lymph node radio localization . Nucl. Med. Commun. 2008. Vol. 29. P. 166-172
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For citation: Chernov VI, Sinilkin IG, Zelchan RV, Medvedeva AA, Lyapunov AYu, Bragina OD, Varlamova NV, Skuridin VS. Experimental Study of the Possibility of Using a New Radiopharmaceutical 99mТс-Al2O3 for Imaging Sentinel Lymph Nodes. Medical Radiology and Radiation Safety. 2016;61(6):68-71. Russian.

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Medical Radiology and Radiation Safety. 2016. Vol. 61.  No. 6. P. 57-63

RADIATION THERAPY

S.S. Gordeyev, V.A. Ivanov, A.O. Rasulov, Yu.A. Barsukov, S.I. Tkachev, Yu.E. Surayeva, M.V. Chernykh, D.V. Kuzmichev, E.N. Kozak, A.G. Malikhov, J.M. Madyarov

Chemoradiotherapy in Complicated Locally Advanced or Recurrent Rectal Cancer Treatment

N.N. Blokhin Russian Cancer Research Center of RAMS, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Purpose: To investigate the toxicity and feasibility of chemoradiotherapy in patients with complicated locally advanced or recurrent rectal cancer.

Material and methods: Patients who received chemoradiotherapy during 2005–2015 for locally advanced or recurrent rectal cancer with fistulas and/or peritumoral abscesses were included in a retrospective analysis. The control group consisted of patients with uncomplicated мsub>4NxM0 rectal cancer. Endpoints included chemoradiotherapy toxicity, R0 resections rate, postoperative morbidity, pathologic complete response rate.

Results: Grade 3-4 toxicity was recorded in 3 (14.3 %) patients in both groups (study group G4 in 1 patient and G3 in 2 patients, control group G3 in 3 patients, p = 0.267). No difference in the incidence of complications of chemoradiotherapy between groups were observed (p = 0,267). Postoperative complications Grade IIIb in the study group occurred in 1 patient (5.5 %), and in 1 patient in the control group (5.5 %). Overall morbidity was similar in both groups (p = 0.293). R0 resection was intended in 18 patients in both groups and performed in 16 (88.8 %) patients in the study group and in 18 (100 %) in control group. pCR was observed in 3 patients in the study group (17.6 %) and in 1 patient (5,2 %) in control group, p = 0,137.

Conclusion: chemoradiotherapy in patients with complicated locally advanced cancer does not lead to a significant increase in toxicity, allowing R0 resection to be performed to the majority of patients after treatment without increase in morbidity.

Key words: rectal cancer, complicated, fistula, chemoradiotherapy, toxicity

REFERENCES

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For citation: Gordeyev SS, Ivanov VA, Rasulov AO, Barsukov YuA, Tkachev SI, Surayeva YuE, Chernykh MV, Kuzmichev DV, Kozak EN, Malikhov AG, Madyarov JM. Chemoradiotherapy in Complicated Locally Advanced or Recurrent Rectal Cancer Treatment. Medical Radiology and Radiation Safety. 2016;61(6):57-63. Russian.

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Medical Radiology and Radiation Safety. 2017. Vol. 62. No. 5. P. 72-83

CHRONICLE

DOI: 10.12737/article_59f30bf2d97d38.88277766

Results of the 64th Session of the United Nations Scientific Committee on the Effects of the Atomic Radiation (UNSCEAR) (Vienna, 29 May – 2 June, 2017)

V.V. Uyba1, A.V. Akleyev2,3, T.V. Azizova4, S.A. Geras’kin5, V.K. Ivanov6, D.F. Ilyasov7, L.A. Karpikova1, A.N. Koterov8, A.I. Kryshev9, S.G. Mikheyenko10, S.A. Romanov4, V.Yu. Usoltsev10, S.M. Shinkarev8

1. Federal Medical and Biological Agency, Moscow.

2. Urals Research Center for Radiation Medicine of the Federal Medical and Biological Agency of Russia, Chelyabinsk.

3. Chelyabinsk State University, Chelyabinsk.

4. Southern Urals Biophysics Institute of Federal Medical and Biological Agency, Ozyorsk, Chelyabinsk Oblast.

5. Russian Institute of Radiology and Agroecology, Obninsk.

6. A. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk.

7. Nuclear Safety Institute of the Russian Academy of Sciences, Moscow.

8. A.I. Burnasyan Federal Medical Biophysical Center of Federal Medical and Biological Agency, Moscow.

9. Research and Production Association “Typhoon” of Roshydromet, Obninsk.

10. State Atomic Energy Corporation “ROSATOM”, Moscow

V.V. Uyba – Head of the Medical and Biological Agency (FMBA of Russia), Dr. Sc. Med., Prof.; A.V. Akleyev – Director of the Urals Research Center for Radiation Medicine, Dr. Sc. Med., Prof.; T.V. Azizova – Deputy Director of Southern Ural Biophysics Institute (SIBI), PhD Med.; S.A. Geras’kin – Head of Laboratory at Russian Institute of Agricultural Radiology and Agroecology, Dr. Sc. Biol., Prof.; V.K. Ivanov – Deputy Director of A. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Dr. Sc. Tech., Prof., Corr. Member of RAS; D.F. Ilyasov – Research worker of the Nuclear Safety Institute of the Russian Academy of Sciences (IBRAE RAN), PhD Econ.; L.A. Karpikova – Head of International Department of FMBA of Russia; A.N. Koterov – Head of Laboratory of the A.I. Burnazyan Federal Medical and Biophysical Center (FMBC) of FMBA of Russia, Dr. Sc. Biol.; A.I. Kryshev –Head of Laboratory, Research and Production Association “Typhoon”, Dr. Sc. Biol.; S.G. Mikheenko – Section Head of State Atomic Energy Corporation “ROSATOM”, S.A. Romanov – Director of Southern Ural Biophysics Institute (SUBI), PhD Biol.; V.Yu. Usoltsev – Chief specialist of the State Atomic Energy Corporation “ROSATOM”; S.M. Shinkarev – Head of Department of the A.I. Burnazyan Federal Medical and Biophysical Center (FMBC) of the FMBA of Russia, Dr. Sc. Tech.

Abstract

The present article is devoted to the main outcomes of the 64th UNSCEAR Session which took place in Vienna during 29 May – 2 June 2017. Within the framework of the meetings of the Working group and subgroups the documents on the following projects were discussed:

– Quality criteria for the Committee’s reviews of epidemiological studies;

– Epidemiological studies of cancer risk due to low dose-rate radiation from environmental sources including the scientific view of the Committee on the dose and dose rate effectiveness factor;

– Biological mechanisms influencing health effects from low-dose radiation exposure;

– Developments since the 2013 UNSCEAR report on the levels and effects of radiation exposure due to the nuclear accident following the great East-Japan earthquake and tsunami: review of 2016 scientific literature including an evaluation of thyroid cancer data in regions affected by the Chernobyl accident;

– Exposure of patients to ionizing radiation;

– Exposure of workers to ionizing radiation;

– Selected evaluations of health effects and of risk inference due to radiation exposure;

Lung cancer from exposure to radon and to penetrating radiation. In course of the discussion some organizational issues such as preparation of UNSCEAR publications, feasibility of establishing Standing Working Groups, public relations work, future research program, report to the General Assembly etc., were considered.

Key words: 64-th UNSCEAR Session, low doses, biological effects, epidemiology, medical exposure, occupational exposure

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For citation: Uyba VV, Akleyev AV, Azizova TV, Geras’kin SA, Ivanov VK, Ilyasov DF, Karpikova LA, Koterov AN, Kryshev AI, Mikheyenko SG, Romanov SA, Usoltsev VYu, Shinkarev SM. Results of the 64th Session of the United Nations Scientific Committee on the Effects of the Atomic Radiation (UNSCEAR) (Vienna, 29 May – 2 June, 2017). Medical Radiology and Radiation Safety. 2017;62(5):72-83. Russian. DOI: 10.12737/article_59f30bf2d97d38.88277766

PDF (RUS) Full-text article (in Russian)

  1. 2017-5-Kurpeshev-eng
  2. 2017-5-Klimanov-eng
  3. 2017-5-Filatova-eng
  4. 2017-5-Ryjkov-eng

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